Glycine-extended gastrin regulates HEK cell growth

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 277, Issue 2 46-2, 1999, Pages

  Stepan, Vinzenz M ^a   Krametter, Dieter F ^a   Matsushima, Masashi ^a   Todisco, Andrea ^a   Delvalle, John ^a   Dickinson, Chris J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cellular proliferation; Cholecystokinin B receptor; Human embryonic kidney cell

Indexed keywords

GASTRIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL GROWTH; CONTROLLED STUDY; GROWTH REGULATION; HORMONAL REGULATION; HORMONE BINDING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0032833018     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.277.2.r572     Document Type: Article

References (52)

1. Blackmore, M., E. Doherty, J. E. Manning, and B. H. Hirst. Autocrine growth stimulation of human renal Wilms tumor G401 cells by a gastrin like peptide. Int. J. Cancer 57: 385-391, 1994.
2. Boel, E., J. Vuust, F. Norris, A. Wind, J. F. Rehfeld, and K. A. Marcker. Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication. Proc. Natl. Acad. Sci. USA 80: 2866-2869, 1983.
3. Bold, R. J., J. Ishizuka, C. M. J. Townsend, and J. C. Thompson. Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem. Biophys. Res. Commun. 202: 1222-1226, 1994.
4. Burgess, T. L., and R. B. Kelly. Constitutive and regulated secretion of proteins. Annu. Rev. Cell Biol. 3: 243-293, 1987.
5. Ciccotosto, G. D., A. McLeish, K. J. Hardy, and A. Shulkes. Expression, processing and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 109: 1142-1153, 1995.
6. DelValle, J., K. Sugano, and T. Yamada. Progastrin and its glycine-extended posttranslational processing intermediates in human gastrointestinal tissues. Gastroenterology 92: 1908-1912, 1987.
7. DelValle, J., K. Sugano, and T. Yamada. Glycine-extended processing intermediates of gastrin and cholecystokinin in human plasma. Gastroenterology 97: 1159-1163, 1989.
8. Dembinski, A. B., and L. R. Johnson. Growth of the pancreas and gastrointestinal mucosa by secretin, caerulein, and pentagastrin. Endocrinology 106: 323-328, 1980.
9. De Weerth, A., L. Jonas, R. Schade, T. Schoneberg, G. Wolf, A. Pace, F. Kirchhoff, M. Schulz, T. Heinig, H. Greten, and T. von Schrenck. Gastrin/cholecystokinin type B receptors in the kidney: molecular, pharmacological, functional characterization, and localization. Eur. J. Clin. Invest. 28: 592-601, 1998.
10. Dickinson, C. J. Relationship of gastrin processing to colon cancer. Gastroenterology 109: 1384-1388, 1995.
11. Dickinson, C. J., T. Takeuchi, Y. Guo, S. Finniss, B. T. Stadler, and T. Yamada. Expression and processing of prohormones in nonendocrine cells. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G553-G560, 1993.
12. Ghosh, K. K., P. R. Martin, and U. Gruenert. Morphological analyses of the blue cone pathway in the retina of a new world monkey, the Marmoset Callithrix jacchus. J. Comp. Neurol. 379: 211-225, 1997.
13. Hakanson, R., and F. Sundler. Trophic effects of gastrin. Scand. J. Gastroenterol. 6, Suppl. 180: 130-136, 1991.
14. Hilsted, L. Glycine-extended gastrin precursors. Regul. Pept. 36: 323-343, 1991.
15. Hilsted, L., L. Bardram, and J. F. Rehfeld. Progastrin maturation during ontogenesis. Accumulation of glycine-extended gastrins in rat antrum at weaning. Biochem. J. 255: 397-402, 1988.
16. Hilsted, L., K. Hint, J. Christiansen, and J. F. Rehfeld. Neither glycine-extended nor the 1-13 fragment of gastrin 17 influences gastric acid secretion in humans. Gastroenterology 94: 96-110, 1988.
17. Iwase, K., B. M. Evers, M. R. Hellmich, Y. S. Guo, S. Higashide, H. J. Kim, and C. M. Townsend. Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 113: 782-790, 1997.
18. Jensen, S., K. Borch, L. Hilsted, and J. F. Rehfeld. Progastrin processing during antral G-cell hypersecretion in humans. Gastroenterology 96: 1063-1070, 1989.
19. Kalindjian, B. S., I. M. Buck, J. M. R. Davies, D. J. Dunstone, M. L. Hudson, C. M. R. Low, I. M. McDonald, M. J. Pether, K. I. M. Steel, M. J. Tozer, and J. G. Vinter. Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons. J. Med. Chem. 39: 1806-1815, 1996.
20. Kochman, M. L., J. Del Valle, C. J. Dickinson, C. R. Boland. Post-translational processing of gastrin in neoplastic human colonic tissue. Biochem. Biophys. Res. Commun. 189: 1165-1169, 1992.
21. Koh, T. J., G. J. Dockray, A. Varro, R. J. Cahill, J. G. Fox, and T. C. Wang. Overexpression of glycine-extended progastrin results in gastric ulceration and goblet cell hyperplasia (Abstract). Gastroenterology 112: A1163, 1997.
22. Kowalski-Chauvel, A., L. Pradayrol, N. Vaysse, and C. Seva. Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors. Biochem. Biophys. Res. Commun. 236: 687-692, 1997.
23. Kopin, A. S., M. Lee, E. W. McBride, L. J. Miller, M. Lu, H. Y. Lin, L. F. Kolakowski, Jr., and M. Beinborn. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Acad. Sci. USA 89: 3605-3609, 1992.
24. Majumdar, A. P. N., and N. Goltermann. Gastric mucosal cell proliferation during development in rats and effects of gastrin. Am. J. Physiol. 242 (Gastrointest. Liver Physiol. 5): G135-G139, 1982.
25. Marino, L. R., B. H. Muglia, and C. J. Dickinson. Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut. Regul. Pept. 50: 73-85, 1994.
26. Matsumoto, M., J. Park, K. Sugano, and T. Yamada. Biological activity of progastrin posttranslational processing intermediates. Am. J. Physiol. 252 (Gastrointest. Liver Physiol. 15): G315-G319, 1987.
27. McWilliams, D. F., S. A. Watson, D. M. Crosbee, D. Michaeli, and R. Seth. Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines. Gut 42: 795-798, 1998.
28. Pauwels, S., H. Desmond, R. Dimaline, and G. J. Dockray. Identification of progastrin in gastrinomas, antrum, and duodenum by a novel radioimmunoassay. J. Clin. Invest. 77: 376-381, 1986.
29. Pisegna, J. R., E. Lew, N. I. Tarasova, J. H. Walsh, and S. A. Wank. The CCKB receptor (CCKBR) in the human kidney mediates gastrin-stimulated urinary sodium excretion (Abstract). Dig. Dis. Sci. 43: 1865, 1998.
30. Rehfeld, J. F. Gastrin and colorectal cancer: a never-ending dispute? Gastroenterology 108: 1307-1309, 1995.
31. Rehfeld, J. F., L. Bardram, and L. Hilsted. Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res. 49: 2840-2843, 1989.
32. Rehfeld, J. F., and H. F. Hansen. Characterization of preprocholecystokinin products in the porcine cerebral cortex: evidence of different processing pathways. J. Biol. Chem. 261: 5832-5840, 1986.
33. Rehfeld, J. F., and L. Hilsted. Gastrin and cancer. Adv. Clin. Chem. 29: 239-262, 1992.
34. Reubi, J. C., J. C. Schaer, and B. Waser. Cholecystokinin (CCK)-Aand CCK-B/gastrin receptors in human tumors. Cancer Res. 57: 1377-1386, 1997.
35. Schalling, M., H. Persson, M. Pelto-Huikko, L. Odum, P. Ekman, C. Gottlieb, T. Hofkelt, and J. F. Rehfeld. Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells. J. Clin. Invest. 86: 660-669, 1990.
36. Seva, C., C. J. Dickinson, M. Sawada, and T. Yamada. Characterization of the glycine-extended gastrin (G-Gly) receptor on AR4-2J cells (Abstract). Gastroenterology 108: A1005, 1995.
37. Seva, C., C. J. Dickinson, and T. Yamada. Growth promoting effects of glycine-extended progastrin. Science 265: 410-412, 1994.
38. Simmons, N. L. A cultured human renal epithelioid cell line responsive to vasoactive intestinal peptide. Exp. Physiol. 75: 309-319, 1990.
39. Singh, P., A. Owlia, R. Espenijo, and B. Dai. Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. J. Biol. Chem. 270: 8429-8438, 1995.
40. Singh, P., A. Owlia, A. Varro, B. Dai, S. Rajaraman, and T. Wood. Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res. 56: 4111-4115, 1996.
41. Stepan, V. M., M. Sawada, T. Yamada, and C. J. Dickinson. Glycine-extended gastrin exerts growth-promoting effects on colonic and pancreatic cells (Abstract). Regul. Pept. 64: 183, 1996.
42. Sugano, K., J. Park, W. O. Dobbins, and T. Yamada. Glycine-extended progastrin processing intermediates: accumulation and cosecretion with gastrin. Am. J. Physiol. 253 (Gastrointest. Liver Physiol. 16): G502-G507, 1987.
43. Todisco, A., Y. Takeuchi, C. Seva, C. J. Dickinson, and T. Yamada. Gastrin and glycine-extended processing intermediates induce different programs of early gene activation. J. Biol. Chem. 270: 28337-28341, 1995.
44. Todisco, A., Y. Takeuchi, A. Uromov, J. Yamada, V. M. Stepan, and T. Yamada. Molecular mechanisms for the growth factor action of gastrin. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G891-G898, 1997.
45. Van Solinge, W. W., L. Odum, and J. F. Rehfeld. Ovarian cancers express and process progastrin. Cancer Res. 53: 1823-1828, 1993.
46. Wang, T. C., T. J. Koh, A. Varro, R. J. Cahill, C. A. Dangler, J. G. Fox, and G. J. Dockray. Processing and proliferative effects of human progastrin in transgenic mice. J. Clin. Invest. 98: 1918-1929, 1996.
47. Watson, S. A., D. Michaeli, S. Grimes, T. M. Morris, G. Robinson, A. Varro, T. A. Justin, and J. D. Hardcastle. Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res. 56: 880-885, 1996.
48. Wilborg, O., L. Berglund, E. Boel, F. Norris, K. Norris, J. F. Rehfeld, K. A. Marcker, and J. Vuust. Structure of a human gastrin gene. Proc. Natl. Acad. Sci. USA 81: 1067-1069, 1984.
49. Withy, R. M., L. F. Rafield, A. K. Beck, H. Hoppe, N. Williams, and J. M. McPherson. Growth factors produced by human embryonic kidney cells that influence megakaryopoiesis include erythropoietin, interleukin 6, and transforming growth factor-beta. J. Cell. Physiol. 153: 362-372, 1992.
50. Yang, Z., R. Strang, G. D. Ciccotosto, D. Fourmy, G. Neumann, R. J. Wettenhall, A. Shulkes, and G. S. Baldwin. Recombinant human progastrin (6-80) stimulates growth of a colon cancer cell line (Abstract). Dig. Dis. Sci. 43: 1860, 1998.
51. Yue, X., H. Kaji, Y. Okimura, T. Matsui, H. Abe, and K. Chihara. Paracrine stimulation of cell growth by cholecystokinin/ gastrin through cholecystokinin-B receptor on GH3 cells in vitro. Neuroendocrinology 64: 280-285, 1996.
52. Zhu, B. T. The competitive and noncompetitive antagonism of receptor-mediated drug actions in the presence of spare receptors. J. Pharmacol. Toxicol. Methods 29: 85-91, 1993.