Spice phenolics inhibit human PMNL 5-lipoxygenase

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 70, Issue 6, 2004, Pages 521-528

  Satya Prasad, N ^a   Raghavendra, R ^a   Lokesh, B R ^a   Akhilender Naidu, K ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

5 Lipoxygenase; Inhibition; PMNL cells; Spice active principles; Spice aqueous extracts

Indexed keywords

ALLYL SULFIDE; ARACHIDONATE 5 LIPOXYGENASE; CAPSAICIN; CINNAMALDEHYDE; CLOVE OIL; CURCUMIN; EUGENOL; LEUKOTRIENE; ONION EXTRACT; PHENOL DERIVATIVE; PIPERINE; QUERCETIN;

ARTICLE; BIOSYNTHESIS; CINNAMON; CONTROLLED STUDY; CORRELATION ANALYSIS; CURCUMA LONGA; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; ONION; PEPPER; PRIORITY JOURNAL; SPECTROFLUOROMETRY; SPICE;

ALLIUM CEPA; CINNAMOMUM VERUM; CURCUMA LONGA; SIGANUS;

EID: 2442617110     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2003.11.006     Document Type: Article

References (31)

1. Ach.P. Reddy, B.R. Lokesh, Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes, Mol. Cell. Biochem. 111 (1992) 117-124.
2. K.A. Naidu, Eugenol: an inhibitor of lipoxygenase dependent lipid peroxidation, Prostaglandins Leukot. Essent. Fatty Acids 53 (1995) 381-384.
3. H.L. Madsen, B.R. Nielsen, G. Bertelsen, L.H. Skibsted, Screening of antioxidative activity of spices: a comparison between assays based on ESR spin trapping and electrochemical measurement of oxygen consumption. Food Chem. 57 (1996) 331-337.
4. S. Shobana, K.A. Naidu, Antioxidant activity of selected Indian Spices, Prostaglandins Leukot. Essent. Fatty acids 62 (2000) 107-110.
5. Ach.P. Reddy, B.R. Lokesh, Studies on anti inflammatory activity of spice principles and dietary n-3 polyunsaturated fatty acids on carrageenan induced inflammation in rats, Ann. Nutr. Metab. 38 (1994) 343-358.
6. Muralidhara, K. Narasimhamurthi, Non-mutagenicity of capsaicin in albino mice, Food Chem. Toxicol. 26 (1988) 955-958.
7. L.G. Menon, R. Kuttan, G. Kuttan, Anti-metastatic activity of curcumin and catechin, Cancer Lett. 141 (1999) 159-165.
8. H. Chen, Z.S. Zhang, Y.L. Zhang, D.Y. Zhou, Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells, Anticancer Res. 19 (1999) 3675-3680.
9. B. Joe, U.J.S.P. Rao, B.R. Lokesh, Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin, Mol. Cell. Biochem. 169 (1997) 125-134.
10. A. Boyum, Isolation of lymphocytes, granulocytes and macrophages, Scand. J. Immunol. Suppl. 5 (1976) 9-15.
11. O.H. Lowry, N.J. Rosebrough, A. Farr, R.J. Randall, Protein measurement with the folin phenol reagent, J. Biol. Chem. 143 (1951) 265-271.
12. D. Aharony, R.L. Stein, Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase, J. Biol. Chem. 261 (1986) 11512-11519.
13. J.R. Cashman, Leukotriene biosynthesis inhibitors, Pharma. Res. 5 (1985) 253-261.
14. R.A. Lewis, K.R. Austen, R.J. Soberman, Leukotrienes and other products of 5-lipoxygenase pathway. Biochemistry and relation to pathobiology of human disease, N. Engl. J. Med. 323 (1990) 645-655.
15. J.R. Harris, Rheumatoid arthritis: pathophysiology and implications for therapy, N. Engl. J. Med. 322 (1990) 1277-1289.
16. R.A. Watts, J.D.L. Isaac, Immunotherapy of rheumatoid arthritis, Ann. Rheum. Dis. Sci. 51 (1992) 577-580.
17. M.J. Laughton, P.J. Evans, M.A. Moroney, J.R.S. Hoult, B. Halliwell, Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary compounds, Biochem. Pharmacol. 43 (1991) 1673-1681.
18. Y. Hsuanyu, H.P. Dunfond, Prostaglandin H synthase kinetics. The effect of substituted phenols on cyclooxygenase activity, The substituent effect on phenolic peroxidation activity, J. Biol. Chem. 267 (1992) 17649-17657.
19. J. Alanko, A. Riutta, I. Mucha, H. Vapatalo, F. Mesjii-Ketela, Modulation of arachidonic acid metabolism by phenols: relation to phenols of hydroxyl groups and peroxyl radical scavenging properties, Free Radic. Biol. Med. 14 (1993) 19-25.
20. J. Alanko, A. Riutta, P. Holm, I. Mucha, H. Vapaatalo, F. Mesa-Ketela, Modulation of arachidonic acid metabolism by phenols: relation to their structure and antioxidant/prooxidant properties, Free Radic. Biol. Med. 26 (1999) 193-201.
21. A. Altmann, O. Werz, M. Steinhilber, M. Schubert-Zsilavecz, Natural compounds as non-redox inhibitors of 5-lipoxygenase, Eur. J. Pharm. Sci. 11 (2000) S75.
22. V.E. Thody, D.R. Buckle, K.A. Foster, Studies on antioxidant activity of 5-lipoxygenase inhibitors, J. Med. Chem. 15 (1987) 416-417.
23. T.F. Slater, K.H. Cheeseman, M.J. Davies, M. Hayashi, O.P. Sharma, S. Nigam, C. Benedetto, Free radical scavenging properties of modulators of eicosanoid metabolism, Adv. Prostaglandin Thromboxane Res. 17 (1987) 1098-1120.
24. U. Takahama, Inhibition of lipoxygenase dependent lipid peroxidation by quercetin: mechanism of antioxidative function, Phytochemistry 24 (1985) 1443-1446.
25. C. Torel, J. Cillard, P. Cillard, Antioxidative activity of flavonoids and reactivity with peroxy radical, Phytochemistry 25 (1986) 383-385.
26. C. Kemal, P. Louis-Flamber, R. Kruponksi-Olsen, A.L. Shorter, Reductive inactivation of soybean lipoxygenase I by catechol a possible mechanism for regulation of lipoxygenase activity, Biochemistry 26 (1987) 7064-7072.
27. M.J. Nelson, D.G. Batt, J.S. Thompson, S.W. Wright, Reduction of active site iron by potent inhibitors of soybean lipoxygenase, FEBS Lett. 204 (1986) 293-296.
28. K.A. Naidu, N.B. Thippeswamy, Inhibition of human low density lipoprotein oxidation by active principles from spices, Mol. Cell. Biochem. 229 (2002) 19-23.
29. M.T. Fernandez, M.L. Mira, M.H. Florencio, K.R. Jennings, Iron and copper chelation by flavonoids: an electronspray mass spectrometry study, J. Inorg. Biochem. 92 (2002) 105-111.
30. B. Joe, B.R. Lokesh, Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages, Lipids 32 (1997) 1173-1180.
31. K.C. Srivastava, A. Bordia, S.K. Verma, Curcumin a major component of food spice turmeric (Curcumin longa) inhibits aggregation of alters eicosanoid metabolism in human blood platelets, Prostaglandins Leukot. Essent. Fatty Acids 52 (1995) 223-225.