메뉴 건너뛰기




Volumn 103, Issue 4, 2009, Pages 295-303

Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor α in a murine model of allergic asthma

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MONOCLONAL ANTIBODY; MUCIN 5AC; OVALBUMIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 78649990706     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60528-5     Document Type: Article
Times cited : (24)

References (52)
  • 1
    • 0029893414 scopus 로고    scopus 로고
    • Airway structure and inflammatory cells in fatal attacks of asthma
    • Carroll N, Carello S, Cooke C, James A. Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J. 1996;9:709-715.
    • (1996) Eur Respir J , vol.9 , pp. 709-715
    • Carroll, N.1    Carello, S.2    Cooke, C.3    James, A.4
  • 2
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med. 1998;339:1194-1200.
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 3
    • 0034129127 scopus 로고    scopus 로고
    • Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways
    • Zuhdi Alimam M, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol. 2000;22:253-260.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 253-260
    • Zuhdi Alimam, M.1    Piazza, F.M.2    Selby, D.M.3    Letwin, N.4    Huang, L.5    Rose, M.C.6
  • 4
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001;163:517-523.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3
  • 5
    • 0033563258 scopus 로고    scopus 로고
    • IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo
    • Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol. 1999;162:6233-6237.
    • (1999) J Immunol , vol.162 , pp. 6233-6237
    • Dabbagh, K.1    Takeyama, K.2    Lee, H.M.3    Ueki, I.F.4    Lausier, J.A.5    Nadel, J.A.6
  • 6
    • 0038652023 scopus 로고    scopus 로고
    • Interleukin-9 induces mucous cell metaplasia independent of inflammation
    • Reader JR, Hyde DM, Schelegle ES, et al. Interleukin-9 induces mucous cell metaplasia independent of inflammation. Am J Respir Cell Mol Biol. 2003;28:664-672.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 664-672
    • Reader, J.R.1    Hyde, D.M.2    Schelegle, E.S.3
  • 7
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103:779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3
  • 8
    • 0037592950 scopus 로고    scopus 로고
    • Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop
    • Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem. 2003;278:17036-17043.
    • (2003) J Biol Chem , vol.278 , pp. 17036-17043
    • Chen, Y.1    Thai, P.2    Zhao, Y.H.3    Ho, Y.S.4    Desouza, M.M.5    Wu, R.6
  • 9
    • 13444310932 scopus 로고    scopus 로고
    • Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa
    • Hauber HP, Daigneault P, Frenkiel S, et al. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J Allergy Clin Immunol. 2005;115:266-271.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 266-271
    • Hauber, H.P.1    Daigneault, P.2    Frenkiel, S.3
  • 10
    • 0036395206 scopus 로고    scopus 로고
    • IL-13 suppresses MUC5AC gene expression and mucin secretion in nasal epithelial cells
    • Kim CH, Song KS, Koo JS, et al. IL-13 suppresses MUC5AC gene expression and mucin secretion in nasal epithelial cells. Acta Otolaryngol. 2002;122:638-643.
    • (2002) Acta Otolaryngol , vol.122 , pp. 638-643
    • Kim, C.H.1    Song, K.S.2    Koo, J.S.3
  • 11
    • 0037593635 scopus 로고    scopus 로고
    • Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells
    • Song KS, Lee WJ, Chung KC, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem. 2003; 278:23243-23250.
    • (2003) J Biol Chem , vol.278 , pp. 23243-23250
    • Song, K.S.1    Lee, W.J.2    Chung, K.C.3
  • 12
    • 28444435861 scopus 로고    scopus 로고
    • Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo
    • Busse PJ, Zhang TF, Srivastava K, et al. Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol. 2005;116:1256-1263.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1256-1263
    • Busse, P.J.1    Zhang, T.F.2    Srivastava, K.3
  • 13
    • 28244479315 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
    • Howarth PH, Babu KS, Arshad HS, et al. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax. 2005;60:1012-1018.
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.H.1    Babu, K.S.2    Arshad, H.S.3
  • 14
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of tumor necrosis factor alpha in refractory asthma
    • Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354: 697-708.
    • (2006) N Engl J Med , vol.354 , pp. 697-708
    • Berry, M.A.1    Hargadon, B.2    Shelley, M.3
  • 15
    • 0034581503 scopus 로고    scopus 로고
    • Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma?
    • Amrani Y, Chen H, Panettieri RA Jr. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir Res. 2000;1:49-53.
    • (2000) Respir Res , vol.1 , pp. 49-53
    • Amrani, Y.1    Chen, H.2    Panettieri Jr., R.A.3
  • 16
    • 0028983633 scopus 로고
    • Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects
    • Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med. 1995;152:76-80.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 76-80
    • Thomas, P.S.1    Yates, D.H.2    Barnes, P.J.3
  • 17
    • 0036727009 scopus 로고    scopus 로고
    • Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma
    • Thomas PS, Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax. 2002;57:774-778.
    • (2002) Thorax , vol.57 , pp. 774-778
    • Thomas, P.S.1    Heywood, G.2
  • 18
    • 0028989599 scopus 로고
    • TNFalpha mediates recruitment of neutrophils and eosinophils during airway inflammation
    • Lukacs NW, Strieter RM, Chensue SW, Widmer M, Kunkel SL. TNFalpha mediates recruitment of neutrophils and eosinophils during airway inflammation. J Immunol. 1995;154:5411-5417.
    • (1995) J Immunol , vol.154 , pp. 5411-5417
    • Lukacs, N.W.1    Strieter, R.M.2    Chensue, S.W.3    Widmer, M.4    Kunkel, S.L.5
  • 19
    • 0025299641 scopus 로고
    • Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium
    • Slungaard A, Vercellotti GM, Walker G, Nelson RD, Jacob HS. Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium. J Exp Med. 1990;171: 2025-2041.
    • (1990) J Exp Med , vol.171 , pp. 2025-2041
    • Slungaard, A.1    Vercellotti, G.M.2    Walker, G.3    Nelson, R.D.4    Jacob, H.S.5
  • 20
    • 0023127850 scopus 로고
    • Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: Induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses
    • Scheurich P, Thoma B, Ucer U, Pfizenmaier K. Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses. J Immunol. 1987;138:1786-1790.
    • (1987) J Immunol , vol.138 , pp. 1786-1790
    • Scheurich, P.1    Thoma, B.2    Ucer, U.3    Pfizenmaier, K.4
  • 22
    • 65249096442 scopus 로고    scopus 로고
    • Pharmacogenetic identification of increased responsiveness in severe asthma with anti-TNF (Golimumab) therapy
    • Meyers D.A. HGA, Wenzel S.A., Lo K, Watt R., Bleecker ER. Pharmacogenetic identification of increased responsiveness in severe asthma with anti-TNF (Golimumab) therapy. J Allergy Clin Immunol. 2008;121: LB29.
    • (2008) J Allergy Clin Immunol , vol.121
    • Meyers, D.A.H.G.A.1    Wenzel, S.A.2    Lo, K.3    Watt, R.4    Bleecker, E.R.5
  • 23
    • 33749438560 scopus 로고    scopus 로고
    • The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
    • Erin EM, Leaker BR, Nicholson GC, et al. The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med. 2006;174:753-762.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 753-762
    • Erin, E.M.1    Leaker, B.R.2    Nicholson, G.C.3
  • 24
    • 0037378345 scopus 로고    scopus 로고
    • Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis
    • Totsuka T, Kanai T, Uraushihara K, et al. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol. 2003;284:G595-603.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Totsuka, T.1    Kanai, T.2    Uraushihara, K.3
  • 25
    • 33746519362 scopus 로고    scopus 로고
    • The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis
    • Uno JK, Kolek OI, Hines ER, et al. The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Gastroenterology. 2006;131:497-509.
    • (2006) Gastroenterology , vol.131 , pp. 497-509
    • Uno, J.K.1    Kolek, O.I.2    Hines, E.R.3
  • 26
    • 24644447506 scopus 로고    scopus 로고
    • TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation
    • Choi IW, Sun K, Kim YS, et al. TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. J Allergy Clin Immunol. 2005;116: 537-543.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 537-543
    • Choi, I.W.1    Sun, K.2    Kim, Y.S.3
  • 27
    • 33644756174 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust
    • Kim J, McKinley L, Natarajan S, et al. Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clin Exp Allergy. 2006;36:122-132.
    • (2006) Clin Exp Allergy , vol.36 , pp. 122-132
    • Kim, J.1    McKinley, L.2    Natarajan, S.3
  • 29
    • 0023694474 scopus 로고
    • Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice
    • Levitt RC, Mitzner W. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J. 1988; 2:2605-2608.
    • (1988) FASEB J , vol.2 , pp. 2605-2608
    • Levitt, R.C.1    Mitzner, W.2
  • 30
    • 34548503905 scopus 로고    scopus 로고
    • Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice
    • Busse PJ, Zhang TF, Srivastava K, Schofield B, Li XM. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice. Clin Exp Allergy. 2007;37:1392-1403.
    • (2007) Clin Exp Allergy , vol.37 , pp. 1392-1403
    • Busse, P.J.1    Zhang, T.F.2    Srivastava, K.3    Schofield, B.4    Li, X.M.5
  • 31
    • 0035190159 scopus 로고    scopus 로고
    • Enhanced expression of mucin genes in a guinea pig model of allergic asthma
    • Li Y, Martin LD, Minnicozzi M, et al. Enhanced expression of mucin genes in a guinea pig model of allergic asthma. Am J Respir Cell Mol Biol. 2001;25:644-651.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 644-651
    • Li, Y.1    Martin, L.D.2    Minnicozzi, M.3
  • 33
    • 0034996176 scopus 로고    scopus 로고
    • Tissue distribution of radioactivity following intranasal administration of radioactive microspheres
    • Eyles JE, Spiers ID, Williamson ED, Alpar HO. Tissue distribution of radioactivity following intranasal administration of radioactive microspheres. J Pharm Pharmacol. 2001;53:601-607.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 601-607
    • Eyles, J.E.1    Spiers, I.D.2    Williamson, E.D.3    Alpar, H.O.4
  • 34
    • 36849021091 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation
    • Hutchison S, Choo-Kang BS, Bundick RV, et al. Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation. Clin Exp Immunol. 2008;151:114-122.
    • (2008) Clin Exp Immunol , vol.151 , pp. 114-122
    • Hutchison, S.1    Choo-Kang, B.S.2    Bundick, R.V.3
  • 35
    • 0142012149 scopus 로고    scopus 로고
    • Mouse model of airway remodeling: Strain differences
    • Shinagawa K, Kojima M. Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med. 2003;168:959-967.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 959-967
    • Shinagawa, K.1    Kojima, M.2
  • 36
    • 34250829615 scopus 로고    scopus 로고
    • Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    • Nakae S, Ho LH, Yu M, et al. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol. 2007;120:48-55.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 48-55
    • Nakae, S.1    Ho, L.H.2    Yu, M.3
  • 37
    • 0035089395 scopus 로고    scopus 로고
    • Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75-and TNF receptor p55-deficient mice
    • Broide DH, Stachnick G, Castaneda D, Nayar J, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75-and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol. 2001;24:304-311.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 304-311
    • Broide, D.H.1    Stachnick, G.2    Castaneda, D.3    Nayar, J.4    Sriramarao, P.5
  • 39
    • 4544274172 scopus 로고    scopus 로고
    • A critical role for eosinophils in allergic airways remodeling
    • Humbles AA, Lloyd CM, McMillan SJ, et al. A critical role for eosinophils in allergic airways remodeling. Science. 2004;305:1776-1779.
    • (2004) Science , vol.305 , pp. 1776-1779
    • Humbles, A.A.1    Lloyd, C.M.2    McMillan, S.J.3
  • 40
    • 0033562979 scopus 로고    scopus 로고
    • Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils
    • Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol. 1999;162:6178-6183.
    • (1999) J Immunol , vol.162 , pp. 6178-6183
    • Cohn, L.1    Homer, R.J.2    MacLeod, H.3    Mohrs, M.4    Brombacher, F.5    Bottomly, K.6
  • 41
    • 0037443649 scopus 로고    scopus 로고
    • A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse
    • Shen HH, Ochkur SI, McGarry MP, et al. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J Immunol. 2003;170:3296-3305.
    • (2003) J Immunol , vol.170 , pp. 3296-3305
    • Shen, H.H.1    Ochkur, S.I.2    McGarry, M.P.3
  • 42
    • 0029944290 scopus 로고    scopus 로고
    • Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
    • Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996;2:449-456.
    • (1996) Nat Med , vol.2 , pp. 449-456
    • Garcia-Zepeda, E.A.1    Rothenberg, M.E.2    Ownbey, R.T.3    Celestin, J.4    Leder, P.5    Luster, A.D.6
  • 43
    • 0036280939 scopus 로고    scopus 로고
    • Activation of p38 mitogenactivated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils
    • Wong CK, Zhang JP, Ip WK, Lam CW. Activation of p38 mitogenactivated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils. Clin Exp Immunol. 2002;128:483-489.
    • (2002) Clin Exp Immunol , vol.128 , pp. 483-489
    • Wong, C.K.1    Zhang, J.P.2    Ip, W.K.3    Lam, C.W.4
  • 44
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725-734.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 46
    • 9144241104 scopus 로고    scopus 로고
    • NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
    • Poynter ME, Cloots R, van Woerkom T, et al. NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol. 2004;173:7003-7009.
    • (2004) J Immunol , vol.173 , pp. 7003-7009
    • Poynter, M.E.1    Cloots, R.2    Van Woerkom, T.3
  • 47
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokineinduced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
    • Pierce JW, Schoenleber R, Jesmok G, et al. Novel inhibitors of cytokineinduced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997;272:21096-21103.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1    Schoenleber, R.2    Jesmok, G.3
  • 48
    • 27744548897 scopus 로고    scopus 로고
    • TNF-alpha triggers mucus production in airway epithelium through an IKKbeta dependent mechanism
    • Lora JM, Zhang DM, Liao SM, et al. TNF-alpha triggers mucus production in airway epithelium through an IKKbeta dependent mechanism. J Biol Chem. 2005.
    • (2005) J Biol Chem
    • Lora, J.M.1    Zhang, D.M.2    Liao, S.M.3
  • 49
    • 2342523999 scopus 로고    scopus 로고
    • Airway mucus hypersecretion in asthma: An undervalued pathology?
    • Rogers DF. Airway mucus hypersecretion in asthma: an undervalued pathology? Curr Opin Pharmacol. 2004;4:241-250.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 241-250
    • Rogers, D.F.1
  • 50
    • 20444462363 scopus 로고    scopus 로고
    • Structural changes in the airways in asthma: Observations and consequences
    • Bai TR, Knight DA. Structural changes in the airways in asthma: observations and consequences. Clin Sci (Lond). 2005;108:463-477.
    • (2005) Clin Sci (Lond) , vol.108 , pp. 463-477
    • Bai, T.R.1    Knight, D.A.2
  • 51
    • 0035451437 scopus 로고    scopus 로고
    • Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease
    • Wu CA, Puddington L, Whiteley HE, et al. Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease. J Immunol. 2001;167:2798-2807.
    • (2001) J Immunol , vol.167 , pp. 2798-2807
    • Wu, C.A.1    Puddington, L.2    Whiteley, H.E.3
  • 52
    • 39149110941 scopus 로고    scopus 로고
    • Use of unrestrained, single-chamber barometric plethysmography to evaluate sensitivity to cholinergic stimulation in mouse models of allergic airway disease
    • Finkelman FD. Use of unrestrained, single-chamber barometric plethysmography to evaluate sensitivity to cholinergic stimulation in mouse models of allergic airway disease. J Allergy Clin Immunol. 2008;121: 334-335.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 334-335
    • Finkelman, F.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.