Role of IRAK-M in Alcohol Induced Liver Injury

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wang, Yipeng ^a,b   Hu, Youjia ^a   Chao, Chen ^a   Yuksel, Muhammed ^a,c,d   Colle, Isabelle ^c,d   Flavell, Richard A ^a   Ma, Yun ^d   Yan, Huiping ^b   Wen, Li ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CD68 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN RECEPTOR ASSOCIATED KINASE M; PHOSPHOTRANSFERASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PHAGOCYTOSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ANALYSIS; FECES ANALYSIS; GENOME ANALYSIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IMMUNOREGULATION; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; WILD TYPE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GENOME-WIDE ASSOCIATION STUDY; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTESTINES; LIVER DISEASES, ALCOHOLIC; METAGENOME; MICE; MICE, KNOCKOUT; PERMEABILITY; PHAGOCYTOSIS; PHYSICAL CHROMOSOME MAPPING; POLYMORPHISM, SINGLE NUCLEOTIDE; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 84874343133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057085     Document Type: Article

References (38)

1. Li TK, (2008) Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs. J Gastro & Hepatol 23Suppl 1: S2-8.
2. Mandrekar P, Szabo G, (2009) Signalling pathways in alcohol-induced liver inflammation. J Hepatol 50: 1258-1266.
3. Seth D, Haber PS, Syn WK, Diehl AM, Day CP, (2011) Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J Gastro & Hepatol 26: 1089-1105.
4. Kim SK, Marusawa H, Eso Y, Nishikawa H, Ueda Y, et al. (2011) Clinical characteristics of non-B non-C hepatocellular carcinoma: a single-center retrospective study. Digestion 84Suppl 1: 43-49.
5. Laso FJ, Iglesias-Osma C, Ciudad J, Lopez A, Pastor I, et al. (1999) Chronic alcoholism is associated with an imbalanced production of Th-1/Th-2 cytokines by peripheral blood T cells. Alcohol Clin Exp Res 23: 1306-1311.
6. Miller AM, Horiguchi N, Jeong WI, Radaeva S, Gao B, (2011) Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res 35: 787-793.
7. Szabo G, Mandrekar P, Petrasek J, Catalano D, (2011) The unfolding web of innate immune dysregulation in alcoholic liver injury. Alcohol Clin Exp Res 35: 782-786.
8. Ajakaiye M, Jacob A, Wu R, Nicastro JM, Coppa GF, et al. (2011) Alcohol and hepatocyte-Kupffer cell interaction (review). Mol Med Report 4: 597-602.
9. Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, et al. (2002) Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416: 750-756.
10. Flannery S, Bowie AG, (2010) The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling. Biochem Pharmacol 80: 1981-1991.
11. Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, et al. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202.
12. Hubbard LL, Moore BB (2010) IRAK-M regulation and function in host defense and immune homeostasis. Infect Dis Rep. 2:pii e9.
13. Biswas A, Wilmanski J, Forsman H, Hrncir T, Hao L, et al. (2011) Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur J Immunol 41: 182-194.
14. Xie Q, Gan L, Wang J, Wilson I, Li L, (2007) Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Mol Immunol 44: 3453-3461.
15. Lech M, Kantner C, Kulkarni OP, Ryu M, Vlasova E, et al. (2011) Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus. Annals Rheu Dis 70: 2207-2217.
16. Koop DR, (2006) Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Res Health 29: 274-280.
17. Sakaguchi S, Takahashi S, Sasaki T, Kumagai T, Nagata K, (2011) Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress. Drug Metab & Pharmacokin 26: 30-46.
18. Aziz-Seible RS, Lee SM, Kharbanda KK, McVicker BL, Casey CA, (2011) Ethanol feeding potentiates the pro-inflammatory response of Kupffer cells to cellular fibronectin. Alcohol Clin Exp Res 35: 717-725.
19. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, et al. (2011) Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 300: G516-525.
20. Vidali M, Stewart SF, Albano E, (2008) Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury. Trends Mol Med 14: 63-71.
21. Lucey MR, Mathurin P, Morgan TR, (2009) Alcoholic hepatitis. N Engl J Med 360: 2758-2769.
22. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
23. Covert MW, Leung TH, Gaston JE, Baltimore D, (2005) Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309: 1854-1857.
24. Enomoto N, Ikejima K, Yamashina S, Hirose M, Shimizu H, et al. (2001) Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res 25: 51S-54S.
25. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG, (2001) Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34: 101-108.
26. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G, (2009) The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol 183: 1320-1327.
27. Kirpich IA, Feng W, Wang Y, Liu Y, Barker DF, et al. (2012) The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res 36: 835-846.
28. Apajalahti JH, Sarkilahti LK, Maki BR, Heikkinen JP, Nurminen PH, et al. (1998) Effective recovery of bacterial DNA and percent-guanine-plus-cytosine-based analysis of community structure in the gastrointestinal tract of broiler chickens. Appl Environ Microbiol 64: 4084-4088.
29. Mathurin P, Deltenre P, (2009) Effect of binge drinking on the liver: an alarming public health issue? Gut 58: 613-617.
30. Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, et al. (2010) Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol 53: 903-910.
31. Akira S, Takeda K, Kaisho T, (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680.
32. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-643.
33. Mehal WZ, Azzaroli F, Crispe IN, (2001) Immunology of the healthy liver: old questions and new insights. Gastroenterology 120: 250-260.
34. Crispe IN, (2009) The liver as a lymphoid organ. Annu Rev Immunol 27: 147-163.
35. Mehal WZ, Azzaroli F, Crispe IN, (2001) Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J Immunol 167: 667-673.
36. Mehal WZ, Juedes AE, Crispe IN, (1999) Selective retention of activated CD8+ T cells by the normal liver. J Immunol 163: 3202-3210.
37. Fox ES, Thomas P, Broitman SA, (1989) Clearance of gut-derived endotoxins by the liver. Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells. Gastroenterology 96: 456-461.
38. Seki S, Habu Y, Kawamura T, Takeda K, Dobashi H, et al. (2000) The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev 174: 35-46.