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Volumn 521, Issue 5, 2013, Pages 1184-1201

Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis

Author keywords

Kv channel; Minocycline; Neurotoxicity; PCNA; Three dimensional morphometric measurement

Indexed keywords

CYCLINE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.5;

EID: 84873831558     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.23228     Document Type: Article
Times cited : (52)

References (63)
  • 1
    • 0028364108 scopus 로고
    • Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding
    • Acarin L, Vela JM, González B, Castellano B. 1994. Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding. J Histochem Cytochem 42: 1033-1041.
    • (1994) J Histochem Cytochem , vol.42 , pp. 1033-1041
    • Acarin, L.1    Vela, J.M.2    González, B.3    Castellano, B.4
  • 2
    • 0033103857 scopus 로고    scopus 로고
    • Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: microglial/macrophage response and major histocompatibility complex class I and II expression
    • Acarin L, González B, Castro AJ, Castellano B. 1999. Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: microglial/macrophage response and major histocompatibility complex class I and II expression. Neuroscience 89: 549-565.
    • (1999) Neuroscience , vol.89 , pp. 549-565
    • Acarin, L.1    González, B.2    Castro, A.J.3    Castellano, B.4
  • 3
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F. 2001. Immune function of microglia. Glia 36: 165-179.
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 4
    • 0042320662 scopus 로고    scopus 로고
    • Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus
    • Ayoub AE, Salm AK. 2003. Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus. J Neurosci 23: 7759-7766.
    • (2003) J Neurosci , vol.23 , pp. 7759-7766
    • Ayoub, A.E.1    Salm, A.K.2
  • 6
    • 0026702955 scopus 로고
    • Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
    • Boje KM, Arora PK. 1992. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587: 250-256.
    • (1992) Brain Res , vol.587 , pp. 250-256
    • Boje, K.M.1    Arora, P.K.2
  • 11
    • 0031817079 scopus 로고    scopus 로고
    • Ion channels in microglia (brain macrophages)
    • Eder C. 1998. Ion channels in microglia (brain macrophages). Am J Physiol 275: C327-C342.
    • (1998) Am J Physiol , vol.275
    • Eder, C.1
  • 12
    • 0025881766 scopus 로고
    • Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain. A light and electron microscopical immunocytochemical study
    • Finsen BR, Sørensen T, Castellano B, Pedersen EB, Zimmer J. 1991. Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain. A light and electron microscopical immunocytochemical study. J Neuroimmunol 32: 159-183.
    • (1991) J Neuroimmunol , vol.32 , pp. 159-183
    • Finsen, B.R.1    Sørensen, T.2    Castellano, B.3    Pedersen, E.B.4    Zimmer, J.5
  • 13
    • 0027354292 scopus 로고
    • Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus
    • Finsen BR, Jørgensen MB, Diemer NH, Zimmer J. 1993. Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus. Glia 7: 41-49.
    • (1993) Glia , vol.7 , pp. 41-49
    • Finsen, B.R.1    Jørgensen, M.B.2    Diemer, N.H.3    Zimmer, J.4
  • 14
    • 23444436221 scopus 로고    scopus 로고
    • Microglia Kv1.3 channels contribute to their ability to kill neurons
    • Fordyce CB, Jagasia R, Zhu X, Schlichter LC. 2005. Microglia Kv1.3 channels contribute to their ability to kill neurons. J Neurosci 25: 7139-7149.
    • (2005) J Neurosci , vol.25 , pp. 7139-7149
    • Fordyce, C.B.1    Jagasia, R.2    Zhu, X.3    Schlichter, L.C.4
  • 15
    • 0026597898 scopus 로고
    • Characterisation of ramified microglial cells: detailed morphology, morphological plasticity and proliferative capability
    • Glenn JA, Ward SA, Stone CR, Booth PL, Thomas WE. 1992. Characterisation of ramified microglial cells: detailed morphology, morphological plasticity and proliferative capability. J Anat 180: 109-118.
    • (1992) J Anat , vol.180 , pp. 109-118
    • Glenn, J.A.1    Ward, S.A.2    Stone, C.R.3    Booth, P.L.4    Thomas, W.E.5
  • 16
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • Graeber MB. 2010. Changing face of microglia. Science 330: 783-788.
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 18
    • 0030601207 scopus 로고    scopus 로고
    • A novel gene Iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    • Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. 1996. A novel gene Iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 224: 855-862.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 855-862
    • Imai, Y.1    Ibata, I.2    Ito, D.3    Ohsawa, K.4    Kohsaka, S.5
  • 20
    • 38049119409 scopus 로고    scopus 로고
    • p38 MAPK, microglial signaling, and neuropathic pain
    • Ji RR, Suter MR. 2007. p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 3: 33.
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 21
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR. 2003. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 23: 4017-4022.
    • (2003) J Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 22
    • 84873847380 scopus 로고    scopus 로고
    • Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping
    • Jinno S, Yamada J. 2012. Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping. Neuron Glia Biol 5: 1-12.
    • (2012) Neuron Glia Biol , vol.5 , pp. 1-12
    • Jinno, S.1    Yamada, J.2
  • 23
    • 0027511579 scopus 로고
    • Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
    • Jørgensen MB, Finsen BR, Jensen MB, Castellano B, Diemer NH, Zimmer J. 1993. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Exp Neurol 120: 70-88.
    • (1993) Exp Neurol , vol.120 , pp. 70-88
    • Jørgensen, M.B.1    Finsen, B.R.2    Jensen, M.B.3    Castellano, B.4    Diemer, N.H.5    Zimmer, J.6
  • 24
    • 0029094436 scopus 로고
    • Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance
    • Kato H, Kogure K, Araki T, Itoyama Y. 1995. Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance. Brain Res 694: 85-93.
    • (1995) Brain Res , vol.694 , pp. 85-93
    • Kato, H.1    Kogure, K.2    Araki, T.3    Itoyama, Y.4
  • 26
    • 39849083520 scopus 로고    scopus 로고
    • Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
    • Kaushal V, Schlichter LC. 2008. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28: 2221-2230.
    • (2008) J Neurosci , vol.28 , pp. 2221-2230
    • Kaushal, V.1    Schlichter, L.C.2
  • 28
    • 0036847840 scopus 로고    scopus 로고
    • Role of p38 and p44/42 mitogen-activated protein kinases in microglia
    • Koistinaho M, Koistinaho J. 2002. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 40: 175-183.
    • (2002) Glia , vol.40 , pp. 175-183
    • Koistinaho, M.1    Koistinaho, J.2
  • 29
    • 0029858944 scopus 로고    scopus 로고
    • Axotomy as an experimental model of neuronal injury and cell death
    • Koliatsos VE, Price DL. 1996. Axotomy as an experimental model of neuronal injury and cell death. Brain Pathol 6: 447-465.
    • (1996) Brain Pathol , vol.6 , pp. 447-465
    • Koliatsos, V.E.1    Price, D.L.2
  • 30
    • 0033573529 scopus 로고    scopus 로고
    • A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation
    • Kotecha SA, Schlichter LC. 1999. A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation. J Neurosci 19: 10680-10693.
    • (1999) J Neurosci , vol.19 , pp. 10680-10693
    • Kotecha, S.A.1    Schlichter, L.C.2
  • 31
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 32
    • 0033911179 scopus 로고    scopus 로고
    • p38 map kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms
    • Lee YB, Schrader JW, Kim SU. 2000. p38 map kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms. Cytokine 12: 874-880.
    • (2000) Cytokine , vol.12 , pp. 874-880
    • Lee, Y.B.1    Schrader, J.W.2    Kim, S.U.3
  • 33
    • 84863118211 scopus 로고    scopus 로고
    • Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity
    • Liu J, Xu C, Chen L, Xu P, Xiong H. 2012. Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity. Cell Death Dis 3: e254.
    • (2012) Cell Death Dis , vol.3
    • Liu, J.1    Xu, C.2    Chen, L.3    Xu, P.4    Xiong, H.5
  • 35
    • 78049512509 scopus 로고    scopus 로고
    • Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity
    • Medders KE, Sejbuk NE, Maung R, Desai MK, Kaul M. 2010. Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity. J Immunol 185: 4883-4895.
    • (2010) J Immunol , vol.185 , pp. 4883-4895
    • Medders, K.E.1    Sejbuk, N.E.2    Maung, R.3    Desai, M.K.4    Kaul, M.5
  • 36
    • 33846880671 scopus 로고    scopus 로고
    • The Sholl analysis of neuronal cell images: semi-log or log-log method?
    • Milošević NT, Ristanović D. 2007. The Sholl analysis of neuronal cell images: semi-log or log-log method? J Theor Biol 245: 130-140.
    • (2007) J Theor Biol , vol.245 , pp. 130-140
    • Milošević, N.T.1    Ristanović, D.2
  • 37
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 38
    • 0026451126 scopus 로고
    • Inflammatory stimuli induce a new K outward current in cultured rat microglia
    • Norenberg W, Gebicke-Haerter PJ, Illes P. 1992. Inflammatory stimuli induce a new K outward current in cultured rat microglia. Neurosci Lett 147: 171-174.
    • (1992) Neurosci Lett , vol.147 , pp. 171-174
    • Norenberg, W.1    Gebicke-Haerter, P.J.2    Illes, P.3
  • 39
    • 0037107002 scopus 로고    scopus 로고
    • Intracellular injection in fixed slices: obtaining complete dendritic arbors of large cells
    • Pace CJ, Tieman DG, Tieman SB. 2002. Intracellular injection in fixed slices: obtaining complete dendritic arbors of large cells. J Neurosci Methods 119: 23-30.
    • (2002) J Neurosci Methods , vol.119 , pp. 23-30
    • Pace, C.J.1    Tieman, D.G.2    Tieman, S.B.3
  • 41
    • 25444484079 scopus 로고    scopus 로고
    • Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
    • Ponomarev ED, Shriver LP, Maresz K, Dittel BN. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 81: 374-389.
    • (2005) J Neurosci Res , vol.81 , pp. 374-389
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Dittel, B.N.4
  • 42
    • 0032814562 scopus 로고    scopus 로고
    • Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
    • Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW. 1999. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30: 77-105.
    • (1999) Brain Res Brain Res Rev , vol.30 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.U.3    Werner, A.4    Jones, L.L.5    Kreutzberg, G.W.6
  • 43
    • 44349154735 scopus 로고    scopus 로고
    • Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images
    • Rodriguez A, Ehlenberger DB, Dickstein DL, Hof PR, Wearne SL. 2008. Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. PLoS ONE 3: e1997.
    • (2008) PLoS ONE , vol.3
    • Rodriguez, A.1    Ehlenberger, D.B.2    Dickstein, D.L.3    Hof, P.R.4    Wearne, S.L.5
  • 44
    • 0023453329 scopus 로고
    • Silhouettes: a graphical aid to the interpretation and validation of cluster analysis
    • Rousseeuw PJ. 1987. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math 20: 53-65.
    • (1987) J Comput Appl Math , vol.20 , pp. 53-65
    • Rousseeuw, P.J.1
  • 45
    • 79961094209 scopus 로고    scopus 로고
    • Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia
    • Schilling T, Eder C. 2011. Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia. J Cell Physiol 226: 3295-3302.
    • (2011) J Cell Physiol , vol.226 , pp. 3295-3302
    • Schilling, T.1    Eder, C.2
  • 47
    • 0023007798 scopus 로고
    • Various types of non-pyramidal hippocampal neurons project to the septum and contralateral hippocampus
    • Schwerdtfeger WK, Buhl E. 1986. Various types of non-pyramidal hippocampal neurons project to the septum and contralateral hippocampus. Brain Res 386: 146-154.
    • (1986) Brain Res , vol.386 , pp. 146-154
    • Schwerdtfeger, W.K.1    Buhl, E.2
  • 48
    • 0025900245 scopus 로고
    • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    • Sedgwick JD, Schwender S, Imrich H, Dörries R, Butcher GW, ter Meulen V. 1991. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci U S A 88: 7438-7442.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7438-7442
    • Sedgwick, J.D.1    Schwender, S.2    Imrich, H.3    Dörries, R.4    Butcher, G.W.5    ter Meulen, V.6
  • 49
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • Sholl DA. 1953. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87: 387-406.
    • (1953) J Anat , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 50
    • 0035149829 scopus 로고    scopus 로고
    • Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods
    • Soltys Z, Ziaja M, Pawlínski R, Setkowicz Z, Janeczko K. 2001. Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods. J Neurosci Res 63: 90-97.
    • (2001) J Neurosci Res , vol.63 , pp. 90-97
    • Soltys, Z.1    Ziaja, M.2    Pawlínski, R.3    Setkowicz, Z.4    Janeczko, K.5
  • 52
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: a review
    • Streit WJ, Graeber MB, Kreutzberg GW. 1988. Functional plasticity of microglia: a review. Glia 1: 301-307.
    • (1988) Glia , vol.1 , pp. 301-307
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 53
    • 0024340657 scopus 로고
    • Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury
    • Streit WJ, Graeber MB, Kreutzberg GW. 1989. Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. Exp Neurol 105: 115-126.
    • (1989) Exp Neurol , vol.105 , pp. 115-126
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 54
    • 0010063566 scopus 로고
    • Who belongs in the family?
    • Thorndike RL. 1953. Who belongs in the family? Psychometrika 18: 267-276.
    • (1953) Psychometrika , vol.18 , pp. 267-276
    • Thorndike, R.L.1
  • 55
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. 2001. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 21: 2580-2528.
    • (2001) J Neurosci , vol.21 , pp. 2580-2528
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 57
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. 2009. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29: 3974-3980.
    • (2009) J Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 58
    • 84944178665 scopus 로고
    • Hierarchical grouping to optimize an objective function
    • Ward JH. 1963. Hierarchical grouping to optimize an objective function. J Am Stat Assoc 58: 236-244.
    • (1963) J Am Stat Assoc , vol.58 , pp. 236-244
    • Ward, J.H.1
  • 59
    • 0025275171 scopus 로고
    • Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form
    • Waseem NH, Lane DP. 1990. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. J Cell Sci 96: 121-129.
    • (1990) J Cell Sci , vol.96 , pp. 121-129
    • Waseem, N.H.1    Lane, D.P.2
  • 60
    • 28844498390 scopus 로고    scopus 로고
    • New Techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
    • Wearne SL, Rodriguez A, Ehlenberger DB, Rocher AB, Hendersion SC, Hof PR. 2005. New Techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales. Neuroscience 136: 661-680.
    • (2005) Neuroscience , vol.136 , pp. 661-680
    • Wearne, S.L.1    Rodriguez, A.2    Ehlenberger, D.B.3    Rocher, A.B.4    Hendersion, S.C.5    Hof, P.R.6
  • 61
    • 82455162547 scopus 로고    scopus 로고
    • Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus
    • Yamada J, Jinno S. 2011. Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus. Neurosci Lett 504: 295-300.
    • (2011) Neurosci Lett , vol.504 , pp. 295-300
    • Yamada, J.1    Jinno, S.2
  • 62
    • 79955482517 scopus 로고    scopus 로고
    • Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy
    • Yamada J, Nakanishi H, Jinno S. 2011. Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy. Neuroscience 182: 1-10.
    • (2011) Neuroscience , vol.182 , pp. 1-10
    • Yamada, J.1    Nakanishi, H.2    Jinno, S.3
  • 63
    • 0033230209 scopus 로고    scopus 로고
    • Spatiotemporal patterns of microglial proliferation in rat brain injured at the postmitotic stage of postnatal development
    • Ziaja M, Janeczko K. 1999. Spatiotemporal patterns of microglial proliferation in rat brain injured at the postmitotic stage of postnatal development. J Neurosci Res 58: 379-386.
    • (1999) J Neurosci Res , vol.58 , pp. 379-386
    • Ziaja, M.1    Janeczko, K.2


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