Clinical review: Practical approach to hyponatraemia and hypernatraemia in critically ill patients

Critical Care

Volumn 17, Issue 1, 2012, Pages

  Overgaard Steensen, Christian ^a,b   Ring, Troels ^c  

^a University of Copenhagen   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYROPHENONE DERIVATIVE; CARBAMAZEPINE; CLOFIBRATE; CYCLOPHOSPHAMIDE; DESMOPRESSIN; DULOXETINE; HYPERTONIC SOLUTION; IFOSFAMIDE; INDAPAMIDE; MIRTAZAPINE; NICOTINE; NONSTEROID ANTIINFLAMMATORY AGENT; OXCARBAZEPINE; OXYTOCIN; PHENOTHIAZINE; SEROTONIN UPTAKE INHIBITOR; SODIUM; THIAZIDE DIURETIC AGENT; VALPROIC ACID; VASOPRESSIN; VENLAFAXINE; VINCRISTINE; VORICONAZOLE; DIURETIC AGENT; VASOPRESSIN DERIVATIVE;

ADULT; CASE REPORT; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ELECTROLYTE BALANCE; HUMAN; HYPERNATREMIA; HYPONATREMIA; HYPOVOLEMIA; INAPPROPRIATE VASOPRESSIN SECRETION; MALE; MEDICAL DECISION MAKING; PRIORITY JOURNAL; PROGNOSIS; REVIEW; WATER DEFICIT; COMPLICATION; CRITICAL ILLNESS; DECISION SUPPORT SYSTEM; DIURESIS; HYPOTHYROIDISM; IATROGENIC DISEASE; PLASMA VOLUME;

CRITICAL ILLNESS; DECISION SUPPORT TECHNIQUES; DIURESIS; DIURETICS; HUMANS; HYPERNATREMIA; HYPONATREMIA; HYPOTHYROIDISM; IATROGENIC DISEASE; INAPPROPRIATE ADH SYNDROME; PLASMA VOLUME; SODIUM CHLORIDE SYMPORTER INHIBITORS; VASOPRESSINS;

EID: 84874378540     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11805     Document Type: Review

References (112)

1. Funk GC, Lindner G, Druml W, Metnitz B, Schwarz C, Bauer P, Metnitz PG. Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med 2010, 36:304-311. 10.1007/s00134-009-1692-0, 19847398.
2. Lindner G, Funk GC, Schwarz C, Kneidinger N, Kaider A, Schneeweiss B, Kramer L, Druml W. Hypernatremia in the critically ill is an independent risk factor for mortality. Am J Kidney Dis 2007, 50:952-957. 10.1053/j.ajkd.2007.08.016, 18037096.
3. Stelfox HT, Ahmed SB, Khandwala F, Zygun D, Shahpori R, Laupland K. The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care units. Crit Care 2008, 12:R162. 10.1186/cc7162, 2646327, 19094227.
4. Darmon M, Timsit JF, Francais A, Nguile-Makao M, Adrie C, Cohen Y, Garrouste-Orgeas M, Goldgran-Toledano D, Dumenil AS, Jamali S, Cheval C, Allaouchiche B, Souweine B, Azoulay E. Association between hypernatraemia acquired in the ICU and mortality: a cohort study. Nephrol Dial Transplant 2010, 25:2510-2515. 10.1093/ndt/gfq067, 20167570.
5. DeVita MV, Gardenswartz MH, Konecky A, Zabetakis PM. Incidence and etiology of hyponatremia in an intensive care unit. Clin Nephrol 1990, 34:163-166.
6. Hoorn EJ, Betjes MG, Weigel J, Zietse R. Hypernatraemia in critically ill patients: too little water and too much salt. Nephrol Dial Transplant 2008, 23:1562-1568. 10.1093/ndt/gfm831, 18065827.
7. Aiyagari V, Deibert E, Diringer MN. Hypernatremia in the neurologic intensive care unit: how high is too high?. J Crit Care 2006, 21:163-172. 10.1016/j.jcrc.2005.10.002, 16769461.
8. Polderman KH, Schreuder WO, Strack van Schijndel RJ, Thijs LG. Hypernatremia in the intensive care unit: an indicator of quality of care?. Crit Care Med 1999, 27:1105-1108. 10.1097/00003246-199906000-00029, 10397213.
9. Kovesdy CP, Lott EH, Lu JL, Malakauskas SM, Ma JZ, Molnar MZ, Kalantar-Zadeh K. Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure. Circulation 2012, 125:677-684. 10.1161/CIRCULATIONAHA.111.065391, 3294276, 22223429.
10. Overgaard-Steensen C. Initial approach to the hyponatremic patient. Acta Anaesthesiol Scand 2011, 55:139-148. 10.1111/j.1399-6576.2010.02311.x, 21029052.
11. Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical inpatients: aetiology, assessment and outcome. QJM 2006, 99:505-511. 10.1093/qjmed/hcl071, 16861720.
12. Huda MS, Boyd A, Skagen K, Wile D, van HC, Watson I, Wong S, Gill G. Investigation and management of severe hyponatraemia in a hospital setting. Postgrad Med J 2006, 82:216-219. 10.1136/pmj.2005.036947, 2563697, 16517805.
13. Edelman IS, Leibman J, O'Meara MP, Birkenfeld LW. Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest 1958, 37:1236-1256. 10.1172/JCI103712, 1062793, 13575523.
14. Overgaard-Steensen C, Larsson A, Bluhme H, Tonnesen E, Frokiaer J, Ring T. Edelman's equation is valid in acute hyponatremia in a porcine model: plasma sodium concentration is determined by external balances of water and cations. Am J Physiol Regul Integr Comp Physiol 2010, 298:R120-R129. 10.1152/ajpregu.00412.2009, 19864338.
15. Rose BD. New approach to disturbances in the plasma sodium concentration. Am J Med 1986, 81:1033-1040. 10.1016/0002-9343(86)90401-8, 3799631.
16. Mallie JP, Ait-Djaffer Z, Laroche F, Mario J, Perrier JC, Voltz C, Halperin ML. Variations in plasma sodium concentration in post-operative patients depend on an electrolyte-free water balance, part of a tonicity balance. Clin Nephrol 1998, 49:287-292.
17. Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med 1999, 106:399-403. 10.1016/S0002-9343(99)00055-8, 10225241.
18. Baylis PH. Osmoregulation and control of vasopressin secretion in healthy humans. Am J Physiol 1987, 253:R671-R678.
19. Schrier RW. An odyssey into the milieu interieur: pondering the enigmas. J Am Soc Nephrol 1992, 2:1549-1559.
20. Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D. Physiology and pathophysiology of renal aquaporins. J Am Soc Nephrol 1999, 10:647-663.
21. Lindner G, Kneidinger N, Holzinger U, Druml W, Schwarz C. Tonicity balance in patients with hypernatremia acquired in the intensive care unit. Am J Kidney Dis 2009, 54:674-679. 10.1053/j.ajkd.2009.04.015, 19515476.
22. Overgaard-Steensen C, Stodkilde-Jorgensen H, Larsson A, Broch-Lips M, Tonnesen E, Frokiaer J, Ring T. Regional differences in osmotic behavior in brain during acute hyponatremia: an in vivo MRI-study of brain and skeletal muscle in pigs. Am J Physiol Regul Integr Comp Physiol 2010, 299:R521-R532. 10.1152/ajpregu.00139.2010, 20445159.
23. Verbalis JG, Gullans SR. Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats. Brain Res 1991, 567:274-282. 10.1016/0006-8993(91)90806-7, 1817731.
24. Pedersen TH, de PF, Nielsen OB. Increased excitability of acidified skeletal muscle: role of chloride conductance. J Gen Physiol 2005, 125:237-246. 10.1085/jgp.200409173, 2217490, 15684096.
25. Sjoblom E, Hojer J, Ludwigs U, Pirskanen R. Fatal hyponatraemic brain oedema due to common gastroenteritis with accidental water intoxication. Intensive Care Med 1997, 23:348-350. 10.1007/s001340050340, 9083241.
26. Vexler ZS, Ayus JC, Roberts TP, Fraser CL, Kucharczyk J, Arieff AI. Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J Clin Invest 1994, 93:256-264. 10.1172/JCI116953, 293760, 8282795.
27. Battison C, Andrews PJ, Graham C, Petty T. Randomized, controlled trial on the effect of a 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med 2005, 33:196-202. 10.1097/01.CCM.0000150269.65485.A6, 15644669.
28. Sarnaik AP, Meert K, Hackbarth R, Fleischmann L. Management of hyponatremic seizures in children with hypertonic saline: a safe and effective strategy. Crit Care Med 1991, 19:758-762. 10.1097/00003246-199106000-00005, 2055051.
29. Worthley LI, Thomas PD. Treatment of hyponatraemic seizures with intravenous 29.2% saline. Br Med J (Clin Res Ed) 1986, 292:168-170. 10.1136/bmj.292.6514.168, 1339038, 3080118.
30. Wright WL. Sodium and fluid management in acute brain injury. Curr Neurol Neurosci Rep 2012, 12:466-473. 10.1007/s11910-012-0284-5, 22622407.
31. Wijdicks EF, Sharbrough FW. New-onset seizures in critically ill patients. Neurology 1993, 43:1042-1044. 10.1212/WNL.43.5.1042, 8492924.
32. Murphy N, Auzinger G, Bernel W, Wendon J. The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure. Hepatology 2004, 39:464-470. 10.1002/hep.20056, 14767999.
33. Tuttolomondo A, Pinto A, Parrinello G, Licata G. Intravenous high-dose furosemide and hypertonic saline solutions for refractory heart failure and ascites. Semin Nephrol 2011, 31:513-522. 10.1016/j.semnephrol.2011.09.006, 22099508.
34. Cansick J, Rees L, Koffman G, Van't Hoff W, Bockenhauer D. A fatal case of cerebral oedema with hyponatraemia and massive polyuria after renal transplantation. Pediatr Nephrol 2009, 24:1231-1234. 10.1007/s00467-008-1100-y, 19153773.
35. Baran D, Hutchinson TA. The outcome of hyponatremia in a general hospital population. Clin Nephrol 1984, 22:72-76.
36. Hew-Butler T, Ayus JC, Kipps C, Maughan RJ, Mettler S, Meeuwisse WH, Page AJ, Reid SA, Rehrer NJ, Roberts WO, Rogers IR, Rosner MH, Siegel AJ, Speedy DB, Stuempfle KJ, Verbalis JG, Weschler LB, Wharam P. Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007. Clin J Sport Med 2008, 18:111-121. 10.1097/JSM.0b013e318168ff31, 18332684.
37. Arieff AI, Llach F, Massry SG. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore) 1976, 55:121-129. 10.1097/00005792-197603000-00002, 1256311.
38. Restuccia T, Gómez-Ansón B, Guevara M, Alessandria C, Torre A, Alayrach ME, Terra C, Martín M, Castellví M, Rami L, Sainz A, Ginès P, Arroyo V. Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis. Hepatology 2004, 39:1613-1622. 10.1002/hep.20237, 15185302.
39. Videen JS, Michaelis T, Pinto P, Ross BD. Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study. J Clin Invest 1995, 95:788-793. 10.1172/JCI117728, 295555, 7860762.
40. Tomlinson BE, Pierides AM, Bradley WG. Central pontine myelinolysis. Two cases with associated electrolyte disturbance. Q J Med 1976, 45:373-386.
41. Sterns RH, Riggs JE, Schochet SS. Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med 1986, 314:1535-1542. 10.1056/NEJM198606123142402, 3713747.
42. Brunner JE, Redmond JM, Haggar AM, Kruger DF, Elias SB. Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. Ann Neurol 1990, 27:61-66. 10.1002/ana.410270110, 2301929.
43. Sterns RH, Cappuccio JD, Silver SM, Cohen EP. Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective. J Am Soc Nephrol 1994, 4:1522-1530.
44. Mount DB. The brain in hyponatremia: both culprit and victim. Semin Nephrol 2009, 29:196-215. 10.1016/j.semnephrol.2009.03.021, 19523569.
45. Lohr JW. Osmotic demyelination syndrome following correction of hyponatremia: association with hypokalemia. Am J Med 1994, 96:408-413. 10.1016/0002-9343(94)90166-X, 8192171.
46. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med 2000, 342:1581-1589. 10.1056/NEJM200005253422107, 10824078.
47. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH. Hyponatremia treatment guidelines 2007: expert panel recommendations. Am J Med 2007, 120:S1-21.
48. Bissram M, Scott FD, Liu L, Rosner MH. Risk factors for symptomatic hyponatraemia: the role of pre-existing asymptomatic hyponatraemia. Intern Med J 2007, 37:149-155. 10.1111/j.1445-5994.2006.01294.x, 17316332.
49. Lin CM, Po HL. Extrapontine myelinolysis after correction of hyponatremia presenting as generalized tonic seizures. Am J Emerg Med 2008, 26:632-636.
50. Vu T, Wong RF, Hamblin PS, Zajac JF, Grossmann MF. Patients presenting with severe hypotonic hyponatremia: etiological factors, assessment, and outcomes. Hosp Pract (Minneap) 2009, 37:128-136.
51. Sterns RH, Nigwekar SU, Hix JK. The treatment of hyponatremia. Semin Nephrol 2009, 29:282-299. 10.1016/j.semnephrol.2009.03.002, 19523575.
52. Moritz ML, Ayus JC. 100 cc 3% sodium chloride bolus: a novel treatment for hyponatremic encephalopathy. Metab Brain Dis 2010, 25:91-96. 10.1007/s11011-010-9173-2, 20221678.
53. Liamis G, Kalogirou M, Saugos V, Elisaf M. Therapeutic approach in patients with dysnatraemias. Nephrol Dial Transplant 2006, 21:1564-1569. 10.1093/ndt/gfk090, 16449285.
54. Perianayagam A, Sterns RH, Silver SM, Grieff M, Mayo R, Hix J, Kouides R. DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol 2008, 3:331-336. 10.2215/CJN.03190807, 2390955, 18235152.
55. Ostermann M, Dickie H, Tovey L, Treacher D. Management of sodium disorders during continuous haemofiltration. Crit Care 2010, 14:418. 10.1186/cc9002, 2911705, 20519032.
56. Wendland EM, Kaplan AA. A proposed approach to the dialysis prescription in severely hyponatremic patients with end-stage renal disease. Semin Dial 2012, 25:82-85. 10.1111/j.1525-139X.2011.00981.x, 21906168.
57. Chung HM, Kluge R, Schrier RW, Anderson RJ. Clinical assessment of extracellular fluid volume in hyponatremia. Am J Med 1987, 83:905-908. 10.1016/0002-9343(87)90649-8, 3674097.
58. Hoyle GE, Chua M, Soiza RL. Volaemic assessment of the elderly hyponatraemic patient: reliability of clinical assessment and validation of bioelectrical impedance analysis. QJM 2011, 104:35-39. 10.1093/qjmed/hcq157, 20823196.
59. Shapiro DS, Sonnenblick M, Galperin I, Melkonyan L, Munter G. Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome. Intern Med J 2010, 40:574-580. 10.1111/j.1445-5994.2010.02217.x, 20298512.
60. Fenske W, Maier SK, Blechschmidt A, Allolio B, Stork S. Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. Am J Med 2010, 123:652-657. 10.1016/j.amjmed.2010.01.013, 20609688.
61. Sanghvi SR, Kellerman PS, Nanovic L. Beer potomania: an unusual cause of hyponatremia at high risk of complications from rapid correction. Am J Kidney Dis 2007, 50:673-680. 10.1053/j.ajkd.2007.07.015, 17900468.
62. Kamel KS, Halperin ML. Managing overly rapid correction of chronic hyponatremia: an ounce of prevention or a pound of cure. J Am Soc Nephrol 2010, 21:2015-2016. 10.1681/ASN.2010101062, 21071525.
63. Glover M, Clayton J. Thiazide-induced hyponatraemia: epidemiology and clues to pathogenesis. Cardiovasc Ther 2012, 30:e219-226. 10.1111/j.1755-5922.2011.00286.x, 21884020.
64. Steele A, Gowrishankar M, Abrahamson S, Mazer CD, Feldman RD, Halperin ML. Postoperative hyponatremia despite near-isotonic saline infusion: a phenomenon of desalination. Ann Intern Med 1997, 126:20-25.
65. Clark BA, Shannon RP, Rosa RM, Epstein FH. Increased susceptibility to thiazide-induced hyponatremia in the elderly. J Am Soc Nephrol 1994, 5:1106-1111.
66. Friedman E, Shadel M, Halkin H, Farfel Z. Thiazide-induced hyponatremia. Reproducibility by single dose rechallenge and an analysis of pathogenesis. Ann Intern Med 1989, 110:24-30.
67. Lee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation 1986, 73:257-267. 10.1161/01.CIR.73.2.257, 3002660.
68. Schrier RW. Use of diuretics in heart failure and cirrhosis. Semin Nephrol 2011, 31:503-512. 10.1016/j.semnephrol.2011.09.005, 22099507.
69. Konstam MA, Gheorghiade M, Burnett JC, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Cook T, Ouyang J, Zimmer C, Orlandi C, . Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA 2007, 297:1319-1331. 10.1001/jama.297.12.1319, 17384437, Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators.
70. Cho C, Logan JL, Lien YH. Massive aquaresis after tolvaptan administration and albumin infusion in a patient with alcoholic cirrhosis. Am J Med 2012, 125:e5-e6.
71. Hew-Butler T. Arginine vasopressin, fluid balance and exercise: is exercise-associated hyponatraemia a disorder of arginine vasopressin secretion. Sports Med 2010, 40:459-479. 10.2165/11532070-000000000-00000, 20524712.
72. Singh S, Bohn D, Carlotti AP, Cusimano M, Rutka JT, Halperin ML. Cerebral salt wasting: truths, fallacies, theories, and challenges. Crit Care Med 2002, 30:2575-2579. 10.1097/00003246-200211000-00028, 12441772.
73. Moritz ML. Syndrome of inappropriate antidiuresis and cerebral salt wasting syndrome: are they different and does it matter. Pediatr Nephrol 2012, 27:689-693. 10.1007/s00467-012-2112-1, 22358189.
74. Connolly ES, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P, . American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2012, 43:1711-1737. 10.1161/STR.0b013e3182587839, 22556195, American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology.
75. Luft FC, Rankin LI, Bloch R, Weyman AE, Willis LR, Murray RH, Grim CE, Weinberger MH. Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men. Circulation 1979, 60:697-706. 10.1161/01.CIR.60.3.697, 455628.
76. Andersen LJ, Andersen JL, Pump B, Bie P. Natriuresis induced by mild hypernatremia in humans. Am J Physiol Regul Integr Comp Physiol 2002, 282:R1754-R1761.
77. Yee AH, Burns JD, Wijdicks EF. Cerebral salt wasting: pathophysiology, diagnosis, and treatment. Neurosurg Clin N Am 2010, 21:339-352. 10.1016/j.nec.2009.10.011, 20380974.
78. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007, 356:2064-2072. 10.1056/NEJMcp066837, 17507705.
79. Fenske W, Stork S, Koschker AC, Blechschmidt A, Lorenz D, Wortmann S, Allolio B. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab 2008, 93:2991-2997. 10.1210/jc.2008-0330, 18477658.
80. Maesaka JK, Imbriano LJ, Ali NM, Ilamathi E. Is it cerebral or renal salt wasting. Kidney Int 2009, 76:934-938. 10.1038/ki.2009.263, 19641485.
81. Sterns RH, Silver SM. Cerebral salt wasting versus SIADH: what difference. J Am Soc Nephrol 2008, 19:194-196. 10.1681/ASN.2007101118, 18216309.
82. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med 2005, 352:1884-1890. 10.1056/NEJMoa042743, 15872203.
83. Smith D, Moore K, Tormey W, Baylis PH, Thompson CJ. Downward resetting of the osmotic threshold for thirst in patients with SIADH. Am J Physiol Endocrinol Metab 2004, 287:E1019-E1023. 10.1152/ajpendo.00033.2004, 15213060.
84. McKinley MJ, Johnson AK. The physiological regulation of thirst and fluid intake. News Physiol Sci 2004, 19:1-6.
85. Anderson RJ, Chung HM, Kluge R, Schrier RW. Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med 1985, 102:164-168.
86. Decaux G. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Semin Nephrol 2009, 29:239-256. 10.1016/j.semnephrol.2009.03.005, 19523572.
87. Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 1957, 23:529-542. 10.1016/0002-9343(57)90224-3, 13469824.
88. Fenske W, Allolio B. The syndrome of inappropriate secretion of antidiuretic hormone: diagnostic and therapeutic advances. Horm Metab Res 2010, 42:691-702. 10.1055/s-0030-1255117, 20607641.
89. Decaux G, Andres C, Gankam KF, Soupart A. Treatment of euvolemic hyponatremia in the intensive care unit by urea. Crit Care 2010, 14:R184. 10.1186/cc9292, 3219290, 20946646.
90. Soupart A, Penninckx R, Stenuit A, Decaux G. Azotemia (48 h) decreases the risk of brain damage in rats after correction of chronic hyponatremia. Brain Res 2000, 852:167-172. 10.1016/S0006-8993(99)02259-3, 10661508.
91. Gross PA, Wagner A, Decaux G. Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet. Kidney Int 2011, 80:594-600. 10.1038/ki.2011.78, 21451459.
92. Kamoi K, Tamura T, Tanaka K, Ishibashi M, Yamaji T. Hyponatremia and osmoregulation of thirst and vasopressin secretion in patients with adrenal insufficiency. J Clin Endocrinol Metab 1993, 77:1584-1588. 10.1210/jc.77.6.1584, 8263145.
93. Yamamoto T, Fukuyama J, Kabayama Y, Harada H. Dual facets of hyponatraemia and arginine vasopressin in patients with ACTH deficiency. Clin Endocrinol (Oxf) 1998, 49:785-792. 10.1046/j.1365-2265.1998.00621.x, 10209567.
94. Arlt W, Allolio B. Adrenal insufficiency. Lancet 2003, 361:1881-1893. 10.1016/S0140-6736(03)13492-7, 12788587.
95. Liamis G, Milionis HJ, Elisaf M. Endocrine disorders: causes of hyponatremia not to neglect. Ann Med 2011, 43:179-187. 10.3109/07853890.2010.530680, 20964584.
96. Park CW, Shin YS, Ahn SJ, Kim SY, Choi EJ, Chang YS, Bang BK. Thyroxine treatment induces upregulation of renin-angiotensin-aldosterone system due to decreasing effective plasma volume in patients with primary myxoedema. Nephrol Dial Transplant 2001, 16:1799-1806. 10.1093/ndt/16.9.1799, 11522861.
97. Liamis G, Tsimihodimos V, Doumas M, Spyrou A, Bairaktari E, Elisaf M. Clinical and laboratory characteristics of hypernatraemia in an internal medicine clinic. Nephrol Dial Transplant 2008, 23:136-143.
98. Moritz ML, Ayus JC. Preventing neurological complications from dysnatremias in children. Pediatr Nephrol 2005, 20:1687-1700. 10.1007/s00467-005-1933-6, 16079988.
99. Chassagne P, Druesne L, Capet C, Menard JF, Bercoff E. Clinical presentation of hypernatremia in elderly patients: a case control study. J Am Geriatr Soc 2006, 54:1225-1230. 10.1111/j.1532-5415.2006.00807.x, 16913989.
100. Palevsky PM, Bhagrath R, Greenberg A. Hypernatremia in hospitalized patients. Ann Intern Med 1996, 124:197-203.
101. Lindner G, Schwarz C, Funk GC. Osmotic diuresis due to urea as the cause of hypernatraemia in critically ill patients. Nephrol Dial Transplant 2012, 27:962-967. 10.1093/ndt/gfr428, 21810766.
102. Raman A, Schoeller DA, Subar AF, Troiano RP, Schatzkin A, Harris T, Bauer D, Bingham SA, Everhart JE, Newman AB, Tylavsky FA. Water turnover in 458 American adults 40-79 yr of age. Am J Physiol Renal Physiol 2004, 286:F394-F401. 10.1152/ajprenal.00295.2003, 14600032.
103. Marko NF. Hypertonic saline, not mannitol, should be considered gold-standard medical therapy for intracranial hypertension. Crit Care 2012, 16:113. 3396262, 22353146.
104. Kahn T. Hypernatremia without water depletion. Clin Nephrol 2011, 76:130-135.
105. Furukawa S, Takaya A, Nakagawa T, Sakaguchi I, Nishi K. Fatal hypernatremia due to drinking a large quantity of shoyu (Japanese soy sauce). J Forensic Leg Med 2011, 18:91-92. 10.1016/j.jflm.2010.11.011, 21315305.
106. Bhave G, Neilson EG. Volume depletion versus dehydration: how understanding the difference can guide therapy. Am J Kidney Dis 2011, 58:302-309. 10.1053/j.ajkd.2011.02.395, 21705120.
107. Kahn A, Brachet E, Blum D. Controlled fall in natremia and risk of seizures in hypertonic dehydration. Intensive Care Med 1979, 5:27-31. 10.1007/BF01738999, 35558.
108. Lee JH, Arcinue E, Ross BD. Brief report: organic osmolytes in the brain of an infant with hypernatremia. N Engl J Med 1994, 331:439-442. 10.1056/NEJM199408183310704, 8035840.
109. Fang C, Mao J, Dai Y, Xia Y, Fu H, Chen Y, Wang Y, Liu A. Fluid management of hypernatraemic dehydration to prevent cerebral oedema: a retrospective case control study of 97 children in China. J Paediatr Child Health 2010, 46:301-303. 10.1111/j.1440-1754.2010.01712.x, 20412412.
110. Righini A, Ramenghi L, Zirpoli S, Mosca F, Triulzi F. Brain apparent diffusion coefficient decrease during correction of severe hypernatremic dehydration. AJNR Am J Neuroradiol 2005, 26:1690-1694.
111. Alshayeb HM, Showkat A, Babar F, Mangold T, Wall BM. Severe hypernatremia correction rate and mortality in hospitalized patients. Am J Med Sci 2011, 341:356-360. 10.1097/MAJ.0b013e31820a3a90, 21358313.
112. Moritz ML, Ayus JC. The changing pattern of hypernatremia in hospitalized children. Pediatrics 1999, 104:435-439. 10.1542/peds.104.3.435, 10469766.