Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1097-1108

  Kokosza, Kamil ^a   Balzarini, Jan ^b   Piotrowska, Dorota G ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,3 Dipolar cycloaddition; Antiviral; Cytostatic; Isoxazolidines; Phosphonates

Indexed keywords

5 ARYLCARBAMOYL 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2 ACETYLPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2 BROMOPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2 CHLOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2 FLUOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2 NITROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (2,4 DIFLUOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 ACETYLPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 BROMOPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 CHLOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 CYANOPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 FLUOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 NITROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (3 TOLYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 ACETYLPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 BROMOPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 CHLOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 CYANOPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 FLUOROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; DIETHYL 5 (4 NITROPHENYLCARBAMOYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; ISOXAZOLIDINE DERIVATIVE; ISOXAZOLIDINE PHOSPHONIC ACID; N (2 ACETHYL 4,5 DIMETHOXYPHENYL)ACRYLAMIDE; N (2 CYANO 4,5 DIMETHOXYPHENYL)ACRYLAMIDE; N (2,4 DIFLUOROPHENYL)ACRYLAMIDE; N (3 CYANOPHENYL)ACRYLAMIDE; N (3 FLUOROPHENYL)ACRYLAMIDE; N ARYLACRYLAMIDE; N METHYL DIETHOXYPHOSPHORYLNITRONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONAVIRUS; COXSACKIE VIRUS B4; CYTOSTASIS; DNA VIRUS; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA INTERACTION; DRUG SCREENING; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS B; MAMMALIAN ORTHOREOVIRUS; NONHUMAN; PARAINFLUENZA VIRUS 3; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA VIRUS; SINDBIS VIRUS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TOROVIRUS; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

ANTIVIRAL AGENTS; CARBAMATES; CELL LINE; CELL PROLIFERATION; CYTOSTATIC AGENTS; DNA VIRUSES; DRUG DESIGN; HELA CELLS; HUMANS; ISOXAZOLES; NUCLEOTIDES; RNA VIRUSES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RNA VIRUSES;

EID: 84873707302     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.007     Document Type: Article

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