The "specific" P-glycoprotein inhibitor tariquidar is also a substrate and an inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

ACS Chemical Neuroscience

Volumn 2, Issue 2, 2011, Pages 82-89

  Kannan, Pavitra ^a,b   Telu, Sanjay ^a   Shukla, Suneet ^c   Ambudkar, Suresh V ^c   Pike, Victor W ^a   Halldin, Christer ^b   Gottesman, Michael M ^c   Innis, Robert B ^a   Hall, Matthew D ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

blood brain barrier; breast cancer resistance protein; drug transporters; P glycoprotein; Positron emission tomography; tariquidar; transport inhibitors

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; DOXORUBICIN; GLYCOPROTEIN P; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 1; TARIQUIDAR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; HUMAN; HUMAN CELL; ISOTOPE LABELING; PRIORITY JOURNAL;

BLOOD-BRAIN BARRIER; BREAST CANCER RESISTANCE PROTEIN; DRUG TRANSPORTERS; P-GLYCOPROTEIN; POSITRON EMISSION TOMOGRAPHY; TARIQUIDAR; TRANSPORT INHIBITORS;

ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; FEMALE; HEK293 CELLS; HUMANS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; QUINOLINES; SUBSTRATE SPECIFICITY;

MUS;

EID: 79951838702     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn100078a     Document Type: Article

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