Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen

Tetrahedron

Volumn 63, Issue 10, 2007, Pages 2283-2291

  Singh, Rajinder ^a   Bhella, Surinderjit Singh ^a   Sexana, A K ^b   Shanmugavel, M ^b   Faruk, Abdul ^a   Ishar, M P S ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Anticancer activity; Cycloadditions; Isoxazolidines; Nitrone; Secondary interactions; Stereoselectivities

Indexed keywords

(2,3 DIPHENYLISOXAZOLIDIN 5 YL)METHANOL; (2,3 DIPHENYLISOXAZOLIDIN 5 YL)METHYL ESTER; FLUOROURACIL; ISOXAZOLIDINE DERIVATIVE; MITOMYCIN C; NITRONE; NUCLEOSIDE; O (2,3 DIPHENYL 5 METHYLISOXAZOLIDIN 4 YL)METHOXYACETOPHENONE; O (2,3 DIPHENYLISOXAZOLIDIN 5 YL)METHOXYACETOPHENONE; O (2,3,5 TRIPHENYLISOXAZOLIDIN 4 YL)METHOXYACETOPHENONE; O (2,5 DIPHENYL 3 NITROPHENYLISOXAZOLIDIN 4 YL)METHOXYACETOPHENONE; O [2 PHENYL 3 (4 ANISYL) 5 METHYLISOXAZOLIDIN 4 YL]METHOXYACETOPHENONE; O [2 PHENYL 3 (4 ANISYL)ISOXAZOLIDIN 5 YL]METHOXYACETOPHENONE; O [2 PHENYL 3 (4 CHLOROPHENYL) 5 METHYLISOXAZOLIDIN 4 YL]METHOXYACETOPHENONE; O [2 PHENYL 3 (4 CHLOROPHENYL) 5 METHYLISOXAZOLIDIN 5 YL]METHOXYACETOPHENONE; O [2 PHENYL 3 (4 NITROPHENYL) 5 METHYLISOXAZOLIDIN 4 YL]METHOXYACETOPHENONE; O [2 PHENYL 3 (4 NITROPHENYL)ISOXAZOLIDIN 5 YL]METHOXYACETOPHENONE; PACLITAXEL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DEFENSE MECHANISM; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 33846807483     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.12.076     Document Type: Article

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