Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: Implications in diabetes mellitus-associated obesity and vascular dysfunction

Hypertension

Volumn 59, Issue 5, 2012, Pages 1069-1078

  Briones, Ana M ^a,d   Cat, Aurelie Nguyen Dinh ^a   Callera, Glaucia E ^a   Yogi, Alvaro ^a   Burger, Dylan ^a   He, Ying ^a   Corrêa, Jose W ^a   Gagnon, Anne Marie ^a   Gomez Sanchez, Celso E ^c   Gomez Sanchez, Elise P ^c   Sorisky, Alexander ^a   Ooi, Teik Chye ^a   Ruzicka, Marcel ^b   Burns, Kevin D ^a   Touyz, Rhian M ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Adipocytes; Aldosterone; Calcineurin NFAT; Obesity; Vascular function

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; CALCINEURIN; CANDESARTAN; CYCLOSPORIN A; EPLERENONE; TACROLIMUS;

ADIPOCYTE; ADIPOGENESIS; ALDOSTERONE BLOOD LEVEL; ALDOSTERONE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIABETIC OBESITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENTERIC ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEROID METABOLISM;

ADIPOCYTES; ALDOSTERONE; ANIMALS; BENZIMIDAZOLES; CALCINEURIN; CELLS, CULTURED; DIABETES COMPLICATIONS; DIABETIC ANGIOPATHIES; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED C57BL; OBESITY; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 84860226019     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.190223     Document Type: Article

References (36)

1. Guzik TJ, Marvar PJ, Czesnikiewicz-Guzik M, Korbut R. Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction. J Physiol Pharmacol. 2007;58:591-610.
2. Wang P, Mariman E, Renes J, Keijer J. The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol. 2008;216:3-13. (Pubitemid 351813090)
3. Gálvez B, de Castro J, Herold D, Dubrovska G, Arribas S, González MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Fernández Alfonso MS. Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol. 2006;26: 1297-1302.
4. Lee RM, Lu C, Su LY, Gao YJ. Endothelium-dependent relaxation factor released by perivascular adipose tissue. J Hypertens. 2009;27:782-790.
5. Yiannikouris F, Gupte M, Putnam K, Cassis L. Adipokines and blood pressure control. Curr Opin Nephrol Hypertens. 2010;19:195-200.
6. Miao CY, Li ZY. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol. 2012;165:643-658.
7. Andersson CX, Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Inflamed adipose tissue, insulin resistance and vascular injury. Diabetes Metab Res Rev. 2008;24:595-603.
8. Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au CL, Yao X, Huang Y. Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice. Antioxid Redox Signal. 2010;13:757-768.
9. Calhoun DA, Sharma K. The role of aldosteronism in causing obesityrelated cardiovascular risk. Cardiol Clin. 2010;28:517-527.
10. Dall'Asta C, Vedani P, Manunta P, Pizzocri P, Marchi M, Paganelli M, Folli F, Pontiroli AE. Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity. Nutr Metab Cardiovasc Dis. 2009;19:110-114.
11. Thatcher S, Yiannikouris F, Gupte M, Cassis L. The adipose reninangiotensin system: role in cardiovascular disease. Mol Cell Endocrinol. 2009;302:111-117.
12. Ehrhart-Bornstein M, Arakelyan K, Krug AW, Scherbaum WA, Bornstein SR. Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res. 2004;30:865-870. (Pubitemid 40070185)
13. Lamounier-Zepter V, Ehrhart-Bornstein M, Bornstein SR. Mineralocorticoidstimulating activity of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2005;19:567-575.
14. Nagase M, Yoshida S, Shibata S, Nagase T, Gotoda T, Ando K, Fujita T. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol. 2006;17:3438-3446. (Pubitemid 44865286)
15. Schinner S, Willenberg HS, Krause D, Schott M, Lamounier-Zepter V, Krug AW, Ehrhart-Bornstein M, Bornstein SR, Scherbaum WA. Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway. Int J Obes (Lond). 2007;31:864-870.
16. Caprio M, Fève B, Claës A, Viengchareun S, Lombès M, Zennaro MC. Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J. 2007;21:2185-2194. (Pubitemid 47026453)
17. Caprio M, Antelmi A, Chetrite G, Muscat A, Mammi C, Marzolla V, Fabbri A, Zennaro MC, Fève B. Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: potential implications for the treatment of metabolic syndrome. Endocrinology. 2011;152:113-125.
18. Campbell JE, Peckett AJ, D'souza AM, Hawke TJ, Riddell MC. Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol Cell Physiol. 2011;300:C198-C209.
19. Guo C, Ricchiuti V, Lian BQ, Yao TM, Coutinho P, Romero JR, Li J, Williams GH, Adler GK. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-, and proinflammatory adipokines. Circulation. 2008;117:2253-2261.
20. Hirata A, Maeda N, Hiuge A, Hibuse T, Fujita K, Okada T, Kihara S, Funahashi T, Shimomura I. Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res. 2009;84:164-172.
21. Tirosh A, Garg R, Adler GK. Mineralocorticoid receptor antagonists and the metabolic syndrome. Curr Hypertens Rep. 2010;12:252-257.
22. Nguyen Dinh Cat A, Briones AM, Callera GE, Yogi A, He Y, Montezano AC, Touyz RM. Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension. 2011;58:479-488.
23. Nithipatikom K, Holmes BB, Isbell MA, Hanke CJ, Gomez-Sanchez CE, Campbell WB. Measurement of steroid synthesis in zona glomerulosa cells by liquid chromatography-electrospray ionization-mass spectrometry: inhibition by nitric oxide. Anal Biochem. 2005;337:203-210. (Pubitemid 40187247)
24. Yamashiro T, Kuge H, Zhang J, Honke K. Calcineurin mediates the angiotensin II-induced aldosterone synthesis in the adrenal glands by up-regulation of transcription of the CYP11B2 gene. J Biochem. 2010;148:115-123.
25. Martínez-Martínez S, Redondo JM. Inhibitors of the calcineurin/NFAT pathway. Curr Med Chem. 2004;11:997-1007. (Pubitemid 38425927)
26. Hoppmann J, Perwitz N, Meier B, Fasshauer M, Hadaschik D, Lehnert H, Klein J. The balance between gluco-and mineralo-corticoid action critically determines inflammatory adipocyte responses. J Endocrinol. 2010;204: 153-164.
27. Li H, Rao A, Hogan PG. Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol. 2011;21:91-103.
28. Ho IC, Kim JH, Rooney JW, Spiegelman BM, Glimcher LH. A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. Proc Natl Acad Sci USA. 1998;95: 15537-15541. (Pubitemid 29018734)
29. Suzuki E, Nishimatsu H, Satonaka H, Walsh K, Goto A, Omata M, Fujita T, Nagai R, Hirata Y. Angiotensin II induces myocyte enhancer factor 2-and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes. Circ Res. 2002;90:1004-1011. (Pubitemid 34633867)
30. Bentley-Lewis R, Adler GK, Perlstein T, Seely EW, Hopkins PN, Williams GH, Garg R. Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab. 2007;92:4472-4475. (Pubitemid 350074772)
31. Tomono Y, Iwai M, Inaba S, Mogi M, Horiuchi M. Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models. Am J Hypertens. 2008;21:206-212. (Pubitemid 351231578)
32. Yamada S. Pleiotropic effects of ARB in metabolic syndrome. Curr Vasc Pharmacol. 2011;9:158-161.
33. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, Heagerty AM. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009;119:1661-1670.
34. Ketonen J, Shi J, Martonen E, Mervaala E. Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice. Circ J. 2010;74:1479-1487.
35. Xavier FE, Aras-López R, Arroyo-Villa I, Campo LD, Salaices M, Rossoni LV, Ferrer M, Balfagón G. Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2 and prostacyclin. Br J Pharmacol. 2008;154:1225-1235. (Pubitemid 351992068)
36. Withers SB, Agabiti-Rosei C, Livingstone DM, Little MC, Aslam R, Malik RA, Heagerty AM. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler Thromb Vasc Biol. 2011;31:908-913.