Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1324-1332

  Colabufo, Nicola A ^a   Contino, Marialessandra ^a   Cantore, Mariangela ^a,b   Capparelli, Elena ^a   Perrone, Maria Grazia ^a   Cassano, Giuseppe ^a   Gasparre, Giuseppe ^a   Leopoldo, Marcello ^a   Berardi, Francesco ^a   Perrone, Roberto ^a  

^a UNIVERSITY OF BARI   (Italy)

^b NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

BCRP; MDR revertant agents; MRP1; Naphthalenyl derivatives; P glycoprotein

Indexed keywords

(6,7 DIMETHOXY 3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) (5 NAPHTHALEN 2 YL FURAN 2 YL) METHANONE; (6,7 DIMETHOXY 3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) [5 (6 METHOXYNAPHTHALEN 2 YL) FURAN 2 YL] METHANONE; 2 (2 BROMONAPHTHALEN 6 YL) 4 (CHLOROMETHYL)OXAZOLE; 2 NAPHTHAMIDE; 4 (CHLOROMETHYL) 2 (2 FLUORONAPHTHALEN 6 YL)OXAZOLE; 4 (CHLOROMETHYL) 2 (2 METHOXYNAPHTHALEN 6 YL)OXAZOLE; 4 (CHLOROMETHYL) 2 (NAPHTHALEN 6 YL)OXAZOLE; 5 (6 METHOXYNAPHTHALEN 2 YL) FURAN 2 CARBOXYLIC ACID; 5 NAPHTHALEN 2 YL FURAN 2 CARBOXYLIC ACID; 6 [4 (CHLOROMETHYL)OXAZOL 2 YL]NAPHTHALEN 2 OL; 6 BROMONAPHTHALENE 2 CARBOTHIOAMIDE; 6 BROMONAPHTHALENE 2 CARBOXAMIDE; 6 FLUORONAPHTHALENE 2 CARBOTHIOAMIDE; 6 FLUORONAPHTHALENE 2 CARBOXAMIDE; 6 HYDROXYNAPHTHALENE 2 CARBOXAMIDE; 6 METHOXYNAPHTHALENE 2 CARBOTHIOAMIDE; 6 METHOXYNAPHTHALENE 2 CARBOXAMIDE; 6,7 DIMETHOXY 2 [5 (6 METHOXYNAPHTHALEN 2 YL) FURAN 2 YL METHYL] 1,2,3,4 TETRAHYDRO 1H ISOQUINOLINE; 6,7 DIMETHOXY 2 [5 NAPHTHALEN (2 YL FURAN 2 YL METHYL)] 1,2,3,4 TETRAHYDRO 1H ISOQUINOLINE; AMIDE; BREAST CANCER RESISTANCE PROTEIN; CARBOXYLIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; NAPHTHALENE 2 CARBOTHIOAMIDE; NAPHTHALENE DERIVATIVE; OXAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; COLUMN CHROMATOGRAPHY; DRUG DESIGN; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; CELL PROLIFERATION; DOGS; DRUG CARRIERS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NAPHTHALENES; OXAZOLES; P-GLYCOPROTEIN; RHODAMINE 123; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLES;

EID: 84873735603     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.021     Document Type: Article

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