Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 501-509

  Piotrowska, Dorota G ^a   Balzarini, Jan ^b   Głowacka, Iwona E ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Cytostatic; Isoxazolidines; Phosphonates; Synthesis; Triazoles

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ALKYNE; AMPHOLYTE; ANTIVIRUS AGENT; BISPHOSPHONIC ACID DERIVATIVE; CYTOSTATIC AGENT; DIETHYL 2 METHYL 5 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 2 METHYL 5 [4 (1 METHYL 1H IMIDAZOL 5 YL) 1H 1,2,3 TRIAZOL 1 YL]ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 2 METHYL 5 [4 (PYRIDIN 2 YL) 1H 1,2,3 TRIAZOL 1 YL]ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 (2 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 (2,4 DIFLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 (3 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 (METHOXYCARBONYL) 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 [(3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 [(3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL] 1H 1,2,3 TRIAZOL 1YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 [(3,4 DIHYDRO 5 METHYL 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 [(6 AMINO 9H PURIN 9 YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 [4 [(ACETYLAMINO) 2 OXOPYRIMIDIN 1 (2H)YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; ISOXAZOLIDINE DERIVATIVE; NUCLEOSIDE ANALOG; NUCLEOTIDE; TIN CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CYCLOADDITION; CYTOSTASIS; DNA VIRUS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RNA VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CYTOSTATIC AGENTS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; NUCLEOTIDES; TRIAZOLES; VIRUSES;

EID: 84855768094     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.021     Document Type: Article

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