Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells

Leukemia Research

Volumn 35, Issue 2, 2011, Pages 268-271

  Abdelwahab, Siddig Ibrahim ^a   Abdul, Ahmad Bustamam ^a   Mohan, Syam ^a   Taha, Manal Mohamed Elhassan ^a   Syam, Suvitha ^a   Ibrahim, Mohamed Yousif ^a   Mariod, Abdelbasit Adam ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Apoptosis; Scanning electron microscope; TUNEL assay; Zerumbone

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; FLUOROURACIL; UNCLASSIFIED DRUG; ZERUMBONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DEGRADATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; NICK END LABELING; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IN SITU NICK-END LABELING; MICROSCOPY, ELECTRON, SCANNING; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SESQUITERPENES;

EID: 78751702643     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.07.025     Document Type: Article

References (10)

1. Yeoh A.E.J., Lu Y., Chan J.Y.S., Chan Y.H., Ariffin H., Kham S.K.Y., et al. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res 2009, 34:276-283.
2. Abdelwahab SI, Abdul AB, Devi N, Elhassan Taha MM, Al-Zubairi AS, Mohan S, et al. Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: involvement of mitochondria-regulated apoptosis. Exp Toxicol Pathol; in press, doi:10.1016/j.etp.2009.06.005.
3. Sakinah S.A., Handayani S.T. Hawariah LPZerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int 2007, 7:4.
4. Murakami A., Hayashi R., Tanaka T., Kwon K.H., Ohigashi H., Safitri R. Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol 2003, 66:1253-1261.
5. Xian M., Ito K., Nakazato T., Shimizu T., Chen C.K., Yamato K., et al. Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci 2007, 98:118-126.
6. Al-Zubairi A.S., Abdul A.B., Syam M.M. Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. Toxicol In Vitro 2010, 24:707-712.
7. Bachmann P.S., Gorman R., Papa R.A., Bardell J.E., Ford J., Kees U.R., et al. Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia. Cancer Res 2007, 67:4482.
8. Mohan S, Bustamam A, Ibrahim S, Al-Zubairi AS, Aspollah M, Abdullah R, et al. In vitro ultramorphological assessment of apoptosis on CEMss induced by linoleic acid-rich fraction from typhonium flagelliforme tuber. ECAM; in press, doi:10.1016/j.leukres.2010.04.023.
9. Mini E., Moroson B.A., Bertino J.R. Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin. Cancer Treat Rep 1987, 71:381-389.
10. Hoffman A., Spetner L.M., Burke M. Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation. Carcinogenesis 2002, 23:1961.