Dependence receptor TrkC is a putative colon cancer tumor suppressor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 8, 2013, Pages 3017-3022

  Genevois, Anne Laure ^a   Ichim, Gabriel ^a   Coissieux, Marie May ^a   Lambert, Marie Pierre ^b   Lavial, Fabrice ^a   Goldschneider, David ^a   Jarrosson Wuilleme, Loraine ^a   Lepinasse, Florian ^a   Gouysse, Géraldine ^a   Herceg, Zdenko ^b   Scoazec, Jean Yves ^a   Tauszig Delamasure, Servane ^a   Mehlen, Patrick ^a  

^a UNIVERSITÉ DE LYON   (France)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Caspase 3; Epigenetic; Genetic; Neurotrophin 3

Indexed keywords

NEUROTROPHIN 3 RECEPTOR;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; COLON CANCER; COLORECTAL CANCER; COLORECTAL TUMOR; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; TUMOR GROWTH;

APOPTOSIS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; LIGANDS; PROMOTER REGIONS, GENETIC; RECEPTOR, TRKC;

EID: 84874283320     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212333110     Document Type: Article

References (50)

1. Martin-Zanca D, Hughes SH, Barbacid M (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319 (6056):743-748.
2. Nakagawara A (2001) Trk receptor tyrosine kinases: A bridge between cancer and neural development. Cancer Lett 169 (2):107-114.
3. Marshall JL, et al. (2005) Phase I trial of orally administered CEP-701, a novel neuro-trophin receptor-linked tyrosine kinase inhibitor. Invest New Drugs 23 (1):31-37.
4. Knapper S, et al. (2006) A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 108 (10):3262-3270.
5. Chan E, et al. (2008) A phase I trial of CEP-701 + gemcitabine in patients with advanced adenocarcinoma of the pancreas. Invest New Drugs 26 (3):241-247.
6. Tauszig-Delamasure S, et al. (2007) The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proc Natl Acad Sci USA 104 (33):13361-13366.
7. Nikoletopoulou V, et al. (2010) Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467 (7311):59-63.
8. Mehlen P, et al. (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395 (6704):801-804.
9. Matsunaga E, et al. (2004) RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 6 (8):749-755.
10. Thibert C, et al. (2003) Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 301 (5634):843-846.
11. Bordeaux MC, et al. (2000) The RET proto-oncogene induces apoptosis: A novel mechanism for Hirschsprung disease. EMBO J 19 (15):4056-4063.
12. Furne C, et al. (2009) EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis. Biochim Biophys Acta 1793 (2):231-238.
13. Boucher J, et al. (2010) A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Sci Signal 3 (151):ra87.
14. Mourali J, et al. (2006) Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Mol Cell Biol 26 (16):6209-6222.
15. Goldschneider D, Mehlen P (2010) Dependence receptors: A new paradigm in cell signaling and cancer therapy. Oncogene 29 (13):1865-1882.
16. Mehlen P, Delloye-Bourgeois C, Chédotal A (2011) Novel roles for Slits and netrins: Axon guidance cues as anticancer targets? Nat Rev Cancer 11 (3):188-197.
17. Cho KR, et al. (1994) The DCC gene: Structural analysis and mutations in colorectal carcinomas. Genomics 19 (3):525-531.
18. Thiebault K, et al. (2003) The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 100 (7):4173-4178.
19. Mehlen P, Fearon ER (2004) Role of the dependence receptor DCC in colorectal cancer pathogenesis. J Clin Oncol 22 (16):3420-3428.
20. Bernet A, et al. (2007) Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 133 (6):1840-1848.
21. Castets M, et al. (2012) DCC constrains tumour progression via its dependence receptor activity. Nature 482 (7386):534-537.
22. Coissieux MM, et al. (2011) Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. Gastroenterology 141 (6):2039-2046.
23. Fitamant J, et al. (2008) Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA 105 (12):4850-4855.
24. Delloye-Bourgeois C, et al. (2009) Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J Natl Cancer Inst 101 (4):237-247.
25. Delloye-Bourgeois C, et al. (2009) Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med 206 (4):833-847.
26. Bouzas-Rodriguez J, et al. (2010) Neurotrophin-3 production promotes human neu-roblastoma cell survival by inhibiting TrkC-induced apoptosis. J Clin Invest 120 (3):850-858.
27. Shibayama E, Koizumi H (1996) Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol 148 (6):1807-1818.
28. Richon VM, Sandhoff TW, Rifkind RA, Marks PA (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 97 (18):10014-10019.
29. Boyer LA, et al. (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441 (7091):349-353.
30. Rhee I, et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416 (6880):552-556.
31. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100 (1):57-70.
32. Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA (2001) Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155 (3):459-470.
33. Bardelli A, et al. (2003) Mutational analysis of the tyrosine kinome in colorectal cancers. Science 300 (5621):949.
34. Miknyoczki SJ, et al. (2002) The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal ade-nocarcinoma xenografts in nude mice. Clin Cancer Res 8 (6):1924-1931.
35. Ohta T, et al. (1997) Neurotrophin-3 expression in human pancreatic cancers. J Pathol 181 (4):405-412.
36. Svensson T, et al. (1997) Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma. Eur J Cancer 33 (12):2058-2063.
37. Brodeur GM, Maris JM, Yamashiro DJ, Hogarty MD, White PS (1997) Biology and genetics of human neuroblastomas. J Pediatr Hematol Oncol 19 (2):93-101.
38. Grotzer MA, et al. (2000) TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol 18 (5):1027-1035.
39. Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL (1994) Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA 91 (26):12867-12871.
40. Eguchi M, et al. (1999) Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t (12;15) (p13;q25). Blood 93 (4):1355-1363.
41. Tognon C, et al. (2002) Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2 (5):367-376.
42. Yagasaki F, et al. (2001) Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t (4;12) (p16;p13) chromosomal translocation. Cancer Res 61 (23):8371-8374.
43. Dubus P, et al. (2001) The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. J Pathol 193 (1):88-94.
44. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998) A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 18 (2):184-187.
45. Muragaki Y, Chou TT, Kaplan DR, Trojanowski JQ, Lee VM (1997) Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. J Neurosci 17 (2):530-542.
46. Yan C, Liang Y, Nylander KD, Schor NF (2002) TrkA as a life and death receptor: Receptor dose as a mediator of function. Cancer Res 62 (17):4867-4875.
47. Lachyankar MB, et al. (1997) TrkA expression decreases the in vivo aggressiveness of C6 glioma cells. Cancer Res 57 (3):532-536.
48. Dadakhujaev S, et al. (2009) Interplay between autophagy and apoptosis in TrkA-induced cell death. Autophagy 5 (1):103-105.
49. Shin SK, et al. (2007) Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 133 (6):1849-1857.
50. Ren J, et al. (2011) DNA hypermethylation as a chemotherapy target. Cell Signal 23 (7):1082-1093.