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Volumn 12, Issue 8, 2011, Pages 702-712

Modulation and absorption of xenobiotics: The synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders

Author keywords

CYP450; MC18; MC266; MC80; MDR; Neurodegenerative disorders; P gp; Rat everted gut sac assay

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450; ELACRIDAR; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; MC 18; MC 266; MC 80; TRACER; UNCLASSIFIED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

EID: 80053463828     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920011798357015     Document Type: Article
Times cited : (19)

References (79)
  • 1
    • 77949371041 scopus 로고    scopus 로고
    • Perspectives of P-glycoprotein modulatingagents in oncology and neurodegenerative diseases: Pharmaceutical,biological, and diagnostic potentials
    • Colabufo, N.A.; Berardi, F.; Cantore, M.; Contino, M.; Inglese, C.;Niso, M.; Perrone, R. Perspectives of P-glycoprotein modulatingagents in oncology and neurodegenerative diseases: pharmaceutical,biological, and diagnostic potentials. J. Med. Chem., 2010,53(5), 1883-1897.
    • (2010) J. Med. Chem. , vol.53 , Issue.5 , pp. 1883-1897
    • Colabufo, N.A.1    Berardi, F.2    Cantore, M.3    Contino, M.4    Inglese, C.5    Niso, M.6    Perrone, R.7
  • 2
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers ofhuman cytochrome P450 3A4
    • Zhou, S.F. Drugs behave as substrates, inhibitors and inducers ofhuman cytochrome P450 3A4. Curr. Drug. Metab., 2008, 9(4),310-322.
    • (2008) Curr. Drug. Metab. , vol.9 , Issue.4 , pp. 310-322
    • Zhou, S.F.1
  • 4
    • 77958004738 scopus 로고    scopus 로고
    • Substrates inhibitors and activatorsof P-glycoprotein: Candidates for radiolabeling and imagingperspectives
    • Colabufo, N.A.; Berardi, F.; Perrone, M.G.; Capparelli, E.; Cantore,M.; Inglese, C.; Perrone, R. Substrates, inhibitors and activatorsof P-glycoprotein: candidates for radiolabeling and imagingperspectives. Curr. Top. Med. Chem., 2010, 10(17), 1703-1714.
    • (2010) Curr. Top. Med. Chem. , vol.10 , Issue.17 , pp. 1703-1714
    • Colabufo, N.A.1    Berardi, F.2    Perrone, M.G.3    Capparelli, E.4    Cantore, M.5    Inglese, C.6    Perrone, R.7
  • 6
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistancemediated multidrug transporter
    • Gottesman, M.M.; Pastan, I. Biochemistry of multidrug resistancemediated multidrug transporter. Annu. Rev. Biochem., 1993, 62,385-427.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 7
    • 0029035777 scopus 로고
    • Prodrugs to improve the oral bioavailabilityof a diacidic nonpeptide angiotensin II antagonist
    • Aungst, B.J.; Blake, J.A.; Rogers, N.J.; Saitoh, H.; Hussain, M.A.;Ensinger, C.L.; Pruitt, J.R. Prodrugs to improve the oral bioavailabilityof a diacidic nonpeptide angiotensin II antagonist. PharmRes., 1995, 12(5), 763-767.
    • (1995) PharmRes. , vol.12 , Issue.5 , pp. 763-767
    • Aungst, B.J.1    Blake, J.A.2    Rogers, N.J.3    Saitoh, H.4    Hussain, M.A.5    Ensinger, C.L.6    Pruitt, J.R.7
  • 11
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
    • Fromm, M.; Kim, R.; Stein, C.; Wilkinson, G.; Roden, D. Inhibitionof P-glycoprotein-mediated drug tansport: a unifying mechanismto explain the interaction between digoxin and quinidine. Circulation,1999, 99, 552-557. (Pubitemid 29061872)
    • (1999) Circulation , vol.99 , Issue.4 , pp. 552-557
    • Fromm, M.F.1    Kim, R.B.2    Stein, C.M.3    Wilkinson, G.R.4    Roden, D.M.5
  • 13
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
    • Hunter, J.; Jepson, M.; Tsuruo, T.; Simmons, N.L.; Hirst, B.H.Functional expression of P-glycoprotein in apical membranes ofhuman intestinal Caco-2 cells. Kinetics of vinblastine secretion andinteraction with modulators. J. Biol. Chem., 1993, 268, 14991-14997. (Pubitemid 23206648)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.20 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, N.L.4    Hirst, B.H.5
  • 14
    • 0029997940 scopus 로고    scopus 로고
    • Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells
    • Cavet, M.E.; West, M.; Simmons, N.L. Transport and epithelialsecretion of the cardiac glycoside, digoxin, by human intestinalepithelial (Caco-2) cells. Br. J. Pharmacol., 1996, 118, 1389-1396. (Pubitemid 26248789)
    • (1996) British Journal of Pharmacology , vol.118 , Issue.6 , pp. 1389-1396
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 15
    • 0029800447 scopus 로고    scopus 로고
    • Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
    • Terao, T.; Hisanaga, E.; Sai, Y.; Tamai, I.; Tsuji, A. Active secretionof drugs from the small intestinal epithelium in rats by Pglycoproteinfunctioning as an absorption barrier. J. Pharm. Pharmacol.,1996, 48, 1083-1089. (Pubitemid 26400301)
    • (1996) Journal of Pharmacy and Pharmacology , vol.48 , Issue.10 , pp. 1083-1089
    • Terao, T.1    Hisanaga, E.2    Sai, Y.3    Tamai, I.4    Tsuji, A.5
  • 17
    • 84873077075 scopus 로고    scopus 로고
    • [11C] MC18 and http://www.ncbi.nlm.nih.gov/books/NBK45980 for [11C]MC266
    • http://www.ncbi.nlm.nih.gov/books/NBK45979 for [11C]MC18 andhttp://www.ncbi.nlm.nih.gov/books/NBK45980 for [11C]MC266
  • 19
    • 0034601776 scopus 로고    scopus 로고
    • Drug binding sites on P-glycoprotein are altered by ATPbinding prior to nucleotide hydrolysis
    • Martin, C.; Berridge, G.; Mistry, P.; Higgins, C.; Charlton, P.; Callaghan,R. Drug binding sites on P-glycoprotein are altered by ATPbinding prior to nucleotide hydrolysis. Biochemistry, 2000, 39,11901-11906.
    • (2000) Biochemistry , vol.39 , pp. 11901-11906
    • Martin, C.1    Berridge, G.2    Mistry, P.3    Higgins, C.4    Charlton, P.5    Callaghan, R.6
  • 21
    • 31844448665 scopus 로고    scopus 로고
    • The translocation mechanismof P-glycoprotein
    • Callaghan, R.; Ford, R.C.; Kerr, I.D. The translocation mechanismof P-glycoprotein. FEBS Lett., 2006, 580, 1056-1063.
    • (2006) FEBS Lett. , vol.580 , pp. 1056-1063
    • Callaghan, R.1    Ford, R.C.2    Kerr, I.D.3
  • 22
    • 0027524642 scopus 로고
    • In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
    • Hyafil, F.; Vergely, C.; Du Vignaud, P.; Grand-Perret, T. In vitroand in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamidederivative. Cancer Res., 1993, 53, 4595-4602. (Pubitemid 23304385)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4595-4602
    • Hyafil, F.1    Vergely, C.2    Du Vignaud, P.3    Grand-Perret, T.4
  • 23
    • 0036229852 scopus 로고    scopus 로고
    • Drugs as P-glycoprotein substrates, inhibitors, and inducers
    • DOI 10.1081/DMR-120001389
    • Kim, R.B. Drugs as P-glycoprotein substrates, inhibitors, and inducers.Drug. Metab. Rev., 2002, 34(1-2), 47-54. (Pubitemid 34311087)
    • (2002) Drug Metabolism Reviews , vol.34 , Issue.1-2 , pp. 47-54
    • Kim, R.B.1
  • 26
    • 0032844759 scopus 로고    scopus 로고
    • Effect of dexamethasone on the intestinal first-pass metabolism of indinavlr in rats: Evidence of cytochrome P-450 a and P-glycoprotein induction
    • Lin, J.H.; Chiba, M.; Chen, I.W.; Nishime, J.A.; deLuna, F.A.;Yamazaki, M.; Lin, Y.J. Effect of dexamethasone on the intestinalfirst-pass metabolism of indinavir in rats: evidence of cytochromeP-450 3A [correction of P-450 A] and p-glycoprotein induction.Drug. Metab. Dispos., 1999, 27(10), 1187-1193. (Pubitemid 29463606)
    • (1999) Drug Metabolism and Disposition , vol.27 , Issue.10 , pp. 1187-1193
    • Lin, J.H.1    Chiba, M.2    Chen, I.-W.3    Nishime, J.A.4    Deluna, F.A.5    Yamazaki, M.6    Lin, Y.J.7
  • 29
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • DOI 10.1097/00008571-200210000-00005
    • Vogelgesang, S.; Cascorbi, I.; Schroeder, E.; Pahnke, J.; Kroemer,H.K.; Siegmund, W.; Kunert-Keil, C.; Walker, L.C.; Warzok, R.W. Deposition of Alzheimer's beta-amyloid is inversely correlatedwith P-glycoprotein expression in the brains of elderly nondementedhumans. Pharmacogenetics, 2002, 12, 535-541. (Pubitemid 35177083)
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 535-541
    • Vogelgesang, S.1    Cascorbi, I.2    Schroeder, E.3    Pahnke, J.4    Kroemer, H.K.5    Siegmund, W.6    Kunert-Keil, C.7    Walker, L.C.8    Warzok, R.W.9
  • 31
    • 63349089378 scopus 로고    scopus 로고
    • P-gp transporter andits role in neurodegenerative diseases
    • Rapposelli, S.; Digiacomo, M.; Balsamo, A. P-gp transporter andits role in neurodegenerative diseases. Curr. Top. Med. Chem.,2009, 9, 209-217.
    • (2009) Curr. Top. Med. Chem. , vol.9 , pp. 209-217
    • Rapposelli, S.1    Digiacomo, M.2    Balsamo, A.3
  • 32
    • 33745736603 scopus 로고    scopus 로고
    • Multidrug resistance: Retrospect and prospects inanti-cancer drug treatment
    • Pérez-Tomás, R. Multidrug resistance: retrospect and prospects inanti-cancer drug treatment. Curr. Med. Chem., 2006, 13, 1859-1876.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 1859-1876
    • Pérez-Tomás, R.1
  • 36
    • 6344250770 scopus 로고    scopus 로고
    • 57 varieties: The human cytochromes P450
    • DOI 10.1517/phgs.5.3.305.29827
    • Lewis, D.F. 57 Varieties: the human cytochromes P450. Pharmacogenomics,2004, 5(3), 305-318. (Pubitemid 38499969)
    • (2004) Pharmacogenomics , vol.5 , Issue.3 , pp. 305-318
    • Lewis, D.F.V.1
  • 38
    • 33846372558 scopus 로고    scopus 로고
    • The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks
    • DOI 10.1016/j.bbagen.2006.09.024, PII S0304416506002960
    • Plant, N. The human cytochrome P450 sub-family: transcriptionalregulation, inter-individual variation and interaction networks. Biochim.Biophys. Acta., 2007, 1770(3), 478-488. (Pubitemid 46136752)
    • (2007) Biochimica et Biophysica Acta - General Subjects , vol.1770 , Issue.3 , pp. 478-488
    • Plant, N.1
  • 41
    • 16444377083 scopus 로고    scopus 로고
    • Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
    • DOI 10.2165/00003088-200544030-00005
    • Zhou, S.; Yung Chan, S.; Cher Goh, B.; Chan, E.; Duan, W.;Huang, M.; McLeod, H.L. Mechanism-based inhibition of cytochromeP450 3A4 by therapeutic drugs. Clin. Pharmacokinet.,2005, 44(3), 279-304. (Pubitemid 40477790)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.3 , pp. 279-304
    • Zhou, S.1    Chan, S.Y.2    Goh, B.C.3    Chan, E.4    Duan, W.5    Huang, M.6    McLeod, H.L.7
  • 42
    • 33847343857 scopus 로고    scopus 로고
    • Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys
    • DOI 10.1124/dmd.106.011288
    • Ogasawara, A.; Kume T.; Kazama E. Effect of oral ketoconazoleon intestinal firs pass effect of midazolam and fexofenadine in cynomolgusmonkeys. Drug. Met. Disp., 2007, 35, 410-418. (Pubitemid 46333904)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.3 , pp. 410-418
    • Ogasawara, A.1    Kume, T.2    Kazama, E.3
  • 43
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting P-glycoprotein
    • Thomas, H.; Coley, H.M. Overcoming multidrug resistance in cancer:an update on the clinical strategy of inhibiting p-glycoprotein.Cancer Control., 2003, 10(2), 159-165. (Pubitemid 36437822)
    • (2003) Cancer Control , vol.10 , Issue.2 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 45
  • 46
    • 0345411341 scopus 로고    scopus 로고
    • P-Glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
    • Wandel, C.; Kim, R.B.; Kajiji, S.; Guengerich, P.; Wilkinson, G.R.;Wood, A.J. P-glycoprotein and cytochrome P-450 3A inhibition:dissociation of inhibitory potencies. Cancer Res., 1999, 59(16),3944-3948. (Pubitemid 29393559)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 3944-3948
    • Wandel, C.1    Richard B, K.2    Kajiji, S.3    Guengerich, F.P.4    Wilkinson, G.R.5    Wood, A.J.J.6
  • 47
    • 0345084436 scopus 로고    scopus 로고
    • The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A: Implications for drug-drug interactions and pharmacological activity of the main metabolite
    • Fischer, V.; Rodríguez-Gascón, A.; Heitz, F.; Tynes, R.; Hauck, C.;Cohen, D.; Vickers, A.E. The multidrug resistance modulator valspodar(PSC 833) is metabolized by human cytochrome P450 3A:implications for drug-drug interactions and pharmacological activityof the main metabolite. Drug. Metab. Dispos., 1998, 26, 802-811. (Pubitemid 28376441)
    • (1998) Drug Metabolism and Disposition , vol.26 , Issue.8 , pp. 802-811
    • Fischer, V.1    Rodriguez-Gascon, A.2    Heitz, F.3    Tynes, R.4    Hauck, C.5    Cohen, D.6    Vickers, A.E.M.7
  • 49
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer.Mechanisms, reversal using modulators of MDR and the role ofMDR modulators in influencing the pharmacokinetics of anticancerdrugs. Eur
    • Krishna, R.; Mayer, L.D. Multidrug resistance (MDR) in cancer.Mechanisms, reversal using modulators of MDR and the role ofMDR modulators in influencing the pharmacokinetics of anticancerdrugs. Eur. J. Pharm. Sci., 2000, 11, 265-283.
    • (2000) J. Pharm. Sci. , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 52
    • 0029809499 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979
    • Dantzig, A.H.; Shepard, R.L.; Cao, J.; Law, K.L.; Ehlhardt, W.J.;Baughman, T.M.; Bumol, T.F.; Starling, J.J. Reversal of Pglycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberanemodulator, LY335979. Cancer Res., 1996,56(18), 4171-4179. (Pubitemid 26305012)
    • (1996) Cancer Research , vol.56 , Issue.18 , pp. 4171-4179
    • Dantzig, A.H.1    Shepard, R.L.2    Cao, J.3    Law, K.L.4    Ehlhardt, W.J.5    Baughman, T.M.6    Bumol, T.F.7    Starling, J.J.8
  • 53
    • 0031765907 scopus 로고    scopus 로고
    • Role of Pglycoproteinand cytochrome P450 3A in limiting oral absorptionof peptides and peptidomimetics
    • Wacher, V.J.; Silverman, J.A.; Zhang, Y.; Benet, L.Z. Role of Pglycoproteinand cytochrome P450 3A in limiting oral absorptionof peptides and peptidomimetics. J. Pharm. Sci., 1998, 87(11),1322-1330.
    • (1998) J. Pharm. Sci. , vol.87 , Issue.11 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 54
    • 1542314451 scopus 로고    scopus 로고
    • Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats
    • DOI 10.1080/00498250310001630215
    • Perloff, M.D.; von Moltke, L.L.; Greenblatt, D.J. Ritonavir anddexamethasone induce expression of CYP3A and P-glycoprotein inrats. Ritonavir and dexamethasone induce expression of CYP3Aand P-glycoprotein in rats. Xenobiotica, 2004, 34(2), 133-150. (Pubitemid 38299715)
    • (2004) Xenobiotica , vol.34 , Issue.2 , pp. 133-150
    • Perloff, M.D.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 55
    • 0033795486 scopus 로고    scopus 로고
    • Potential role of Pglycoproteinin affecting hepatic metabolism of drugs
    • Chiou, W.L.; Chung, S.M.; Wu, T.C. Potential role of Pglycoproteinin affecting hepatic metabolism of drugs. Pharm. Res.,2000, 17(8), 903-905.
    • (2000) Pharm. Res. , vol.17 , Issue.8 , pp. 903-905
    • Chiou, W.L.1    Chung, S.M.2    Wu, T.C.3
  • 56
    • 22844451077 scopus 로고    scopus 로고
    • Role of efflux pumps and metabolising enzymes in drug delivery
    • DOI 10.1517/17425247.2.4.683
    • Katragadda, S.; Budda, B.; Anand, B.S.; Mitra, A.K. Role of effluxpumps and metabolising enzymes in drug delivery. Expert. Opin.Drug Deliv., 2005, 2(4), 683-705. (Pubitemid 41038680)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.4 , pp. 683-705
    • Katragadda, S.1    Budda, B.2    Anand, B.S.3    Mitra, A.K.4
  • 57
    • 9444267085 scopus 로고    scopus 로고
    • Functional interaction of intestinal CYP3A4 and P-glycoprotein
    • DOI 10.1111/j.1472-8206.2004.00291.x
    • Kivisto, K.T.; Niemi, M.; Fromm, M.F. Functional interaction ofintestinal CYP3A4 and P-glycoprotein. Fundam. Clin. Pharmacol.,2004, 18(6), 621-626. (Pubitemid 39564261)
    • (2004) Fundamental and Clinical Pharmacology , vol.18 , Issue.6 , pp. 621-626
    • Kivisto, K.T.1    Niemi, M.2    Fromm, M.F.3
  • 58
    • 0026457407 scopus 로고
    • Bioavailability of cyclosporine with concomitant rifampin administrationis markedly less than predicted by hepatic enzyme induction
    • Hebert, M.F.; Roberts, J.P.; Prueksaritanont, T.; Benet, L.Z.Bioavailability of cyclosporine with concomitant rifampin administrationis markedly less than predicted by hepatic enzyme induction.Clin. Pharmacol. Ther., 1992, 52, 453-455.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 453-455
    • Hebert, M.F.1    Roberts, J.P.2    Prueksaritanont, T.3    Benet, L.Z.4
  • 59
    • 23844483271 scopus 로고    scopus 로고
    • Cyclophosphamide-methotrexate 'metronomic' chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation
    • DOI 10.1093/annonc/mdi240
    • Bocci, G.; Tuccori, M.; Emmenegger, U., Liguori, V.; Falcone, A.;Kerbel, R.S.; Del Tacca, M. Cyclophosphamidemethotrexate 'metronomic'chemotherapy for the palliative treatment of metastaticbreast cancer. A comparative pharmacoeconomic evaluation. Ann.Oncol., 2005, 16, 1243-1252. (Pubitemid 41166506)
    • (2005) Annals of Oncology , vol.16 , Issue.8 , pp. 1243-1252
    • Bocci, G.1    Tuccori, M.2    Emmenegger, U.3    Liguori, V.4    Falcone, A.5    Kerbel, R.S.6    Del Tacca, M.7
  • 60
    • 34249844568 scopus 로고    scopus 로고
    • Clinical pharmacology of cyclophosphamideand ifosfamide
    • Zhang, J.; Tian, Q.; Zhou, S.F. Clinical Pharmacology of Cyclophosphamideand Ifosfamide. Current. Drug. Therapy, 2006, 1, 55-84.
    • (2006) Current. Drug. Therapy , vol.1 , pp. 55-84
    • Zhang, J.1    Tian, Q.2    Zhou, S.F.3
  • 61
    • 0033980182 scopus 로고    scopus 로고
    • P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
    • Fromm, M.F. P-glycoprotein: a defense mechanism limiting oralbioavailability and CNS accumulation of drugs. Int. J. Clin. Pharmacol.Ther., 2000, 38(2), 69-74. (Pubitemid 30077981)
    • (2000) International Journal of Clinical Pharmacology and Therapeutics , vol.38 , Issue.2 , pp. 69-74
    • Fromm, M.F.1
  • 63
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. A family of drugtransporters: the multidrug resistance-associated proteins. J. Natl.Cancer Inst., 2000, 92(16), 1295-302. (Pubitemid 30662093)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.16 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 67
    • 36949024918 scopus 로고    scopus 로고
    • The conduct of drug metabolism studies considered good practice (II): In vitro experiments
    • DOI 10.2174/138920007782798207
    • Jia, L.; Liu, X. The conduct of drug metabolism studies consideredgood practice (II): in vitro experiments. Curr. Drug Met., 2007, 8,822-829. (Pubitemid 350238912)
    • (2007) Current Drug Metabolism , vol.8 , Issue.8 , pp. 822-829
    • Jia, L.1    Liu, X.2
  • 68
  • 69
    • 0031659639 scopus 로고    scopus 로고
    • An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine
    • Barthe, L.; Woodley, J.F.; Kenworthy, S.; Houin, G. An improvedeverted gut sac as a simple and accurate technique to measureparacellular transport across the small intestine. Eur. J. Drug. Metab.Pharmacokinet., 1998, 23(2), 313-323. (Pubitemid 28401125)
    • (1998) European Journal of Drug Metabolism and Pharmacokinetics , vol.23 , Issue.2 , pp. 313-323
    • Barthe, L.1    Woodley, J.F.2    Kenworthy, S.3    Houin, G.4
  • 70
    • 0032951089 scopus 로고    scopus 로고
    • Transport of Rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A- related compounds
    • Yumoto, R.; Murakami, T.; Nakamoto, Y.; Hasegawa, R.; Nagai,J.; Takano, M. Transport of Rhodamine 123, a P-glycoprotein substrate,across rat intestine and Caco-2 cells monolayers in the presenceof cytochrome P-450 3A-related compounds. J. Pharmacol.Exp. Ther., 1999, 289, 149-155. (Pubitemid 29156023)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.289 , Issue.1 , pp. 149-155
    • Yumoto, R.1    Murakami, T.2    Nakamoto, Y.3    Hasegawa, R.4    Nagai, J.5    Takano, M.6
  • 71
    • 0027524642 scopus 로고
    • In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
    • Hyafil, F.; Vergely, C.; Du Vignaud, P.; Grand-Perret, T. In vitroand in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamidederivative. Cancer Res., 1993, 53, 4595-4602. (Pubitemid 23304385)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4595-4602
    • Hyafil, F.1    Vergely, C.2    Du Vignaud, P.3    Grand-Perret, T.4
  • 74
    • 0343416856 scopus 로고    scopus 로고
    • Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery
    • DOI 10.1016/S0169-409X(97)00043-4, PII S0169409X97000434
    • Hebert, M.F. Contributions of hepatic and intestinal metabolismand P-glycoprotein to cyclosporine and tacrolimus oral drug delivery.Adv. Drug Deliv. Rev., 1997, 27, 201-214. (Pubitemid 27417873)
    • (1997) Advanced Drug Delivery Reviews , vol.27 , Issue.2-3 , pp. 201-214
    • Hebert, M.F.1
  • 77
    • 0038241171 scopus 로고    scopus 로고
    • Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease
    • DOI 10.1097/00008571-200305000-00004
    • Drozdzik, M.; Bialecka, M.; Mysliwiec, K.; Honczarenko, K.;Stankiewicz, J.; Sych, Z. Polymorphism in the P-glycoprotein drugtransporter MDR1 gene: a possible link between environmental andgenetic factors in Parkinson's disease. Pharmacogenetics, 2003,13, 259-263. (Pubitemid 36583992)
    • (2003) Pharmacogenetics , vol.13 , Issue.5 , pp. 259-263
    • Drozdzik, M.1    Bialecka, M.2    Mysliwiec, K.3    Honczarenko, K.4    Stankiewicz, J.5    Sych, Z.6
  • 79
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • DOI 10.1097/00008571-200210000-00005
    • Vogelgesang, S.; Cascorbi, I.; Schroeder, E.; Pahnke, J.; Kroemer,H.K.; Siegmund, W.; Kunert-Keil, C.; Walker, L.C.; Warzok, R.W.Deposition of Alzheimer's beta-amyloid is inversely correlatedwith P-glycoprotein expression in the brains of elderly nondementedhumans. Pharmacogenetics, 2002, 12, 535-541. (Pubitemid 35177083)
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 535-541
    • Vogelgesang, S.1    Cascorbi, I.2    Schroeder, E.3    Pahnke, J.4    Kroemer, H.K.5    Siegmund, W.6    Kunert-Keil, C.7    Walker, L.C.8    Warzok, R.W.9


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