The involvement of diadenosine 5′,5‴-P1,P4-tetraphosphate in cell cycle arrest and regulation of apoptosis

Biochemical Pharmacology

Volumn 65, Issue 2, 2003, Pages 227-235

  Vartanian, Amalia A ^a   Suzuki, H ^b   Poletaev, Andrey I ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Ap4A; Apoptosis; Bcl 2; Cell cycle; CEM SS; HL60

Indexed keywords

CYCLIN DEPENDENT KINASE; DIADENOSINE TETRAPHOSPHATE; PROTEIN BCL 2; PROTEIN P21; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL ACTIVITY; CELL CYCLE; CELL STRAIN HL 60; CONTROLLED STUDY; DEPHOSPHORYLATION; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; TUMOR GROWTH;

ANIMALS; APOPTOSIS; CDC2-CDC28 KINASES; CELL CYCLE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DINUCLEOSIDE PHOSPHATES; DRUG INTERACTIONS; G1 PHASE; HL-60 CELLS; HUMANS; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINOBLASTOMA PROTEIN; S PHASE;

EID: 0037437792     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01481-8     Document Type: Article

References (35)

1. 4A and other dinucleoside polyphosphates. Boca Raton, FL: CRC Press; 1992, p. 63-79.
2. Pintor J., Diaz-Hernandez M., Gualix J., Gomez-Villafuertes R., Hernando F., Miras-Portugal M.T. Diadenosine polyphosphate receptor from rat and guinea pig brain to human nervous system. Pharmacol. Ther. 87:2000;103-115.
3. Flores N.A., Stavrou B.M., Sheridan D.J. The effect of diadenosine polyphosphates on the cardiovascular system. Cardiovasc. Res. 42:1999;15-26.
4. 4A and Other Dinucleoside Polyphosphates. Boca Raton, FL: CRC Press; 1992, p. 151-204.
5. nA), a novel class of signalling molecules? FEBS Lett. 427:1998;157-163.
6. McLennan A.G. Dinucleoside polyphosphates - friends or foe? Pharmacol. Ther. 87:2000;103-115.
7. 4A ratio in human cell cultures. FEBS Lett. 415:1997;160-162.
8. 4A induces apoptosis in human cultured cells. FEBS Lett. 456:1999;175-180.
9. Reed J.C. Mechanism of apoptosis. Am. J. Pathol. 157:2000;1415-1430.
10. Kaufman S.H., Gores G.J. Apoptosis in cancer: cause and cure. Bioessay. 22:2000;1007-1018.
11. Solary E., Droin N., Bettaieb A., Corcos L., Dimanche-Boitrel M.T., Garrido C. Positive and negative regulation of apoptotic pathway by cytotoxic agents in hematological malignancies. Leukemia. 14:2000;1833-1849.
12. Berger N.A. DNA synthesis in permeabilized mouse L cells. Biochim. Biophys. Acta. 425:1976;1-17.
13. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk interacting protein Cp1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
14. DiCommo D., Gallie B.L., Bremner R. Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Semin. Cancer Biol. 10:2000;255-269.
15. Weinberg R.A. Phosphorylation of retinoblastoma by cdk2. Cell. 81:1995;323-330.
16. Akiyama T., Ohuchi T., Sumida S., Matsumoti K., Toyoshima K. Phosphorylation of retinoblastoma protein and cell cycle control. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7900-7904.
17. Morgan S.E., Cadena R.S., Raimondi S.C., Beck W.T. Selection of human leukemic CEM cells for resistance to DNA topoisomerase II catalytic inhibitor ICRF-187 results in increasing levels of topoisomerase II-alpha and altered G2/M checkpoint and apoptotic response. Mol. Pharmacol. 57:2000;296-307.
18. Kusumoto M., Ogawa T., Mizumoto K., Ueno H., Niiyama H., Sato N., Nakamura M., Tanaka M. Adenovirus-mediated p53 gene transduction inhibits telomerase II activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cells. Clin. Cancer Res. 5:1999;2140-2147.
19. Sert V., Cans C., Tasca C., Bret-Bennis L., Oswald E., Ducommun B., De Rycke J. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene. 18:1999;6296-6304.
20. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., Beach D. p21 is a universal inhibitor of cyclin kinases. Nature. 366:1993;701-704.
21. Barton G.J., Cohen P.T.W., Barford D. Conversion analysis and structure prediction of the serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphate from E. coli suggest homology to the protein phosphatases. Eur. J. Biochem. 229:1994;225-237.
22. Shi L., Carmichael W.W., Kennely P.J. Cyanobacterial PPP family protein phosphatases possess multifunctional capabilities and are resistant to microcystin-LR. J. Biol. Chem. 274:1999;10039-10046.
23. Akiyama T., Toyoshima K. Variable mutations of the pRB gene in small-cell lung carcinoma. Oncogene. 5:1990;179-183.
24. Harbour J.W., Douglas C.D. Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2:2000;E65-E67.
25. Collins S.J. The HL60 promyelocytic leukemia cell line: proliferation. Blood. 70:1987;1233-1244.
26. 4A as a signal. Trends Biochem. Sci. 23:1999;157-159.
27. Juan G., Tragaros F., James W.M., Ray J.M., Roberge M., Sauve D.M., Anderson H., Dranzynkiewicz Z. Histone H3 phosphorylation and expression of cyclin A and B1 measured in individual cells during their progression through G2 and mitosis. Cytometry. 32:1998;71-77.
28. Francis J.M., Heyworth C.M., Spooncer E., Pierce A., Dexter T.M., Wetton A. Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells. J. Biol. Chem. 275:2000;39137-39145.
29. Yamamoto A.M., Eloy L., Bach J.-F., Garchon H.-J. N-terminal cleavage of Bcl-2 by a novel cellular non-ICE cysteine proteinase. Leukemia. 12:1998;1467-1472.
30. 4-tetraphosphate with divalent metal ions, biogenic amines and poly(dT). Biochem. Biophys. Res. Commun. 120:1984;1037-1042.
31. Fedeel B., Hassan Z., Hellstrom-Linberg E., Henter J.-I., Orrenius S., Zhivotovsky B. Cleavage of Bcl-2 is an early event in chemotheraphy-induced apoptosis of human leukemia cells. Leukemia. 13:1999;719-723.
32. Tan X., Martin S.J., Green D.R., Wang J.Y.J. Degradation of retinoblastoma protein in tumor necrosis factor and CD95-induced cell death. J. Biol. Chem. 272:1997;9613-9616.
33. Baker J.C., Ames B.N. Alteration in level of 5′adenyl dinucleotide following DNA damage in normal human fibroblasts and in fibroblasts derived from patients with xeroderma pigmentosum. Mutat. Res. 208:1988;87-93.
34. Baker J.C., Jacobson M.K. Alteration of adenyl nucleotide metabolism by environmental stress. Proc. Natl. Acad. Sci. U.S.A. 83:1986;2350-2352.
35. Roth W., Weller M. Chemotherapy and immunotherapy of malignant glioma: molecular mechanism and clinical perspectives. Mol. Cell Life Sci. 56:1999;481-506.