The effect of oral tolerance on the allergic airway response in younger and aged mice

Journal of Asthma

Volumn 50, Issue 2, 2013, Pages 122-132

  Birmingham, Janette M ^a   Patil, Sangita ^a   Li, Xiu Min ^a   Busse, Paula J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Asthma; Murine model; Oral tolerance

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA;

AGE DISTRIBUTION; AGED; ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EOSINOPHIL COUNT; FEMALE; HISTOLOGY; IMMUNOLOGICAL TOLERANCE; LUNG LAVAGE; LYMPHOCYTE COUNT; MACROPHAGE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; SENSITIZATION;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FEMALE; HISTOCYTOCHEMISTRY; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; OVALBUMIN; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, REGULATORY;

EID: 84873628050     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.753455     Document Type: Article

References (70)

1. Wu HY, Weiner HL. Oral tolerance. Immunol Res 2003; 28(3):265-284
2. Mayer L, Shao L. Therapeutic potential of oral tolerance. Nat Rev Immunol 2004; 4(6):407-419
3. Weiner HL. Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001; 3 (11):947-954
4. Samsom JN. Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa. Crit Rev Immunol 2004; 24(3):157-177
5. Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995; 376(6536):177-180
6. Samsom JN, van Berkel LA, van Helvoort JM, Unger WW, Jansen W, Thepen T, Mebius RE, Verbeek SS, Kroal G. Fc gamma RIIB regulates nasal and oral tolerance: A role for dendritic cells. J Immunol 2005; 174 (9):5279-5287
7. Fitzgerald DC, Zhang GX, Yu S, Cullimore ML, Zhao Z, Rostami A. Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling. J Neuroimmunol 2012; 247 (1-2):32-37
8. Matta B, Jha P, Bora PS, Bora NS. Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4 CD25 T-regulatory cells. Immunol Cell Biol 2010; 88 (2):187-196
9. Keller AC, Mucida D, Gomes E, Faquim-Mauro E, Faria AM, Rodriguez D, Russo M. Hierarchical suppression of asthma-like responses by mucosal tolerance. J Allergy Clin Immunol 2006; 117 (2):283-290
10. Berin MC. Mechanisms of allergic sensitization to foods: Bypassing immune tolerance pathways. Immunol Allergy Clin North Am 2012; 32(1):1-10
11. Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25()CD4() regulatory T cells by oral antigen administration. J Immunol 2001; 167(8):4245-4253
12. Faria AM, Garcia G, Rios MJ, Michalaros CL, Vaz NM. Decrease in susceptibility to oral tolerance induction and occurrence of oral immunization to ovalbumin in 20-38-week-old mice. The effect of interval between oral exposures and rate of antigen intake in the oral immunization. Immunology 1993; 78(1):147-151
13. de Faria AM, Ficker SM, Speziali E, Menezes JS, Stransky B, Silva Rodrigues V, Vaz NM. Aging affects oral tolerance induction but not its maintenance in mice. Mech Ageing Dev 1998; 102(1):67-80
14. Russo M, Nahori MA, Lefort J, Gomes E, de Castro Keller A, Rodriguez D, Ribeiro OG, Adriouch S, Gallois V, de Faria AM, Vargaftig BB. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am J Respir Cell Mol Biol 2001; 24(5):518-526
15. Zureik M, Orehek J. Diagnosis and severity of asthma in the elderly: Results of a large survey in 1,485 asthmatics recruited by lung specialists. Respiration 2002; 69(3):223-228
16. King MJ, Bukantz SC, Phillips S, Mohapatra SS, Tamulis T, Lockey RF. Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients. Allergy Asthma Proc 2004; 25(5):321-325
17. Huss K, Naumann PL, Mason PJ, Nanda JP, Huss RW, Smith CM, Hamilton RG. Asthma severity, atopic status, allergen exposure and quality of life in elderly persons. Ann Allergy Asthma Immunol 2001; 86(5):524-530
18. Burrows B, Barbee RA, Cline MG, Knudson RJ, Lebowitz MD. Characteristics of asthma among elderly adults in a sample of the general population. Chest 1991; 100(4):935-942
19. Rogers L, Cassino C, Berger KI, Goldring RM, Norman RG, Klugh T, Reibman J. Asthma in the elderly: Cockroach sensitization and severity of airway obstruction in elderly nonsmokers. Chest 2002; 122(5): 1580-1586
20. Busse PJ, Lurslurchachai L, Sampson HA, Halm EA, Wisnivesky J. Perennial allergen-specific immunoglobulin E levels among inner-city elderly asthmatics. J Asthma 2010; 47(7):781-5
21. Ariano R, Panzani RC, Augeri G. Late onset asthma clinical and immunological data: Importance of allergy. J Investig Allergol Clin Immunol 1998; 8(1):35-41
22. Bellia V, Pedone C, Catalano F, Zito A, Davi E, Palange S, Forastiere F, Incalzi RA. Asthma in the elderly: Mortality rate and associated risk factors for mortality. Chest 2007; 132(4):1175-1182
23. Moorman JERR, Johnson CA, King M, Minor P, Bailey C, Scalia MR, Akinbami LJ. Centers for Disease Control and Prevention (CDC). National surveillance for asthma-United States, 1980-2004. MMWR Surveill Summ 2007; 56(SS08):1-14, 8-54
24. Diette GBKJ, Dominici F et al., eds. Why do older adults have higher rates of hospitalization for asthma than younger adults? American Thoracic Society International Conference; 2000; Toronto, Canada
25. NAEPP Working Group Report: Considerations for Diagnosis and Managing Asthma in the Elderly 1996. Report No/NIH Publication No. 96-3662
26. Eyles J, Brimacombe M, Chaulk P, Stoddart G, Pranger T, Moase O. What determines health? To where should we shift resources? Attitudes towards the determinants of health among multiple stakeholder groups in Prince Edward Island, Canada. Soc Sci Med 2001; 53(12):1611-1619
27. Busse PJ, Zhang TF, Srivastava K, Schofield B, Li XM. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and-challenged mice. Clin Exp Allergy 2007; 37(9):1392-1403
28. Busse PJ, Zhang TF, Srivastava K, Lin BP, Schofield B, Sealfon SC, Li XM. Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol 2005; 116(6):1256-1263
29. Busse PJ, Zhang TF, Schofield B, Kilaru S, Patil S, Li XM. Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma. Ann Allergy Asthma Immunol 2009; 103(4):295-303
30. Carson WFt, Guernsey LA, Singh A, Vella AT, Schramm CM, Thrall RS. Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int Arch Allergy Immunol 2008; 145(3):231-243
31. Bochner BS, Busse WW. Allergy and asthma. J Allergy Clin Immunol 2005; 115(5):953-959
32. Ci X, Chu X, Wei M, Yang X, Cai Q, Deng X. Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. PLoS One 2012; 7(4):e34634
33. Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ. The translational repressor Tcell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett 2012; 146(1-2):8-14
34. Olson N, Kasahara DI, Hristova M, Bernstein R, Janssen-Heininger Y, van der Vliet A. Modulation of NF-{kappa}B and HIF-1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol 2011; 44(6):813-23
35. Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noël A, Cataldo DD. Mouse models of asthma: A comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm Res 2009; 58(12):845-854
36. Kato H, Fujihashi K, Kato R, Dohi T, Hagiwara Y, Kataoka K, Kobayashi R, MgGhee JR. Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions. Int Immunol 2003; 15 (2):145-158
37. Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL. Oral tolerance induced by continuous feeding: Enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun 2003; 20(2):135-145
38. Wakabayashi A, UtsuyamaM,Hosoda T, Sato K, TakahashiH, Hirokawa K. Induction of immunological tolerance by oral, but not intravenous and intraportal, administration of ovalbumin and the difference between young and old mice. J Nutr Health Aging 2006; 10(3):183-191
39. Bulati M, Buffa S, Candore G, Caruso C, Dunn-Walters DK, Pellicano M, Wu YC, Colonna Romano G. B cells and immunosenescence: A focus on IgG IgD-CD27-(DN) B cells in aged humans. Ageing Res Rev 2011; 10(2):274-284
40. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. J Immunol 2000; 165 (9):5352-5359
41. Speziali E, Santiago AF, Fernandes RM, Vaz NM, Menezes JS, Faria AM. Specific immune responses but not basal functions of B and T cells are impaired in aged mice. Cell Immunol 2009; 256(1-2):1-5
42. Frasca D, Riley RL, Blomberg BB. Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF. Exp Gerontol 2007; 42 (3):192-203
43. Faria AM, Weiner HL. Oral tolerance: Therapeutic implications for autoimmune diseases. Clin Dev Immunol 2006; 13(2-4):143-157
44. Kraal G, Samsom JN, Mebius RE. The importance of regional lymph nodes for mucosal tolerance. Immunol Rev 2006; 213:119-130
45. Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y. Changes of CD4 CD25 Foxp3 regulatory T cells in aged Balb/c mice. J Leukoc Biol 2007; 81(6):1386-1394
46. Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 2008; 181(3):1835-1848
47. Chiu BC, Stolberg VR, Zhang H, Chensue SW. Increased Foxp3() Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice. Mech Ageing Dev 2007; 128(11-12):618-627
48. Gregg R, Smith CM, Clark FJ, Dunnion D, Khan N, Chakraverty R, Nayak L, Moss PA. The number of human peripheral blood CD4 CD25high regulatory T cells increases with age. Clin Exp Immunol 2005; 140(3):540-546
49. Hwang KA, Kim HR, Kang I. Aging and human CD4() regulatory T cells. Mech Ageing Dev 2009; 130(8):509-517
50. Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009; 39 (9):1314-1323
51. Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S. CD4 CD25 Foxp3 T cells and CD4 CD25-Foxp3 T cells in aged mice. J Immunol 2006; 176(11):6586-6593
52. Nagatani K, Dohi M, To Y, Tanaka R, Okunishi K, Nakagome K, Sagawa K, Tanno Y, Komagata Y, Yamamoto K. Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma. J Immunol 2006; 176(3):1481-1489
53. Burchell JT, Wikstrom ME, Stumbles PA, Sly PD, Turner DJ. Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells. Am J Physiol Lung Cell Mol Physiol 2009; 296(3):L307-L319
54. Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4 CD25 regulatory T cells is interleukin 10 dependent. J Exp Med 2005; 202(11):1539-1547
55. Kearley J, Robinson DS, Lloyd CM. CD4 CD25 regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008; 122(3):617-624.e6
56. Schaefer U, Machida T, Vorlova S, Strickland S, Levi R. The plasminogen activator system modulates sympathetic nerve function. J Exp Med 2006; 203(9):2191-2200
57. Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Köhl J, Belkaid Y, Wills-Karp M. CD4 CD25 T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005; 202(11):1549-1561
58. Hartl D, Koller B, Mehlhorn AT, Reinhardt D, Nicolai T, Schendel DJ, Griese M, Krauss-Etschmann S. Quantitative and functional impairment of pulmonary CD4 CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007; 119(5):1258-1266
59. Provoost S, Maes T, vanDurme YM,Gevaert P, Bachert C, Schmidt-Weber CB, Brusselle GG, Joos GF, Tournoy KG. Decreased FOXP3 protein expression in patients with asthma. Allergy 2009; 64(10): 1539-1546
60. Vale-Pereira S, Todo-Bom A, Geraldes L, Schmidt-Weber C, Akdis CA, FoxP M-PA. 3, GATA-3 and T-bet expression in elderly asthma. Clin Exp Allergy 2011; 41(4):490-496
61. Zhang TF, Srivastava K, WenMC, Yang N, Cao J, Busse P, Birmingham N, Goldfarb J, Li XM. Pharmacology and immunological actions of a herbal medicine ASHMI (TM) on allergic asthma. Phytother Res 2010; 24 (7):1047-1055
62. Burrows B, Lebowitz MD, Barbee RA, Cline MG. Findings before diagnoses of asthma among the elderly in a longitudinal study of a general population sample. J Allergy Clin Immunol 1991; 88(6): 870-877
63. Litonjua AA, Sparrow D, Weiss ST, O'Connor GT, Long AA, Ohman JL Jr. Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study. Am J Respir Crit Care Med 1997; 156(1):23-27
64. Parameswaran K, Hildreth AJ, Taylor IK, Keaney NP, Bansal SK. Predictors of asthma severity in the elderly: Results of a community survey in Northeast England. J Asthma 1999; 36(7):613-618
65. Asero R. Efficacy of injection immunotherapy with ragweed and birch pollen in elderly patients. Int Arch Allergy Immunol 2004; 135(4):332-335
66. Korn S, Schumann C, Kropf C, Stoiber K, Thielen A, Taube C, Buhl R. Effectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthma. Ann Allergy Asthma Immunol 2010; 105(4):313-319
67. Maykut RJ, Kianifard F, Geba GP. Response of older patients with IgEmediated asthma to omalizumab: A pooled analysis. J Asthma 2008; 45(3):173-181
68. Quadrelli SA, Roncoroni A. Features of asthma in the elderly. J Asthma 2001; 38(5):377-389
69. Reed CE. Asthma in the elderly: Diagnosis and management. J Allergy Clin Immunol 2010; 126(4):681-7
70. Sin DD, Tu JV. Inhaled corticosteroid therapy reduces the risk of rehospitalization and all-cause mortality in elderly asthmatics. Eur Respir J 2001; 17(3):380-385.