Dose-dependent endothelial cell growth and stiffening by aldosterone: Endothelial protection by eplerenone

Journal of Hypertension

Volumn 25, Issue 3, 2007, Pages 639-647

  Hillebrand, Uta ^a   Schillers, Hermann ^a   Riethmüller, Christoph ^a   Stock, Christian ^a   Wilhelmi, Marianne ^a   Oberleithner, Hans ^a   Hausberg, Martin ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Aldosterone; Atomic force microscopy; Cell growth; Cell stiffness; EAHy926; Eplerenone; HCAEC

Indexed keywords

ALDOSTERONE; EPLERENONE;

ARTERY ENDOTHELIUM; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL GROWTH; CELL STRUCTURE; CELL SURFACE; CELL SWELLING; CELL VOLUME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; HORMONE ACTION; HUMAN; HUMAN CELL; INCUBATION TIME; PATHOPHYSIOLOGY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 33846829686     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328013f492     Document Type: Article

References (37)

1. Robert-Nicoud M, Flahaut M, Elalouf JM, Nicod M, Salinas M, Bens M, et al. Transcriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin. Proc Natl Acad Sci U S A 2001; 98:2712-2716.
2. Endemann DH, Touyz RM, Iglarz M, Savoia C, Schiffrin EL. Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 2004; 43:1252-1257.
3. Safar ME, Avolio A. Aldosterone antagonism and arterial stiffness. Hypertension 2004; 43:e3.
4. Struthers AD, MacDonald TM. Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res 2004; 61:663-670.
5. Golestaneh N, Klein C, Valamanesh F, Suarez G, Agarwal MK, Mirshahi M. Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton. Biochem Biophys Res Commun 2001; 280:1300-1306.
6. Oberleithner H, Ludwig T, Riethmuller C, Hillebrand U, Albermann L, Schafer C, et al. Human endothelium: target for aldosterone. Hypertension 2004; 43:952-956.
7. Oberleithner H. Unorthodox sites and modes of aldosterone action. News Physiol Sci 2004; 19:51-54.
8. Stachenfeld NS, DiPietro L, Kokoszka CA, Silva C, Keefe DL, Nadel ER. Physiological variability of fluid-regulation hormones in young women. J Appl Physiol 1999; 86:1092-1096.
9. + exchange. Cardiovasc Res 2006; 69:916-924.
10. Peng X, Haldar S, Deshpande S, Irani K, Kass DA. Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension 2003; 41:378-381.
11. Schneider SW, Matzke R, Radmacher M, Oberleithner H. Shape and volume of living aldosterone-sensitive cells imaged with the atomic force microscope. Methods Mol Biol 2004; 242:255-279.
12. Deng DX, Tsalenko A, Vailaya A, Ben Dor A, Kundu R, Estay I, et al. Differences in vascular bed disease susceptibility reflect differences in gene expression response to atherogenic stimuli. Circ Res 2006; 98:200-208.
13. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridisation. Proc Natl Acad Sci U S A 1983; 80:3734-3737.
14. Binnig G, Quate CF, Gerber C. Atomic force microscope. Phys Rev Lett 1986; 56:930-934.
15. Kataoka N, Iwaki K, Hashimoto K, Mochizuki S, Ogasawara Y, Sato M, et al. Measurements of endothelial cell-to-cell and cell-to-substrate gaps and micromechanical properties of endothelial cells during monocyte adhesion. Proc Natl Acad Sci U S A 2002; 99:15638-15643.
16. Mathur AB, Collinsworth AM, Reichert WM, Kraus WE, Truskey GA. Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. J Biomech 2001; 34:1545-1553.
17. Hoh JH, Schoenenberger CA. Surface morphology and mechanical properties of MDCK monolayers by atomic force microscopy. J Cell Sci 1994; 107:1105-1114.
18. Oberleithner H, Schneider SW, Albermann L, Hillebrand U, Ludwig T, Riethmuller C, et al. Endothelial cell swelling by aldosterone. J Membr Biol 2003; 196:163-172.
19. Palmer LG, Frindt G. Aldosterone and potassium secretion by the cortical collecting duct. Kidney Int 2000; 57:1324-1328.
20. Pesen D, Hoh JH. Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells. FEBS Lett 2005; 579:473-476.
21. Brown NJ. Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens 2005; 14:235-241.
22. Szekeres M, Nadasy GL, Dezsi L, Orosz M, Tokes A, Monos E. Segmental differences in geometric, elastic and contractile characteristics of small intramural coronary arteries of the rat. J Vasc Res 1998; 35:332-344.
23. Ibegbuna V, Nicolaides AN, Sowade O, Leon M, Geroulakos G. Venous elasticity after treatment with Daflon 500 mg. Angiology 1997; 48:45-49.
24. Pesen D, Hoh JH. Micromechanical architecture of the endothelial cell cortex. Biophys J 2005; 88:670-679.
25. Davies PF, Zilberberg J, Helmke BP. Spatial microstimuli in endothelial mechanosignaling. Circ Res 2003; 92:359-370.
26. Apodaca G. Modulation of membrane traffic by mechanical stimuli. Am J Physiol Renal Physiol 2002; 282:F179-F190.
27. Mathur AB, Truskey GA, Reichert WM. Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. Biophys J 2000; 78:1725-1735.
28. Nishizaka MK, Zaman MA, Green SA, Renfroe KY, Calhoun DA. Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation 2004; 109:2857-2861.
29. Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation 2002; 106:2848-2853.
30. Blacher J, Amah G, Girerd X, Kheder A, Ben Mais H, London GM, Safar ME. Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension. Am J Hypertens 1997; 10:1326-1334.
31. Barenbrock M, Kosch M, Hausberg M. Sodium intake and vessel wall properties of large arteries. J Hypertens 2003; 21:33-35.
32. Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, Laurent S. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002; 39:10-15.
33. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34:1203-1206.
34. Hu X, Li S, McMahon EG, Lala DS, Rudolph AE. Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone. Mini Rev Med Chem 2005; 5:709-718.
35. Weinberger MH, Roniker B, Krause SL, Weiss RJ. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens 2002; 15:709-716.
36. Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, et al. Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway. Hypertension 2005; 45:538-544.
37. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348:1309-1321.