A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies

New England Journal of Medicine

Volumn 342, Issue 5, 2000, Pages 301-307

  Imagawa, Akihisa ^a,b   Hanafusa, Toshiaki ^a   Miyagawa, Jun Ichiro ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN ANTIBODY;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE CLASSIFICATION; ENZYME ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; KETOACIDOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AMYLASES; AUTOANTIBODIES; BIOPSY; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; GLUTAMATE DECARBOXYLASE; HEMOGLOBIN A, GLYCOSYLATED; HISTOCOMPATIBILITY TESTING; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; PANCREAS; PANCREATIC ELASTASE;

EID: 0034598761     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200002033420501     Document Type: Article

References (26)

1. Eisenbarth GS. Type I diabetes mellitus: a chronic autoimmune disease. N Engl J Med 1986;314:1360-8.
2. Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 1994;15:516-42.
3. Hanafusa T, Miyazaki A, Miyagawa J, et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1990;33:105-11.
4. Itoh N, Hanafusa T, Miyazaki A, et al. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993;92:2313-22.
5. Imagawa A, Hanafusa T, Itoh N, et al. Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1999;42:574-8.
6. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986;29:267-74.
7. Lernmark Å, Klöppel G, Stenger D, et al. Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch 1995;425:631-40.
8. Myers MA, Rabin DU, Rowley MJ. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 1995;44:1290-5.
9. Christie MR, Roll U, Payton MA, Hatfield EC, Ziegler AG. Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 1997;20:965-70.
10. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-97
11. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
12. Yamada K, Nonaka K. Diabetic ketoacidosis in young obese Japanese men. Diabetes Care 1996;19:671.
13. Schmidli RS, Colman PG, Bonifacio E. Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies: the Second International GADAB Workshop. Diabetes 1995;44:636-40.
14. Powell M, Chen S, Tanaka H, et al. Autoantibodies to IA-2 in IDDM - measurements with a new immunoprecipitation assay. J Endocrinol 1997;155:Suppl 2:P27. abstract.
15. Vardi P, Dib SA, Tuttleman M, et al. Competitive insulin autoantibody assay: prospective evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 1987;36:1286-91.
16. Kawasaki E, Abiru N, Yano M, et al. Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid diseases: relation to competitive insulin autoantibodies. J Autoimmun 1995;8:633-43.
17. Imagawa A, Itoh N, Hanafusa T, et al. Autoimmune endocrine disease induced by recombinant interferon-alpha therapy for chronic active type C hepatitis. J Clin Endocrinol Metab 1995;80:992-6.
18. Imagawa A, Nakajima H, Itoh N, et al. Mitochondrial DNA mutations in pancreatic biopsy specimens from IDDM patients. Diabetes Res Clin Pract 1995;30:79-87.
19. Yasunaga S, Kimura A, Hamaguchi K, Rønningen KS, Sasazuki T. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 1996;47:37-48.
20. Stirling GA. The exocrine pancreas: non-neoplastic disorders. In: Wight DGD, ed. Systemic pathology. 3rd ed. Vol. II. London: Churchill Livingstone, 1994:621-47.
21. Kimura N, Fujiya H, Yamaguchi K, Takahashi T, Nagura H. Vanished islets with pancreatitis in acute-onset insulin-dependent diabetes mellitus in an adult. Arch Pathol Lab Med 1994;118:84-8. [Erratum, Arch Pathol Lab Med 1994;118:864.]
22. Wakisaka M, Nunoi K, Wada M, et al. Two cases of abrupt onset type 1 diabetes associated with elevation of clastase 1 and diabetic ketoacidosis. J Jpn Diabetes Soc 1987;30:619-24. abstract.
23. Gaines KL, Kayes SG, Wilson GL. Altered pathogenesis in encephalomyocarditis virus (D variant)-infected diabetes-susceptible and resistant strains of mice. Diabetologia 1986;29:313-20.
24. Hartig PC, Webb SR. Heterogeneity of a human isolate of Coxsackie B4: biological differences. J Infect 1983;6:43-8.
25. Karjalainen J, Salmela P, Ilonen J, Surcel H-M, Knip M. A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 1989;320: 881-6.
26. Imagawa A, Itoh N, Hanafusa T, et al. High prevalence of antibodies to glutamic acid decarboxylase in comparison to islet cell antibodies in patients with long-standing insulin-dependent diabetes mellitus. Res Commun Mol Pathol Pharmacol 1996;92:43-52.