Synergistic chondroprotective effect of α-tocopherol, ascorbic acid, and selenium as well as glucosamine and chondroitin on oxidant induced cell death and inhibition of matrix metalloproteinase-3 - studies in cultured chondrocytes

Molecules

Volumn 15, Issue 1, 2010, Pages 27-39

  Graeser, Anne Christin ^a   Giller, Katrin ^a   Wiegand, Heike ^a   Barella, Luca ^b   Boesch Saadatmandi, Christine ^a   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b Bayer Consumer Care AG   (Switzerland)

Author keywords

Ascorbic acid; Chondrocytes; Chondroitin; Glucosamine; Inflammation; Metalloproteinases; Oxidative stress; Selenium; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CHONDROITIN; GLUCOSAMINE; INTERLEUKIN 1BETA; MESSENGER RNA; OXIDIZING AGENT; SELENIUM; STROMELYSIN; TERT BUTYL HYDROPEROXIDE;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; SECRETION; TUMOR CELL LINE;

ALPHA-TOCOPHEROL; ASCORBIC ACID; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; CHONDROITIN; CYTOPROTECTION; DRUG SYNERGISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSAMINE; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 3; OXIDANTS; RNA, MESSENGER; SELENIUM; TERT-BUTYLHYDROPEROXIDE;

EID: 75749086395     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15010027     Document Type: Article

References (34)

1. Pattoli, M.A.; MacMaster, J.F.; Gregor, K.R.; Burke, J.R. Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. J. Pharmacol. Exp. Ther. 2005, 315, 382-388.
2. Choi, E.J.; Bae, S.C.; Yu, R.; Youn, J.; Sung, M.K. Dietary vitamin E and quercetin modulate inflammatory responses of collagen-induced arthritis in mice. J. Med. Food. 2009, 12, 770-775.
3. Kurz, B.; Jost, B.; Schünke M. Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice. Osteoarth. Cartilage 2002, 10, 119-126. (Pubitemid 34110797)
4. van Vugt, R.M.; Rijken, P.J.; Rietveld, A.G.; van Vugt, A.C.; Dijkmans, B.A. Antioxidant intervention in rheumatoid arthritis: Results of an open pilot study. Clin. Rheumatol. 2008, 27, 771-775.
5. Bae, S.C.; Kim, S.J.; Sung, M.K. Inadequate antioxidant nutrient intake and altered plasma antioxidant status of rheumatoid arthritis patients. J. Am. Coll. Nutr. 2003, 22, 311-315.
6. Wang, Y.; Hodge, A.M.; Wluka, A.E.; English, D.R.; Giles, G.G.; O'Sullivan, R.; Forbes, A.; Cicuttini, F.M. Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: A cross-sectional study. Arthritis Res. Ther. 2007, 9, R66.
7. Dodge, G.R.; Jimenez, S.A. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarth. Cartilage 2003, 11, 424-432.
8. Legendre, F.; Baugé, C.; Roche, R.; Saurel, A.S.; Pujol, J.P. Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1 beta-stimulated chondrocytes-study in hypoxic alginate bead cultures. Osteoarth. Cartilage 2008, 16, 105-114.
9. Shikhman, A.R.; Kuhn, K.; Alaaeddine, N.; Lotz, M. N-acetylglucosamine prevents IL-1 betamediated activation of human chondrocytes. J. Immunol. 2001, 166, 5155-5160. (Pubitemid 32280730)
10. Hitchon, C.A.; El-Gabalawy, H.S. Oxidation in rheumatoid arthritis. Arthritis Res. Ther. 2004, 6, 265-278.
11. Packer, L.; Weber, S.U.; Rimbach, G. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J. Nutr. 2001, 131, 369-373. (Pubitemid 32115383)
12. Rimbach, G.; Minihane, A.M.; Majewicz, J.; Fischer, A.; Pallauf, J.; Virgli, F.; Weinberg, P.D. Regulation of cell signalling by vitamin E. Proc. Nutr. Soc. 2002, 61, 415-425.
13. Ursini, F.; Maiorino, M.; Roveri, A. Phospholipid hydroperoxide glutathione peroxidase (PHGPx): More than an antioxidant enzyme? Biomed. Environ. Sci. 1997, 10, 327-332. (Pubitemid 127472095)
14. Fischer, A.; Pallauf, J.; Gohil, K.; Weber, S.U.; Packer, L.; Rimbach, G. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochem. Biophys. Res. Commun. 2001, 285, 470-475. (Pubitemid 32918094)
15. Allen, N.E.; Appleby, P.N.; Roddam, A.W.; Tjonneland, A.; Johnsen, N.F.; Overvad, K.; Boeing, H.; Weikert, S.; Kaaks, R.; Linseisen, J.; Trichopoulou, A.; Misirli, G.; Trichopoulos, D.; Sacerdote, C.; Grioni, S.; Palli, D.; Tumino, R.; Bueno-de-Mesquita, H.B.; Kiemeney, L.A.; Barricarte, A.; Larrañaga, N.; Sánchez, M.J.; Agudo, A.; Tormo, M.J.; Rodriguez, L.; Stattin, P.; Hallmans, G.; Bingham, S.; Khaw, K.T.; Slimani, N.; Rinaldi, S.; Boffetta, P.; Riboli, E.; Key, T.J. Plasma selenium concentration and prostate cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am. J. Clin. Nutr. 2008, 88, 1567-1575.
16. Bader, N.; Bosy-Westphal, A.; Koch, A.; Rimbach, G.; Weimann, A.; Poulsen, H.E.; Müller, M.J. Effect of hyperbaric oxygen and vitamin C. and E supplementation on biomarkers of oxidative stress in healthy men. Br. J. Nutr. 2007, 98, 826-833.
17. Behrens, W.A.; Madère, R. Alpha- and gamma tocopherol concentrations in human serum. J. Am. Coll. Nutr. 1986, 5, 91-96.
18. Majewicz, J.; Rimbach, G.; Proteggente, A.R.; Lodge, J.K.; Kraemer, K.; Minihane, A.M. Dietary vitamin C. down-regulates inflammatory gene expression in apoE4 smokers. Biochem. Biophys. Res. Commun. 2005, 338, 951-955.
19. Proteggente, A.R.; Rota, C.; Majewicz, J.; Rimbach, G.; Minihane, A.M.; Kramer, K.; Lodge, J.K. Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alphatocopherol: A biokinetik study in apoE4 male subjects. Free Radic Biol. Med. 2006, 40, 2080-2091.
20. Schleicher, R.L.; Carroll, M.D.; Ford, E.S.; Lacher, D.A. Serum vitamin C. and the prevalence of vitamin C. deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am. J. Clin. Nutr. 2009, 90, 1252-1263.
21. Persiani, S.; Roda, E.; Rovati, L.C.; Locatelli, M.; Giacovelli, G.; Roda, A. Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man. Osteoarth. Cartilage 2005, 13, 1041-1049. (Pubitemid 41672501)
22. Volpi, N. Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers. Osteoarth. Cartilage 2002, 10, 768-777. (Pubitemid 35153717)
23. Daheshia, M.; Yao, J.Q. The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J. Rheumatol. 2008, 35, 2306-2312.
24. Gebauer, M.; Saas, J.; Sohler, F.; Haag, J.; Söder, S.; Pieper, M.; Bartnik, E.; Beninga, J.; Zimmer, R.; Aigner, T. Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL1beta. Osteoarth. Cartilage 2005, 13, 697-708. (Pubitemid 41025123)
25. Murphy, G.; Nagase, H. Progress in matrix metalloproteinase research. Mol. Aspects Med. 2008, 29, 290-308.
26. Sandy, J.D.; Thompson, V.; Verscharen, C.; Gamett, D. Chondrocyte-mediated catabolism of aggrecan: Evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid. Arch. Biochem. Biophys. 1999, 367, 258-264. (Pubitemid 29394173)
27. Rauchman, M.I.; Wasserman, J.C; Cohen, D.M.; Perkins, D.L.; Hebert, S.C.; Milford, E.; Gullans, S.R. Expression of GLUT-2 cDNA in human B lymphocytes: Analysis of glucose transport using flow cytometry. Biochim. Biophys. Acta 1992, 1111, 231-238.
28. Gouze, J.N.; Bianchi, A.; Bécuwe, P.; Dauça, M.; Netter, P.; Magdalou, J.; Terlain, B.; Bordji, K. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. FEBS Lett. 2002, 510, 166-170. (Pubitemid 34093818)
29. Bond, M.; Baker, A.H.; Newby, A.C. Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts. Biochem. Biophys. Res. Commun. 1999, 264, 561-567.
30. Iovu, M.; Dumais, G.; du Souich, P. Anti-inflammatory activity of chondroitin sulfate. Osteoarth. Cartilage 2008, 16, 14-18.
31. Klatt, A.R.; Klinger, G.; Paul-Klausch, B.; Kühn, G.; Renno, J.H.; Wagener, R.; Paulsson, M.; Schmidt, J.; Malchau, G.; Wielckens, K. Matrilin-3 activates the expression of osteoarthritisassociated genes in primary human chondrocytes. FEBS Lett. 2009, 583, 3611-3617.
32. Borenfreund, E.; Puerner, J.A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett. 1985, 24, 119-124.
33. Valacchi, G.; Rimbach, G.; Saliou, C.; Weber, S.U.; Packer, L. Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1 alpha gene expression in human keratinocytes. Toxicology 2001, 165, 225-234. (Pubitemid 32778315)
34. Wagner, A.E.; Ernst, I.; Iori, R.; Desel, C.; Rimbach, G. Sulforaphane but not ascorbigen, indole3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. Exp. Dermatol. 2009, [Epub ahead of print].