In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage

Toxicological Sciences

Volumn 131, Issue 2, 2013, Pages 470-479

  Behrsing, Holger P ^a   Furniss, Michael J ^a   Davis, Myrtle ^b   Tomaszewski, Joseph E ^b   Parchment, Ralph E ^a  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytokines; In vitro; Inflammation; Lung injury; Lung slices; NSC 710305; PCLS; Phortress; Pulmonary toxicity.

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE LYSYLAMIDE DIHYDROCHLORIDE; ANTINEOPLASTIC AGENT; CYTOKINE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RESPONSE; EX VIVO STUDY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG INJURY; LUNG SLICE; LUNG TOXICITY; MALE; NONHUMAN; RAT; TISSUE CULTURE; TISSUE INJURY;

ANIMALS; CYTOKINES; INFLAMMATION MEDIATORS; LUNG; LYSINE; MALE; RATS; RATS, INBRED F344; THIAZOLES;

EID: 84873833485     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs319     Document Type: Article

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