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Volumn 13, Issue 12, 2005, Pages 1041-1049

Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man

Author keywords

Bioavailability; Glucosamine sulfate; Human; Mechanism of action; Pharmacokinetics

Indexed keywords

GLUCOSAMINE; GLUCOSAMINE SULFATE; VIARTRIL S; XICIL;

EID: 27944440047     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2005.07.009     Document Type: Article
Times cited : (154)

References (50)
  • 1
    • 0343698374 scopus 로고    scopus 로고
    • Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis
    • T.E. McAlindon M.P. La Valley J.P. Gulin D.T. Felson Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis JAMA 283 2000 1469-1475
    • (2000) JAMA , vol.283 , pp. 1469-1475
    • McAlindon, T.E.1    La Valley, M.P.2    Gulin, J.P.3    Felson, D.T.4
  • 2
    • 0038494028 scopus 로고    scopus 로고
    • Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. A comprehensive meta-analysis
    • F. Richy O. Bruyere O. Ethgen M. Cucherat Y. Henrotin J.Y. Reginster Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. A comprehensive meta-analysis Arch Intern Med 163 2003 1514-1522
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1514-1522
    • Richy, F.1    Bruyere, O.2    Ethgen, O.3    Cucherat, M.4    Henrotin, Y.5    Reginster, J.Y.6
  • 4
    • 0035956653 scopus 로고    scopus 로고
    • Long-term effects of glucosamine sulfate on osteoarthritis progression: A randomised, placebo-controlled clinical trial
    • J.Y. Reginster R. Deroisy L.C. Rovati R.L. Lee E. Lejeune O. Bruyere Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled clinical trial Lancet 357 2001 251-256
    • (2001) Lancet , vol.357 , pp. 251-256
    • Reginster, J.Y.1    Deroisy, R.2    Rovati, L.C.3    Lee, R.L.4    Lejeune, E.5    Bruyere, O.6
  • 5
    • 0037078298 scopus 로고    scopus 로고
    • Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study
    • K. Pavelka J. Gatterova M. Olejarova S. Machacek G. Giacovelli L.C. Rovati Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study Arch Intern Med 162 2002 2113-2123
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2113-2123
    • Pavelka, K.1    Gatterova, J.2    Olejarova, M.3    Machacek, S.4    Giacovelli, G.5    Rovati, L.C.6
  • 6
    • 0141615567 scopus 로고    scopus 로고
    • Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials
    • K. Pavelka O. Bruyere L.C. Rovati M. Olejárova G. Giacovelli J.Y. Reginster Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials Osteoarthritis Cartilage 11 2003 730-737
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 730-737
    • Pavelka, K.1    Bruyere, O.2    Rovati, L.C.3    Olejárova, M.4    Giacovelli, G.5    Reginster, J.Y.6
  • 7
    • 2342618233 scopus 로고    scopus 로고
    • Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: Evidence from two 3-year studies
    • O. Bruyere K. Pavelka L.C. Rovati R. Deroisy M. Olejarova J. Gatterova et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: Evidence from two 3-year studies Menopause 11 2004 138-143
    • (2004) Menopause , vol.11 , pp. 138-143
    • Bruyere, O.1    Pavelka, K.2    Rovati, L.C.3    Deroisy, R.4    Olejarova, M.5    Gatterova, J.6
  • 8
    • 0034821815 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism and excretion of glucosamine sulfate: A review
    • I. Setnikar L.C. Rovati Absorption, distribution, metabolism and excretion of glucosamine sulfate: A review Arzneimittelforschung 51 2001 699-725
    • (2001) Arzneimittelforschung , vol.51 , pp. 699-725
    • Setnikar, I.1    Rovati, L.C.2
  • 9
    • 2342467428 scopus 로고    scopus 로고
    • "If it feels good, do it" use of glucosamine sulfate to prevent the progression of osteoarthritis in postmenopausal women
    • T.A. Einhorn "If it feels good, do it" use of glucosamine sulfate to prevent the progression of osteoarthritis in postmenopausal women Menopause 11 2004 134-135
    • (2004) Menopause , vol.11 , pp. 134-135
    • Einhorn, T.A.1
  • 10
    • 0024314577 scopus 로고
    • The biology of osteoarthritis
    • D. Hamerman The biology of osteoarthritis N Engl J Med 320 1989 1322-1330
    • (1989) N. Engl. J. Med. , vol.320 , pp. 1322-1330
    • Hamerman, D.1
  • 11
    • 27944486881 scopus 로고
    • Dietary Supplement Health and Education Act of 1994, Pub. L. No. 103-417, 103rd Congress; Oct 25
    • Dietary Supplement Health and Education Act of 1994, Pub. L. No. 103-417, 103rd Congress; Oct 25, 1994.
    • (1994)
  • 12
    • 0036843215 scopus 로고    scopus 로고
    • Active ingredient consistency of commercially available glucosamine sulfate products
    • A.S. Russell A. Aghazadeh-Habashi F. Jamali Active ingredient consistency of commercially available glucosamine sulfate products J Rheumatol 29 2002 2407-2409
    • (2002) J. Rheumatol. , vol.29 , pp. 2407-2409
    • Russell, A.S.1    Aghazadeh-Habashi, A.2    Jamali, F.3
  • 13
    • 0032732070 scopus 로고    scopus 로고
    • Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee
    • J.B. Houpt R. McMillan C. Wein S.D. Paget-Dellio Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee J Rheumatol 26 1999 2423-2430
    • (1999) J. Rheumatol. , vol.26 , pp. 2423-2430
    • Houpt, J.B.1    McMillan, R.2    Wein, C.3    Paget-Dellio, S.D.4
  • 14
    • 0034132101 scopus 로고    scopus 로고
    • Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee
    • J.P. Rindone D. Hiller E. Collacott N. Nordhaugen G. Arriola Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee West J Med 172 2000 91-94
    • (2000) West J. Med. , vol.172 , pp. 91-94
    • Rindone, J.P.1    Hiller, D.2    Collacott, E.3    Nordhaugen, N.4    Arriola, G.5
  • 15
    • 0036111702 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee
    • R. Hughes A. Carr A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee Rheumatology 41 2002 279-284
    • (2002) Rheumatology , vol.41 , pp. 279-284
    • Hughes, R.1    Carr, A.2
  • 16
    • 5644226142 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis
    • J. Cibere J.A. Kopec A. Thorne J. Singer J. Canvin D.B. Robinson et al. Randomised, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis Arthritis Care Res 51 2004 738-745
    • (2004) Arthritis Care Res. , vol.51 , pp. 738-745
    • Cibere, J.1    Kopec, J.A.2    Thorne, A.3    Singer, J.4    Canvin, J.5    Robinson, D.B.6
  • 17
    • 0142094505 scopus 로고    scopus 로고
    • Why are clinical trials of glucosamine no longer uniformly positive?
    • T. McAlindon Why are clinical trials of glucosamine no longer uniformly positive? Rheum Dis Clin North Am 29 2003 789-801
    • (2003) Rheum. Dis. Clin. North Am. , vol.29 , pp. 789-801
    • McAlindon, T.1
  • 20
    • 0036708636 scopus 로고    scopus 로고
    • The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs
    • A. Adebowale J. Du Z. Liang J.L. Leslie N.D. Eddington The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs Biopharm Drug Dispos 23 2002 217-235
    • (2002) Biopharm. Drug Dispos. , vol.23 , pp. 217-235
    • Adebowale, A.1    Du, J.2    Liang, Z.3    Leslie, J.L.4    Eddington, N.D.5
  • 21
    • 3543122955 scopus 로고    scopus 로고
    • The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse
    • J. Du N. White N.D. Eddington The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse Biopharm Drug Dispos 25 2004 109-116
    • (2004) Biopharm. Drug Dispos. , vol.25 , pp. 109-116
    • Du, J.1    White, N.2    Eddington, N.D.3
  • 22
    • 12344329227 scopus 로고    scopus 로고
    • Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses
    • S. Laverty J.D. Sandy C. Celeste P. Vachon J.F. Marier A.H.K. Plaas Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses Arthritis Rheum 52 2005 181-191
    • (2005) Arthritis Rheum. , vol.52 , pp. 181-191
    • Laverty, S.1    Sandy, J.D.2    Celeste, C.3    Vachon, P.4    Marier, J.F.5    Plaas, A.H.K.6
  • 23
    • 0003455042 scopus 로고    scopus 로고
    • Guidance for Industry on Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations
    • Center for Drug Evaluation and Research. Rockville, MD: US Food and Drug Administration
    • Center for Drug Evaluation and Research Guidance for Industry on Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations 2003 US Food and Drug Administration Rockville, MD
    • (2003)
  • 24
    • 0024240807 scopus 로고
    • Kinetics of disposition of xenobiotics and their metabolites
    • B.J. Houston Kinetics of disposition of xenobiotics and their metabolites Drug Metabol Drug Interact 6 1988 47-83
    • (1988) Drug Metabol. Drug Interact. , vol.6 , pp. 47-83
    • Houston, B.J.1
  • 27
    • 0035025558 scopus 로고    scopus 로고
    • Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfate in articular cartilage explants
    • E.A. Noyszewski K. Wroblewski G.R. Dodge S. Kudchodkar J. Beers A.V. Sarma et al. Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfate in articular cartilage explants Arthritis Rheum 44 2001 1089-1095
    • (2001) Arthritis Rheum. , vol.44 , pp. 1089-1095
    • Noyszewski, E.A.1    Wroblewski, K.2    Dodge, G.R.3    Kudchodkar, S.4    Beers, J.5    Sarma, A.V.6
  • 28
    • 0032211837 scopus 로고    scopus 로고
    • Glucosamine sulfate stimulates proteoglycan production in human chondrocytes in vitro
    • C. Bassleer L.C. Rovati P. Franchimont Glucosamine sulfate stimulates proteoglycan production in human chondrocytes in vitro Osteoarthritis Cartilage 6 1998 427-434
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 427-434
    • Bassleer, C.1    Rovati, L.C.2    Franchimont, P.3
  • 30
    • 0038344684 scopus 로고    scopus 로고
    • Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
    • G.R. Dodge S.A. Jimenez Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes Osteoarthritis Cartilage 11 2003 424-432
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 424-432
    • Dodge, G.R.1    Jimenez, S.A.2
  • 31
    • 0032189902 scopus 로고    scopus 로고
    • Chondrocyte-mediated catabolism of aggrecan: Aggreganase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine
    • J.D. Sandy D. Gamett V. Thompson C. Verscharen Chondrocyte-mediated catabolism of aggrecan: Aggreganase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine Biochem J 335 1998 59-66
    • (1998) Biochem. J. , vol.335 , pp. 59-66
    • Sandy, J.D.1    Gamett, D.2    Thompson, V.3    Verscharen, C.4
  • 32
    • 8444240454 scopus 로고    scopus 로고
    • 35S-sulfate with cultured human chondrocytes to determine the effect of glucosamine concentration on formation of chondroitin sulfate
    • 35S-sulfate with cultured human chondrocytes to determine the effect of glucosamine concentration on formation of chondroitin sulfate Arthritis Rheum 50 2004 3574-3579
    • (2004) Arthritis Rheum. , vol.50 , pp. 3574-3579
    • Mroz, P.J.1    Silbert, J.E.2
  • 35
    • 0035956661 scopus 로고    scopus 로고
    • Glucosamine for osteoarthritis: Dawn of a new era?
    • T. McAlindon Glucosamine for osteoarthritis: Dawn of a new era? Lancet 357 2001 247-248
    • (2001) Lancet , vol.357 , pp. 247-248
    • McAlindon, T.1
  • 36
    • 10744224265 scopus 로고    scopus 로고
    • EULAR recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
    • K.M. Jordan N.K. Arden M. Doherty J.W.J. Bijlsma P. Dieppe K. Gunther et al. EULAR recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) Ann Rheum Dis 62 2003 1145-1155
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 1145-1155
    • Jordan, K.M.1    Arden, N.K.2    Doherty, M.3    Bijlsma, J.W.J.4    Dieppe, P.5    Gunther, K.6
  • 37
    • 0034745403 scopus 로고    scopus 로고
    • Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes
    • J.N. Gouze K. Bordji S. Gulberti B. Terlain P. Netter J. Magdalou et al. Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes Arthritis Rheum 44 2001 351-360
    • (2001) Arthritis Rheum. , vol.44 , pp. 351-360
    • Gouze, J.N.1    Bordji, K.2    Gulberti, S.3    Terlain, B.4    Netter, P.5    Magdalou, J.6
  • 38
    • 0035871802 scopus 로고    scopus 로고
    • N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes
    • A.R. Shikhman K. Kuhn N. Alaaeddine M. Lotz N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes J Immunol 166 2001 5155-5160
    • (2001) J. Immunol. , vol.166 , pp. 5155-5160
    • Shikhman, A.R.1    Kuhn, K.2    Alaaeddine, N.3    Lotz, M.4
  • 39
    • 0037116589 scopus 로고    scopus 로고
    • Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway
    • J.N. Gouze A. Bianchi P. Becuwe M. Dauca P. Netter J. Magdalou et al. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway FEBS Lett 510 2002 166-170
    • (2002) FEBS Lett. , vol.510 , pp. 166-170
    • Gouze, J.N.1    Bianchi, A.2    Becuwe, P.3    Dauca, M.4    Netter, P.5    Magdalou, J.6
  • 41
    • 27944500026 scopus 로고    scopus 로고
    • The mechanism of action of glucosamine sulfate in osteoarthritis: IL-1β-mediated reactive oxygen species generation and modulation of NK-kB pathway
    • (Abstract)
    • O. Letari S. Colombo T. Zanelli T. Piepoli F. Makovec L.C. Rovati The mechanism of action of glucosamine sulfate in osteoarthritis: IL-1β-mediated reactive oxygen species generation and modulation of NK-kB pathway (Abstract) Arthritis Rheum 48 9 Suppl 2003 664
    • (2003) Arthritis Rheum. , vol.48 , Issue.SUPPL. 9 , pp. 664
    • Letari, O.1    Colombo, S.2    Zanelli, T.3    Piepoli, T.4    Makovec, F.5    Rovati, L.C.6
  • 42
    • 27944441894 scopus 로고    scopus 로고
    • Glucosamine and chondroitin sulfate regulate inflammatory mediators
    • (Abstract)
    • P.S. Chan J.P. Caron M.W. Orth Glucosamine and chondroitin sulfate regulate inflammatory mediators (Abstract) Osteoarthritis Cartilage 12 Suppl B 2004 P325
    • (2004) Osteoarthritis Cartilage , vol.12 , Issue.SUPPL. B
    • Chan, P.S.1    Caron, J.P.2    Orth, M.W.3
  • 43
    • 27944483127 scopus 로고    scopus 로고
    • Glucosamine and chondroitin sulfate regulate IL-1 induced gene expression
    • (Abstract)
    • P.S. Chan J.P. Caron M.W. Orth Glucosamine and chondroitin sulfate regulate IL-1 induced gene expression (Abstract) Osteoarthritis Cartilage 12 Suppl B 2004 P326
    • (2004) Osteoarthritis Cartilage , vol.12 , Issue.SUPPL. B
    • Chan, P.S.1    Caron, J.P.2    Orth, M.W.3
  • 45
    • 0034109155 scopus 로고    scopus 로고
    • Application to a cartilage targeting strategy: Synthesis and in vivo biodistribution of (14)C-labeled quaternary ammonium-glucosamine conjugates
    • I. Giraud M. Rapp J.C. Maurizis J.C. Madelmont Application to a cartilage targeting strategy: Synthesis and in vivo biodistribution of (14)C-labeled quaternary ammonium-glucosamine conjugates Bioconjug Chem 11 2000 212-218
    • (2000) Bioconjug. Chem. , vol.11 , pp. 212-218
    • Giraud, I.1    Rapp, M.2    Maurizis, J.C.3    Madelmont, J.C.4
  • 47
    • 0037339424 scopus 로고    scopus 로고
    • Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulphur amino acids
    • F. Cordoba M.E. Nimni Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulphur amino acids Osteoarthritis Cartilage 11 2003 228-230
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 228-230
    • Cordoba, F.1    Nimni, M.E.2
  • 48
    • 0002598423 scopus 로고
    • Pharmaceutic factors affecting drug bioavailability
    • editors. 2nd edn. Norwark (CT): Appleton-Century-Crofts
    • Shargel L, Yu ABC, editors. Pharmaceutic factors affecting drug bioavailability In: Applied biopharmaceutics and pharmacokinetics. 2nd edn. Norwark (CT): Appleton-Century-Crofts;1985. p. 74-78.
    • (1985) Applied Biopharmaceutics and Pharmacokinetics , pp. 74-78
    • Shargel, L.1    Yu, A.B.C.2
  • 49
    • 27944441474 scopus 로고    scopus 로고
    • Glucosamine/Chondroitin Arthritis Intervention Trial
    • Glucosamine/Chondroitin Arthritis Intervention Trial Available from http://www.nihgait.org
  • 50
    • 84868654593 scopus 로고    scopus 로고
    • A method of preparing mixed glucosamine salts
    • inventors Aug 13
    • De Wan M, Volpi G, inventors. A method of preparing mixed glucosamine salts. US patent 5,847,107; Aug 13, 1997.
    • (1997) US Patent 5,847,107
    • De Wan, M.1    Volpi, G.2


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