The Brain in Hyponatremia: Both Culprit and Victim

Seminars in Nephrology

Volumn 29, Issue 3, 2009, Pages 196-215

  Mount, David B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

aquaporin; cell volume; hyponatremia; K Cl cotransport; magnocellular; osmotic demyelination; thirst; TRP1; TRP4; Vasopressin

Indexed keywords

AQUAPORIN 4; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; OXYGEN; SODIUM CHLORIDE; VANILLOID RECEPTOR; VASOPRESSIN;

ACUTE DISEASE; ARTICLE; BLOOD OSMOLARITY; BLOOD PRESSURE; BLOOD VOLUME; BRAIN DISEASE; BRAIN EDEMA; CELL VOLUME; CENTRAL NERVOUS SYSTEM FUNCTION; CHRONIC DISEASE; DEMYELINATING DISEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; HUMAN; HYPERCAPNIA; HYPONATREMIA; HYPOVOLEMIA; HYPOXIA; INAPPROPRIATE VASOPRESSIN SECRETION; MOLECULAR BIOLOGY; NERVE CELL NETWORK; NERVE CONDUCTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROENDOCRINE SYSTEM; NONHUMAN; OSMORECEPTOR; OSMOSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PLASMA OSMOLALITY; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; RESPIRATORY FAILURE; SENSORY NERVE CELL; SERUM OSMOLALITY; SYNAPTIC TRANSMISSION; THIRST; VASOPRESSIN RELEASE; WATER TRANSPORT;

ANIMALS; BRAIN; DEMYELINATING DISEASES; HUMANS; HYPONATREMIA; MODELS, BIOLOGICAL; OSMOSIS; THIRST; VASOPRESSINS;

EID: 66749146139     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2009.03.021     Document Type: Article

References (134)

1. McKenna K., and Thompson C. Osmoregulation in clinical disorders of thirst appreciation. Clin Endocrinol (Oxf) 49 (1998) 139-152
2. Verbalis J.G., and Berl T. Disorders of water balance. In: Brenner B.M. (Ed). The Kidney. 8th ed. (2008), Saunders, Philadelphia 459-546
3. Bourque C.W. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci 9 (2008) 519-531
4. McKinley M.J., Cairns M.J., Denton D.A., et al. Physiological and pathophysiological influences on thirst. Physiol Behav 81 (2004) 795-803
5. Pasantes-Morales H., Lezama R.A., Ramos-Mandujano G., and Tuz K.L. Mechanisms of cell volume regulation in hypo-osmolality. Am J Med 119 (2006) S4-S11
6. Ayus J.C., Achinger S.G., and Arieff A. Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Renal Physiol 295 (2008) F619-F624
7. Baylis P.H. Osmoregulation and control of vasopressin secretion in healthy humans. Am J Physiol 253 (1987) R671-R678
8. Robertson G.L., Aycinena P., and Zerbe R.L. Neurogenic disorders of osmoregulation. Am J Med 72 (1982) 339-353
9. Uretsky B.F., Verbalis J.G., Generalovich T., Valdes A., and Reddy P.S. Plasma vasopressin response to osmotic and hemodynamic stimuli in heart failure. Am J Physiol 248 (1985) H396-H402
10. Stachenfeld N.S., Splenser A.E., Calzone W.L., Taylor M.P., and Keefe D.L. Sex differences in osmotic regulation of AVP and renal sodium handling. J Appl Physiol 91 (2001) 1893-1901
11. Davison J.M., Gilmore E.A., Durr J., Robertson G.L., and Lindheimer M.D. Altered osmotic thresholds for vasopressin secretion and thirst in human pregnancy. Am J Physiol 246 (1984) F105-F109
12. Sladek C.D., and Somponpun S.J. Estrogen receptors: their roles in regulation of vasopressin release for maintenance of fluid and electrolyte homeostasis. Front Neuroendocrinol 29 (2008) 114-127
13. Miller M.A., DeVries G.J., al-Shamma H.A., and Dorsa D.M. Decline of vasopressin immunoreactivity and mRNA levels in the bed nucleus of the stria terminalis following castration. J Neurosci 12 (1992) 2881-2887
14. Pak T.R., Chung W.C., Hinds L.R., and Handa R.J. Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells. Endocrinology 148 (2007) 3371-3382
15. Ikeda Y., Tanaka I., Oki Y., et al. Testosterone normalizes plasma vasopressin response to osmotic stimuli in men with hypogonadism. Endocr J 40 (1993) 387-392
16. Calzone W.L., Silva C., Keefe D.L., and Stachenfeld N.S. Progesterone does not alter osmotic regulation of AVP. Am J Physiol Regul Integr Comp Physiol 281 (2001) R2011-R2020
17. Somponpun S.J., and Sladek C.D. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. J Neurosci 23 (2003) 4261-4269
18. Somponpun S.J., and Sladek C.D. Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration. J Neuroendocrinol 16 (2004) 544-549
19. Robertson G.L. Abnormalities of thirst regulation. Kidney Int 25 (1984) 460-469
20. Fitzsimons J.T. Angiotensin, thirst, and sodium appetite. Physiol Rev 78 (1998) 583-686
21. Sakai K., Agassandian K., Morimoto S., et al. Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest 117 (2007) 1088-1095
22. Kong J., Zhang Z., Li D., et al. Loss of vitamin D receptor produces polyuria by increasing thirst. J Am Soc Nephrol 19 (2008) 2396-2405
23. Yuan W., Pan W., Kong J., et al. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem 282 (2007) 29821-29830
24. Li Y.C., Kong J., Wei M., Chen Z.F., Liu S.Q., and Cao L.P. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110 (2002) 229-238
25. Lazartigues E., Sinnayah P., Augoyard G., Gharib C., Johnson A.K., and Davisson R.L. Enhanced water and salt intake in transgenic mice with brain-restricted overexpression of angiotensin (AT1) receptors. Am J Physiol Regul Integr Comp Physiol 295 (2008) R1539-R1545
26. McKinley M.J., Walker L.L., Alexiou T., et al. Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin. Am J Physiol Regul Integr Comp Physiol 294 (2008) R1533-R1543
27. Phillips P.A., Rolls B.J., Ledingham J.G., Morton J.J., and Forsling M.L. Angiotensin II-induced thirst and vasopressin release in man. Clin Sci (Lond) 68 (1985) 669-674
28. Oldenburg B., MacDonald G.J., and Shelley S. Controlled trial of enalapril in patients with chronic fluid overload undergoing dialysis. Br Med J (Clin Res Ed) 296 (1988) 1089-1091
29. Yamamoto T., Shimizu M., Morioka M., Kitano M., Wakabayashi H., and Aizawa N. Role of angiotensin II in the pathogenesis of hyperdipsia in chronic renal failure. JAMA 256 (1986) 604-608
30. Graziani G., Badalamenti S., Del Bo A., et al. Abnormal hemodynamics and elevated angiotensin II plasma levels in polydipsic patients on regular hemodialysis treatment. Kidney Int 44 (1993) 107-114
31. Izzedine H., Fardet L., Launay-Vacher V., Dorent R., Petitclerc T., and Deray G. Angiotensin-converting enzyme inhibitor-induced syndrome of inappropriate secretion of antidiuretic hormone: case report and review of the literature. Clin Pharmacol Ther 71 (2002) 503-507
32. Arinzon Z.H., Lehman Y.A., and Fidelman Z.G. Cilazapril-induced SIADH. J Am Geriatr Soc 49 (2001) 1735
33. Shaikh Z.H., Taylor H.C., Maroo P.V., and Llerena L.A. Syndrome of inappropriate antidiuretic hormone secretion associated with lisinopril. Ann Pharmacother 34 (2000) 176-179
34. Al-Mufti H.I., and Arieff A.I. Captopril-induced hyponatremia with irreversible neurologic damage. Am J Med 79 (1985) 769-771
35. Lehr D., Goldman H.W., and Casner P. Renin-angiotensin role in thirst: paradoxical enhancement of drinking by angiotensin converting enzyme inhibitor. Science 182 (1973) 1031-1034
36. Cadnapaphornchai M.A., Rogachev B., Summer S.N., et al. Evidence for bradykinin as a stimulator of thirst. Am J Physiol Renal Physiol 286 (2004) F875-F880
37. Smith D., Moore K., Tormey W., Baylis P.H., and Thompson C.J. Downward resetting of the osmotic threshold for thirst in patients with SIADH. Am J Physiol Endocrinol Metab 287 (2004) E1019-E1023
38. Verney E.B. The antidiuretic hormone and the factors which determine its release. Proc R Soc Lond B Biol Sci 135 (1947) 25-106
39. McKinley M.J., Denton D.A., Oldfield B.J., De Oliveira L.B., and Mathai M.L. Water intake and the neural correlates of the consciousness of thirst. Semin Nephrol 26 (2006) 249-257
40. Bourque C.W., Ciura S., Trudel E., Stachniak T.J., and Sharif-Naeini R. Neurophysiological characterisation of osmosensitive neurons. Exp Physiol 92 (2007) 499-505
41. Sewards T.V., and Sewards M.A. The awareness of thirst: proposed neural correlates. Conscious Cogn 9 (2000) 463-487
42. Oliet S.H., and Bourque C.W. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons. Nature 364 (1993) 341-343
43. McKinley M.J., Mathai M.L., McAllen R.M., et al. Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis. J Neuroendocrinol 16 (2004) 340-347
44. McKinley M.J., Mathai M.L., Pennington G., Rundgren M., and Vivas L. Effect of individual or combined ablation of the nuclear groups of the lamina terminalis on water drinking in sheep. Am J Physiol 276 (1999) R673-R683
45. Egan G., Silk T., Zamarripa F., et al. Neural correlates of the emergence of consciousness of thirst. Proc Natl Acad Sci U S A 100 (2003) 15241-15246
46. Baylis P.H., and Thompson C.J. Osmoregulation of vasopressin secretion and thirst in health and disease. Clin Endocrinol (Oxf) 29 (1988) 549-576
47. Hamamura M., Nunez D.J., Leng G., Emson P.C., and Kiyama H. c-fos may code for a common transcription factor within the hypothalamic neural circuits involved in osmoregulation. Brain Res 572 (1992) 42-51
48. Shi P., Martinez M.A., Calderon A.S., Chen Q., Cunningham J.T., and Toney G.M. Intra-carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus. J Physiol 586 (2008) 5231-5245
49. Ciura S., and Bourque C.W. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 26 (2006) 9069-9075
50. Anderson J.W., Washburn D.L., and Ferguson A.V. Intrinsic osmosensitivity of subfornical organ neurons. Neuroscience 100 (2000) 539-547
51. Qiu D.L., Shirasaka T., Chu C.P., et al. Effect of hypertonic saline on rat hypothalamic paraventricular nucleus magnocellular neurons in vitro. Neurosci Lett 355 (2004) 117-120
52. Zhang Z., and Bourque C.W. Osmometry in osmosensory neurons. Nat Neurosci 6 (2003) 1021-1022
53. Zhang Z., and Bourque C.W. Calcium permeability and flux through osmosensory transduction channels of isolated rat supraoptic nucleus neurons. Eur J Neurosci 23 (2006) 1491-1500
54. Oliet S.H., and Bourque C.W. Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons. Neuron 16 (1996) 175-181
55. Colbert H.A., Smith T.L., and Bargmann C.I. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17 (1997) 8259-8269
56. Liedtke W., Choe Y., Marti-Renom M.A., et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103 (2000) 525-535
57. Mizuno A., Matsumoto N., Imai M., and Suzuki M. Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285 (2003) C96-C101
58. Strotmann R., Harteneck C., Nunnenmacher K., Schultz G., and Plant T.D. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2 (2000) 695-702
59. Liedtke W., Tobin D.M., Bargmann C.I., and Friedman J.M. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A 100 Suppl 2 (2003) 14531-14536
60. Liedtke W., and Friedman J.M. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A 100 (2003) 13698-13703
61. Tsushima H., and Mori M. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1736-R1741
62. Sharif Naeini R., Witty M.F., Seguela P., and Bourque C.W. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 9 (2006) 93-98
63. Suzuki M., Sato J., Kutsuwada K., Ooki G., and Imai M. Cloning of a stretch-inhibitable nonselective cation channel. J Biol Chem 274 (1999) 6330-6335
64. Taylor A.C., McCarthy J.J., and Stocker S.D. Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. Am J Physiol Regul Integr Comp Physiol 294 (2008) R1285-R1293
65. Wainwright A., Rutter A.R., Seabrook G.R., Reilly K., and Oliver K.R. Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. J Comp Neurol 474 (2004) 24-42
66. Bourque C.W., Voisin D.L., and Chakfe Y. Stretch-inactivated cation channels: cellular targets for modulation of osmosensitivity in supraoptic neurons. Prog Brain Res 139 (2002) 85-94
67. Voisin D.L., Chakfe Y., and Bourque C.W. Coincident detection of CSF Na+ and osmotic pressure in osmoregulatory neurons of the supraoptic nucleus. Neuron 24 (1999) 453-460
68. McKinley M.J., Denton D.A., and Weisinger R.S. Sensors for antidiuresis and thirst--osmoreceptors or CSF sodium detectors?. Brain Res 141 (1978) 89-103
69. Chakfe Y., and Bourque C.W. Excitatory peptides and osmotic pressure modulate mechanosensitive cation channels in concert. Nat Neurosci 3 (2000) 572-579
70. Zhang Z., and Bourque C.W. Amplification of transducer gain by angiotensin II-mediated enhancement of cortical actin density in osmosensory neurons. J Neurosci 28 (2008) 9536-9544
71. Chakfe Y., Zhang Z., and Bourque C.W. IL-1beta directly excites isolated rat supraoptic neurons via upregulation of the osmosensory cation current. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1183-R1190
72. Jorgensen H., Kjaer A., Knigge U., Moller M., and Warberg J. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. J Neuroendocrinol 15 (2003) 564-571
73. Jorgensen H., Riis M., Knigge U., Kjaer A., and Warberg J. Serotonin receptors involved in vasopressin and oxytocin secretion. J Neuroendocrinol 15 (2003) 242-249
74. Mikkelsen J.D., Hay-Schmidt A., and Kiss A. Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors. Ann N Y Acad Sci 1018 (2004) 65-70
75. Ho S.S., Chow B.K., and Yung W.H. Serotonin increases the excitability of the hypothalamic paraventricular nucleus magnocellular neurons. Eur J Neurosci 25 (2007) 2991-3000
76. Jacob S., and Spinler S.A. Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother 40 (2006) 1618-1622
77. Stephenson C.P., Hunt G.E., Topple A.N., and McGregor I.S. The distribution of 3,4-methylenedioxymethamphetamine "Ecstasy"-induced c-fos expression in rat brain. Neuroscience 92 (1999) 1011-1023
78. Fallon J.K., Shah D., Kicman A.T., et al. Action of MDMA (ecstasy) and its metabolites on arginine vasopressin release. Ann N Y Acad Sci 965 (2002) 399-409
79. Brvar M., Kozelj G., Osredkar J., Mozina M., Gricar M., and Bunc M. Polydipsia as another mechanism of hyponatremia after 'ecstasy' (3,4 methyldioxymethamphetamine) ingestion. Eur J Emerg Med 11 (2004) 302-304
80. Campbell G.A., and Rosner M.H. The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clin J Am Soc Nephrol 3 (2008) 1852-1860
81. Fraser C.L., and Arieff A.I. Epidemiology, pathophysiology, and management of hyponatremic encephalopathy. Am J Med 102 (1997) 67-77
82. Fraser C.L., and Arieff A.I. Fatal central diabetes mellitus and insipidus resulting from untreated hyponatremia: a new syndrome. Ann Intern Med 112 (1990) 113-119
83. Arieff A.I. Influence of hypoxia and sex on hyponatremic encephalopathy. Am J Med 119 (2006) S59-S64
84. Ayus J.C., and Arieff A.I. Pulmonary complications of hyponatremic encephalopathy. Noncardiogenic pulmonary edema and hypercapnic respiratory failure. Chest 107 (1995) 517-521
85. Soupart A., Penninckx R., Stenuit A., and Decaux G. Lack of major hypoxia and significant brain damage in rats despite dramatic hyponatremic encephalopathy. J Lab Clin Med 130 (1997) 226-231
86. Baumann A., Audibert G., McDonnell J., and Mertes P.M. Neurogenic pulmonary edema. Acta Anaesthesiol Scand 51 (2007) 447-455
87. Ayus J.C., Varon J., and Arieff A.I. Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med 132 (2000) 711-714
88. Siegel A.J., Verbalis J.G., Clement S., et al. Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion. Am J Med 120 (2007) 461e11-7
89. Ellison D.H., and Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 356 (2007) 2064-2072
90. Janicic N., and Verbalis J.G. Evaluation and management of hypo-osmolality in hospitalized patients. Endocrinol Metab Clin North Am 32 (2003) 459-481 vii
91. Nielsen S., Nagelhus E.A., Amiry-Moghaddam M., Bourque C., Agre P., and Ottersen O.P. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17 (1997) 171-180
92. Solenov E., Watanabe H., Manley G.T., and Verkman A.S. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol 286 (2004) C426-C432
93. Manley G.T., Fujimura M., Ma T., et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6 (2000) 159-163
94. Yang B., Zador Z., and Verkman A.S. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem 283 (2008) 15280-15286
95. Sorani M.D., Zador Z., Hurowitz E., Yan D., Giacomini K.M., and Manley G.T. Novel variants in human Aquaporin-4 reduce cellular water permeability. Hum Mol Genet 17 (2008) 2379-2389
96. Papadopoulos M.C., Manley G.T., Krishna S., and Verkman A.S. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18 (2004) 1291-1293
97. Melton J.E., Patlak C.S., Pettigrew K.D., and Cserr H.F. Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia. Am J Physiol 252 (1987) F661-F669
98. Olson J.E., Sankar R., Holtzman D., James A., and Fleischhacker D. Energy-dependent volume regulation in primary cultured cerebral astrocytes. J Cell Physiol 128 (1986) 209-215
99. Blanz J., Schweizer M., Auberson M., et al. Leukoencephalopathy upon disruption of the chloride channel ClC-2. J Neurosci 27 (2007) 6581-6589
100. Rust M.B., Alper S.L., Rudhard Y., et al. Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest 117 (2007) 1708-1717
101. Boettger T., Rust M.B., Maier H., et al. Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J 22 (2003) 5422-5434
102. Howard H.C., Mount D.B., Rochefort D., et al. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet 32 (2002) 384-392
103. Byun N., and Delpire E. Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice. Neurobiol Dis 28 (2007) 39-51
104. Ringel F., and Plesnila N. Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells. Neurosci Lett 442 (2008) 219-223
105. Lenertz L.Y., Lee B.H., Min X., et al. Properties of WNK1 and implications for other family members. J Biol Chem 280 (2005) 26653-26658
106. Kahle K.T., Ring A.M., and Lifton R.P. Molecular physiology of the WNK kinases. Annu Rev Physiol 70 (2008) 329-355
107. Moriguchi T., Urushiyama S., Hisamoto N., et al. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280 (2005) 42685-42693
108. Vitari A.C., Thastrup J., Rafiqi F.H., et al. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J 397 (2006) 223-231
109. Gagnon K.B., England R., and Delpire E. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol Cell Biol 26 (2006) 689-698
110. Falin R.A., Morrison R., Ham A.J., and Strange K. Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel. J Gen Physiol 133 (2009) 29-42
111. Videen J.S., Michaelis T., Pinto P., and Ross B.D. Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study. J Clin Invest 95 (1995) 788-793
112. Ayus J.C., Armstrong D., and Arieff A.I. Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int 69 (2006) 1319-1325
113. Gocht A., and Colmant H.J. Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol 6 (1987) 262-270
114. Martin R.J. Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J Neurol Neurosurg Psychiatry 75 Suppl 3 (2004) iii22-iii28
115. Verbalis J.G., and Martinez A.J. Neurological and neuropathological sequelae of correction of chronic hyponatremia. Kidney Int 39 (1991) 1274-1282
116. Laureno R. Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol 13 (1983) 232-242
117. Soupart A., Penninckx R., Crenier L., Stenuit A., Perier O., and Decaux G. Prevention of brain demyelination in rats after excessive correction of chronic hyponatremia by serum sodium lowering. Kidney Int 45 (1994) 193-200
118. Verbalis J.G., and Gullans S.R. Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. Brain Res 606 (1993) 19-27
119. Lien Y.H., Shapiro J.I., and Chan L. Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis. J Clin Invest 88 (1991) 303-309
120. Sterns R.H., Thomas D.J., and Herndon R.M. Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. Kidney Int 35 (1989) 69-75
121. Lien Y.H. Role of organic osmolytes in myelinolysis. A topographic study in rats after rapid correction of hyponatremia. J Clin Invest 95 (1995) 1579-1586
122. Silver S.M., Schroeder B.M., and Sterns R.H. Brain uptake of myoinositol after exogenous administration. J Am Soc Nephrol 13 (2002) 1255-1260
123. Silver S.M., Schroeder B.M., Sterns R.H., and Rojiani A.M. Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. J Neuropathol Exp Neurol 65 (2006) 37-44
124. DeLuca G.C., Nagy Z., Esiri M.M., and Davey P. Evidence for a role for apoptosis in central pontine myelinolysis. Acta Neuropathol 103 (2002) 590-598
125. Alfieri R.R., Cavazzoni A., Petronini P.G., et al. Compatible osmolytes modulate the response of porcine endothelial cells to hypertonicity and protect them from apoptosis. J Physiol 540 (2002) 499-508
126. Maallem S., Mutin M., Gonzalez-Gonzalez I.M., Zafra F., and Tappaz M.L. Selective tonicity-induced expression of the neutral amino-acid transporter SNAT2 in oligodendrocytes in rat brain following systemic hypertonicity. Neuroscience 153 (2008) 95-107
127. Adler S., Verbalis J.G., and Williams D. Effect of rapid correction of hyponatremia on the blood-brain barrier of rats. Brain Res 679 (1995) 135-143
128. Adler S., Martinez J., Williams D.S., and Verbalis J.G. Positive association between blood brain barrier disruption and osmotically-induced demyelination. Mult Scler 6 (2000) 24-31
129. Baker E.A., Tian Y., Adler S., and Verbalis J.G. Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia. Exp Neurol 165 (2000) 221-230
130. Sugimura Y., Murase T., Takefuji S., et al. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol 192 (2005) 178-183
131. Perianayagam A., Sterns R.H., Silver S.M., et al. DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol 3 (2008) 331-336
132. Oya S., Tsutsumi K., Ueki K., and Kirino T. Reinduction of hyponatremia to treat central pontine myelinolysis. Neurology 57 (2001) 1931-1932
133. Qi X., Inagaki K., Sobel R.A., and Mochly-Rosen D. Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest 118 (2008) 173-182
134. Robertson G.L., Shelton R.L., and Athar S. The osmoregulation of vasopressin. Kidney Int 10 (1976) 25-37