The effect of triethylene glycol dimethacrylate on p53-dependent G2 arrest in human gingival fibroblasts

Biomaterials

Volumn 31, Issue 33, 2010, Pages 8530-8538

  Mavrogonatou, Eleni ^a   Eliades, Theodore ^b   Eliades, George ^c   Kletsas, Dimitris ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cell cycle; DCFH DA; MAPKs; P53 siRNA; Proliferation; TEGDMA

Indexed keywords

CELL CYCLE; DCFH-DA; MAPKS; P53 SIRNA; PROLIFERATION; TEGDMA;

ACRYLIC MONOMERS; CELL CULTURE; DENTAL COMPOSITES; FIBROBLASTS; GLYCOLS; OXYGEN; PHOSPHORYLATION; RESINS;

RNA;

CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P53; RESIN; RETINOBLASTOMA PROTEIN; TRIETHYLENE GLYCOL DIMETHACRYLATE;

ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; GENOTOXICITY; GINGIVA; HUMAN; HUMAN CELL; MOUTH CAVITY; PRIORITY JOURNAL; WESTERN BLOTTING;

CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; FIBROBLASTS; G2 PHASE; GINGIVA; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; PHOSPHORYLATION; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957322519     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.07.074     Document Type: Article

References (57)

1. Spahl W., Budzikiewicz H., Geurtsen W. Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry. J Dent 1998, 26:137-145.
2. Geurtsen W. Substances released from dental resin composites and glass ionomer cements. Eur J Oral Sci 1998, 106:687-695.
3. Schweikl H., Spagnuolo G., Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res 2006, 85:870-877.
4. Engelmann J., Leyhausen G., Leibfritz D., Geurtsen W. Effect of TEGDMA on the intracellular glutathione concentration of human gingival fibroblasts. J Biomed Mater Res 2002, 63:746-751.
5. Stanislawski L., Lefeuvre M., Bourd K., Soheili-Majd E., Goldberg M., Perianin A. TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. J Biomed Mater Res A 2003, 66:476-482.
6. Volk J., Engelmann J., Leyhausen G., Geurtsen W. Effects of three resin monomers on the cellular glutathione concentration of cultured human gingival fibroblasts. Dent Mater 2006, 22:499-505.
7. Lefeuvre M., Amjaad W., Goldberg M., Stanislawski L. TEGDMA induces mitochondrial damage and oxidative stress in human gingival fibroblasts. Biomaterials 2005, 26:5130-5137.
8. Kleinsasser N.H., Schmid K., Sassen A.W., Harreus U.A., Staudenmaier R., Folwaczny M., et al. Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 2006, 27:1762-1770.
9. Kleinsasser N.H., Wallner B.C., Harreus U.A., Kleinjung T., Folwaczny M., Hickel R., et al. Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. J Dent 2004, 32:229-234.
10. Schweikl H., Hartmann A., Hiller K.A., Spagnuolo G., Bolay C., Brockhoff G., et al. Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent Mater 2007, 23:688-695.
11. Schweikl H., Altmannberger I., Hanser N., Hiller K.A., Bolay C., Brockhoff G., et al. The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells. Biomaterials 2005, 26:4111-4118.
12. Spagnuolo G., Galler K., Schmalz G., Cosentino C., Rengo S., Schweikl H. Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells. J Dent Res 2004, 83:703-707.
13. Schwartz D., Rotter V. p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol 1998, 8:325-336.
14. Eckhardt A., Gerstmayr N., Hiller K.A., Bolay C., Waha C., Spagnuolo G., et al. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials 2009, 30:2006-2014.
15. Schweikl H., Hiller K.A., Eckhardt A., Bolay C., Spagnuolo G., Stempfl T., et al. Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials 2008, 29:1377-1387.
16. Samuelsen J.T., Dahl J.E., Karlsson S., Morisbak E., Becher R. Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK. Dent Mater 2007, 23:34-39.
17. Irwin M.S., Kondo K., Marin M.C., Cheng L.S., Hahn W.C., Kaelin W.G. Chemosensitivity linked to p73 function. Cancer Cell 2003, 3:403-410.
18. Taoufik K., Mavrogonatou E., Eliades T., Papagiannoulis L., Eliades G., Kletsas D. Effect of blue light on the proliferation of human gingival fibroblasts. Dent Mater 2008, 24:895-900.
19. Eliades T., Pratsinis H., Kletsas D., Eliades G., Makou M. Characterization and cytotoxicity of ions released from stainless steel and nickel-titanium orthodontic alloys. Am J Orthod Dentofacial Orthop 2004, 125:24-29.
20. Mavrogonatou E., Kletsas D. High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response. DNA Repair (Amst) 2009, 8:930-943.
21. Smith J.A., Weidemann M.J. Further characterization of the neutrophil oxidative burst by flow cytometry. J Immunol Methods 1993, 162:261-268.
22. Cowan K.J., Storey K.B. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 2003, 206:1107-1115.
23. Zhang W., Liu H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002, 12:9-18.
24. Bartek J., Lukas J. Pathways governing G1/S transition and their response to DNA damage. FEBS Lett 2001, 490:117-122.
25. Perez-Cadahia B., Drobic B., Davie J.R. H3 phosphorylation: dual role in mitosis and interphase. Biochem Cell Biol 2009, 87:695-709.
26. Hume W.R., Gerzina T.M. Bioavailability of components of resin-based materials which are applied to teeth. Crit Rev Oral Biol Med 1996, 7:172-179.
27. Janke V., von Neuhoff N., Schlegelberger B., Leyhausen G., Geurtsen W. TEGDMA causes apoptosis in primary human gingival fibroblasts. J Dent Res 2003, 82:814-818.
28. Moharamzadeh K., Van Noort R., Brook I.M., Scutt A.M. Cytotoxicity of resin monomers on human gingival fibroblasts and HaCaT keratinocytes. Dent Mater 2007, 23:40-44.
29. Volk J., Leyhausen G., Dogan S., Geurtsen W. Additive effects of TEGDMA and hydrogenperoxide on the cellular glutathione content of human gingival fibroblasts. Dent Mater 2007, 23:921-926.
30. Theilig C., Tegtmeier Y., Leyhausen G., Geurtsen W. Effects of BisGMA and TEGDMA on proliferation, migration, and tenascin expression of human fibroblasts and keratinocytes. J Biomed Mater Res 2000, 53:632-639.
31. Harorli O.T., Bayindir Y.Z., Altunkaynak Z., Tatar A. Cytotoxic effects of TEGDMA on THP-1 cells in vitro. Med Oral Patol Oral Cir Bucal 2009, 14:e489-e493.
32. Engelmann J., Volk J., Leyhausen G., Geurtsen W. ROS formation and glutathione levels in human oral fibroblasts exposed to TEGDMA and camphorquinone. J Biomed Mater Res B Appl Biomater 2005, 75:272-276.
33. Eckhardt A., Muller P., Hiller K.A., Krifka S., Bolay C., Spagnuolo G., et al. Influence of TEGDMA on the mammalian cell cycle in comparison with chemotherapeutic agents. Dent Mater 2010, 26:232-241.
34. Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004, 73:39-85.
35. Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358:15-16.
36. Canman C.E., Chen C.Y., Lee M.H., Kastan M.B. DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. Cold Spring Harb Symp Quant Biol 1994, 59:277-286.
37. Negrini S., Gorgoulis V.G., Halazonetis T.D. Genomic instability - an evolving hallmark of cancer. Nat Rev Mol Cell Biol 2010, 11:220-228.
38. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
39. Dulic V., Kaufmann W.K., Wilson S.J., Tlsty T.D., Lees E., Harper J.W., et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994, 76:1013-1023.
40. Mittnacht S. Control of pRB phosphorylation. Curr Opin Genet Dev 1998, 8:21-27.
41. Urcan E., Scherthan H., Styllou M., Haertel U., Hickel R., Reichl F.X. Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites. Biomaterials 2010, 31:2010-2014.
42. Angiero F., Farronato G., Dessy E., Magistro S., Seramondi R., Farronato D., et al. Evaluation of the cytotoxic and genotoxic effects of orthodontic bonding adhesives upon human gingival papillae through immunohistochemical expression of p53, p63 and p16. Anticancer Res 2009, 29:3983-3987.
43. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282:1497-1501.
44. Lee S.J., Moon G.S., Jung K.H., Kim W.J., Moon S.K. c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. Food Chem Toxicol 2010, 48:277-283.
45. Taylor W.R., DePrimo S.E., Agarwal A., Agarwal M.L., Schonthal A.H., Katula K.S., et al. Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell 1999, 10:3607-3622.
46. Flatt P.M., Tang L.J., Scatena C.D., Szak S.T., Pietenpol J.A. p53 regulation of G(2) checkpoint is retinoblastoma protein dependent. Mol Cell Biol 2000, 20:4210-4223.
47. Agarwal M.L., Agarwal A., Taylor W.R., Stark G.R. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A 1995, 92:8493-8497.
48. Stewart N., Hicks G.G., Paraskevas F., Mowat M. Evidence for a second cell cycle block at G2/M by p53. Oncogene 1995, 10:109-115.
49. Thannickal V.J., Fanburg B.L. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000, 279:L1005-L1028.
50. Tibbles L.A., Woodgett J.R. The stress-activated protein kinase pathways. Cell Mol Life Sci 1999, 55:1230-1254.
51. Obata T., Brown G.E., Yaffe M.B. MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit Care Med 2000, 28:N67-N77.
52. Sheikh-Hamad D., Gustin M.C. MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. Am J Physiol Ren Physiol 2004, 287:F1102-F1110.
53. Krifka S., Petzel C., Hiller K.A., Frank E.M., Bosl C., Spagnuolo G., et al. Resin monomer-induced differential activation of MAP kinases and apoptosis in mouse macrophages and human pulp cells. Biomaterials 2010, 31:2964-2975.
54. Ishikawa Y., Kitamura M. Dual potential of extracellular signal-regulated kinase for the control of cell survival. Biochem Biophys Res Commun 1999, 264:696-701.
55. Padda R., Wamsley-Davis A., Gustin M.C., Ross R., Yu C., Sheikh-Hamad D. MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells. Am J Physiol Ren Physiol 2006, 291:F874-F881.
56. Ceraline J., Deplanque G., Duclos B., Limacher J.M., Hajri A., Noel F., et al. Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents. Int J Cancer 1998, 75:432-438.
57. Kawamura K., Morita N., Domiki C., Fujikawa-Yamamoto K., Hashimoto M., Iwabuchi K., et al. Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Cancer Sci 2006, 97:252-258.