Aortic valve: Turning over a new leaf(let) in endothelial phenotypic heterogeneity

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 8, 2004, Pages 1331-1333

  Davies, Peter F ^a,b   Passerini, Anthony G ^a,b   Simmons, Craig A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; RHO KINASE;

AORTA VALVE; AORTA VALVE DISEASE; ARTERY ENDOTHELIUM; ATHEROGENESIS; CALCIFICATION; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL STRUCTURE; EDITORIAL; ENDOTHELIUM CELL; ENVIRONMENTAL FACTOR; EPIGENETICS; EXTRACELLULAR MATRIX; FOCAL ADHESION; GENE ACTIVATION; GENE EXPRESSION; HEART CYCLE; HEART HEMODYNAMICS; HEART VALVE REPLACEMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCLEROSIS; SHEAR STRESS; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TISSUE STRUCTURE; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; AORTIC VALVE; CELL POLARITY; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; HEART VALVE DISEASES; HEMORHEOLOGY; HUMANS; MAMMALS; ORGAN SPECIFICITY; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 3943086319     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000130659.89433.c1     Document Type: Editorial

References (23)

1. Schoen FJ, Levy RJ. Tissue heart valves: current challenges and future research perspectives. J Biomed Mater Res. 1999;47:439-465.
2. Muller AM, Cronen C, Kupferwasser LI, Oelert H, Muller KM, Kirkpatrick CJ. Expression of endothelial cell adhesion molecules on heart valves: up-regulation in degeneration as well as acute endocarditis. J Pathol. 2000;191:54-60.
3. Poggianti E, Venneri L, Chubuchny V, Jambrik Z, Baroncini LA, Picano E. Aortic valve sclerosis is associated with systemic endothelial dysfunction. J Am Coll Cardiol. 2003;41:136-141.
4. Flaherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK, Fry DL. Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circ Res. 1972;30:23-33.
5. Dewey CF, Gimbrone MA, Bussolari SR, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Engin. 1981;103:177-185.
6. Remuzzi A, Dewey CF, Davies PF, Gimbrone MA. Orientation of endothelial cells in shear fields in vitro. Biorheology. 1984;21:617-630.
7. Butcher JT, Penrod AM, Garcia AJ, Nerem RM. Unique morphology and focal adhesion development of valvular endothelial cellsin static and fluid flow environments. Arterioscler Thromb Vasc Biol 2004;24:1429-1434.
8. Deck JD. Endothelial cell orientation on aortic valve leaflets. Cardiovasc Res. 1986;20:760-767.
9. Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A. 2003;100:10623-10628.
10. Topper JN, Gimbrone MA. Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol Med Today. 1999;5:40-46.
11. Garcia-Cardena G, Comander J, Anderson KR, Blackman BR, Gimbrone MA. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001;98:4478-4485.
12. Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T, Cybulsky MI. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci U S A. 2000;97:9052-9057.
13. Passerini AG, Polacek DC, Shi C, Francesco NM, Manduchi E, Grant G, Pritchard WP, Powell SJ, Chang G, Stoeckert C, Davies PF. Coexisting pro-inflammatory and anti-oxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci U S A. 2004;101:2482-2487.
14. Jackman RW. Persistence of axial orientation cues in regenerating intima of cultured aortic explants. Nature. 1982;296:80-83.
15. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. Embo J. 2001;20:4639-4647.
16. Farivar RS, Cohn LH, Soltesz EG, Mihaljevic T, Rawn JD, Byrne JG. Transcriptional profiling and growth kinetics of endothelium reveals differences between cells derived from porcine aorta versus aortic valve. Eur J Cardiothorac Surg. 2003;24:527-534.
17. Polacek DC, Passerini AG, Shi C, Francesco NM, Manduchi E, Grant G, Powell SJ, Bischof H, Winkler H, Stoeckert C, Davies PF. Fidelity and enhanced sensitivity of differential transcription profiles following linear amplification of nanogram amounts of endothelial mRNA. Physiological Genomics. 2003;13:147-156.
18. Simmons CA, Zilberberg J, Francesco NM, Shi C, Riley R, Davies PF. Transcriptional profiles of endothelium from opposite sides of the aortic valve suggest a link between hemodynamics and valvular calcification. Cardiovasc Pathol. 2004;13(suppl.):186. Abstract.
19. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 1994;90:844-853.
20. Gimbrone MA Jr, Anderson KR, Topper JN, Langille BL, Clowes AW, Bercel S, Davies MG, Stenmark KR, Frid MG, Weiser-Evans MC, Aldashev AA, Nemenoff RA, Majesky MW, Landerholm TE, Lu J, Ito WD, Arras M, Scholz D, Imhof B, Aurrand-Lions M, Schaper W, Nagel TE, Resnick N, Dewey CF, Davies PF. Special communication: the critical role of mechanical forces in blood vessel development, physiology and pathology. J Vasc Surg. 1999;29:1104-1151.
21. Davies PF, Polacek DC, Shi C, Helmke BP. The convergence of hemodynamics, genomics, and endothelial structure, in studies of the focal origin of atherosclerosis. Biorheology. 2002;39:299-306.
22. Sarphie TG. Surface responses of aortic valve endothelia from diet-induced, hypercholesterolemic rabbits. Atherosclerosis. 1985;54:283-299.
23. Tompkins RG, Schnitzer JJ, Yarmush ML. Macromolecular transport within heart valves. Circ Res. 1989;64:1213-1223.