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Volumn 11, Issue 2, 2013, Pages 239-250

Aortic stenosis: A general overview of clinical, pathophysiological and therapeutic aspects

Author keywords

angiotensin converting enzyme inhibitors; aortic stenosis; aortic valve; biomarkers; pathogenesis; pathophysiology; proteomics; statins

Indexed keywords

ATORVASTATIN; BIOLOGICAL MARKER; EZETIMIBE; ROSUVASTATIN; SIMVASTATIN;

EID: 84873921778     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.12.171     Document Type: Review
Times cited : (18)

References (90)
  • 2
    • 34247139786 scopus 로고    scopus 로고
    • The epidemiology of valvular heart disease: A growing public health problem
    • Supino PG, Borer JS, Preibisz J, Bornstein A. The epidemiology of valvular heart disease: a growing public health problem. Heart Fail. Clin. 2(4), 379-393 (2006).
    • (2006) Heart Fail. Clin , vol.2 , Issue.4 , pp. 379-393
    • Supino, P.G.1    Borer, J.S.2    Preibisz, J.3    Bornstein, A.4
  • 3
    • 80054937214 scopus 로고    scopus 로고
    • Calcific aortic valve disease: Not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group
    • Rajamannan NM, Evans FJ, Aikawa E et al. Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease -2011 update. Circulation 124(16), 1783-1791 (2011).
    • (2011) Executive Summary: Calcific Aortic Valve Disease -2011 Update. Circulation , vol.124 , Issue.16 , pp. 1783-1791
    • Rajamannan, N.M.1    Evans, F.J.2    Aikawa, E.3
  • 5
    • 0027530386 scopus 로고
    • Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves
    • Beppu S, Suzuki S, Matsuda H, Ohmori F, Nagata S, Miyatake K. Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves. Am. J. Cardiol. 71(4), 322-327 (1993).
    • (1993) Am. J. Cardiol , vol.71 , Issue.4 , pp. 322-327
    • Beppu, S.1    Suzuki, S.2    Matsuda, H.3    Ohmori, F.4    Nagata, S.5    Miyatake, K.6
  • 6
    • 0014082975 scopus 로고
    • Percentage of left ventricular stroke work loss A simple hemodynamic concept for estimation of severity in valvular aortic stenosis
    • Tobin JR Jr, Rahimtoola SH, Blundell PE, Swan HJ. Percentage of left ventricular stroke work loss. A simple hemodynamic concept for estimation of severity in valvular aortic stenosis. Circulation 35(5), 868-879 (1967).
    • (1967) Circulation , vol.35 , Issue.5 , pp. 868-879
    • Tobin Jr., J.R.1    Rahimtoola, S.H.2    Blundell, P.E.3    Swan, H.J.4
  • 8
    • 33747116680 scopus 로고    scopus 로고
    • American College of Cardiology/American Heart Association Task Force on Practice Guidlines, Society of Cardiovascular A, Society for Cardiovascular A et al
    • ACC/AHA 2006 Guidelines for the Management of Patients with Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease): Developed in Collaboration with the Society of Cardiovascular Anesthesiologists: Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
    • American College of Cardiology/American Heart Association Task Force on Practice Guidlines, Society of Cardiovascular A, Society for Cardiovascular A et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 114(5), e84-e231 (2006).
    • (2006) Circulation , vol.114 , Issue.5
  • 9
    • 33847134400 scopus 로고    scopus 로고
    • Task force on the management of valvular hearth disease of the european society of Cardiology; Esc committee for practice guidelines. Guidelines on the management of valvular heart disease: The task force on the management of valvular heart disease of the european society of cardiology
    • Vahanian A, Baumgartner H, Bax J et al.; Task Force on the Management of Valvular Hearth Disease of the European Society of Cardiology; ESC Committee for Practice Guidelines. Guidelines on the management of valvular heart disease: The Task Force on the Management of valvular heart disease of the European Society of Cardiology. Eur. Heart J. 28(2), 230-268 (2007).
    • (2007) Eur. Heart J , vol.28 , Issue.2 , pp. 230-268
    • Vahanian, A.1    Baumgartner, H.2    Bax, J.3
  • 10
    • 0017836844 scopus 로고
    • Effects of successful, uncomplicated valve replacement on ventricular hypertrophy, volume, and performance in aortic stenosis and in aortic incompetence
    • Pantely G, Morton M, Rahimtoola SH. Effects of successful, uncomplicated valve replacement on ventricular hypertrophy, volume, and performance in aortic stenosis and in aortic incompetence. J. Thorac. Cardiovasc. Surg. 75(3), 383-391 (1978).
    • (1978) J. Thorac. Cardiovasc. Surg , vol.75 , Issue.3 , pp. 383-391
    • Pantely, G.1    Morton, M.2    Rahimtoola, S.H.3
  • 11
    • 0025240348 scopus 로고
    • The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis
    • Pellikka PA, Nishimura RA, Bailey KR, Tajik AJ. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J. Am. Coll. Cardiol. 15(5), 1012-1017 (1990).
    • (1990) J. Am. Coll. Cardiol , vol.15 , Issue.5 , pp. 1012-1017
    • Pellikka, P.A.1    Nishimura, R.A.2    Bailey, K.R.3    Tajik, A.J.4
  • 12
    • 21044446833 scopus 로고    scopus 로고
    • Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up
    • Pellikka PA, Sarano ME, Nishimura RA et al. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation 111(24), 3290-3295 (2005).
    • (2005) Circulation , vol.111 , Issue.24 , pp. 3290-3295
    • Pellikka, P.A.1    Sarano, M.E.2    Nishimura, R.A.3
  • 13
    • 38649095954 scopus 로고    scopus 로고
    • The benefits of early valve replacement in asymptomatic patients with severe aortic stenosis
    • Brown ML, Pellikka PA, Schaff HV et al. The benefits of early valve replacement in asymptomatic patients with severe aortic stenosis. J. Thorac. Cardiovasc. Surg. 135(2), 308-315 (2008).
    • (2008) J. Thorac. Cardiovasc. Surg , vol.135 , Issue.2 , pp. 308-315
    • Brown, M.L.1    Pellikka, P.A.2    Schaff, H.V.3
  • 14
    • 84944151076 scopus 로고    scopus 로고
    • Guidelines on the management of valvular heart disease (version 2012): The joint task force on the management of valvular heart disease of the european society of cardiology (esc) and the european association for cardio-thoracic surgery (eacts)
    • Vahanian A, Alfieri O, Andreotti F et al. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur. J. Cardiothorac. Surg. 42(4), S1-S44 (2012).
    • (2012) Eur. J. Cardiothorac. Surg , vol.42 , Issue.4
    • Vahanian, A.1    Alfieri, O.2    Andreotti, F.3
  • 15
    • 33751425983 scopus 로고    scopus 로고
    • Phenotypic characterization of isolated valvular interstitial cell subpopulations
    • Blevins TL, Carroll JL, Raza AM, Grande-Allen KJ. Phenotypic characterization of isolated valvular interstitial cell subpopulations. J. Heart Valve Dis. 15(6), 815-822 (2006).
    • (2006) J. Heart Valve Dis , vol.15 , Issue.6 , pp. 815-822
    • Blevins, T.L.1    Carroll, J.L.2    Raza, A.M.3    Grande-Allen, K.J.4
  • 16
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • Liu AC, Joag VR, Gotlieb AI. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am. J. Pathol. 171(5), 1407-1418 (2007).
    • (2007) Am. J. Pathol , vol.171 , Issue.5 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 17
    • 62549151245 scopus 로고    scopus 로고
    • Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential
    • Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am. J. Pathol. 174(3), 1109-1119 (2009).
    • (2009) Am. J. Pathol , vol.174 , Issue.3 , pp. 1109-1119
    • Chen, J.H.1    Yip, C.Y.2    Sone, E.D.3    Simmons, C.A.4
  • 18
    • 3943086319 scopus 로고    scopus 로고
    • Aortic valve: Turning over a new leaf(let) in endothelial phenotypic heterogeneity
    • Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arterioscler. Thromb. Vasc. Biol. 24(8), 1331-1333 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , Issue.8 , pp. 1331-1333
    • Davies, P.F.1    Passerini, A.G.2    Simmons, C.A.3
  • 19
    • 17644380642 scopus 로고    scopus 로고
    • Spatial heterogeneity of endothelial phenotypes correlates with sidespecific vulnerability to calcification in normal porcine aortic valves
    • Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with sidespecific vulnerability to calcification in normal porcine aortic valves. Circ. Res. 96(7), 792-799 (2005).
    • (2005) Circ. Res , vol.96 , Issue.7 , pp. 792-799
    • Simmons, C.A.1    Grant, G.R.2    Manduchi, E.3    Davies, P.F.4
  • 20
    • 0027991976 scopus 로고
    • Characterization of the early lesion ofdegenerative' valvular aortic stenosis. histological and immunohistochemical studies
    • Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 90(2), 844-853 (1994).
    • (1994) Circulation , vol.90 , Issue.2 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3    Gown, A.M.4    O'Brien, K.D.5
  • 22
    • 0027477079 scopus 로고
    • Prevalence of aortic valve abnormalities in the elderly: An echocardiographic study of a random population sample
    • Lindroos M, Kupari M, Heikkilä J, Tilvis R. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J. Am. Coll. Cardiol. 21(5), 1220-1225 (1993).
    • (1993) J. Am. Coll. Cardiol , vol.21 , Issue.5 , pp. 1220-1225
    • Lindroos, M.1    Kupari, M.2    Heikkilä, J.3    Tilvis, R.4
  • 23
    • 64049108554 scopus 로고    scopus 로고
    • Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: Implications for degenerative aortic valve disease
    • Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease. Am. J. Physiol. Heart Circ. Physiol. 296(3), H756-H764 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol , vol.296 , Issue.3
    • Balachandran, K.1    Sucosky, P.2    Jo, H.3    Yoganathan, A.P.4
  • 24
    • 77954568359 scopus 로고    scopus 로고
    • Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner
    • Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner. Am. J. Pathol. 177(1), 49-57 (2010).
    • (2010) Am. J. Pathol , vol.177 , Issue.1 , pp. 49-57
    • Balachandran, K.1    Sucosky, P.2    Jo, H.3    Yoganathan, A.P.4
  • 25
    • 58749105840 scopus 로고    scopus 로고
    • Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells
    • discussion 578
    • Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN. Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells. J. Heart Valve Dis. 17(5), 571-577; discussion 578 (2008).
    • (2008) J. Heart Valve Dis , vol.17 , Issue.5 , pp. 571-577
    • Metzler, S.A.1    Pregonero, C.A.2    Butcher, J.T.3    Burgess, S.C.4    Warnock, J.N.5
  • 26
    • 11044223619 scopus 로고    scopus 로고
    • Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner
    • Xing Y, Warnock JN, He Z, Hilbert SL, Yoganathan AP. Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner. Ann. Biomed. Eng. 32(11), 1461-1470 (2004).
    • (2004) Ann. Biomed. Eng , vol.32 , Issue.11 , pp. 1461-1470
    • Xing, Y.1    Warnock, J.N.2    He, Z.3    Hilbert, S.L.4    Yoganathan, A.P.5
  • 27
    • 0032936072 scopus 로고    scopus 로고
    • Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves
    • Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler. Thromb. Vasc. Biol. 19(5), 1218-1222 (1999).
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , Issue.5 , pp. 1218-1222
    • Olsson, M.1    Thyberg, J.2    Nilsson, J.3
  • 28
    • 0028329052 scopus 로고
    • Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves
    • Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J. Am. Coll. Cardiol. 23(5), 1162-1170 (1994).
    • (1994) J. Am. Coll. Cardiol , vol.23 , Issue.5 , pp. 1162-1170
    • Olsson, M.1    Dalsgaard, C.J.2    Haegerstrand, A.3    Rosenqvist, M.4    Rydén, L.5    Nilsson, J.6
  • 29
    • 0037314647 scopus 로고    scopus 로고
    • Progression of aortic valve stenosis: TGF-β-1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    • 465; discussion 465
    • Jian B, Narula N, Li QY, Mohler ER 3rd, Levy RJ. Progression of aortic valve stenosis: TGF-β-1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann. Thorac. Surg. 75(2), 457-465; discussion 465 (2003).
    • (2003) Ann. Thorac. Surg , vol.75 , Issue.2 , pp. 457-462
    • Jian, B.1    Narula, N.2    Li, Q.Y.3    Mohler III, E.R.4    Levy, R.J.5
  • 30
    • 10744223993 scopus 로고    scopus 로고
    • Interleukin-1 β promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis
    • Kaden JJ, Dempfle CE, Grobholz R et al. Interleukin-1 β promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Atherosclerosis 170(2), 205-211 (2003).
    • (2003) Atherosclerosis , vol.170 , Issue.2 , pp. 205-211
    • Kaden, J.J.1    Dempfle, C.E.2    Grobholz, R.3
  • 31
    • 20144377112 scopus 로고    scopus 로고
    • Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    • Kaden JJ, Dempfle CE, Grobholz R et al. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc. Pathol. 14(2), 80-87 (2005).
    • (2005) Cardiovasc. Pathol , vol.14 , Issue.2 , pp. 80-87
    • Kaden, J.J.1    Dempfle, C.E.2    Grobholz, R.3
  • 32
    • 79958147911 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis: Methods, models, and mechanisms
    • Miller JD, Weiss RM, Heistad DD. Calcific aortic valve stenosis: methods, models, and mechanisms. Circ. Res. 108(11), 1392-1412 (2011).
    • (2011) Circ. Res , vol.108 , Issue.11 , pp. 1392-1412
    • Miller, J.D.1    Weiss, R.M.2    Heistad, D.D.3
  • 33
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller JD, Chu Y, Brooks RM, Richenbacher WE, Peña-Silva R, Heistad DD. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J. Am. Coll. Cardiol. 52(10), 843-850 (2008).
    • (2008) J. Am. Coll. Cardiol , vol.52 , Issue.10 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3    Richenbacher, W.E.4    Peña-Silva, R.5    Heistad, D.D.6
  • 34
    • 67249120424 scopus 로고    scopus 로고
    • Lowering plasma cholesterol levels halts progression of aortic valve disease in mice
    • Miller JD, Weiss RM, Serrano KM et al. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119(20), 2693-2701 (2009).
    • (2009) Circulation , vol.119 , Issue.20 , pp. 2693-2701
    • Miller, J.D.1    Weiss, R.M.2    Serrano, K.M.3
  • 35
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • Cucoranu I, Clempus R, Dikalova A et al. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ. Res. 97(9), 900-907 (2005).
    • (2005) Circ. Res , vol.97 , Issue.9 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3
  • 36
    • 0037159283 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma
    • O'Brien KD, Shavelle DM, Caulfield MT et al. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 106(17), 2224-2230 (2002).
    • (2002) Circulation , vol.106 , Issue.17 , pp. 2224-2230
    • O'Brien, K.D.1    Shavelle, D.M.2    Caulfield, M.T.3
  • 37
    • 7044237097 scopus 로고    scopus 로고
    • Induction of local angiotensin II-producing systems in stenotic aortic valves
    • Helske S, Lindstedt KA, Laine M et al. Induction of local angiotensin II-producing systems in stenotic aortic valves. J. Am. Coll. Cardiol. 44(9), 1859-1866 (2004).
    • (2004) J. Am. Coll. Cardiol , vol.44 , Issue.9 , pp. 1859-1866
    • Helske, S.1    Lindstedt, K.A.2    Laine, M.3
  • 38
    • 77749246325 scopus 로고    scopus 로고
    • Prognostic factors for progression of early-and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) retrospective analysis
    • Yamamoto K, Yamamoto H, Yoshida K et al. Prognostic factors for progression of early-and late-stage calcific aortic valve disease in Japanese: the Japanese Aortic Stenosis Study (JASS) retrospective analysis. Hypertens. Res. 33(3), 269-274 (2010).
    • (2010) Hypertens. Res , vol.33 , Issue.3 , pp. 269-274
    • Yamamoto, K.1    Yamamoto, H.2    Yoshida, K.3
  • 39
    • 59449092756 scopus 로고    scopus 로고
    • Calcific aortic stenosis: Lessons learned from experimental and clinical studies
    • Rajamannan NM. Calcific aortic stenosis: lessons learned from experimental and clinical studies. Arterioscler. Thromb. Vasc. Biol. 29(2), 162-168 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , Issue.2 , pp. 162-168
    • Rajamannan, N.M.1
  • 41
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • Rajamannan NM, Subramaniam M, Rickard D et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 107(17), 2181-2184 (2003).
    • (2003) Circulation , vol.107 , Issue.17 , pp. 2181-2184
    • Rajamannan, N.M.1    Subramaniam, M.2    Rickard, D.3
  • 42
    • 0030937408 scopus 로고    scopus 로고
    • Osteopontin is associated with bioprosthetic heart valve calcification in humans
    • Shen M, Marie P, Farge D et al. Osteopontin is associated with bioprosthetic heart valve calcification in humans. C. R. Acad. Sci. III 320(1), 49-57 (1997).
    • (1997) C. R. Acad. Sci. III , vol.320 , Issue.1 , pp. 49-57
    • Shen, M.1    Marie, P.2    Farge, D.3
  • 43
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix
    • Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler. Thromb. Vasc. Biol. 29(6), 936-942 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , Issue.6 , pp. 936-942
    • Yip, C.Y.1    Chen, J.H.2    Zhao, R.3    Simmons, C.A.4
  • 44
    • 0034800126 scopus 로고    scopus 로고
    • Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-β-mediated transdifferentiation in vitro
    • Paranya G, Vineberg S, Dvorin E et al. Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-β-mediated transdifferentiation in vitro. Am. J. Pathol. 159(4), 1335-1343 (2001).
    • (2001) Am. J. Pathol , vol.159 , Issue.4 , pp. 1335-1343
    • Paranya, G.1    Vineberg, S.2    Dvorin, E.3
  • 45
    • 21344439830 scopus 로고    scopus 로고
    • Age-associated aortic stenosis in apolipoprotein E-deficient mice
    • Tanaka K, Sata M, Fukuda D et al. Age-associated aortic stenosis in apolipoprotein E-deficient mice. J. Am. Coll. Cardiol. 46(1), 134-141 (2005).
    • (2005) J. Am. Coll. Cardiol , vol.46 , Issue.1 , pp. 134-141
    • Tanaka, K.1    Sata, M.2    Fukuda, D.3
  • 46
    • 66949118241 scopus 로고    scopus 로고
    • Role of the MAPK/ERK pathway in valvular interstitial cell calcification
    • Gu X, Masters KS. Role of the MAPK/ERK pathway in valvular interstitial cell calcification. Am. J. Physiol. Heart Circ. Physiol. 296(6), H1748-H1757 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol , vol.296 , Issue.6
    • Gu, X.1    Masters, K.S.2
  • 47
    • 33747161337 scopus 로고    scopus 로고
    • Role of human valve interstitial cells in valve calcification and their response to atorvastatin
    • Osman L, Yacoub MH, Latif N, Amrani M, Chester AH. Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation 114(1 Suppl.), I547-I552 (2006).
    • (2006) Circulation , vol.114 , Issue.1 SUPPL.
    • Osman, L.1    Yacoub, M.H.2    Latif, N.3    Amrani, M.4    Chester, A.H.5
  • 48
    • 59449090300 scopus 로고    scopus 로고
    • Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment
    • Monzack EL, Gu X, Masters KS. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. Arterioscler. Thromb. Vasc. Biol. 29(2), 246-253 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , Issue.2 , pp. 246-253
    • Monzack, E.L.1    Gu, X.2    Masters, K.S.3
  • 49
    • 77955943689 scopus 로고    scopus 로고
    • Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: A role for inflammation
    • Hjortnaes J, Butcher J, Figueiredo JL et al. Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur. Heart J. 31(16), 1975-1984 (2010).
    • (2010) Eur. Heart J , vol.31 , Issue.16 , pp. 1975-1984
    • Hjortnaes, J.1    Butcher, J.2    Figueiredo, J.L.3
  • 50
    • 33746429527 scopus 로고    scopus 로고
    • Lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis
    • Ortlepp JR, Pillich M, Schmitz F et al. Lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis. J. Heart Valve Dis. 15(4), 502-508 (2006).
    • (2006) J. Heart Valve Dis , vol.15 , Issue.4 , pp. 502-508
    • Ortlepp, J.R.1    Pillich, M.2    Schmitz, F.3
  • 51
    • 0023231642 scopus 로고
    • Aortic and mitral valve calcification in patients with end-stage renal disease
    • Maher ER, Young G, Smyth-Walsh B, Pugh S, Curtis Jr. Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet 2(8564), 875-877 (1987).
    • (1987) Lancet , vol.2 , Issue.8564 , pp. 875-877
    • Maher, E.R.1    Young, G.2    Smyth-Walsh, B.3    Pugh, S.4    Curtis, J.R.5
  • 52
    • 40949148662 scopus 로고    scopus 로고
    • Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis
    • Linhartová K, Veselka J, Sterbáková G, Racek J, Topolcan O, Cerbák R. Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circ. J. 72(2), 245-250 (2008).
    • (2008) Circ. J , vol.72 , Issue.2 , pp. 245-250
    • Linhartová, K.1    Veselka, J.2    Sterbáková, G.3    Racek, J.4    Topolcan, O.5    Cerbák, R.6
  • 53
    • 0028051762 scopus 로고
    • Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: Links between osteoporosis and cardiovascular disease?
    • Banks LM, Lees B, MacSweeney JE, Stevenson JC. Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: links between osteoporosis and cardiovascular disease? Eur. J. Clin. Invest. 24(12), 813-817 (1994).
    • (1994) Eur. J. Clin. Invest , vol.24 , Issue.12 , pp. 813-817
    • Banks, L.M.1    Lees, B.2    MacSweeney, J.E.3    Stevenson, J.C.4
  • 54
    • 28944433579 scopus 로고    scopus 로고
    • Aortic valve calcification: Association with bone mineral density and cardiovascular risk factors
    • Aksoy Y, Yagmur C, Tekin GO et al. Aortic valve calcification: association with bone mineral density and cardiovascular risk factors. Coron. Artery Dis. 16(6), 379-383 (2005).
    • (2005) Coron. Artery Dis , vol.16 , Issue.6 , pp. 379-383
    • Aksoy, Y.1    Yagmur, C.2    Tekin, G.O.3
  • 55
    • 70149123804 scopus 로고    scopus 로고
    • Vascular calcification and bone disease: The calcification paradox
    • Persy V, D'Haese P. Vascular calcification and bone disease: the calcification paradox. Trends Mol. Med. 15(9), 405-416 (2009).
    • (2009) Trends Mol. Med , vol.15 , Issue.9 , pp. 405-416
    • Persy, V.1    D'Haese, P.2
  • 56
    • 0031540602 scopus 로고    scopus 로고
    • A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve
    • Huntington K, Hunter AG, Chan KL. A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J. Am. Coll. Cardiol. 30(7), 1809-1812 (1997).
    • (1997) J. Am. Coll. Cardiol , vol.30 , Issue.7 , pp. 1809-1812
    • Huntington, K.1    Hunter, A.G.2    Chan, K.L.3
  • 57
    • 12744280946 scopus 로고    scopus 로고
    • Heterogeneous geographic distribution of patients with aortic valve stenosis: Arguments for new aetiological hypothesis
    • Le Gal G, Bertault V, Bezon E, Cornily JC, Barra JA, Blanc JJ. Heterogeneous geographic distribution of patients with aortic valve stenosis: arguments for new aetiological hypothesis. Heart 91(2), 247-249 (2005).
    • (2005) Heart , vol.91 , Issue.2 , pp. 247-249
    • Le Gal, G.1    Bertault, V.2    Bezon, E.3    Cornily, J.C.4    Barra, J.A.5    Blanc, J.J.6
  • 58
    • 0034768262 scopus 로고    scopus 로고
    • The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis
    • Ortlepp JR, Hoffmann R, Ohme F, Lauscher J, Bleckmann F, Hanrath P. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart 85(6), 635-638 (2001).
    • (2001) Heart , vol.85 , Issue.6 , pp. 635-638
    • Ortlepp, J.R.1    Hoffmann, R.2    Ohme, F.3    Lauscher, J.4    Bleckmann, F.5    Hanrath, P.6
  • 59
    • 0028967366 scopus 로고
    • Vitamin-Dreceptor-gene polymorphisms and change in lumbar-spine bone mineral density
    • Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour JP. Vitamin-Dreceptor-gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 345(8947), 423-424 (1995).
    • (1995) Lancet , vol.345 , Issue.8947 , pp. 423-424
    • Ferrari, S.1    Rizzoli, R.2    Chevalley, T.3    Slosman, D.4    Eisman, J.A.5    Bonjour, J.P.6
  • 60
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in NOTCH1 cause aortic valve disease
    • Garg V, Muth AN, Ransom JF et al. Mutations in NOTCH1 cause aortic valve disease. Nature 437(7056), 270-274 (2005).
    • (2005) Nature , vol.437 , Issue.7056 , pp. 270-274
    • Garg, V.1    Muth, A.N.2    Ransom, J.F.3
  • 61
    • 0042343900 scopus 로고    scopus 로고
    • Oestrogen receptor α gene polymorphism is related to aortic valve sclerosis in postmenopausal women
    • Nordström P, Glader CA, Dahlén G et al. Oestrogen receptor α gene polymorphism is related to aortic valve sclerosis in postmenopausal women. J. Intern. Med. 254(2), 140-146 (2003).
    • (2003) J. Intern. Med , vol.254 , Issue.2 , pp. 140-146
    • Nordström, P.1    Glader, C.A.2    Dahlén, G.3
  • 62
    • 0142053965 scopus 로고    scopus 로고
    • Association between apolipoprotein e alleles and calcific valvular heart disease
    • Novaro GM, Sachar R, Pearce GL, Sprecher DL, Griffin BP. Association between apolipoprotein E alleles and calcific valvular heart disease. Circulation 108(15), 1804-1808 (2003).
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1804-1808
    • Novaro, G.M.1    Sachar, R.2    Pearce, G.L.3    Sprecher, D.L.4    Griffin, B.P.5
  • 63
    • 0033044171 scopus 로고    scopus 로고
    • Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia
    • Kawaguchi A, Miyatake K, Yutani C et al. Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia. Am. Heart J. 137(3), 410-418 (1999).
    • (1999) Am. Heart J , vol.137 , Issue.3 , pp. 410-418
    • Kawaguchi, A.1    Miyatake, K.2    Yutani, C.3
  • 64
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 114(19), 2065-2069 (2006).
    • (2006) Circulation , vol.114 , Issue.19 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3    Young, S.G.4    Heistad, D.D.5
  • 65
    • 24644510707 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemiainduced calcification in the aortic valves via the Lrp5 receptor pathway
    • Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC. Atorvastatin inhibits hypercholesterolemiainduced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 112(9 Suppl.), I229-I234 (2005).
    • (2005) Circulation , vol.112 , Issue.9 SUPPL.
    • Rajamannan, N.M.1    Subramaniam, M.2    Caira, F.3    Stock, S.R.4    Spelsberg, T.C.5
  • 66
    • 0037024284 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve
    • Rajamannan NM, Subramaniam M, Springett M et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 105(22), 2660-2665 (2002).
    • (2002) Circulation , vol.105 , Issue.22 , pp. 2660-2665
    • Rajamannan, N.M.1    Subramaniam, M.2    Springett, M.3
  • 67
    • 20044364836 scopus 로고    scopus 로고
    • Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve
    • Rajamannan NM, Subramaniam M, Stock SR et al. Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart 91(6), 806-810 (2005).
    • (2005) Heart , vol.91 , Issue.6 , pp. 806-810
    • Rajamannan, N.M.1    Subramaniam, M.2    Stock, S.R.3
  • 68
    • 4444332263 scopus 로고    scopus 로고
    • Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis
    • Rosenhek R, Rader F, Loho N et al. Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis. Circulation 110(10), 1291-1295 (2004).
    • (2004) Circulation , vol.110 , Issue.10 , pp. 1291-1295
    • Rosenhek, R.1    Rader, F.2    Loho, N.3
  • 69
    • 20344364674 scopus 로고    scopus 로고
    • Scottish aortic stenosis and lipid lowering trial, impact on regression (saltire) investigators A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    • Cowell SJ, Newby DE, Prescott RJ et al.; Scottish Aortic Stenosis and Lipid Lowering Trial, Impact on Regression (SALTIRE) Investigators. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N. Engl. J. Med. 352(23), 2389-2397 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.23 , pp. 2389-2397
    • Cowell, S.J.1    Newby, D.E.2    Prescott, R.J.3
  • 70
    • 52649120889 scopus 로고    scopus 로고
    • SEAS Investigators. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebø AB, Pedersen TR, Boman K et al.; SEAS Investigators. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N. Engl. J. Med. 359(13), 1343-1356 (2008).
    • (2008) N. Engl. J. Med , vol.359 , Issue.13 , pp. 1343-1356
    • Rossebø, A.B.1    Pedersen, T.R.2    Boman, K.3
  • 71
    • 74949091630 scopus 로고    scopus 로고
    • Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: Results of the aortic stenosis progression observation: Measuring effects of rosuvastatin (ASTRONOMER) trial
    • Chan KL, Teo K, Dumesnil JG, Ni A, Tam J; ASTRONOMER Investigators. Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation 121(2), 306-314 (2010).
    • (2010) Circulation , vol.121 , Issue.2 , pp. 306-314
    • Chan, K.L.1    Teo, K.2    Dumesnil, J.G.3    Ni, A.4    Tam, J.5    Investigators, A.6
  • 72
    • 33846593363 scopus 로고    scopus 로고
    • Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis
    • Moura LM, Ramos SF, Zamorano JL et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J. Am. Coll. Cardiol. 49(5), 554-561 (2007).
    • (2007) J. Am. Coll. Cardiol , vol.49 , Issue.5 , pp. 554-561
    • Moura, L.M.1    Ramos, S.F.2    Zamorano, J.L.3
  • 73
    • 67249164067 scopus 로고    scopus 로고
    • Lipid lowering in aortic stenosis: Still some light at the end of the tunnel?
    • Helske S, Otto CM. Lipid lowering in aortic stenosis: still some light at the end of the tunnel? Circulation 119(20), 2653-2655 (2009).
    • (2009) Circulation , vol.119 , Issue.20 , pp. 2653-2655
    • Helske, S.1    Otto, C.M.2
  • 74
    • 50949107980 scopus 로고    scopus 로고
    • Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis
    • Antonini-Canterin F, Hîrsu M, Popescu BA et al. Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis. Am. J. Cardiol. 102(6), 738-742 (2008).
    • (2008) Am. J. Cardiol , vol.102 , Issue.6 , pp. 738-742
    • Antonini-Canterin, F.1    Hîrsu, M.2    Popescu, B.A.3
  • 75
    • 79960539641 scopus 로고    scopus 로고
    • European association for cardiovascular p, rehabilitation, esc/eas guidelines for the management of dyslipidaemias: The task force for the management of dyslipidaemias of the european society of cardiology (esc) and the european atherosclerosis society (eas
    • Reiner Z, Catapano AL, De Backer G et al. European Association for Cardiovascular P, Rehabilitation, ESC/EAS guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur. Heart J. 32(14), 1769-1818 (2011).
    • (2011) Eur. Heart J , vol.32 , Issue.14 , pp. 1769-1818
    • Reiner, Z.1    Catapano, A.L.2    De Backer, G.3
  • 76
    • 33947579076 scopus 로고    scopus 로고
    • Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits
    • Arishiro K, Hoshiga M, Negoro N et al. Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits. J. Am. Coll. Cardiol. 49(13), 1482-1489 (2007).
    • (2007) J. Am. Coll. Cardiol , vol.49 , Issue.13 , pp. 1482-1489
    • Arishiro, K.1    Hoshiga, M.2    Negoro, N.3
  • 77
    • 78651461435 scopus 로고    scopus 로고
    • Ramipril retards development of aortic valve stenosis in a rabbit model: Mechanistic considerations
    • Ngo DT, Stafford I, Sverdlov AL et al. Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations. Br. J. Pharmacol. 162(3), 722-732 (2011).
    • (2011) Br. J. Pharmacol , vol.162 , Issue.3 , pp. 722-732
    • Ngo, D.T.1    Stafford, I.2    Sverdlov, A.L.3
  • 78
    • 17644373433 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    • O'Brien KD, Probstfield JL, Caulfield MT et al. Angiotensin-converting enzyme inhibitors and change in aortic valve calcium. Arch. Intern. Med. 165(8), 858-862 (2005).
    • (2005) Arch. Intern. Med , vol.165 , Issue.8 , pp. 858-862
    • O'Brien, K.D.1    Probstfield, J.L.2    Caulfield, M.T.3
  • 79
    • 10644248275 scopus 로고    scopus 로고
    • Vascular proteomics: Linking proteomic and metabolomic changes
    • Mayr M, Mayr U, Chung YL, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. Proteomics 4(12), 3751-3761 (2004).
    • (2004) Proteomics , vol.4 , Issue.12 , pp. 3751-3761
    • Mayr, M.1    Mayr, U.2    Chung, Y.L.3    Yin, X.4    Griffiths, J.R.5    Xu, Q.6
  • 80
    • 8444228846 scopus 로고    scopus 로고
    • Biomarkers of cardiac disease
    • Marian AJ, Nambi V. Biomarkers of cardiac disease. Expert Rev. Mol. Diagn. 4(6), 805-820 (2004).
    • (2004) Expert Rev. Mol. Diagn , vol.4 , Issue.6 , pp. 805-820
    • Marian, A.J.1    Nambi, V.2
  • 81
    • 0034659815 scopus 로고    scopus 로고
    • Proteomics to study genes and genomes
    • Pandey A, Mann M. Proteomics to study genes and genomes. Nature 405(6788), 837-846 (2000).
    • (2000) Nature , vol.405 , Issue.6788 , pp. 837-846
    • Pandey, A.1    Mann, M.2
  • 82
    • 84866406934 scopus 로고    scopus 로고
    • Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: Identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure
    • Mebazaa A, Vanpoucke G, Thomas G et al. Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure. Eur. Heart J. 33(18), 2317-2324 (2012).
    • (2012) Eur. Heart J , vol.33 , Issue.18 , pp. 2317-2324
    • Mebazaa, A.1    Vanpoucke, G.2    Thomas, G.3
  • 84
    • 1842636201 scopus 로고    scopus 로고
    • Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: Possible role in human atherosclerosis
    • Yang Y, Trent MB, He N et al. Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 173(2), 211-221 (2004).
    • (2004) Atherosclerosis , vol.173 , Issue.2 , pp. 211-221
    • Yang, Y.1    Trent, M.B.2    He, N.3
  • 85
    • 84856338164 scopus 로고    scopus 로고
    • Inside human aortic stenosis: A proteomic analysis of plasma
    • Gil-Dones F, Darde VM, Alonso-Orgaz S et al. Inside human aortic stenosis: a proteomic analysis of plasma. J. Proteomics 75(5), 1639-1653 (2012).
    • (2012) J. Proteomics , vol.75 , pp. 1639-1653
    • Gil-Dones, F.1    Darde, V.M.2    Alonso-Orgaz, S.3
  • 87
    • 35248887511 scopus 로고    scopus 로고
    • Association of high α2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass
    • Fiore CE, Celotta G, Politi GG et al. Association of high α2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Atherosclerosis 195(1), 110-115 (2007).
    • (2007) Atherosclerosis , vol.195 , Issue.1 , pp. 110-115
    • Fiore, C.E.1    Celotta, G.2    Politi, G.G.3
  • 88
    • 26444541329 scopus 로고    scopus 로고
    • Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients
    • Wang AY, Woo J, Lam CW et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol. Dial. Transplant. 20(8), 1676-1685 (2005).
    • (2005) Nephrol. Dial. Transplant , vol.20 , Issue.8 , pp. 1676-1685
    • Wang, A.Y.1    Woo, J.2    Lam, C.W.3
  • 89
    • 85047694301 scopus 로고    scopus 로고
    • The serum protein α2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    • Schafer C, Heiss A, Schwarz A et al. The serum protein α2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J. Clin. Invest. 112(3), 357-366 (2003).
    • (2003) J. Clin. Invest , vol.112 , Issue.3 , pp. 357-366
    • Schafer, C.1    Heiss, A.2    Schwarz, A.3


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