In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy

Journal of Cardiovascular Magnetic Resonance

Volumn 15, Issue 1, 2013, Pages

  Dodd, Michael S ^a   Ball, Vicky ^a   Bray, Rosalind ^a   Ashrafian, Houman ^a   Watkins, Hugh ^a   Clarke, Kieran ^a   Tyler, Damian J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLOROACETIC ACID; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; CARBON; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIET RESTRICTION; GENE MUTATION; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART MUSCLE METABOLISM; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; 129 MOUSE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECT; ENERGY METABOLISM; HEART MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; SPECIES DIFFERENCE; TIME; WISTAR RAT;

ANIMALS; CARBON ISOTOPES; DICHLOROACETIC ACID; ENERGY METABOLISM; FASTING; INFUSIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED BALB C; MICE, INBRED C57BL; MYOCARDIUM; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, WISTAR; SPECIES SPECIFICITY; TIME FACTORS;

MLCS; MLOWN;

EID: 84873939752     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-15-19     Document Type: Article

References (52)

1. Bakermans AJ, Geraedts TR, Van Weeghel M, Denis S, João Ferraz M, Aerts JMFG, Aten J, Nicolay K, Houten SM, Prompers JJ. Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function. Circulation. Cardiovascular Imaging 2011; 4:65-558.
2. Kurtz DM, Rinaldo P, Rhead WJ, Tian L, Millington DS, Vockley J, Hamm DA, Brix AE, Lindsey JR, Pinkert CA, O'Brien WE, Wood PA. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc. Natl. Acad. Sci. USA 1998; 95:15592-7.
3. Guellich A, Damy T, Lecarpentier Y, Conti M, Claes V, Samuel J-L, Quillard J, Hébert J-L, Pineau T, Coirault C. Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. Am J Physiol Heart Circ Physiol 2007; 293:H93-H102.
4. Liao R, Jain M, Cui L, D'Agostino J, Aieollo F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-Specific Overexpression of GLUT1 Prevents the Development of Heart Failure Attributable to Pressure Overload in Mice. Circulation 2002; 106:2125-2131.
5. Cary HH, Beckman AO. A quartz photoelectric spectrophotometer. J Opt Soc Am 1941; 31:682-689.
6. Kim HY, Wang TC, Ma YC. Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. Analytical Chemistry 1994; 66:3977-82.
7. Griffin JL, Atherton H, Shockcor J, Atzori L. Metabolomics as a tool for cardiac research. Nature Reviews. Cardiology 2011. 8:630-43.
8. Labarthe F, Khairallah M, Bouchard B, Stanley WC, Des Rosiers C. Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid. Am J Physiol Heart Circ Physiol 2005; 288:1425-1436.
9. Neurohr KJ, Barrett EJ, Shulman RG. In vivo carbon-13 nuclear magnetic resonance studies of heart metabolism. Proc. Natl. Acad. Sci. USA 1983; 80:1603-1607.
10. Laughlin MR, Taylor J, Chesnick AS, DeGroot M, Balaban RS. Pyruvate and lactate metabolism in the in vivo dog heart. Am J Physiol 1993; 264:H2068-H79.
11. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K. Increase in signal-To-noise ratio of > 10, 000 times in liquid-state NMR. Proc. Natl. Acad. Sci. USA 2003; 100:10158-10163.
12. Golman K, Ardenkjaer-Larsen JH, Petersson JS, Mansson S, Leunbach I. Molecular imaging with end ogenous substances. Proc. Natl. Acad. Sci. USA 2003; 100:10435-10439.
13. Golman K, Olsson LE, Axelsson O, Mansson S, Karlsson M, Petersson JS. Molecular imaging using hyperpolarized 13C. Br J Radiol 2003; 76:S118-S127.
14. Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ. In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc. Natl. Acad. Sci. USA 2008; 105:12051-6.
15. Merritt ME, Harrison C, Storey C, Jeffrey FM, Sherry AD, Malloy CR: Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc. Natl. Acad. Sci. USA 2007, 104:19773-19777.
16. Dodd MS, Ball DR, Schroeder MA, Le Page LM, Atherton HJ, Heather LC, Seymour A-M, Ashrafian H, Watkins H, Clarke K, Tyler DJ. In Vivo Alterations in Cardiac Metabolism and Function in the Spontaneously Hypertensive Rat Heart. Cardiovascular Research 2012; 95:69-76.
17. Schroeder MA, Swietach P, Atherton HJ, Gallagher FA, Lee P, Radda GK, Clarke K, Tyler DJ. Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: A 13C and 31P magnetic resonance spectroscopy study. Cardiovascular Research 2010; 86:82-91.
18. Atherton HJ, Dodd MS, Heather LC, Schroeder MA, Griffin JL, Radda GK, Clarke K, Tyler DJ. Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: A combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. Circulation 2011; 123:2552-61.
19. Atherton HJ, Schroeder MA, Dodd MS, Heather LC, Carter EE, Cochlin LE, Nagel S, Sibson NR, Radda GK, Clarke K, Tyler DJ. Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised (13)C MRS. NMR in Biomedicine 2011; 24:201-8.
20. Lau AZ, Chen AP, Ghugre NR, Ramanan V, Lam WW, Connelly K, Wright G, Cunningham CH. Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart. Magnetic Resonance in Medicine 2010; 64:31-1323.
21. Bohndiek SE, Kettunen MI, Hu DE, Witney TH, Kennedy BW, Gallagher FA, Brindle KM: Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy. Mol Cancer Ther 2010, 9:3278-3288.
22. Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nature Medicine 2007; 13:1382-1387.
23. Witney TH, Kettunen MI, Day SE, Hu DE, Neves AA, Gallagher FA, Fulton SM, Brindle KM. A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia 2009; 11:82-574. 1 p following 582.
24. Tyler DJ. Cardiovascular Applications of Hyperpolarized MRI. Current Cardiovascular Imaging Reports 2011; 4:108-115.
25. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-Acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. The Lancet 1963; 1:785.
26. Schneider JE, Cassidy PJ, Lygate C, Tyler DJ, Wiesmann F, Grieve SM, Hulbert K, Clarke K, Neubauer S. Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. JMRI 2003; 18:691-701.
27. Tyler D, Lygate C, Schneider J, Cassidy P, Neubauer S, Clarke K. CINE-MR Imaging of the Normal and Infarcted Rat Heart Using an 11.7 T Vertical Bore MR System. Journal of Cardiovascular Magnetic Resonance 2006; 8:327-333.
28. Wolfensohn S, Lloyd M. Handbook of Laboratory Animal Management and Welfare. John Wiley & Sons 2008; 432.
29. Gurley SB, Clare SE, Snow KP, Hu A, Meyer TW, Coffman TM. Impact of genetic background on nephropathy in diabetic mice. American Journal of physiology. Heart and circulatory physiology 2006; 290:F214-F222.
30. Berglund E, Li C, Poffenberger G, Ayala J. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 2008; 57:1790-1799.
31. Hyperpolarized Pyruvate Injection in Subjects With Prostate Cancer - Full Text View - ClinicalTrials.gov: Hyperpolarized Pyruvate Injection in Subjects With Prostate Cancer - Full Text View - ClinicalTrials.gov. Hyperpolarized Pyruvate Injection in Subjects With Prostate Cancer - Full Text View - ClinicalTrials.gov: Hyperpolarized Pyruvate Injection in Subjects With Prostate Cancer - Full Text View - ClinicalTrials.gov; [http://clinicaltrials.gov/ct2/show/NCT01229618].
32. Ardenkjaer-Larsen JH, Leach AM, Clarke N, Urbahn J, Anderson D, Skloss TW. Dynamic nuclear polarization polarizer for sterile use intent. NMR in biomedicine 2011; 24:927-32.
33. New Prostate Cancer Imaging Shows Real-Time Tumor Metabolism | News | UCSF Medical Center: 2010 [http://www.ucsfhealth.org/news/2010/11/new-prostate-cancer-imaging-shows-real-Time-Tumor-metabolism.html].
34. Schroeder MA, Clarke K, Neubauer S, Tyler DJ. Hyperpolarized magnetic resonance: A novel technique for the in vivo assessment of cardiovascular disease. Circulation 2011; 124:1580-94.
35. Cassidy PJ, Schneider JE, Grieve SM, Lygate CA, Tyler DJ, Neubauer S, Clarke K. An animal handling system for small animals in vivo MR. In ISMRM (Abstract) 2005; 488.
36. Naressi A, Couturier C, Castang I, De Beer R, Graveron-Demilly D. Javabased graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med 2001; 31:269-286.
37. Zierhut ML, Yen Y-FF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson 2010; 202:85-92.
38. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005; 112:2686-95.
39. Whitehouse S, Cooper RH, Randle PJ. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochemical Journal 1974; 141:761-774.
40. Kato-Weinstein J, Lingohr MK, Orner G, Thrall BD, Bull RJ. Effects of dichloroacetate on gly cogen metabolism in B6C3F1 mice. Toxicology 1998; 130:54-141.
41. Holness MJ, Sugden MC. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochemical Society Transactions 2003; 31:1143-51.
42. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-Activated receptor α (PPAR alpha) in the cellular fasting response: The PPAR α -null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. USA 1999; 96:7473-7478.
43. Muoio DM, MacLean PS, Lang DB, Li S, Houmard J, Way JM, Winegar D, Corton JC, Dohm GL, Kraus WE. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferatoractivated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of Biological Chemistry 2002; 277:97-26089.
44. Wu P, Sato J, Zhao Y, Jaskiewicz J, Popov KM, Harris RA. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochemical Journal 1998; 329:197-201.
45. Huang B, Wu P, Bowker-Kinley MM, Harris RA. Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-Activated receptor-Alpha ligands, glucocorticoids, and insulin. Diabetes 2002; 51:276-83.
46. Wray J, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D. The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. PloS one 2009; 4:7421.
47. Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochemical Journal 1998; 329:191-196.
48. Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace A, Clarke K, Griffin JL. A functional analysis of mouse models of cardiac disease through metabolic profiling. The Journal of Biological Chemistry 2005; 280:9-7530.
49. Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk: ApfCD mouse. FEBS letters 2000; 484:169-74.
50. Lauzier B, Vaillant F, Gélinas R, Bouchard B, Brownsey R, Thorin E, Tardif J-C, Des Rosiers C. Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts. American Journal of Physiology. Heart and Circulatory Physiology 2011; 300:52-845.
51. Schreyer S, Wilson DL, LeBoeuf RC. C57BL/6 mice fed high fat diets as models for diabetes-Accelerated atherosclerosis. Atherosclerosis 1998; 136:17-24.
52. Vaillant F, Lauzier B, Poirier I, Gelinas R, Thorin E, Rosiers CH D. Metabolic and functional phenotyping of ex vivo atherosclerotic mouse working hearts. The difference is in the control strain [Abstract]. In European Society of Cardiology, Congress 2011; :5434.