The effect of glucosamine sulfate on the proliferative potential and glycosaminoglycan synthesis of nucleus pulposus intervertebral disc cells

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Volumn 38, Issue 4, 2013, Pages 308-314

  Mavrogonatou, Eleni ^a   Kletsas, Dimitris ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Blyscan; glucosamine sulfate; intervertebral disc; MAPKs; nucleus pulposus; osmolality; proteoglycans

Indexed keywords

GLUCOSAMINE SULFATE; GLYCOSAMINOGLYCAN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; TETRAZOLIUM; THYMIDINE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CELL VIABILITY; DNA SYNTHESIS; HOMEOSTASIS; HYPEROSMOTIC STRESS; INCUBATION TEMPERATURE; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; NONHUMAN; NUCLEUS PULPOSUS; OSMOLALITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATTLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOSAMINOGLYCANS; INTERVERTEBRAL DISC; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SULFATASES; TIME FACTORS;

EID: 84874113934     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31826a0a8d     Document Type: Article

References (44)

1. Hua J, Sakamoto K, Nagaoka I. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutro-phils. J Leukoc Biol 2002; 71: 632-40.
2. RafiMM, Yadav PN, Rossi AO. Glucosamine inhibits LPS-induced COX-2 and iNOS expression in mouse macrophage cells (RAW 264.7) by inhibition of p38-MAP kinase and transcription factor NF-kappaB. Mol Nutr Food Res 2007; 51: 587-93.
3. Dodge GR, Jimenez SA. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage 2003; 11: 424-32.
4. Wen ZH, Tang CC, Chang YC, et al. Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes. Osteoarthritis Cartilage 2010; 18: 1192-202.
5. McCarty MF. The neglect of glucosamine as a treatment for osteo-arthritis-a personal perspective. Med Hypotheses 1994; 42: 323-7.
6. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001; 357: 251-6.
7. Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002; 162: 2113-23.
8. McAlindon TE, LaValley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283: 1469-75.
9. Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford) 2002; 41: 279-84.
10. Chard J, Dieppe P. Glucosamine for osteoarthritis: magic, hype, or confusion? It's probably safe-but there's no good evidence that it works. BMJ 2001; 322: 1439-40.
11. Rozendaal RM, Uitterlinden EJ, van Osch GJ, et al. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial. Osteoarthritis Cartilage 2009; 17: 427-32.
12. Wu YL, Kou YR, Ou HL, et al. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol 2010; 635: 219-26.
13. Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage 1998; 6: 427-34.
14. Sandy JD, Gamett D, Thompson V, et al. Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine. Biochem J 1998; 335 (pt 1): 59-66.
15. Gouze JN, Bianchi A, Becuwe P, et al. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. FEBS Lett 2002; 510: 166-70.
16. Largo R, Alvarez-Soria MA, Diez-Ortego I, et al. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoar-thritic chondrocytes. Osteoarthritis Cartilage 2003; 11: 290-8.
17. Le Maitre CL, Pockert A, Buttle DJ, et al. Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 2007; 35: 652-5.
18. Walsh AJ, O'Neill CW, Lotz JC. Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro. Spine J 2007; 7: 601-8.
19. van Blitterswijk WJ, van de Nes JC, Wuisman PI. Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report. BMC Complement Altern Med 2003; 3: 2.
20. Mavrogonatou E, Kletsas D. Differential response of nucleus pulp-osus intervertebral disc cells to high salt, sorbitol and urea. J Cell Physiol 2012; 227: 1179-87.
21. Mavrogonatou E, Kletsas D. High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response. DNA Repair (Amst) 2009; 8: 930-43.
22. Mavrogonatou E, Kletsas D. Effect of varying osmotic conditions on the response of bovine nucleus pulposus cells to growth factors and the activation of the ERK and Akt pathways. J Orthop Res 2010; 28: 1276-82.
23. Derfoul A, Miyoshi AD, Freeman DE, et al. Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage 2007; 15: 646-55.
24. Meulyzer M, Vachon P, Beaudry F, et al. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride. Osteoarthritis Cartilage 2009; 17: 228-34.
25. Mavrogonatou E, Eliades T, Eliades G, et al. The effect of triethyl-ene glycol dimethacrylate on p53-dependent G2 arrest in human gingival fibroblasts. Biomaterials 2010; 31: 8530-8.
26. Urban JP. The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans 2002; 30: 858-64.
27. Reginster J Y. Chondromodulation in 2003: dream or reality? Rev Med Suisse Romande 2004; 124: 85-7.
28. Persiani S, Roda E, Rovati LC, et al. Glucosamine oral bioavail-ability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man. Osteoarthritis Cartilage 2005; 13: 1041-9.
29. Persiani S, Rotini R, Trisolino G, et al. Synovial and plasma glu-cosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose. Osteoarthritis Cartilage 2007; 15: 764-72.
30. de Mattei M, Pellati A, Pasello M, et al. High doses of glucos-amine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cartilage 2002; 10: 816-25.
31. Graeser AC, Giller K, Wiegand H, et al. Synergistic chondropro-tective effect of alpha-tocopherol, ascorbic acid, and selenium as well as glucosamine and chondroitin on oxidant induced cell death and inhibition of matrix metalloproteinase-3-studies in cultured chondrocytes. Molecules 2010; 15: 27-39.
32. Hong H, Park YK, Choi MS, et al. Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride. J Dermatol Sci 2009; 56: 43-50.
33. Varghese S, Theprungsirikul P, Sahani S, et al. Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. Osteoarthritis Cartilage 2007; 15: 59-68.
34. Liang CM, Tai MC, Chang YH, et al. Glucosamine inhibits epidermal growth factor-induced proliferation and cell-cycle progression in retinal pigment epithelial cells. Mol Vis 2010; 16: 2559-71.
35. Venkatesan N, Barre L, Magdalou J, et al. Modulation of xylo-syltransferase I expression provides a mechanism regulating gly-cosaminoglycan chain synthesis during cartilage destruction and repair. Faseb J 2009; 23: 813-22.
36. Hirao M, Tamai N, Tsumaki N, et al. Oxygen tension regulates chondrocyte differentiation and function during endochondral ossi-fication. J Biol Chem 2006; 281: 31079-92.
37. Getachew R, Ballinger ML, Burch ML, et al. PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology 2010; 151: 4356-67.
38. Clarkin CE, Allen S, Kuiper NJ, et al. Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogen-esis. J Cell Physiol 2011; 226: 749-61.
39. Lu HT, Liang YC, Sheu MT, et al. Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem 2008; 104: 38-50.
40. d'Abusco AS, Calamia V, Cicione C, et al. Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes. Arthritis Res Ther 2007;9:R104.
41. Lin YC, Liang YC, Sheu MT, et al. Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways. Rheumatol Int 2008; 28: 1009-16.
42. Rajapakse N, Kim MM, Mendis E, et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signaling. Immunology 2008; 123: 348-57.
43. Jang BC, Sung SH, Park JG, et al. Glucosamine hydrochloride spe-cifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. J Biol Chem 2007; 282: 27622-32.
44. Qu CJ, Karjalainen HM, Helminen HJ, et al. The lack of effect of glucosamine sulphate on aggrecan mRNA expression and (35) S-sulphate incorporation in bovine primary chondrocytes. Biochim Biophys Acta 2006; 1762: 453-9.