Influenza neuraminidase inhibitors: Structure-based design of a novel inhibitor series

Biochemistry

Volumn 42, Issue 3, 2003, Pages 718-727

  Stoll, Vincent ^a   Stewart, Kent D ^a   Maring, Clarence J ^a   Muchmore, Steven ^a   Giranda, Vincent ^a   Gu, Yu gui Y ^a   Wang, Gary ^a   Chen, Yuanwei ^a   Sun, Minghua ^a   Zhao, Chen ^a   Kennedy, April L ^a   Madigan, Darold L ^a   Xu, Yibo ^a   Saldivar, Ayda ^a   Kati, Warren ^a   Laver, Graeme ^b   Sowin, Thomas ^a   Sham, Hing L ^a   Greer, Jonathan ^a   Kempf, Dale ^a  

^a ABBOTT LABORATORIES   (United States)

^b Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES;

CRYSTAL STRUCTURE; LEAD COMPOUNDS; PROTEINS;

BIOCHEMISTRY;

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; CYCLOPENTANE DERIVATIVE; PYRROLIDINE DERIVATIVE; SIALIDASE INHIBITOR; VIRUS SIALIDASE; ZANAMIVIR;

ARTICLE; COMBINATORIAL CHEMISTRY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; ENZYME ACTIVE SITE; INFLUENZA VIRUS; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINES; ANIMALS; BINDING SITES; BIRDS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; DRUG DESIGN; ENZYME INHIBITORS; ESTERS; INFLUENZA A VIRUS; MODELS, MOLECULAR; NANOTECHNOLOGY; NEURAMINIDASE; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

INFLUENZA VIRUS; RNA VIRUSES;

EID: 0037469141     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0205449     Document Type: Article

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