Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans

European Heart Journal

Volumn 32, Issue 10, 2011, Pages 1275-1286

  Thum, Thomas ^a   Schmitter, Kerstin ^a,b   Fleissner, Felix ^a   Wiebking, Volker ^a,b   Dietrich, Bernd ^a,b   Widder, Julian D ^b   Jazbutyte, Virginija ^a   Hahner, Stefanie ^b   Ertl, Georg ^b   Bauersachs, Johann ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Medizinische Klinik und Poliklinik I   (Germany)

Author keywords

Aldosterone; Endothelial function; Endothelial progenitor cells; Primary hyperaldosteronism; Reactive oxygen species

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EPLERENONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; METOPROLOL; MINERALOCORTICOID RECEPTOR; PLACEBO; REACTIVE OXYGEN METABOLITE; SPIRONOLACTONE;

ADULT; ANIMAL CELL; ARTERIAL STIFFNESS; ARTICLE; BLOOD PRESSURE; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL HOMING; CELL MIGRATION; CELL PROLIFERATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERALDOSTERONISM; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA INTERFERENCE; VASCULARIZATION;

ALDOSTERONE; ALDOSTERONE ANTAGONISTS; ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERALDOSTERONISM; MALE; MICE; MIDDLE AGED; REACTIVE OXYGEN SPECIES; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE; STEM CELLS; VASODILATION;

EID: 79957503877     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq254     Document Type: Article

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