Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Ng, Kuan Beng ^a   Bustamam, Ahmad ^a   Sukari, Mohd Aspollah ^a   Abdelwahab, Siddig Ibrahim ^b   Mohan, Syam ^c   Buckle, Michael James Christopher ^c   Kamalidehghan, Behnam ^c   Nadzri, Nabilah Muhammad ^a   Anasamy, Theebaa ^a   A Hadi, A Hamid ^c   Rahman, Heshu Sulaiman ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b JAZAN UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Anticancer; Boesenbergia rotunda; Boesenbergin A; CEMss; Cytotoxicity

Indexed keywords

ANTILEUKEMIC AGENT; BOESENBERGIN A; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; HEAT SHOCK PROTEIN 70; HERBACEOUS AGENT; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BOESENBERGIA ROTUNDA; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHROMATIN CONDENSATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DETERMINATION; DNA FRAGMENTATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; LYMPHOBLASTOID CELL LINE; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; NITROBLUE TETRAZOLIUM TEST; PROTEOMICS; RHIZOME; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANNEXIN A5; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CHALCONES; CHROMATIN; DNA FRAGMENTATION; G2 PHASE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHYTOTHERAPY; PLANT EXTRACTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RHIZOME; SIGNAL TRANSDUCTION; ZINGIBERACEAE;

EID: 84874027127     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-41     Document Type: Article

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