Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner

Journal of Biological Chemistry

Volumn 282, Issue 38, 2007, Pages 27622-27632

  Jang, Byeong Churl ^a   Sung, Su Haeng ^a   Park, Jong Gu ^a   Park, Jong Wook ^a   Jae, Hoon Bae ^a   Dong, Hoon Shin ^a   Park, Gi Young ^a   Han, Seung Bum ^a   Suhz, Seong Il ^a  

^a Keimyung University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ENZYME INHIBITION; GENE EXPRESSION; GLYCOSYLATION; TUMORS;

CYCLOHEXIMIDE; GALACTOSAMINE; GLUCOSAMINE HYDROCHLORIDE; PROTEASOMAL INHIBITORS;

CARBOHYDRATES;

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; GLUCOSAMINE; INTERLEUKIN 1BETA; TUNICAMYCIN;

ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM CELL; GLYCOSYLATION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION;

CELL LINE, TUMOR; CHLORIDES; CYCLOOXYGENASE 2; DINOPROSTONE; EPITHELIUM; GALACTOSAMINE; GLUCOSAMINE; GLYCOSYLATION; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LUNG; MODELS, BIOLOGICAL; OSTEOARTHRITIS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 34948874369     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610778200     Document Type: Article

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