Dihydropyridine Ca2+ channel blockers increase cytosolic [Ca2+] by activating Ca2+-sensing receptors in pulmonary arterial smooth muscle cells

Circulation Research

Volumn 112, Issue 4, 2013, Pages 640-650

  Yamamura, Aya ^a,b   Yamamura, Hisao ^c   Guo, Qiang ^a   Zimnicka, Adriana M ^a   Wan, Jun ^a   Ko, Eun A ^a   Smith, Kimberly A ^a   Pohl, Nicole M ^a   Song, Shanshan ^a   Zeifman, Amy ^a   Makino, Ayako ^a   Yuan, Jason X J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b KINJO GAKUIN UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Ca2+ sensing receptor; calcium channel blocker; nicardipine; nifedipine; pulmonary hypertension; smooth muscle cell

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL; CALCIUM SENSING RECEPTOR; DIHYDROPYRIDINE; DILTIAZEM; NIFEDIPINE; SMALL INTERFERING RNA; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; CARDIOPULMONARY HEMODYNAMICS; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIC LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELLS, CULTURED; CYTOSOL; DISEASE PROGRESSION; HUMANS; HYPERTENSION, PULMONARY; INOSITOL PHOSPHATES; MALE; MONOCROTALINE; MYOCYTES, SMOOTH MUSCLE; NAPHTHALENES; NIFEDIPINE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCIUM-SENSING; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION; VASOCONSTRICTION;

EID: 84874234302     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.300897     Document Type: Article

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