Age-Dependent Decrease and Alternative Splicing of Methionine Synthase mRNA in Human Cerebral Cortex and an Accelerated Decrease in Autism

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Muratore, Christina R ^a   Hodgson, Nathaniel W ^a   Trivedi, Malav S ^a   Abdolmaleky, Hamid M ^b   Persico, Antonio M ^c   Lintas, Carla ^c   De La Monte, Suzanne ^d   Deth, Richard C ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; MESSENGER RNA; METHIONINE; METHIONINE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; AUTISM; BINDING SITE; BRAIN CORTEX; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; LIFESPAN; MALE; OXIDATION; PRESCHOOL CHILD; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN DOMAIN; RNA TRANSCRIPTION; SCHOOL CHILD;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADOLESCENT; ADULT; AGE FACTORS; ALTERNATIVE SPLICING; AUTISTIC DISORDER; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION REGULATION; GENE ORDER; HUMANS; INFANT; INFANT, NEWBORN; MALE; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SULFUR; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN B 12; YOUNG ADULT;

EID: 84874242535     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056927     Document Type: Article

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