Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: Role of endothelin-1

American Journal of Hypertension

Volumn 15, Issue 2 I, 2002, Pages 164-169

  Park, Jeong Bae ^a   Schiffrin, Ernesto L ^b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Collagen; endothelin receptor antagonist; hypertension; Mineralocorticoid; myocardium

Indexed keywords

5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; ALDOSTERONE; COLLAGEN; DYE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; MINERALOCORTICOID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; HEART MUSCLE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HYPERTENSION; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING;

ALDOSTERONE; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; AORTIC DISEASES; BLOOD PRESSURE; BODY WEIGHT; CARDIOMYOPATHIES; COLLAGEN; DANSYL COMPOUNDS; ENDOTHELIN-1; FIBROSIS; HEART; HYPERTROPHY; MALE; MYOCARDIUM; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN;

EID: 0036178760     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(01)02291-9     Document Type: Article

References (37)

1. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
2. Remodeling and reparation of the cardiovascular system
3. Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone
4. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II
5. Effects of endothelins on collagen turnover in cardiac fibroblasts
6. Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amiloride
7. The cardiac structure - Function relationship and the reninangiotensin-aldosterone system in hypertension and heart failure
8. 1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility
9. Remodeling of the rat right and left ventricles in experimental hypertension
10. Left ventricular fibrosis in renovascular hypertensive rats: Effect of losartan and spironolactone
11. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat
12. A receptor antagonism
13. Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats
14. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
15. In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosterone acetate-salt hypertensive rats
16. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy
17. A receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats
18. Endothelin is a potent mitogen for rat vascular smooth muscle cells
19. Growth factor activity of endothelin on vascular smooth muscle
20. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy
21. Increased endothelin-1 gene expression in the endothelium of coronary arteries and endocardium in the DOCA-salt hypertensive rat
22. Prolonged endothelin blockade prevents hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats
23. B receptor antagonist
24. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor
25. Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart
26. Production of aldosterone in isolated rat blood vessels
27. Activation of cardiac aldosterone production in rat myocardial infarction. Effect of angiotensin II receptor blockade and role in cardiac fibrosis
28. Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells
29. Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts
30. Vascular binding sites and biological activity of vasopressin in DOCA-salt hypertensive rats
31. 1 vasopressin antagonism on small artery structure and vascular expression of preproendothelin-1 in DOCA-salt hypertensive rats
32. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat
33. Mineralocorticoids, hypertension, and cardiac fibrosis
34. Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion
35. Determinants of cardiac fibrosis in experimental hypermineralocorticoid states
36. A receptor antagonism
37. Structure and function of small arteries in salt-induced hypertension. Effects of chronic endothelin-subtype-A-receptor blockade