Intracellular events regulating cross-presentation

Frontiers in Immunology

Volumn 3, Issue JUN, 2012, Pages

  Wagner, Claudia S ^a   Grotzke, Jeffrey E ^a   Cresswell, Peter ^a  

^a YALE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dendritic cell; Endocytosis; MHC class I; Phagocytosis

Indexed keywords

EID: 84874042007     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00138     Document Type: Article

References (104)

1. Ackerman, A.L., and Cresswell, P. (2003). Regulation of MHC class I transport in human dendritic cells and the dendritic-like cell line KG-1. J. Immunol. 170,4178-4188.
2. Ackerman, A. L., Giodini, A., and Cresswell, P. (2006). A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity 25,607-617.
3. Ackerman, A. L., Kyritsis, C., Tampe, R., and Cresswell, P. (2003). Early phagosomes in dendritic cells form a cellular compartment sufficient for crosspresentationof exogenousantigens.Proc.Natl.Acad.Sci.U.S.A.100, 12889-12894.
4. Bagai, R., Valujskikh, A., Canaday, D. H., Bailey, E., Lalli, P. N., Harding, C. V., and Heeger, P. S. (2005). Mouseendothelialcellscross-present lymphocyte-derived antigen on class I MHC via a TAP1and proteasomedependent pathway. J. Immunol. 174, 7711-7715.
5. Bedoui, S., Whitney, P. G., Waithman, J., Eidsmo, L., Wakim, L., Caminschi, I., Allan, R. S., Wojtasiak, M., Shortman, K., Carbone, F. R., Brooks, A. G., and Heath, W. R. (2009). Crosspresentation of viral and self antigens by skin-derived CD103 dendritic cells. Nat. Immunol. 10,488-495.
6. Belizaire, R., and Unanue, E. R. (2009). Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc. Natl. Acad. Sci. U.S.A.106,17463-17468.
7. Berwin, B., Hart, J. P., Rice, S., Gass, C., Pizzo, S. V., Post, S. R., and Nicchitta, C. V. (2003). Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBOJ. 22, 6127-6136.
8. Bevan, M. J. (1976). Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143,1283-1288.
9. Blander, J. M., and Medzhitov, R. (2004). Regulation of phagosome maturation by signals from Toll-like receptors. Science 304,1014-1018.
10. Blander, J. M., and Medzhitov, R. (2006a).Onregulationofphagosome maturationandantigenpresentation. Nat. Immunol. 7,1029-1035.
11. Blander, J. M., and Medzhitov, R. (2006b). Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808-812.
12. Bonifaz, L., Bonnyay, D., Mahnke, K., Rivera, M., Nussenzweig, M. C., and Steinman,R.M. (2002). Efficienttargeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex c+lass I products and peripheral CD8 T cell tolerance. J. Exp. Med. 196,1627-1638.
13. Bozzacco, L., Trumpfheller, C., Siegal, F. P., Mehandru, S., Markowitz, M., Carrington, M., Nussenzweig, M. C., Piperno, A. G., and Steinman, R. M. (2007). DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 T cells in a spectrum of human MHC I haplotypes. Proc. Natl. Acad. Sci. U.S.A. 104,1289-1294.
14. Braun, S., Matuschewski, K., Rape, M., Thoms, S., and Jentsch, S. (2002). Role of the ubiquitin-selective CDC48(UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J. 21,615-621.
15. Burgdorf, S., Lukacs-Kornek, V., and Kurts,C.(2006).Themannosereceptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J. Immunol. 176, 6770-6776.
16. Burgdorf, S., Scholz, C., Kautz, A., Tampe, R., and Kurts, C. (2008). Spatialandmechanisticseparationof cross-presentation and endogenous antigen presentation. Nat. Immunol. 9,558-566.
17. Cebrian, I., Visentin, G., Blanchard, N., Jouve, M., Bobard, A., Moita, C., Enninga, J., Moita, L. F., Amigorena, S.,and Savina,A. (2011). Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells. Cell 147, 1355-1368.
18. Cella, M., Engering, A., Pinet, V., Pieters, J., and Lanzavecchia, A. (1997). Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388, 782-787.
19. Crozat, K., Tamoutounour, S., Vu Manh, T. P., Fossum, E., Luche, H., Ardouin, L., Guilliams, M., Azukizawa, H., Bogen, B., Malissen, B., Henri,S.,andDalod,M.(2011). Cuttingedge:expressionof XCR1defines mouse lymphoid-tissue resident and migratory+dendritic cells of the CD8alpha type. J. Immunol. 187, 4411-4415.
20. Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T., Didonato, J., Dziarski, R., Akira, S., Schoenberger, S. P., and Raz, E. (2003). A subset of Toll-like receptor ligandsinducescross-presentation by bone marrow-derived dendritic cells. J. Immunol. 170,4102-4110.
21. Delamarre, L., Holcombe, H., and Mellman, I. (2003). Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J. Exp. Med. 198, 111-122.
22. Delamarre, L., Pack, M., Chang, H., Mellman, I., and Trombetta, E. S. (2005). Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307, 1630-1634.
23. Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J., and Jeannin, P. (2002). Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17,353-362.
24. den Haan, J.M., and Bevan, M.J. (2002). Constitutive versus activationdependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo. J. Exp. Med. 196,817-827.
25. Di Pucchio, T., Chatterjee, B., SmedSorensen, A., Clayton, S., Palazzo, A., Montes, M., Xue, Y., Mellman, I., Banchereau, J., and Connolly, J. E. (2008). Direct proteasomeindependent cross-presentation of viral antigen by plasmacytoid dendriticcellsonmajorhistocompatibility complex class I. Nat. Immunol. 9, 551-557.
26. Dong, M., Bridges, J. P., Apsley, K., Xu, Y., and Weaver, T. E. (2008). ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol. Biol. Cell 19, 2620-2630.
27. Drutman, S. B., and Trombetta, E. S. (2010). Dendritic cells continue to capture and present antigens after maturation in vivo. J. Immunol. 185, 2140-2146.
28. Fonteneau, J. F., Kavanagh, D. G., Lirvall, M., Sanders, C., Cover, T. L., Bhardwaj, N., and Larsson, M. (2003).Characterization of the MHC class Icross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 102, 4448-4455.
29. Gagnon, E., Duclos, S., Rondeau, C., Chevet, E., Cameron, P. H., Steele-Mortimer, O., Paiement, J., Bergeron, J.J.,and Desjardins,M.(2002).Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell 110,119-131.
30. Gil-Torregrosa,B.C.,Lennon-Dumenil, A. M., Kessler, B., Guermonprez, P., Ploegh, H. L., Fruci, D., Van Endert, P., and Amigorena, S. (2004). Control of cross-presentation during dendritic cell maturation. Eur. J. Immunol. 34, 398-407.
31. Giodini, A., and Cresswell, P. (2008). Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells. EMBO J. 27, 201-211.
32. Giodini, A., Rahner, C., and Cresswell, P. (2009). Receptor-mediated phagocytosis elicits cross-presentation in nonprofessional antigen-presenting cells. Proc. Natl.Acad. Sci. U.S.A.106, 3324-3329.
33. Goldszmid, R. S., Coppens, I., Lev, A., Caspar, P., Mellman, I., and Sher, A. (2009). Host ERparasitophorous vacuole interaction provides a route of entry for antigencross-presentation in Toxoplasma gondii-infected dendritic cells. J. Exp. Med. 206,399-410.
34. Graham, D. B., Stephenson, L. M., Lam, S. K., Brim, K., Lee, H. M., Bautista, J., Gilfillan, S., Akilesh, S., Fujikawa, K., and Swat, W. (2007). An ITAM-signaling pathway controls cross-presentation of particulate but notsolubleantigensindendriticcells. J. Exp. Med. 204,2889-2897.
35. Grotzke, J. E., Harriff, M. J., Siler, A. C., Nolt, D., Delepine, J., Lewinsohn, D. A., and Lewinsohn, D. M. (2009). The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog. 5, e1000374. doi: 10.1371/ journal.ppat.1000374
36. Guermonprez, P., Saveanu, L., Kleijmeer, M., Davoust, J., Van Endert, P., and Amigorena, S. (2003). ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature 425,397-402.
37. Heath, W. R., Belz, G. T., Behrens, G. M., Smith, C. M., Forehan, S. P., Parish, I. A., Davey, G. M., Wilson, N. S., Carbone, F. R., and Villadangos, J. A. (2004). Crosspresentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199, 9-26.
38. Henri, S., Poulin, L. F., Tamoutounour, S., Ardouin, L., Guilliams, M., De Bovis, B., Devilard, E., Viret, C., Azukizawa, H., Kissenpfennig, A., and Malissen, B. (2010). CD207+ CD103+dermaldendriticcellscrosspresent keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J. Exp. Med. 207, 189-206.
39. Henri, S., Siret, C., Machy, P., Kissenpfennig, A., Malissen, B., and Leserman, L. (2007). Mature DC from skin and skin-draining LN retain the ability to acquire and efficiently present targeted antigen. Eur. J. Immunol. 37, 1184-1193.
40. Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., Schreiber, R. D., Murphy, T. L., and Murphy, K. M. (2008). Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100.
41. Houde, M., Bertholet, S., Gagnon, E., Brunet, S., Goyette, G., Laplante, A., Princiotta, M. F., Thibault, P., Sacks, D., and Desjardins, M. (2003). Phagosomes are competent organelles for antigen crosspresentation. Nature 425, 402-406.
42. Ichiyanagi, T., Imai, T., Kajiwara, C., Mizukami, S., Nakai, A., Nakayama, T., and Udono, H. (2010). Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. J. Immunol. 185, 2693-2700.
43. Imai, J., Hasegawa, H., Maruya, M., Koyasu, S., and Yahara, I. (2005). Exogenous antigens are processed through the endoplasmic reticulumassociated degradation (ERAD) in cross-presentation by dendritic cells. Int. Immunol. 17, 45-53.
44. Imai, T., Kato, Y., Kajiwara, C., Mizukami, S., Ishige, I., Ichiyanagi, T., Hikida, M., Wang, J. Y., and Udono, H. (2011). Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 108,16363-16368.
45. Jancic,C.,Savina,A.,Wasmeier,C.,Tolmachova, T., El-Benna, J., Dang, P. M., Pascolo, S., Gougerot-Pocidalo, M. A.,Raposo,G.,Seabra,M. C.,and Amigorena, S. (2007). Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat. Cell Biol. 9, 367-378.
46. Jarosch, E., Taxis, C.,Volkwein, C., Bordallo, J., Finley, D., Wolf, D. H., and Sommer, T. (2002). Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat. Cell Biol. 4,134-139.
47. Jung, S., Unutmaz, D., Wong, P., Sano, G., De Los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E. G., Littman, D. R., and Lang, R. A. (2002). In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+T cells by exogenous cell-associated antigens. Immunity 17, 211-220.
48. Kamath, A. T., Henri, S., Battye, F., Tough, D. F., and Shortman, K. (2002). Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 100, 1734-1741.
49. Kirschke, H., Wiederanders, B., Bromme, D., and Rinne, A. (1989). Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. Biochem. J. 264,467-473.
50. Klechevsky, E., Flamar, A. L., Cao, Y., Blanck, J. P., Liu, M., O'Bar, A., Agouna-Deciat, O., Klucar, P., Thompson-Snipes, L., Zurawski, S., Reiter, Y., Palucka, A. K., Zurawski, G., and Banchereau, J. (2010). Cross-priming CD8+ Tcellsby targeting antigens to human dendritic cells through DCIR. Blood 116, 1685-1697.
51. Koopmann, J. O., Albring, J., Huter, E., Bulbuc, N., Spee, P., Neefjes, J., Hammerling, G. J., and Momburg, F. (2000). Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec 61p channel. Immunity 13, 117-127.
52. Kostova, Z., Tsai, Y. C., and Weissman, A. M. (2007). Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin. Cell Dev. Biol. 18, 770-779.
53. Kovacsovics-Bankowski, M., and Rock, K.L.(1995).Aphagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267,243-246.
54. Laroux, F. S., Romero, X., Wetzler, L., Engel, P., and Terhorst, C. (2005). Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.J.Immunol.175,5596-5600.
55. Lee, R. J., Liu, C. W., Harty, C., Mccracken, A. A., Latterich, M., Romisch, K., Demartino, G. N., Thomas, P. J., and Brodsky, J. L. (2004). Uncoupling retrotranslocation and degradation in the ER-associated degradation of a soluble protein. EMBO J. 23, 2206-2215.
56. Lelouard, H., Ferrand, V., Marguet, D., Bania, J., Camosseto, V., David, A., Gatti, E., and Pierre, P. (2004). Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins. J. Cell Biol. 164,667-675.
57. Lennon-Dumenil, A. M., Bakker, A. H., Maehr, R., Fiebiger, E., Overkleeft, H. S., Rosemblatt, M., Ploegh, H. L., and Lagaudriere-Gesbert, C. (2002). Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J. Exp. Med. 196,529-540.
58. Li, G., Zhou, X., Zhao, G., Schindelin, H., and Lennarz,W. J. (2005). Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Proc. Natl. Acad. Sci. U.S.A. 102, 15809-15814.
59. Lin,M.L.,Zhan,Y.,Proietto,A.I.,Prato, S., Wu, L., Heath, W. R., Villadangos, J. A., and Lew, A. M. (2008). Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset. Proc. Natl. Acad. Sci. U.S.A. 105,3029-3034.
60. Lipson, C., Alalouf, G., Bajorek, M., Rabinovich, E., Atir-Lande, A., Glickman, M., and Bar-Nun, S. (2008). A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates. J. Biol. Chem. 283,7166-7175.
61. Lutz, M. B., Rovere, P., Kleijmeer, M. J., Rescigno, M., Assmann, C. U., Oorschot, V. M., Geuze, H. J., Trucy, J., Demandolx, D., Davoust, J., and Ricciardi-Castagnoli, P. (1997). Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells. J. Immunol. 159, 3707-3716.
62. Machy, P., Serre, K., and Leserman, L. (2000). Class I-restricted presentation of exogenous antigen acquired by Fcgamma receptor-mediated endocytosis is regulated in dendritic cells. Eur. J. Immunol. 30, 848-857.
63. Mayer, T. U., Braun, T., and Jentsch, S. (1998). Role of the proteasome in membrane extraction of ashort-lived ER-transmembrane protein. EMBO J. 17,3251-3257.
64. Merzougui, N., Kratzer, R., Saveanu, L., and Van Endert, P. (2011). A proteasome-dependent, TAP-independent pathway for cross-presentation of phagocytosed antigen. EMBO Rep. 12,1257-1264.
65. Molinari, M., Galli, C., Piccaluga, V., Pieren, M., and Paganetti, P. (2002). Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER. J. Cell Biol. 158, 247-257.
66. Morreale, G., Conforti, L., Coadwell, J., Wilbrey, A. L., and Coleman, M. P. (2009). Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins. FEBS J. 276, 1208-1220.
67. Muller-Taubenberger, A., Lupas, A. N., Li, H., Ecke, M., Simmeth, E., and Gerisch, G. (2001). Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis. EMBO J. 20,6772-6782.
68. Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., and Harding, C. V. (1993). Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361,359-362.
69. Platt, C. D., Ma, J. K., Chalouni, C., Ebersold, M., Bou-Reslan, H., Carano,R. A.,Mellman,I.,and Delamarre, L. (2010). Mature dendritic cells use endocytic receptors to capture and present antigens. Proc. Natl. Acad. Sci. U.S.A. 107, 4287-4292.
70. Rabinovich, E., Kerem, A., Frohlich, K. U., Diamant, N., and Bar-Nun, S. (2002). AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol. Cell. Biol. 22,626-634.
71. Regnault, A., Lankar, D., Lacabanne, V., Rodriguez, A., Thery, C., Rescigno, M., Saito, T., Verbeek, S., Bonnerot, C., Ricciardi-Castagnoli, P., and Amigorena, S. (1999a). Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class Irestricted antigen presentation after immune complex internalization. J. Exp. Med. 189,371-380.
72. Rescigno, M., Citterio, S., Thery, C., Rittig, M., Medaglini, D., Pozzi, G., Amigorena, S., and Ricciardi-Castagnoli, P. (1998). Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 95,5229-5234.
73. Russell, D. G., and Yates, R. M. (2007). Toll-like receptors and phagosome maturation. Nat. Immunol. 8, 217; Author reply 217-218.
74. Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martinez, D., Hernanz-Falcon, P., Rosewell, I., and ReiseSousa,C.(2009).Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458,899-903.
75. Sancho, D., Mourao-Sa, D., Joffre, O. P., Schulz, O., Rogers, N. C., Pennington, D. J., Carlyle, J. R., and Reis e Sousa, C. (2008). Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118,2098-2110.
76. Sanjuan,M. A.,Dillon,C. P.,Tait,S. W., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., and Green, D. R. (2007). Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450, 1253-1257.
77. Savina, A., Jancic, C., Hugues, S., Guermonprez, P., Vargas, P., Moura, I. C., Lennon-Dumenil, A. M., Seabra, M. C., Raposo, G., and Amigorena, S. (2006). NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126, 205-218.
78. Savina,A.,Peres,A.,Cebrian,I.,Carmo, N., Moita, C., Hacohen, N., Moita, L. F., and Amigorena, S. (2009). The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells. Immunity 30,544-555.
79. Schnorrer, P., Behrens, G. M., Wilson, N. S., Pooley, J. L., Smith, C. M., El-Sukkari, D., Davey, G., Kupresanin, F., Li, M., Maraskovsky, E., Belz, G. T., Carbone, F. R., Shortman, K., Heath, W. R., and Villadangos, J. A. (2006). The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture. Proc. Natl. Acad. Sci. U.S.A. 103, 10729-10734.
80. Schulze, A., Standera, S., Buerger, E., Kikkert, M.,Van Voorden, S., Wiertz, E., Koning, F., Kloetzel, P. M., and Seeger, M. (2005). The ubiquitindomain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J. Mol. Biol. 354,1021-1027.
81. Shakushiro, K., Yamasaki, Y., Nishikawa, M., and Takakura, Y. (2004). Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells. Immunology 112,211-218.
82. Shen, L., Sigal, L. J., Boes, M., and Rock, K. L. (2004). Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21, 155-165.
83. Singh, R., and Cresswell, P. (2010). Defective cross-presentation of viral antigens in GILT-free mice. Science 328,1394-1398.
84. Swanson, J.A., and Hoppe, A.D.(2004). The coordination of signaling during Fc receptor-mediated phagocytosis. J. Leukoc. Biol. 76,1093-1103.
85. Tacken, P. J., De Vries, I. J., Gijzen, K., Joosten, B., Wu, D., Rother, R. P., Faas, S. J., Punt, C. J., Torensma, R., Adema, G. J., and Figdor, C. G. (2005). Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106,1278-1285.
86. Taylor, M., Navarro-Garcia, F., Huerta, J., Burress, H., Massey, S., Ireton, K., and Teter, K. (2010). Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol. J. Biol. Chem. 285,31261-31267.
87. Trombetta, E. S., Ebersold, M., Garrett, W., Pypaert, M., and Mellman, I. (2003).Activationof lysosomal function during dendritic cell maturation. Science 299,1400-1403.
88. Ushioda, R., Hoseki, J., Araki, K., Jansen, G., Thomas, D. Y., and Nagata, K. (2008). ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Science 321,569-572.
89. van Montfoort, N., Camps, M. G., Khan, S., Filippov, D. V., Weterings, J. J., Griffith, J. M., Geuze, H. J., Van Hall, T., Verbeek, J. S., Melief, C. J., and Ossendorp, F. (2009). Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity. Proc. Natl. Acad. Sci. U.S.A. 106,6730-6735.
90. Vembar, S. S., and Brodsky, J. L. (2008). One step at a time: endoplasmic reticulum-associated degradation. Nat. Rev. Mol. Cell Biol. 9, 944-957.
91. Villadangos, J. A., Schnorrer, P., and Wilson, N. S. (2005). Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces. Immunol. Rev. 207,191-205.
92. Villadangos, J. A., and Shortman, K. (2010). Found in translation: the human equivalent of mouse CD8+ dendritic cells. J. Exp. Med. 207, 1131-1134.
93. Vulcano, M., Dusi, S., Lissandrini, D., Badolato, R., Mazzi, P., Riboldi, E., Borroni, E., Calleri, A., Donini, M., Plebani, A., Notarangelo, L., Musso, T., and Sozzani, S. (2004). Toll receptor-mediated regulation of NADPH oxidase in human dendritic cells. J. Immunol. 173, 5749-5756.
94. Wagner, C. S., and Cresswell, P. (2012). TLR and nucleotide-binding oligomerization domain-like receptor signals differentially regulate exogenous antigen presentation. J. Immunol. 188,686-693.
95. Weck, M. M., Grunebach, F., Werth, D., Sinzger, C., Bringmann, A., and Brossart, P. (2007). TLR ligands differentially affect uptake and presentation of cellular antigens. Blood 109,3890-3894.
96. West, M. A., Wallin, R. P., Matthews, S. P., Svensson, H. G., Zaru, R., Ljunggren, H. G., Prescott, A. R., and Watts, C. (2004). Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science 305,1153-1157.
97. Wilson, N. S., Behrens, G. M., Lundie, R. J., Smith, C. M., Waithman, J., Young, L., Forehan, S. P., Mount, A., Steptoe, R. J., Shortman, K. D., De Koning-Ward, T. F., Belz, G. T., Carbone, F. R., Crabb, B. S., Heath, W. R., and Villadangos, J. A. (2006). Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs crosspresentation and antiviral immunity. Nat. Immunol. 7,165-172.
98. Wilson, N. S., and Villadangos, J. A. (2005).Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications. Adv. Immunol. 86,241-305.
99. Yates, R. M., Hermetter, A., and Russell, D. G. (2005). The kinetics of phagosome maturation as a function of phagosome/lysosome fusion and acquisition of hydrolytic activity. Traffic 6, 413-420.
100. Yates, R. M., and Russell, D. G. (2005). Phagosome maturation proceeds independently of stimulation of tolllike receptors 2 and 4. Immunity 23, 409-417.
101. Ye, Y.,Meyer, H. H.,and Rapoport, T.A. (2001). The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414,652-656.
102. Ye, Y., Shibata, Y., Kikkert, M., Van-Voorden, S., Wiertz, E., and Rapoport, T. A. (2005). Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. U.S.A. 102, 14132-14138.
103. Zehner, M., Chasan, A. I., Schuette, V., Embgenbroich, M., Quast, T., Kolanus, W., and Burgdorf, S.(2011). Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proc. Natl. Acad. Sci. U.S.A. 108, 9933-9938.
104. Zhong, X., Shen, Y., Ballar, P., Apostolou, A., Agami, R., and Fang, S. (2004). AAA ATPase p97/valosincontaining protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J. Biol. Chem. 279, 45676-45684.