Panduratin a inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-KappaB translocation

Molecules

Volumn 16, Issue 3, 2011, Pages 2583-2598

  Cheah, Shiau Chuen ^a   Appleton, David R ^a,b   Lee, Sui Ting ^a   Lam, May Lynn ^c   Hadi, A Hamid A ^a   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

Author keywords

Apoptosis; High Content Screening; NF B; Panduratin A; Real time Cellular Analyzer

Indexed keywords

CHALCONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PANDURATIN A;

APOPTOSIS; ARTICLE; CELL DIVISION; CELL LINE; DRUG EFFECT; HUMAN; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

APOPTOSIS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELL LINE; CHALCONES; HUMANS; NF-KAPPA B;

EID: 79953103430     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16032583     Document Type: Article

References (25)

1. Tuchinda, P.; Reutrakul, V.; Claeson, P.; Pongprayoon, U.; Sematong, T.; Santisuk, T.; Taylor, W.C. Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata. Phytochemistry 2002, 59, 169-173. (Pubitemid 34123581)
2. Trakoontivakorn, G.; Nakahara, K.; Shinmoto, H.; Takenaka, M.; Onishi-Kameyama, M.; Ono, H.; Yoshida, M.; Nagata, T.; Tsushida, T. Structural analysis of a novel antimutagenic compound, 4-Hydroxypanduratin A, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult.) against mutagenic heterocyclic amines. J. Agric. Food Chem. 2001, 49, 3046-3050. (Pubitemid 32826108)
3. Yun, J.M.; Kwon, H.; Mukhtar, H.; Hwang, J.K. Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells. Planta Med. 2005, 71, 501-507. (Pubitemid 40910594)
4. Yun, J.M.; Kweon, M.H.; Kwon, H.; Hwang, J.K.; Mukhtar, H. Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgenindependent human prostate cancer cells PC3 and DU145. Carcinogenesis 2006, 27, 1454-1464. (Pubitemid 43985420)
5. Cen, D.; Gonzalez, R.I.; Buckmeier, J.A.; Kahlon, R.S.; Tohidian, N.B.; Meyskens, F.L., Jr. Disulfiram induces apoptosis in human melanoma cells: A redox-related process. Mol. Cancer Ther. 2002, 1, 197-204.
6. Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
7. Sethi, G.; Tergaonkar, V. Potential pharmacological control of the NF-kappaB pathway. Trends Pharmacol. Sci. 2009, 30, 313-321.
8. Aggarwal, B.B; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71, 1397-1421.
9. Giuliano, K.A.; DeBasio, R.L.; Dunlay, R.T. High-content screening: A new approach to easing key bottle necks in the drug discovery process. J. Biomol. Screen 1997, 2, 249-259. (Pubitemid 127690015)
10. Chassoux, D.; Franchi, J.; Cao, T.T.; Debey, P. DNA content by in situ fluorescence imaging and S-phase detection, with chromatin structure preserved. Anal. Quant. Cytol. Histol. 1999, 21, 489-497. (Pubitemid 30010815)
11. Taraphdar, A.K.; Roy, M.; Bhattacharya, R.K. Natural products as inducers of apoptosis: Implication for cancer theraphy and prevention. Curr. Sci. 2001, 80, 1387-1396. (Pubitemid 33620231)
12. Singh, R.P.; Dhanalakshmi, S.; Agarwal, R. Phytochemicals as cell cycle modulators-a less toxic approach in halting human cancers. Cell Cycle 2002, 1, 156-161.
13. Fu, Y.; Hsieh, T.C.; Guo, J.; Kunicki, J.; Lee, M.Y.; Darzynkiewicz, Z.; Wu, J.M. Licochalcone- A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem. Biophys. Res. Commun. 2004, 322, 263-270. (Pubitemid 39093864)
14. Wang, T.H.; Wang, H.S.; Soong, Y.K. Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer 2000, 88, 2619-2628.
15. Cortez, D.; Guntuku, S.; Qin, J.; Elledge, S.J. ATR and ATRIP: Partners in checkpoint signaling. Science 2001, 294, 1713-1716. (Pubitemid 33104841)
16. Gourlay, C.W.; Ayscough, K.R. A role for actin in aging and apoptosis. Biochem. Soc. Trans. 2005, 33, 1260-1264. (Pubitemid 41779662)
17. Ly, J.D.; Grubb, D.R.; Lawen, A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis 2003, 8, 115-128. (Pubitemid 36553052)
18. Arends, M.J.; Wyllie, A.H. Apoptosis: Mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 1991, 32, 223-254.
19. Kroemer, G.; Reed, J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6, 513-519. (Pubitemid 30305900)
20. Krajewski, S.; Krajewska, M.; Ellerby, L.M.; Welsh, K.; Xie, Z.; Deveraux, Q.L.; Salvesen, G.S.; Bredesen, D.E.; Rosenthal, R.E.; Fiskum, G.; Reed, J.C. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc. Natl. Acad. Sci. USA 1999, 96, 5752-5757. (Pubitemid 29234690)
21. Mignotte, B.; Vayssiere, J.L. Mitochondria and apoptosis. Eur. J. Biochem. 1998, 252, 1-15. (Pubitemid 28089952)
22. Aggarwal, B.B. Nuclear factor-kappaB: The enemy within. Cancer Cell 2004, 6, 203-208.
23. Schon, M.; Wienrich, B.G.; Kneitz, S.; Sennefelder, H.; Amschler, K.P; Vohringer, V.; Weber, O.; Stiewe, T.; Ziegelbauer, K.; Schon, M.P. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. J. Natl. Cancer Inst. 2008, 100, 862-875. (Pubitemid 351881954)
24. Tuntiwachwuttikul, P.; Pancharoen, O.; Reutrakul, V.; Byrne, L.T. (1'RS,2'SR,6'RS)-(2-6-dihydroxy- 4-methoxyphenyl)[3'-methyl-2'-(3''-methylbut- 2''-enyl)-6'-phenylcyclohex-3'-enyl]- methanone (panduratin-A) - a constituent of the red rhizomes of a variety of Boesenbergia pandurata. Aust. J. Chem. 1984. 37, 449-453.
25. Lovborg, H.; Nygren, P., Larsson, R. Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and the cyanoguanidine CHS 828. Mol. Cancer Ther. 2004, 3, 521-526. (Pubitemid 39193730)