Endothelial progenitor cells in primary aldosteronism: A biomarker of severity for aldosterone vasculopathy and prognosis

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 10, 2011, Pages 3175-3183

  Wu, Vin Cent ^a   Lo, Shyh Chyi ^a   Chen, Yuh Lien ^a   Huang, Po Hsun ^b   Tsai, Chia Ti ^a   Liang, Chan Jung ^a   Kuo, Chin Chi ^a   Kuo, Yih Shing ^a   Lee, Bai Chin ^a   Wu, En Ling ^a   Lin, Yen Hung ^a   Sun, Yun Yu ^a   Lin, Shuei Liong ^a   Chen, Jaw Wen ^b   Lin, Shing Jong ^b   Wu, Kwan Dun ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIURETIC AGENT; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE;

ADRENAL CORTEX ADENOMA; ADRENALECTOMY; ADULT; ALDOSTERONE BLOOD LEVEL; ANGIOGENESIS; ARTERIAL STIFFNESS; ARTICLE; CELL COUNT; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; ENDOTHELIAL PROGENITOR CELL; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN CELL; HYPERALDOSTERONISM; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE PERIOD; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TREATMENT OUTCOME; VASCULAR DISEASE;

ADENOMA; ADULT; AGED; ALDOSTERONE; APOPTOSIS; ARTERIES; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CELL AGING; CELL COUNT; CELL PROLIFERATION; DISEASE PROGRESSION; ENDOTHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERALDOSTERONISM; HYPERTENSION; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; REACTIVE OXYGEN SPECIES; REGIONAL BLOOD FLOW; STEM CELLS; TREATMENT OUTCOME; VASCULAR DISEASES;

EID: 80053477934     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1135     Document Type: Article

References (42)

1. Tomaschitz A, Pilz S, Ritz E, Meinitzer A, Boehm BO, März W 2010 Plasma aldosterone levels are associated with increased cardiovascular mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Eur Heart J 31:1237-1247
2. Rocha R, Funder JW 2002 The pathophysiology of aldosterone in the cardiovascular system. Ann NY Acad Sci 970:89-100 (Pubitemid 35286086)
3. Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ 2005 Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 45:1243-1248 (Pubitemid 40523144)
4. Bergmann A, Eulenberg C, Wellner M, Rolle S, Luft F, Kettritz R 2010 Aldosterone abrogates nuclear factor κB-mediated tumor necrosis factor α production in human neutrophils via the mineralocorticoid receptor. Hypertension 55:370-379
5. Tsai CT, Chiang FT, Tseng CD, Hwang JJ, Kuo KT, Wu CK, Yu CC, Wang YC, Lai LP, Lin JL 2010 Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation. J Am Coll Cardiol 55:758-770
6. Caprio M, Newfell BG, La Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ 2008 Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 102:1359-1367
7. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T 2003 Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348:593-600 (Pubitemid 36204953)
8. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M, Nickenig G 2005 Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353:999-1007 (Pubitemid 41262334)
9. Schmidt-Lucke C, Rössig L, Fichtlscherer S, Vasa M, Britten M, Kämper U, Dimmeler S, Zeiher AM 2005 Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 111:2981-2987 (Pubitemid 40814192)
10. Cheng S, Cohen KS, Shaw SY, Larson MG, Hwang SJ, McCabe EL, Martin RP, Klein RJ, Hashmi B, Hoffmann U, Fox CS, Vasan RS, O'Donnell CJ, Wang TJ 2010 Association of colony-forming units with coronary artery and abdominal aortic calcification. Circulation 122:1176-1182
11. Ladage D, Schützeberg N, Dartsch T, Krausgrill B, Halbach M, Zobel C, Müller-Ehmsen J 2011 Hyperaldosteronism is associated with a decrease in number and altered growth factor expression of endothelial progenitor cells in rats. Int J Cardiol 149:152-156
12. Kobayashi N, Fukushima H, Takeshima H, Koguchi W, Mamada Y, Hirata H, Machida Y, Suzuki N, Yokotsuka F, Tabei K, Kobayashi E, Fukuda N, Ishimitsu T 2010 Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb. Am J Hypertens 23:1007-1013
13. Verhovez A, Zeoli A, Williams TA, Morello F, Brizzi MF, Veglio F, Mulatero P 2008 Primary aldosteronism (PA) and endothelial progenitor cell (EPC) bioavailability. Clin Endocrinol (Oxf) 69:528-534
14. Alzamora R, Marusic ET, Gonzalez M, Michea L 2003 Non-genomic effect of aldosterone on Na+, K+-adenosine triphosphatase in arterial vessels. Endocrinology 144:1266-1272 (Pubitemid 36428468)
15. Wu VC, Kuo CC, Chang HW, Tsai CT, Lin CY, Lin LY, Lin YH, Wang SM, Huang KH, Fang CC, Ho YL, Liu KL, Chang CC, ChuehSC, Lin SL, Yen RF, Wu KD; TAIPIA Study Group 2010 Diagnosis of primary aldosteronism: comparison of post-captopril active renin concentration and plasma renin activity. Clin Chim Acta 411:657-663
16. Wu VC, Chang HW, Liu KL, Lin YH, Chueh SC, Lin WC, Ho YL, Huang JW, Chiang CK, Yang SY, Chen YM, Wang SM, Huang KH, Hsieh BS, Wu KD 2009 Primary aldosteronism: diagnostic accuracy of the losartan and captopril tests. Am J Hypertens 22:821-827
17. Kuo HK, Chen CY, Liu HM, Yen CJ, Chang KJ, Chang CC, Yu YH, Lin LY, Hwang JJ 2010 Metabolic risks, white matter hyperintensities, and arterial stiffness in high-functioning healthy adults. Int J Cardiol 143:184-191
18. Hsu SP, Wu MS, Yang CC, Huang KC, Liou SY, Hsu SM, Chien CT 2007 Chronic green tea extract supplementation reduces hemodialysis-enhanced production of hydrogen peroxide and hypochlorous acid, atherosclerotic factors, and proinflammatory cytokines. Am J Clin Nutr 86:1539-1547
19. Wu VC, Chueh SC, Chang HW, Lin LY, Liu KL, Lin YH, Ho YL, Lin WC, Wang SM, Huang KH, Hung KY, Kao TW, Lin SL, Yen RF, Chen YM, Hsieh BS, Wu KD 2009 Association of kidney function with residual hypertension after treatment of aldosterone-producing adenoma. Am J Kidney Dis 54:665-673
20. Chen YH, Lin SJ, Lin FY, Wu TC, Tsao CR, Huang PH, Liu PL, Chen YL, Chen JW 2007 High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 56:1559-1568
21. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S 2001 Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89:E1-E7
22. Wang SH, Lin SJ, Chen YH, Lin FY, Shih JC, Wu CC, Wu HL, Chen YL 2009 Late outgrowth endothelial cells derived from Wharton jelly in human umbilical cord reduce neointimal formation after vascular injury: involvement of pigment epithelium-derived factor. Arterioscler Thromb Vasc Biol 29:816-822
23. Huang PH, Chen YH, Wang CH, Chen JS, Tsai HY, Lin FY, Lo WY, Wu TC, Sata M, Chen JW, Lin SJ 2009 Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 29:1179-1184
24. Huang PH, Chen YH, Tsai HY, Chen JS, Wu TC, Lin FY, Sata M, Chen JW, Lin SJ 2010 Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability. Arterioscler Thromb Vasc Biol 30:869-877
25. Woo MJ, Reiter JP, Karr AF 2008 Estimation of propensity scores using generalized additive models. Stat Med 27:3805-3816
26. Madero M, Wassel CL, Peralta CA, Najjar SS, Sutton-Tyrrell K, Fried L, Canada R, Newman A, Shlipak MG, Sarnak MJ 2009 Cystatin C associates with arterial stiffness in older adults. J Am Soc Nephrol 20:1086-1093
27. Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J 2011 Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans. Eur Heart J 32:1275-1286
28. Ortiz RM, Mamalis A, Navar LG 2009 Aldosterone receptor antagonism reduces urinary C-reactive protein excretion in angiotensin II-infused, hypertensive rats. J Am Soc Hypertens 3:184-191
29. Stehr CB, Mellado R, Ocaranza MP, Carvajal CA, Mosso L, Becerra E, Solis M, García L, Lavandero S, Jalil J, Fardella CE 2010 Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients. J Hypertens 28:2120-2126
30. Thum T, Fraccarollo D, Thum S, Schultheiss M, Daiber A, Wenzel P, Munzel T, Ertl G, Bauersachs J 2007 Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Arterioscler Thromb Vasc Biol 27:748-754 (Pubitemid 46606702)
31. Verma S, Kuliszewski MA, Li SH, Szmitko PE, Zucco L, Wang CH, Badiwala MV, Mickle DA, Weisel RD, Fedak PW, Stewart DJ, Kutryk MJ 2004 C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109:2058-2067 (Pubitemid 38620212)
32. Kusche-Vihrog K, Urbanova K, Blanqué A, Wilhelmi M, Schillers H, Kliche K, Pavenstädt H, Brand E, Oberleithner H 2011 C-reactive protein makes human endothelium stiff and tight. Hypertension 57:231-237
33. Bernini G, Galetta F, Franzoni F, Bardini M, Taurino C, Bernardini M, Ghiadoni L, Bernini M, Santoro G, Salvetti A 2008 Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism. J Hypertens 26:2399-2405
34. Nishizaka MK, Zaman MA, Green SA, Renfroe KY, Calhoun DA 2004 Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation 109:2857-2861 (Pubitemid 38780298)
35. Horita Y, Inenaga T, Nakahama H, Ishibashi-Ueda H, Kawano Y, Nakamura S, Horio T, Okuda N, Ando M, Takishita S 2001 Cause of residual hypertension after adrenalectomy in patients with primary aldosteronism. Am J Kidney Dis 37:884-889 (Pubitemid 32471846)
36. Marumo T, Uchimura H, Hayashi M, Hishikawa K, Fujita T 2006 Aldosterone impairs bone marrow-derived progenitor cell formation. Hypertension 48:490-496 (Pubitemid 44253745)
37. Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J 2007 Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nature medicine 13:189-197
38. Wilkinson-Berka JL, Tan G, Jaworski K, Miller AG 2009 Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Circ Res 104:124-133
39. Michel F, Ambroisine ML, Duriez M, Delcayre C, Levy BI, Silvestre JS 2004 Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway. Circulation 109:1933-1937 (Pubitemid 38544481)
40. Massaad C, Houard N, Lombès M, Barouki R 1999 Modulation of human mineralocorticoid receptor function by protein kinase A. Mol Endocrinol 13:57-65 (Pubitemid 29022279)
41. + exchanger in proximal S3 segment: role of cytosolic calcium. Am J Physiol Renal Physiol 295:F1342-F1352
42. Takeda Y, Yoneda T, Demura M, Furukawa K, Miyamori I, Mabuchi H 2001 Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats. J Hypertens 19:635-639 (Pubitemid 32280957)