Synthesis and evaluation of new N6-substituted adenosine-5′-N-methylcarboxamides as A3 adenosine receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3078-3087

  Devine, Shane M ^a   Gregg, Alison ^a,b   Figler, Heidi ^c   McIntosh, Kate ^a   Urmaliya, Vijay ^a   Linden, Joel ^c   Pouton, Colin W ^a   White, Paul J ^a   Bottle, Steven E ^b   Scammells, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

A3 Adenosine receptor; Adenosine agonist; Cardioprotection

Indexed keywords

6 N (1,1,3,3 TETRAMETHYLISOINDOLIN 2 YLOXYL 5 YL METHYL)ADENOSINE; 6 N (1,1,3,3 TETRAMETHYLISOINDOLIN 2 YLOXYL 5 YL METHYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (1,1,3,3 TETRAMETHYLISOINDOLIN 2 YLOXYL 5 YL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (1,1,3,3 TETRAMETHYLISOINDOLIN 5 YL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (2,2,5,5 TETRAMETHYLPYRROLIDIN 1 YLOXYL 3 YL METHYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (2,2,6,6 TETRAMETHYLPIPERIDIN 1 YLOXYL 4 YL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (2,2,6,6 TETRAMETHYLPIPERIDIN 4 YL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N (3,5 DI TERT BUTYL 4 HYDROXYPHENETHYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 (2 AMINOETHYL) 2,6 DI TERT BUTYLPHENOL]ADENOSINE; 6 N [4 [2 (1,1,3,3 TETRAMETHYLISOINDOLIN 2 YLOXYL 5 AMIDO)ETHYL]PHENYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,4,5 TRIMETHOXYBENZAMIDO)ETHYL]BENZYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,4,5 TRIMETHOXYBENZAMIDO)ETHYL]PHENYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,5 DI TERT BUTYL 4 HYDROXYBENZAMIDO)ETHYL]BENZYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,5 DI TERT BUTYL 4 HYDROXYBENZAMIDO)ETHYL]PHENYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,5 DI TERT BUTYLBENZAMIDO)ETHYL]BENZYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [2 (3,5 DI TERT BUTYLBENZAMIDO)ETHYL]PHENYL]ADENOSINE 5' N METHYLCARBOXAMIDE; 6 N [4 [4 (3,5 DI TERT BUTYL 4 HYDROXYPHENETHYLAMINO) 4 OXOBUTANAMIDO]BENZYL]ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE 5' (N METHYLCARBOXAMIDE); ADENOSINE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART PROTECTION; NONHUMAN; RAT;

ADENOSINE; ANIMALS; BINDING SITES; CARDIOTONIC AGENTS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; MOLECULAR STRUCTURE; MYOCYTES, CARDIAC; RATS; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951205834     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.047     Document Type: Article

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