Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells

Cell Calcium

Volumn 45, Issue 3, 2009, Pages 216-225

  Liu, Guangming ^a   Hu, Xin ^a   Chakrabarty, Subhas ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Calcium sensing receptor; Drug sensitivity; Paclitaxel; Survivin

Indexed keywords

CALCIUM SENSING RECEPTOR; ESTROGEN RECEPTOR; PACLITAXEL; SURVIVIN;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; EXTRACELLULAR CALCIUM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION;

EID: 61449101517     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2008.10.004     Document Type: Article

References (49)

1. Brown E.M., Pollak M., and Hebert S.C. The extracellular calcium-sensing receptor: its role in health and disease. Ann. Rev. Med. 49 (1998) 15-29
2. (2+)-sensing receptor from bovine parathyroid. Nature 366 (1993) 575-580
3. Brown E.M., and MacLeod R.J. Extracellular calcium sensing and extracellular calcium signaling. Physiol. Rev. 81 (2001) 239-297
4. Rodland K.D. The role of the calcium-sensing receptor in cancer. Cell Calcium 35 (2004) 291-295
5. Chakrabarty S., Radjendirane V., Appelman H., and Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of ß-catenin/TCF activation. Cancer Res. 63 (2003) 67-71
6. (2+) and 1.25-dihydroxyvitamin D(3). Cancer Res. 65 (2005) 493-498
7. Bhagavathula N., Kelley E.A., Reddy M., Nerusu K.C., Leonard C., Fay K., et al. Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. Br. J. Cancer 93 (2005) 1364-1371
8. 2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. Int. J. Cancer 121 (2007) 1455-1462
9. Xue L., Lipkin M., Newmark H., and Wang J. Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice. J. Natl. Cancer Inst. 91 (1999) 176-181
10. Jacobson E.A., James K.A., Newmark H.L., and Carroll K.K. Effects of dietary fat, calcium, and vitamin D on growth and mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene in female Sprague-Dawley rats. Cancer Res. 49 (1989) 6300-6303
11. Zaridze D., Lifanova Y., Maximovitch D., Day N.E., and Duffy S.W. Diet, alcohol consumption and reproductive factors in a case-control study of breast cancer in Moscow. Int. J. Cancer 48 (1991) 493-501
12. Negri E., La Vecchia C., Franceschi S., D'Avanzo B., Talamini R., Parpinel M., et al. Intake of selected micronutrients and the risk of breast cancer. Int. J. Cancer 65 (1996) 140-144
13. Kampman E., Slattery M.L., Caan B., and Potter J.D. Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control 11 (2000) 459-466
14. Lamprecht S.A., and Lipkin M. Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat. Rev. Cancer 3 (2003) 601-614
15. Lipkin M. Preclinical and early human studies of calcium and colon cancer prevention. Ann. N. Y. Acad. Sci. 889 (1999) 120-127
16. Sellers T.A., Bazyk A.E., Bostick R.M., Kushi L.H., Olson J.E., Anderson K.E., et al. Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 9 (1998) 357-367
17. Wargovich M.J., Jimenez A., McKee K., Steele V.E., Velasco M., Woods J., et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21 (2000) 1149-1155
18. Wu K., Willett W.C., Fuchs C.S., Colditz G.A., and Giovannucci E.L. Calcium intake and risk of colon cancer in women and men. J. Natl. Cancer Inst. 94 (2002) 437-446
19. Cheng I., Klingensmith M.E., Chattopadhyay N., Kifor O., Butters R.R., Soybel D.I., et al. Identification and localization of the extracellular calcium-sensing receptor in human breast. J. Clin. Endocrinol. Metab. 83 (1998) 703-707
20. Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Butters R.R., and Brown E.M. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 141 (2000) 4357-4364
21. VanHouten J.N. Calcium sensing by the mammary gland. J. Mammary Gland Biol. Neoplasia. 10 (2005) 129-139
22. Knight W.A., Livingston R.B., Gregory E.J., and McGuire W.L. Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res. 37 (1977) 4669-4671
23. Maynard P.V., Blamey R.W., Elston C.W., Haybittle J.L., and Griffiths K. Estrogen receptor assay in primary breast cancer and early recurrence of the disease. Cancer Res. 38 (1978) 4292-4295
24. Osborne C.K., Yochmowitz M.G., Knight III W.A., and McGuire W.L. The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer S46 (1980) 2884-2888
25. Croton R., Cooke T., Holt S., George W.D., Nicolson R., and Griffiths K. Oestrogen receptors and survival in early breast cancer. Br. Med. J. 283 (1981) 1289-1291
26. Howell A., Barnes D.M., Harland R.N., Redford J., Bramwell V.H., Wilkinson M.J., et al. Steroid-hormone receptors in survival after first relapse in breast cancer. Lancet 1 (1984) 588-591
27. Hawkins R.A., White G., Bundred N.J., Dixon J.M., Miller W.R., Stewart H.J., et al. Prognostic significance of oestrogen and progesterone receptor activities in breast cancer. Br. J. Surg. 74 (1987) 1009-1013
28. Cummings S.R., Eckert S., Krueger K.A., Grady D., Powles T.J., Cauley J.A., et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. J. Am. Med. Assoc. 281 (1999) 2189-2197
29. Williams M.R., Todd J.H., Ellis I.O., Dowle C.S., Haybittle J.L., Elston C.W., et al. Oestrogen receptors in primary and advanced breast cancer: an eight year review of 704 cases. Br. J. Cancer 55 (1987) 67-73
30. Thorpe S.M. Estrogen and progesterone receptor determinations in breast cancer, technology, biology and clinical significance. Acta Oncol. 27 (1988) 1-19
31. McCullough M.L., Rodriguez C., Diver W.R., Feigelson H.S., Stevens V.L., Thun M.J., et al. Dairy, calcium, and vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 2898-2904
32. Journe F., Dumon J.C., Kheddoumi N., Fox J., Laios I., Leclercq G., et al. Extracellular calcium downregulates estrogen receptor alpha and increases its transcriptional activity through calcium-sensing receptor in breast cancer cells. Bone 35 (2004) 479-488
33. Ling X., Bernacki R.J., Brattain M.G., and Li F. Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2/M arrest. J. Biol. Chem. 279 (2004) 15196-15203
34. Ferrario A., Rucker N., Wong S., Luna M., and Gomer C.J. Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Cancer Res. 67 (2007) 4989-4995
35. Li F., Ambrosini G., Chu E.Y., Plescia J., Tognin S., Marchisio P.C., et al. Control of apoptosis and mitotic spindle checkpoint by surviving. Nature 396 (1998) 580-584
36. Pillai S., Bikle D.D., Mancianti M.L., Cline P., and Hincenbergs M. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J. Cell Physiol. 143 (1990) 294-302
37. Yuspa S.H., Kilkenny A.E., Steinert P.M., and Roop D.R. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J. Cell Biol. 109 (1989) 1207-1217
38. Pillai S., and Bikle D.D. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25-dihydroxyvitamin D3. J. Cell Physiol. 146 (1991) 94-100
39. Woods C.M., Zhu J., McQueney P.A., Bollag D., and Lazarides E. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol. Med. 1 (1995) 506-526
40. Ireland C.M., and Pittman S.M. Tubulin alterations in taxol-induced apoptosis parallel those observed with other drugs. Biochem. Pharmacol. 49 (1995) 1491-1499
41. Fan W. Possible mechanisms of paclitaxel-induced apoptosis. Biochem. Pharmacol. 57 (1999) 1215-1221
42. Boehmerie W., Splittgerber U., McKenzie K.M., Johnston D.G., Austin D.J., and Ehrlich B.E. Paclitaxel induces calcium oscillations via 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 18356-18361
43. Sergeev I.N. Calcium signaling in cancer and vitamin D. J. Steroid Biochem. Mol. Biol. 97 (2005) 145-151
44. Dusso A.S., Brown A.J., and Slatopolsky E. Vitamin D. Am. J. Physiol. Renal. Physiol. 289 (2005) F8-F28
45. Harris D.M., and Go V.L. Vitamin D and colon carcinogenesis. J. Nutr. S134 (2004) 3463-3471
46. Laaksonen M., Kärkkäinen M., Outila T., Vanninen T., Ray C., and Lamberg-Allardt C. Vitamin D receptor gene BsmI-polymorphism in Finnish premenopausal and postmenopausal women: its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors. J. Bone. Miner. Metab. 20 (2002) 383-390
47. Canaff L., and Hendy G.N. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J. Biol. Chem. 277 (2002) 30337-30350
48. Colston K.W., Berger U., and Coombes R.C. Possible role for vitamin D in controlling breast cancer cell proliferation. Lancet 1 (1989) 188-191
49. Welsh J., Wietzke J.A., Zinser G.M., Smyczek S., Romu S., Tribble E., et al. Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J. Steroid Biochem. Mol. Biol. 83 (2002) 85-92