Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Chemical Research in Toxicology

Volumn 26, Issue 2, 2013, Pages 280-289

  Carletti, Eugénie ^a,b,c,d   Colletier, Jacques Philippe ^a,b,c   Schopfer, Lawrence M ^e   Santoni, Gianluca ^a,b,c,d   Masson, Patrick ^a,b,c,d,e   Lockridge, Oksana ^e   Nachon, Florian ^d   Weik, Martin ^a,b,c,f  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CNRS   (France)

^c UNIV GRENOBLE ALPES   (France)

^d INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CRESYLSALIGENIN PHOSPHATE; ORGANOPHOSPHATE; PHENYLALANINE; UNCLASSIFIED DRUG; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; SIMULATION; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHO CELLS; CHOLINESTERASE INHIBITORS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MASS SPECTROMETRY; MICE; MOLECULAR DYNAMICS SIMULATION; ORGANOPHOSPHORUS COMPOUNDS; RECOMBINANT PROTEINS; TRITOLYL PHOSPHATES;

EID: 84874083619     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3004505     Document Type: Article

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