메뉴 건너뛰기




Volumn 18, Issue 45, 2012, Pages 6560-6570

Role of gastrin-peptides in Barrett's and colorectal carcinogenesis

Author keywords

Barrett's esophagus; C terminal flanking peptide; Colorectal cancer; Esophageal adenocarcinoma; Gastrin; Glycine extended gastrins; Hypergastrinemia; Progastrin; Proton pump inhibitors

Indexed keywords

ANTACID AGENT; AZOXYMETHANE; CARBOXYPEPTIDASE H; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ RECEPTOR; CYCLOOXYGENASE 2; FURIN; GASTRIN; GASTRIN 17; GASTRIN 34; GASTRIN RELEASING PEPTIDE; HISTAMINE H2 RECEPTOR ANTAGONIST; LIPOCORTIN 2; MITOGEN ACTIVATED PROTEIN KINASE; OMEPRAZOLE; PHOSPHATIDYLINOSITOL 3 KINASE; PROGASTRIN; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

EID: 84873899553     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i45.6560     Document Type: Review
Times cited : (28)

References (98)
  • 1
    • 67449132488 scopus 로고    scopus 로고
    • Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation
    • Beales IL, Ogunwobi OO. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 2009; 42: 305-318
    • (2009) J Mol Endocrinol , vol.42 , pp. 305-318
    • Beales, I.L.1    Ogunwobi, O.O.2
  • 2
    • 1542344358 scopus 로고    scopus 로고
    • Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice
    • Cobb S, Wood T, Ceci J, Varro A, Velasco M, Singh P. Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice. Cancer 2004; 100: 1311-1323
    • (2004) Cancer , vol.100 , pp. 1311-1323
    • Cobb, S.1    Wood, T.2    Ceci, J.3    Varro, A.4    Velasco, M.5    Singh, P.6
  • 3
    • 14644442984 scopus 로고    scopus 로고
    • Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production
    • Colucci R, Blandizzi C, Tanini M, Vassalle C, Breschi MC, Del Tacca M. Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. Br J Pharmacol 2005; 144: 338-348
    • (2005) Br J Pharmacol , vol.144 , pp. 338-348
    • Colucci, R.1    Blandizzi, C.2    Tanini, M.3    Vassalle, C.4    Breschi, M.C.5    Del Tacca, M.6
  • 6
    • 0026315966 scopus 로고
    • A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter
    • Merchant JL, Demediuk B, Brand SJ. A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter. Mol Cell Biol 1991; 11: 2686-2696
    • (1991) Mol Cell Biol , vol.11 , pp. 2686-2696
    • Merchant, J.L.1    Demediuk, B.2    Brand, S.J.3
  • 7
    • 0023720197 scopus 로고
    • Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria
    • Brand SJ, Stone D. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. J Clin Invest 1988; 82: 1059-1066
    • (1988) J Clin Invest , vol.82 , pp. 1059-1066
    • Brand, S.J.1    Stone, D.2
  • 8
    • 0026065917 scopus 로고
    • Plasma gastrin, daytime intragastric pH, and nocturnal acid output before and at 1 and 7 months after eradication of Helicobacter pylori in duodenal ulcer subjects
    • McColl KE, Fullarton GM, Chittajalu R, el Nujumi AM, MacDonald AM, Dahill SW, Hilditch TE. Plasma gastrin, daytime intragastric pH, and nocturnal acid output before and at 1 and 7 months after eradication of Helicobacter pylori in duodenal ulcer subjects. Scand J Gastroenterol 1991; 26: 339-346
    • (1991) Scand J Gastroenterol , vol.26 , pp. 339-346
    • McColl, K.E.1    Fullarton, G.M.2    Chittajalu, R.3    el Nujumi, A.M.4    McDonald, A.M.5    Dahill, S.W.6    Hilditch, T.E.7
  • 9
    • 0027278404 scopus 로고
    • Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17
    • Mulholland G, Ardill JE, Fillmore D, Chittajallu RS, Fullarton GM, McColl KE. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut 1993; 34: 757-761
    • (1993) Gut , vol.34 , pp. 757-761
    • Mulholland, G.1    Ardill, J.E.2    Fillmore, D.3    Chittajallu, R.S.4    Fullarton, G.M.5    McColl, K.E.6
  • 14
    • 0028958467 scopus 로고
    • Pathways of processing of the gastrin precursor in rat antral mucosa
    • Varro A, Voronina S, Dockray GJ. Pathways of processing of the gastrin precursor in rat antral mucosa. J Clin Invest 1995; 95: 1642-1649
    • (1995) J Clin Invest , vol.95 , pp. 1642-1649
    • Varro, A.1    Voronina, S.2    Dockray, G.J.3
  • 15
    • 0021745882 scopus 로고
    • Biosynthesis of tyrosine O-sulfated gastrins in rat antral mucosa
    • Brand SJ, Klarlund J, Schwartz TW, Rehfeld JF. Biosynthesis of tyrosine O-sulfated gastrins in rat antral mucosa. J Biol Chem 1984; 259: 13246-13252
    • (1984) J Biol Chem , vol.259 , pp. 13246-13252
    • Brand, S.J.1    Klarlund, J.2    Schwartz, T.W.3    Rehfeld, J.F.4
  • 16
    • 50449087916 scopus 로고    scopus 로고
    • The art of measuring gastrin in plasma: A dwindling diagnostic discipline?
    • Rehfeld JF. The art of measuring gastrin in plasma: a dwindling diagnostic discipline? Scand J Clin Lab Invest 2008; 68: 353-361
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 353-361
    • Rehfeld, J.F.1
  • 18
    • 0017122988 scopus 로고
    • Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subjects
    • Walsh JH, Isenberg JI, Ansfield J, Maxwell V. Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subjects. J Clin Invest 1976; 57: 1125-1131
    • (1976) J Clin Invest , vol.57 , pp. 1125-1131
    • Walsh, J.H.1    Isenberg, J.I.2    Ansfield, J.3    Maxwell, V.4
  • 19
    • 0034213130 scopus 로고    scopus 로고
    • Closing the gastrin loop in pancreatic carcinoma: Coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma
    • Goetze JP, Nielsen FC, Burcharth F, Rehfeld JF. Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 2000; 88: 2487-2494
    • (2000) Cancer , vol.88 , pp. 2487-2494
    • Goetze, J.P.1    Nielsen, F.C.2    Burcharth, F.3    Rehfeld, J.F.4
  • 20
    • 0027391418 scopus 로고
    • Identification of progastrin derived peptides in colorectal carcinoma extracts
    • Nemeth J, Taylor B, Pauwels S, Varro A, Dockray GJ. Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 1993; 34: 90-95
    • (1993) Gut , vol.34 , pp. 90-95
    • Nemeth, J.1    Taylor, B.2    Pauwels, S.3    Varro, A.4    Dockray, G.J.5
  • 21
    • 0024374893 scopus 로고
    • Gastrin in human bronchogenic carcinomas: Constant expression but variable processing of progastrin
    • Rehfeld JF, Bardram L, Hilsted L. Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res 1989; 49: 2840-2843
    • (1989) Cancer Res , vol.49 , pp. 2840-2843
    • Rehfeld, J.F.1    Bardram, L.2    Hilsted, L.3
  • 22
    • 0035173783 scopus 로고    scopus 로고
    • Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma
    • Siddheshwar RK, Gray JC, Kelly SB. Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma. Gut 2001; 48: 47-52
    • (2001) Gut , vol.48 , pp. 47-52
    • Siddheshwar, R.K.1    Gray, J.C.2    Kelly, S.B.3
  • 23
    • 0030902066 scopus 로고    scopus 로고
    • Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors
    • Reubi JC, Schaer JC, Waser B. Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res 1997; 57: 1377-1386
    • (1997) Cancer Res , vol.57 , pp. 1377-1386
    • Reubi, J.C.1    Schaer, J.C.2    Waser, B.3
  • 24
    • 0028947441 scopus 로고
    • Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors
    • Singh P, Owlia A, Espeijo R, Dai B. Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors. J Biol Chem 1995; 270: 8429-8438
    • (1995) J Biol Chem , vol.270 , pp. 8429-8438
    • Singh, P.1    Owlia, A.2    Espeijo, R.3    Dai, B.4
  • 25
    • 0026550278 scopus 로고
    • Physiology and pathophysiology of gastrin
    • Walsh JH. Physiology and pathophysiology of gastrin. Mt Sinai J Med 1992; 59: 117-124
    • (1992) Mt Sinai J Med , vol.59 , pp. 117-124
    • Walsh, J.H.1
  • 27
    • 3042696851 scopus 로고    scopus 로고
    • Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: Targets for treatment
    • Rengifo-Cam W, Singh P. Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment. Curr Pharm Des 2004; 10: 2345-2358
    • (2004) Curr Pharm Des , vol.10 , pp. 2345-2358
    • Rengifo-Cam, W.1    Singh, P.2
  • 29
    • 33846280842 scopus 로고    scopus 로고
    • Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells
    • Singh P, Wu H, Clark C, Owlia A. Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells. Oncogene 2007; 26: 425-440
    • (2007) Oncogene , vol.26 , pp. 425-440
    • Singh, P.1    Wu, H.2    Clark, C.3    Owlia, A.4
  • 30
    • 34248589304 scopus 로고    scopus 로고
    • Role of Annexin-II in GI cancers: Interaction with gastrins/progastrins
    • Singh P. Role of Annexin-II in GI cancers: interaction with gastrins/progastrins. Cancer Lett 2007; 252: 19-35
    • (2007) Cancer Lett , vol.252 , pp. 19-35
    • Singh, P.1
  • 33
    • 0032980318 scopus 로고    scopus 로고
    • Glycineextended gastrin exerts growth-promoting effects on human colon cancer cells
    • Stepan VM, Sawada M, Todisco A, Dickinson CJ. Glycineextended gastrin exerts growth-promoting effects on human colon cancer cells. Mol Med 1999; 5: 147-159
    • (1999) Mol Med , vol.5 , pp. 147-159
    • Stepan, V.M.1    Sawada, M.2    Todisco, A.3    Dickinson, C.J.4
  • 34
    • 0025325652 scopus 로고
    • Enterochromaffin-like cell carcinoids in the rat gastric mucosa following long-term administration of ranitidine
    • Havu N, Mattsson H, Ekman L, Carlsson E. Enterochromaffin-like cell carcinoids in the rat gastric mucosa following long-term administration of ranitidine. Digestion 1990; 45: 189-195
    • (1990) Digestion , vol.45 , pp. 189-195
    • Havu, N.1    Mattsson, H.2    Ekman, L.3    Carlsson, E.4
  • 35
    • 0025681360 scopus 로고
    • Efficacy and safety of omeprazole in the long-term treatment of peptic ulcer and reflux oesophagitis resistant to ranitidine
    • discussion 76
    • Brunner GH, Lamberts R, Creutzfeldt W. Efficacy and safety of omeprazole in the long-term treatment of peptic ulcer and reflux oesophagitis resistant to ranitidine. Digestion 1990; 47 Suppl 1: 64-68; discussion 76
    • (1990) Digestion , vol.47 , Issue.SUPPL. 1 , pp. 64-68
    • Brunner, G.H.1    Lamberts, R.2    Creutzfeldt, W.3
  • 36
  • 38
    • 0024999305 scopus 로고
    • Serum gastrin levels during long-term omeprazole treatment
    • Koop H, Klein M, Arnold R. Serum gastrin levels during long-term omeprazole treatment. Aliment Pharmacol Ther 1990; 4: 131-138
    • (1990) Aliment Pharmacol Ther , vol.4 , pp. 131-138
    • Koop, H.1    Klein, M.2    Arnold, R.3
  • 39
    • 0026649379 scopus 로고
    • Increased tissue concentrations of the gastrin precursor in patients treated with omeprazole
    • Nemeth J, Varro A, Bridson J, Walker R, Dockray GJ. Increased tissue concentrations of the gastrin precursor in patients treated with omeprazole. Eur J Clin Invest 1992; 22: 638-644
    • (1992) Eur J Clin Invest , vol.22 , pp. 638-644
    • Nemeth, J.1    Varro, A.2    Bridson, J.3    Walker, R.4    Dockray, G.J.5
  • 40
    • 0034789948 scopus 로고    scopus 로고
    • Glycine-extended gastrin promotes the invasiveness of human colon cancer cells
    • Kermorgant S, Lehy T. Glycine-extended gastrin promotes the invasiveness of human colon cancer cells. Biochem Biophys Res Commun 2001; 285: 136-141
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 136-141
    • Kermorgant, S.1    Lehy, T.2
  • 41
    • 0026079050 scopus 로고
    • Partial gastric corpectomy results in hypergastrinemia and development of gastric enterochromaffinlikecell carcinoids in the rat
    • Mattsson H, Havu N, Bräutigam J, Carlsson K, Lundell L, Carlsson E. Partial gastric corpectomy results in hypergastrinemia and development of gastric enterochromaffinlikecell carcinoids in the rat. Gastroenterology 1991; 100: 311-319
    • (1991) Gastroenterology , vol.100 , pp. 311-319
    • Mattsson, H.1    Havu, N.2    Bräutigam, J.3    Carlsson, K.4    Lundell, L.5    Carlsson, E.6
  • 43
    • 0035863511 scopus 로고    scopus 로고
    • Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis
    • Watson SA, Smith AM. Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis. Cancer Res 2001; 61: 625-631
    • (2001) Cancer Res , vol.61 , pp. 625-631
    • Watson, S.A.1    Smith, A.M.2
  • 48
    • 0027215052 scopus 로고
    • Ovarian cancers express and process progastrin
    • van Solinge WW, Odum L, Rehfeld JF. Ovarian cancers express and process progastrin. Cancer Res 1993; 53: 1823-1828
    • (1993) Cancer Res , vol.53 , pp. 1823-1828
    • van Solinge, W.W.1    Odum, L.2    Rehfeld, J.F.3
  • 49
    • 0033671373 scopus 로고    scopus 로고
    • Gastrin and gastrin receptor activation: An early event in the adenoma-carcinoma sequence
    • Smith AM, Watson SA. Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence. Gut 2000; 47: 820-824
    • (2000) Gut , vol.47 , pp. 820-824
    • Smith, A.M.1    Watson, S.A.2
  • 50
    • 4444382263 scopus 로고    scopus 로고
    • Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett' s esophagus: A possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors
    • Konturek PC, Nikiforuk A, Kania J, Raithel M, Hahn EG, Mühldorfer S. Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett' s esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. Dig Dis Sci 2004; 49: 1075-1083
    • (2004) Dig Dis Sci , vol.49 , pp. 1075-1083
    • Konturek, P.C.1    Nikiforuk, A.2    Kania, J.3    Raithel, M.4    Hahn, E.G.5    Mühldorfer, S.6
  • 51
    • 0024330157 scopus 로고
    • Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach
    • Ryberg B, Bishop AE, Bloom SR, Carlsson E, Håkanson R, Larsson H, Mattsson H, Polak JM, Sundler F. Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach. Regul Pept 1989; 25: 235-246
    • (1989) Regul Pept , vol.25 , pp. 235-246
    • Ryberg, B.1    Bishop, A.E.2    Bloom, S.R.3    Carlsson, E.4    Håkanson, R.5    Larsson, H.6    Mattsson, H.7    Polak, J.M.8    Sundler, F.9
  • 52
    • 56049120292 scopus 로고    scopus 로고
    • Glycine-extended gastrin stimu-lates proliferation via JAK2-and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells
    • Ogunwobi OO, Beales IL. Glycine-extended gastrin stimu-lates proliferation via JAK2-and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells. Mol Cell Endocrinol 2008; 296: 94-102
    • (2008) Mol Cell Endocrinol , vol.296 , pp. 94-102
    • Ogunwobi, O.O.1    Beales, I.L.2
  • 53
    • 0026794272 scopus 로고
    • Inter-relationship between serum gastrin levels, gastric mucosal histology and gastric endocrine cell growth
    • Creutzfeldt W, Lamberts R. Inter-relationship between serum gastrin levels, gastric mucosal histology and gastric endocrine cell growth. Digestion 1992; 51 Suppl 1: 76-81
    • (1992) Digestion , vol.51 , Issue.SUPPL. 1 , pp. 76-81
    • Creutzfeldt, W.1    Lamberts, R.2
  • 55
    • 0027162316 scopus 로고
    • Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis
    • Lamberts R, Creutzfeldt W, Strüber HG, Brunner G, Solcia E. Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. Gastroenterology 1993; 104: 1356-1370
    • (1993) Gastroenterology , vol.104 , pp. 1356-1370
    • Lamberts, R.1    Creutzfeldt, W.2    Strüber, H.G.3    Brunner, G.4    Solcia, E.5
  • 58
    • 0027293072 scopus 로고
    • Chronic endogenous hypergastrinemia in humans: Evidence for a mitogenic effect on the colonic mucosa
    • Sobhani I, Lehy T, Laurent-Puig P, Cadiot G, Ruszniewski P, Mignon M. Chronic endogenous hypergastrinemia in humans: evidence for a mitogenic effect on the colonic mucosa. Gastroenterology 1993; 105: 22-30
    • (1993) Gastroenterology , vol.105 , pp. 22-30
    • Sobhani, I.1    Lehy, T.2    Laurent-Puig, P.3    Cadiot, G.4    Ruszniewski, P.5    Mignon, M.6
  • 59
    • 0030008296 scopus 로고    scopus 로고
    • Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome
    • Orbuch M, Venzon DJ, Lubensky IA, Weber HC, Gibril F, Jensen RT. Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome. Dig Dis Sci 1996; 41: 604-613
    • (1996) Dig Dis Sci , vol.41 , pp. 604-613
    • Orbuch, M.1    Venzon, D.J.2    Lubensky, I.A.3    Weber, H.C.4    Gibril, F.5    Jensen, R.T.6
  • 62
    • 0029112258 scopus 로고
    • Relationship of gastrin processing to colon cancer
    • Dickinson CJ. Relationship of gastrin processing to colon cancer. Gastroenterology 1995; 109: 1384-1388
    • (1995) Gastroenterology , vol.109 , pp. 1384-1388
    • Dickinson, C.J.1
  • 63
    • 0028907930 scopus 로고
    • Does endoscopic surveillance in esophageal columnar metaplasia (Barrett's esophagus) have any real value?
    • Tytgat GN. Does endoscopic surveillance in esophageal columnar metaplasia (Barrett's esophagus) have any real value? Endoscopy 1995; 27: 19-26
    • (1995) Endoscopy , vol.27 , pp. 19-26
    • Tytgat, G.N.1
  • 65
    • 0026028040 scopus 로고
    • Rising incidence of adenocarcinoma of the esophagus and gastric cardia
    • Blot WJ, Devesa SS, Kneller RW, Fraumeni JF. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991; 265: 1287-1289
    • (1991) JAMA , vol.265 , pp. 1287-1289
    • Blot, W.J.1    Devesa, S.S.2    Kneller, R.W.3    Fraumeni, J.F.4
  • 67
    • 0033580405 scopus 로고    scopus 로고
    • Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    • Lagergren J, Bergström R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-831
    • (1999) N Engl J Med , vol.340 , pp. 825-831
    • Lagergren, J.1    Bergström, R.2    Lindgren, A.3    Nyrén, O.4
  • 68
    • 0032782622 scopus 로고    scopus 로고
    • Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression
    • Ouatu-Lascar R, Fitzgerald RC, Triadafilopoulos G. Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression. Gastroenterology 1999; 117: 327-335
    • (1999) Gastroenterology , vol.117 , pp. 327-335
    • Ouatu-Lascar, R.1    Fitzgerald, R.C.2    Triadafilopoulos, G.3
  • 70
    • 1542615086 scopus 로고    scopus 로고
    • An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus
    • Harris JC, Clarke PA, Awan A, Jankowski J, Watson SA. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Res 2004; 64: 1915-1919
    • (2004) Cancer Res , vol.64 , pp. 1915-1919
    • Harris, J.C.1    Clarke, P.A.2    Awan, A.3    Jankowski, J.4    Watson, S.A.5
  • 71
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001; 1: 11-21
    • (2001) Nat Rev Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 72
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93: 705-716
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 73
    • 0038192391 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma
    • Lagorce C, Paraf F, Vidaud D, Couvelard A, Wendum D, Martin A, Fléjou JF. Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma. Histopathology 2003; 42: 457-465
    • (2003) Histopathology , vol.42 , pp. 457-465
    • Lagorce, C.1    Paraf, F.2    Vidaud, D.3    Couvelard, A.4    Wendum, D.5    Martin, A.6    Fléjou, J.F.7
  • 75
    • 0037219463 scopus 로고    scopus 로고
    • Protective association of aspirin/NSAIDs and esophageal cancer: A systematic review and meta-analysis
    • Corley DA, Kerlikowske K, Verma R, Buffler P. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 2003; 124: 47-56
    • (2003) Gastroenterology , vol.124 , pp. 47-56
    • Corley, D.A.1    Kerlikowske, K.2    Verma, R.3    Buffler, P.4
  • 78
    • 0043167965 scopus 로고    scopus 로고
    • The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence
    • Rahme E, Barkun AN, Toubouti Y, Bardou M. The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence. Gastroenterology 2003; 125: 404-412
    • (2003) Gastroenterology , vol.125 , pp. 404-412
    • Rahme, E.1    Barkun, A.N.2    Toubouti, Y.3    Bardou, M.4
  • 79
    • 0036308913 scopus 로고    scopus 로고
    • Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus
    • Kaur BS, Khamnehei N, Iravani M, Namburu SS, Lin O, Triadafilopoulos G. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Gastroenterology 2002; 123: 60-67
    • (2002) Gastroenterology , vol.123 , pp. 60-67
    • Kaur, B.S.1    Khamnehei, N.2    Iravani, M.3    Namburu, S.S.4    Lin, O.5    Triadafilopoulos, G.6
  • 80
    • 0141649329 scopus 로고    scopus 로고
    • COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer
    • Piazuelo E, Jimenez P, Lanas A. COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. Curr Pharm Des 2003; 9: 2267-2280
    • (2003) Curr Pharm Des , vol.9 , pp. 2267-2280
    • Piazuelo, E.1    Jimenez, P.2    Lanas, A.3
  • 81
    • 0028050404 scopus 로고
    • Growth-promoting effects of glycine-extended progastrin
    • Seva C, Dickinson CJ, Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994; 265: 410-412
    • (1994) Science , vol.265 , pp. 410-412
    • Seva, C.1    Dickinson, C.J.2    Yamada, T.3
  • 82
    • 0023931443 scopus 로고
    • Neither glycineextended gastrin nor the 1-13 fragment of gastrin 17 influences gastric acid secretion in humans
    • Hilsted L, Hint K, Christiansen J, Rehfeld JF. Neither glycineextended gastrin nor the 1-13 fragment of gastrin 17 influences gastric acid secretion in humans. Gastroenterology 1988; 94: 96-102
    • (1988) Gastroenterology , vol.94 , pp. 96-102
    • Hilsted, L.1    Hint, K.2    Christiansen, J.3    Rehfeld, J.F.4
  • 83
    • 0023224312 scopus 로고
    • Biological activity of progastrin posttranslational processing intermediates
    • Matsumoto M, Park J, Sugano K, Yamada T. Biological activity of progastrin posttranslational processing intermediates. Am J Physiol 1987; 252: G315-G319
    • (1987) Am J Physiol , vol.252
    • Matsumoto, M.1    Park, J.2    Sugano, K.3    Yamada, T.4
  • 84
    • 0024542843 scopus 로고
    • Progastrin processing during antral G-cell hypersecretion in humans
    • Jensen S, Borch K, Hilsted L, Rehfeld JF. Progastrin processing during antral G-cell hypersecretion in humans. Gastroenterology 1989; 96: 1063-1070
    • (1989) Gastroenterology , vol.96 , pp. 1063-1070
    • Jensen, S.1    Borch, K.2    Hilsted, L.3    Rehfeld, J.F.4
  • 85
    • 0028982966 scopus 로고
    • Expression, processing, and secretion of gastrin in patients with colorectal carcinoma
    • Ciccotosto GD, McLeish A, Hardy KJ, Shulkes A. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 1995; 109: 1142-1153
    • (1995) Gastroenterology , vol.109 , pp. 1142-1153
    • Ciccotosto, G.D.1    McLeish, A.2    Hardy, K.J.3    Shulkes, A.4
  • 86
    • 34547621429 scopus 로고    scopus 로고
    • Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B
    • Rengifo-Cam W, Umar S, Sarkar S, Singh P. Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. Cancer Res 2007; 67: 7266-7274
    • (2007) Cancer Res , vol.67 , pp. 7266-7274
    • Rengifo-Cam, W.1    Umar, S.2    Sarkar, S.3    Singh, P.4
  • 87
    • 0344925874 scopus 로고    scopus 로고
    • Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP
    • Wu H, Owlia A, Singh P. Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP. Am J Physiol Gastrointest Liver Physiol 2003; 285: G1097-G1110
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Wu, H.1    Owlia, A.2    Singh, P.3
  • 89
    • 0027140743 scopus 로고
    • Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers
    • Vishwanatha JK, Chiang Y, Kumble KD, Hollingsworth MA, Pour PM. Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers. Carcinogenesis 1993; 14: 2575-2579
    • (1993) Carcinogenesis , vol.14 , pp. 2575-2579
    • Vishwanatha, J.K.1    Chiang, Y.2    Kumble, K.D.3    Hollingsworth, M.A.4    Pour, P.M.5
  • 91
    • 0025108770 scopus 로고
    • Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas
    • Azuma T, Magami Y, Habu Y, Kawai K, Taggart RT, Walsh JH. Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas. J Gastroenterol Hepatol 1990; 5: 525-529
    • (1990) J Gastroenterol Hepatol , vol.5 , pp. 525-529
    • Azuma, T.1    Magami, Y.2    Habu, Y.3    Kawai, K.4    Taggart, R.T.5    Walsh, J.H.6
  • 92
    • 33244495716 scopus 로고    scopus 로고
    • Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways
    • Beales IL, Ogunwobi O. Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. Mol Cell Endocrinol 2006; 247: 140-149
    • (2006) Mol Cell Endocrinol , vol.247 , pp. 140-149
    • Beales, I.L.1    Ogunwobi, O.2
  • 95
    • 0033561308 scopus 로고    scopus 로고
    • Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
    • Koh TJ, Dockray GJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Wang TC. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 1999; 103: 1119-1126
    • (1999) J Clin Invest , vol.103 , pp. 1119-1126
    • Koh, T.J.1    Dockray, G.J.2    Varro, A.3    Cahill, R.J.4    Dangler, C.A.5    Fox, J.G.6    Wang, T.C.7
  • 97
    • 78649815108 scopus 로고    scopus 로고
    • The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway
    • Patel O, Marshall KM, Bramante G, Baldwin GS, Shulkes A. The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. Regul Pept 2010; 165: 224-231
    • (2010) Regul Pept , vol.165 , pp. 224-231
    • Patel, O.1    Marshall, K.M.2    Bramante, G.3    Baldwin, G.S.4    Shulkes, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.