Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death

Pharmacological Reports

Volumn 64, Issue 6, 2012, Pages 1515-1525

  Calderón Montaño, José M ^a   Burgos Morón, Estefanía ^a   Orta, Manuel L ^a   Pastor, Nuria ^a   Perez Guerrero, Concepción ^a   Austin, Caroline A ^b   Mateos, Santiago ^a   López Lázaro, Miguel ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

DNA damage response; DNA topoisomerases; Homologous recombination; Non homologous end joining; Nucleotide excision repair

Indexed keywords

CATALASE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GAMMA HISTONE H2AX; HISTONE H2AX; PHENYLGLYOXAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DEATH; CELL GROWTH; CELL LINE; CELL VIABILITY; CLONOGENIC ASSAY; COMET ASSAY; CONTROLLED STUDY; CYTOMETRY; CYTOTOXICITY; DNA DAMAGE; DNA END JOINING REPAIR; EXCISION REPAIR; GROWTH INHIBITION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LEUKEMIA CELL; LUNG CANCER; LUNG FIBROBLAST; NONHUMAN; TARDIS ASSAY;

EID: 84873720448     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(12)70949-0     Document Type: Article

References (33)

1. Binaschi M, Zagotto G, Palumbo M, Zunino F, Farinosi R, Capranico G: Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: sequence specificity and structural drug determinants. Cancer Res, 1997, 57, 1710-1716. (Pubitemid 27199664)
2. Bryant HE, Ying S, Helleday T: Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells. Mutat Res, 2006, 599, 116-123. (Pubitemid 44041507)
3. Cowell IG, Tilby MJ, Austin CA: An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis, 2011, 26, 253-260.
4. Daroui P, Desai SD, Li TK, Liu AA, Liu LF: Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death. J Biol Chem, 2004, 279, 14587-14594. (Pubitemid 38618846)
5. Gatto B, Richter S, Moro S, Capranico G, Palumbo M: The topoisomerase II poison clerocidin alkylates nonpaired guanines of DNA: implications for irreversible stimulation of DNA cleavage. Nucleic Acids Res, 2001, 29, 4224-4230. (Pubitemid 33019566)
6. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA: DNA repair pathways as targets for cancer therapy. Nat Rev Cancer, 2008, 8, 193-204. (Pubitemid 351301852)
7. Kai M, Ohkura Y, Yonekura S, Iwasaki M: Chemiluminescence determination of guanine and its nucleosides and nucleotides using phenylglyoxal. Anal Chim Acta, 1994, 287, 75-81. (Pubitemid 24071470)
8. Li TK, Chen AY, Yu C, Mao Y, Wang H, Liu LF: Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev, 1999, 13, 1553-1560. (Pubitemid 29297923)
9. Lobrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA: gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle, 2010, 9, 662-669.
10. Lopez-Lazaro M: A new view of carcinogenesis and an alternative approach to cancer therapy. Mol Med, 2010, 16, 144-153.
11. Lopez-Lazaro M: Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy. Cancer Lett, 2007, 252, 1-8.
12. Lopez-Lazaro M, Calderon-Montano JM, Burgos-Moron E, Austin CA: Green tea constituents (-)-epi-gallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. Mutagenesis, 2011, 26, 489-498.
13. Lopez-Lazaro M, Willmore E, Elliott SL, Austin CA: Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells. Int J Cancer, 2008, 123, 2217-2221.
14. Lopez-Lazaro M, Willmore E, Jobson A, Gilroy KL, Curtis H, Padget K, Austin CA: Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod, 2007, 70, 1884-1888.
15. Luo J, Solimini NL, Elledge SJ: Principles of cancer therapy: oncogene and non-oncogene addiction. Cell, 2009, 136, 823-837.
16. Meschini R, Marotta E, Berni A, Filippi S, Fiore M, Mancinelli P, Natarajan AT, Palitti F: DNA repair deficiency and BPDE-induced chromosomal alterations in CHO cells. Mutat Res, 2008, 637, 93-100. (Pubitemid 350256766)
17. Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A et al.: DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med, 2005, 352, 1529-1538. (Pubitemid 40517093)
18. Nitiss JL: DNA topoisomerase II and its growing repertoire of biological functions. Nat Rev Cancer, 2009, 9, 327-337.
19. Nitiss JL: Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer, 2009, 9, 338-350.
20. Park YS, Koh YH, Takahashi M, Miyamoto Y, Suzuki K, Dohmae N, Takio K et al.: Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185. Free Radic Res, 2003, 37, 205-211. (Pubitemid 36124347)
21. Pastor N, Lopez-Lazaro M, Tella JL, Baos R, Hiraldo F, Cortes F: Assessment of genotoxic damage by the comet assay in white storks (Ciconia ciconia) after the Doñana Ecological Disaster. Mutagenesis, 2001, 16, 219-223. (Pubitemid 32447754)
22. Pommier Y: Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer, 2006, 6, 789-802.
23. Schumacker PT: Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell, 2006, 10, 175-176.
24. Shapiro R, Hachmann J: The reaction of guanine derivatives with 1,2-dicarbonyl compounds. Biochemistry, 1966, 5, 2799-2807.
25. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res, 1988, 175, 184-191.
26. Sordet O, Goldman A, Pommier Y: Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes. Mol Cancer Ther, 2006, 5, 3139-3144. (Pubitemid 46092056)
27. Sordet O, Khan QA, Kohn KW, Pommier Y: Apoptosis induced by topoisomerase inhibitors. Curr Med Chem Anticancer Agents, 2003, 3, 271-290. (Pubitemid 36758302)
28. Szatrowski TP, Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res, 1991, 51, 794-798.
29. Takahashi K: The reaction of phenylglyoxal with arginine residues in proteins. J Biol Chem, 1968, 243, 6171-6179.
30. Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med, 2004, 10, 789-799. (Pubitemid 39070849)
31. Wang JC: Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol, 2002, 3, 430-440.
32. Watters GP, Smart DJ, Harvey JS, Austin CA: H2AX phosphorylation as a genotoxicity endpoint. Mutat Res, 2009, 679, 50-58.
33. Willmore E, Frank AJ, Padget K, Tilby MJ, Austin CA: Etoposide targets topoisomerase IIα and IIβ in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique. Mol Pharmacol, 1998, 54, 78-85. (Pubitemid 28337589)