Gastrin and gastrin receptor activation: An early event in the adenoma-carcinoma sequence

Gut

Volumn 47, Issue 6, 2000, Pages 820-824

  Smith, A M ^a   Watson, S A ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Adenomas; Autocrine; Colon; Gastrin; Polyps

Indexed keywords

GASTRIN; GASTRIN RECEPTOR;

ADULT; AGED; ARTICLE; COLON ADENOCARCINOMA; COLON MUCOSA; COLON POLYP; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CARCINOMA; RECTUM POLYP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADENOMA; AGED; CARCINOMA; COLONIC NEOPLASMS; COLONIC POLYPS; DISEASE PROGRESSION; FEMALE; GASTRINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0033671373     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.6.820     Document Type: Article

References (38)

1. Colon cancer: A review of the epidemiology
2. The evolution of cancer of the colon and rectum
3. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer
4. Stimulation of growth of a colon cancer cell line by gastrin
5. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin
6. Growth of colorectal carcinoma cells: Regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide
7. Pentagastrin stimulates in vitro growth of normal and malignant human colon epithelial cells
8. Gastrin stimulates growth of colon cancer
9. Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice
10. Clinical significance of gastrin receptors in human colon cancers
11. Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas
12. Gastrin receptor gene expression in several human carcinomas
13. Glycine-extended gastrin acts as an autocrine growth factor in a non-transformed colon cell line
14. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon
15. The human gastrin/cholecystokinin type B receptor gene: Alternative splice donor site in exon 4 generates two variant mRNAs
16. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines
17. Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide
18. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma
19. Identification of progastrin derived peptides in colorectal carcinoma extracts
20. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma
21. Post-translational processing of gastrin in neoplastic human colonic tissues
22. Expression but incomplete maturation of progastrin in colorectal carcinomas
23. Detection of gastrin mRNA in fresh human colonic carcinomas by reverse transcription-polymerase chain reaction
24. Processing and proliferative effects of human progastrin in transgenic mice
25. Optimisation of DNA and RNA extraction from archival formalin-fixed tissue
26. Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines
27. Gastric carcinoid expresses the gastrin autocrine pathway
28. The human gastrin precursor. Characterization of phosphorylated forms and fragments
29. Expression of gastrin/CCKB receptor isoforms in gastrointestinal tumour cells: Relationship to gastrin secretion
30. PCR cloning and sequence of gastrin mRNA from carcinoma cell lines
31. Nuclear expression of an epitope of the CCK-B/gastrin receptor
32. Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor
33. Expression of variant CD44-messenger RNA in colorectal adenocarcinomas and adenomatous polyps in humans
34. APC mutations occur in early colorectal tumorigenesis
35. Identification of c-MYC as a target of the APC pathway
36. Gastrin precursors are present in adenomas in the mouse polyposis coli model APC1638N
37. Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia
38. Gastrin and colorectal cancer: A prospective study