Glycine-Extended Gastrin Promotes the Growth of Lung Cancer

Cancer Research

Volumn 64, Issue 1, 2004, Pages 196-201

  Koh, Theodore J ^a   Field, John K ^b   Varro, Andrea ^b   Liloglou, Triantafillos ^b   Fielding, Pat ^b   Cui, Guanglin ^a   Houghton, JeanMarie ^a   Dockray, Graham J ^b   Wang, Timothy C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN DERIVATIVE; GLYCINE EXTENDED GASTRIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN TISSUE; LUNG ALVEOLUS CELL CARCINOMA; LUNG CANCER; MAJOR CLINICAL STUDY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; GASTRINS; GLYCINE; HUMANS; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; MIDDLE AGED; PROGNOSIS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 1642535583     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2112     Document Type: Article

References (38)

1. Landis, S. H., Murray, T., Bolden, S., and Wingo, P. A. Cancer statistics, 1998. CA - Cancer J. Clin., 48: 6-29, 1998.
2. Quinn, M., Babb, P., Brock, A., Kirby, E., and Jones, J. Cancer Trends in England and Wales, 1950-1999. London: Office for National Statistics, 2001.
3. Patz, E. F., Jr., Goodman, P. C., and Bepler, G. Screening for lung cancer. N. Engl. J. Med., 343: 1627-1633, 2000.
4. Devereux, T. R., Taylor, J. A., and Barrett, J. C. Molecular mechanisms of lung cancer: interaction of environmental and genetic factors. Chest, 109 (Suppl.): 14S-19S, 1996.
5. Liloglou, T., Scholes, A. G., Spandidos, D. A., Vaughan, E. D., Jones, A. S., and Field, J. K. p53 mutations in squamous cell carcinoma of the head and neck predominate in a subgroup of former and present smokers with a low frequency of genetic instability. Cancer Res., 57: 4070-4074, 1997.
6. Xinarianos, G., Liloglou, T., Prime, W., Maloney, P., Callaghan, J., Fielding, P., Gosney, J. R., and Field, J. K. hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas. Cancer Res., 60: 4216-4221, 2000.
7. Xinarianos, G., Liloglou, T., Prime, W. Sourvinos, G., Karachristos, A., Gosney, J. R., Spandidos, D. A., and Field, J. K. p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinomas. Int. J. Cancer, 101: 248-252, 2002.
8. Smyth, J. F. Cancer genetics and cell and molecular biology: is this the way forward? Chest, 109 (Suppl.): 125S-129S, 1996.
9. Wang, T. C., Dangler, C. A., Chen, D., Goldenring, J. R., Koh, T., Raychowdhury, R., Coffey, R. J., Ito, S., Varro, A., Dockray, G. J., and Fox, J. G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology, 118: 36-47, 2000.
10. Koh, T. J., and Chen, D. Gastrin as a growth factor in the gastrointestinal tract. Regul. Pept., 93: 37-44, 2000.
11. Rehfeld, J. F., Bardram, L., and Hilsted, L. Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res., 49: 2840-2843, 1989.
12. Zhou, Q., Zhang, H., Pang, X., Yang, J., Tain, Z., Wu, Z., and Yang, Z. Pre- and postoperative sequential study on the serum gastrin level in patients with lung cancer. J. Surg. Oncol., 51: 22-25, 1992.
13. Zhou, Q., Yang, Z., Yang, J., Tian, Z., and Zhang, H. The diagnostic significance of gastrin measurement of bronchoalveolar lavage fluid for lung cancer. J. Surg. Oncol., 50: 121-124, 1992.
14. Dowlati, A., Bury, T., Corhay, J. L., Weber, T., Lamproye, A., Mendes, P., and Radermecker, M. Gastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease. Thorax, 51: 1270-1272, 1996.
15. Hollande, F., Imdahl, A., Mantamadiotis, T., Ciccotosto, G. D., Shulkes, A., and Baldwin, G. S. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology, 113: 1576-1588, 1997.
16. Wang, T. C., Koh, T. J., Varro, A., Cahill, R. J., Dangler, C. A., Fox, J. G., and Dockray, G. J. Processing and proliferative effects of human progastrin in transgenic mice. J. Clin. Investig., 98: 1918-1929, 1996.
17. Aly, A., Shulkes, A., and Baldwin, G. S. Short term infusion of glycine-extended gastrin (17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. Int. J. Cancer, 94: 307-313, 2001.
18. Seva, C., Dickinson, C. J., and Yamada, T. Growth-promoting effects of glycine-extended progastrin. Science (Wash. DC), 265: 410-412, 1994.
19. Stepan, V. M., Sawada, M., Todisco, A., and Dickinson, C. J. Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells. Mol. Med., 5: 147-159, 1999.
20. Singh, P., Velasco, M., Given, R., Varro, A., and Wang, T. C. Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology, 119: 162-171, 2000.
21. Singh, P., Velasco, M., Given, R., Wargovich, M., Varro, A., and Wang, T. C. Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM. Am. J. Physiol. Gastrointest. Liver Physiol., 278: G390-G399, 2000.
22. Koh, T. J., Bulitta, C. J., Fleming, J. V., Dockray, G. J., Varro, A., and Wang, T. C. Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J. Clin. Investig., 106: 533-539, 2000.
23. Watson, S. A. Oncogenic targets of β-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis. Lancet, 357: 572-573, 2001.
24. Kermorgant, S., and Lehy, T. Glycine-extended gastrin promotes the invasiveness of human colon cancer cells. Biochem. Biophys. Res. Commun., 285: 136-141, 2001.
25. Koh, T. J., Dockray, G. J., Varro, A., Cahill, R. J., Dangler, C. A., Fox, J. G., and Wang, T. C. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J. Clin. Investig., 103: 1119-1126, 1999.
26. Mahler, J. F., Stokes, W., Mann, P. C., Takaoka, M., and Maronpot, R. R. Spontaneous lesions in aging FVB/N mice. Toxicol. Pathol., 24: 710-716, 1996.
27. Kononen, J., Bubendorf, L., Kallioniemi, A., Barlund, M., Schraml, P., Leighton, S., Torhorst, J., Mihatsch, M. J., Sauter, G., and Kallioniemi, O. P. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med., 4: 844-847, 1998.
28. Leversha, M. A., Fielding, P., Watson, S., Gosney, J. R., and Field, J. K. Expression of p53, pRB, and p16 in lung tumours: a validation study on tissue microarrays. J. Pathol., 200: 610-619, 2003.
29. Johnson, L., Mercer, K., Greenbaum, D., Bronson, R. T., Crowley, D., Tuveson, D. A., and Jacks, T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (Lond.), 410: 1111-1116, 2001.
30. Jackson, E. L., Willis, N., Mercer, K., Bronson, R. T., Crowley, D., Montoya, R., Jacks, T., and Tuveson, D. A. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev., 15: 3243-3248, 2001.
31. Hollande, F., Choquet, A., Blanc, E. M., Lee, D. J., Bali, J. P., and Baldwin, G. S. Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric epithelial cells. J. Biol. Chem., 276: 40402-40410, 2001.
32. Brown, D., Yallampalli, U., Owlia, A., and Singh, P. pp60c-Src kinase mediates growth effects of the full-length precursor progastrinl-80 peptide on rat intestinal epithelial cells, in vitro. Endocrinology, 144: 201-211, 2003.
33. Beer, D. G., Kardia, S. L., Huang, C. C., Giordano, T. J., Levin, A. M., Misek, D. E., Lin, L., Chen, G., Gharib, T. G., Thomas, D. G., Lizyness, M. L., Kuick, R., Hayasaka, S., Taylor, J. M., Iannettoni, M. D., Orringer, M. B., and Hanash, S. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med., 8: 816-824, 2002.
34. Heighway, J., Knapp, T., Boyce, L., Brennand, S., Field, J. K., Betticher, D. C., Ratschiller, D., Gugger, M., Donovan, M., Lasek, A., and Rickert, P. Expression profiling of primary non-small cell lung cancer for target identification. Oncogene, 21: 7749-7763, 2002.
35. Tuveson, D. A., and Jacks, T. Modeling human lung cancer in mice: similarities and shortcomings. Oncogene, 18: 5318-5324, 1999.
36. Devereux, T. R., Anderson, M. W., and Belinsky, S. A. Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse. Carcinogenesis (Lond.), 12: 299-303, 1991.
37. Shafarenko, M., Mahler, J., Cochran, C., Kisielewski, A., Golding, E., Wiseman, R., and Goodrow, T. Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene. Carcinogenesis (Lond.), 18: 1423-1426, 1997.
38. Nakata, H., Wang, S. L., Chung, D. C., Westwick, J. K., and Tillotson, L. G. Oncogenic ras induces gastrin gene expression in colon cancer. Gastroenterology, 115: 1144-1153, 1998.