Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma

Gut

Volumn 48, Issue 1, 2001, Pages 47-52

  Siddheshwar, R K ^a   Gray, J C ^b   Kelly, S B ^a  

^a NORTH TYNESIDE GENERAL HOSPITAL   (United Kingdom)

^b TEESSIDE UNIVERSITY   (United Kingdom)

Author keywords

Colorectal carcinoma; Glycine extended gastrin; Progastrin

Indexed keywords

ANTIBODY; GASTRIN; GLYCINE; PROGASTRIN;

ADULT; AGED; AMIDATION; ARTICLE; COLON POLYP; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIET RESTRICTION; DYSPLASIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PROCESSING; RADIOIMMUNOASSAY; RECTUM POLYP;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, BACTERIAL; CARCINOMA; CASE-CONTROL STUDIES; COLONIC POLYPS; COLORECTAL NEOPLASMS; FEMALE; GASTRINS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; PROTEIN PRECURSORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0035173783     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.1.47     Document Type: Article

References (47)

1. Chronic endogenous hypergastrinaemia in humans: Evidence for a mitogenic effect on the colonic mucosa
2. Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia
3. Stimulation of growth of a colon cancer cell line by gastrin
4. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin
5. Gastrin stimulates growth of colon cancer
6. Hypergastrinaemia and colorectal carcinogenesis in the rat
7. Developmental expression of the gastrin and cholecystokinin genes in rat colon
8. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line
9. Identification of progastrin derived peptides in colorectal carcinoma extracts
10. Growth-promoting effects of glycine-extended progastrin
11. Processing and proliferative effects of human progastrin in transgenic mice
12. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice
13. Clinical significance of gastrin receptors in human colon cancers
14. Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice
15. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines
16. Gastrin receptor antagonist C1-988 inhibits growth of human colon cancer in vivo and in vitro
17. Gastrin sensitivity of primary human colorectal cancer: The effect of gastrin receptor antagonism
18. Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer
19. Serum gastrin concentrations in colorectal cancer patients
20. Postprandial hypergastrinaemia in patients with colorectal cancer
21. Serum gastrin in colonic polyps
22. Elevated gastrin levels in patients with colon cancer or adenomatous polyps
23. Serum gastrin levels in patients with colorectal cancer and adenomatous polyps: A prospective study
24. Elevated serum gastrin levels in patients with colorectal neoplasia
25. Level of serum gastrin as a predictor of liver metastasis from colorectal cancer
26. Gastrin and colorectal cancer: A prospective study
27. Serum levels of gastrin in patients with colorectal neoplasia
28. Gastrin and colorectal cancer. Evidence against an association
29. Serum gastrin is not higher in subjects with colonic neoplasia
30. Gastrin levels in colorectal cancer
31. Serum gastrin levels and colorectal neoplasia
32. Role of circulating gastrin in colorectal adenomas and carcinomas
33. Gastrin levels in patients with colorectal cancer
34. Plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumour resection
35. Relationship of gastrin processing to colon cancer
36. Gastrin biosynthesis in the antrum of patients with pernicious anemia
37. Expression, processing and secretion of gastrin in patients with colorectal carcinoma
38. Serum gastrin levels are normal in patients with colorectal polyps
39. Risk for colorectal adenocarcinoma in pernicious anaemia
40. Cancer risk following pernicious anaemia
41. Progastrin and glycine extended gastrin-17 are overexpressed in pernicious anaemia patients
42. Prolonged hypergastrinaemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome
43. Omeprazole-induced hypergastrinemia does not influence growth of colon carcinoma
44. Gastric morphology, function, and immunology in first-degree relatives of probands with pernicious anemia and controls
45. Post-translational processing of gastrin in neoplastic human colonic tissues
46. Gastrin, gastrin receptors and colorectal carcinoma
47. Expression but incomplete maturation of progastrin in colorectal carcinomas