Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

FEBS Letters

Volumn 583, Issue 17, 2009, Pages 2939-2946

  Gajiwala, Ketan S ^a   Margosiak, Stephen ^a   Lu, Jia ^a   Cortez, Joseph ^a   Su, Ying ^a   Nie, Zhe ^a   Appelt, Krzysztof ^a  

^a Quorex Pharmaceuticals   (United States)

Author keywords

Enzyme inhibition; FabH; Fatty acid biosynthesis; Protein structure; Substrate specificity

Indexed keywords

BACTERIAL PROTEIN; FABH PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; HAEMOPHILUS INFLUENZAE; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; STAPHYLOCOCCUS AUREUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; STAPHYLOCOCCUS AUREUS;

EID: 69249236972     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.08.001     Document Type: Article

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