Novel Schiff-Base-Derived FabH Inhibitors with Dioxygenated Rings as Antibiotic Agents

ChemMedChem

Volumn 8, Issue 3, 2013, Pages 433-441

  Zhou, Yang ^a   Du, Qian Ru ^a   Sun, Jian ^a   Li, Jing Ran ^a   Fang, Fei ^a   Li, Dong Dong ^a   Qian, Yong ^a   Gong, Hai Bin ^b   Zhao, Jing ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

ketoacyl ACP synthaseIII; Antibacterial agents; Dioxygenated rings; FabH; Inhibitors

Indexed keywords

2 (4 BROMOPHENYL) N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]ETHANAMINE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE III INHIBITOR; 4 BROMO N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]ANILINE; 4 CHLORO N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]ANILINE; 5 CHLORO N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]PYRIDIN 2 AMINE; ACYLTRANSFERASE INHIBITOR; ANTIBIOTIC AGENT; KANAMYCIN B; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1 (4 METHOXYPHENYL)METHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1 (FURAN 2 YL)METHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1 [4 (TRIFLUOROMETHYL)PHENYL]METHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1 PHENYLETHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1 PHENYLMETHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 1H PYRAZOL 3 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 2 (3H INDOL 2 YL)ETHANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 4 FLUOROANILINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE] 4 METHOXYANILIN; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]ANILINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]BUTAN 1 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]CYCLOHEXANAMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]DODECAN 1 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]HEXADECAN 1 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]HEXAN 1 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]METHYLPROPAN 2 AMINE; N [(3,4 DIHYDRO 2H BENZO[B][1,4]DIOXEPIN 7 YL)METHYLENE]OCTAN 1 AMINE; SCHIFF BASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PSEUDOMONAS FLUORESCENS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; ENZYME INHIBITORS; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; SCHIFF BASES;

EID: 84874306300     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200587     Document Type: Article

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