Mechanisms of Allergic Sensitization to Foods: Bypassing Immune Tolerance Pathways

Immunology and Allergy Clinics of North America

Volumn 32, Issue 1, 2012, Pages 1-10

  Berin, M Cecilia ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adjuvant; Dendritic cell; Epicutaneous; Innate immunity; IT reg; Oral tolerance

Indexed keywords

FOOD ALLERGEN; IMMUNOLOGICAL ADJUVANT;

ANTIGEN SPECIFICITY; DISEASE MODEL; FOOD ALLERGY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IN VIVO STUDY; INNATE IMMUNITY; MUCOSAL IMMUNITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DENDRITIC CELLS; FOOD; FOOD HYPERSENSITIVITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNIZATION; MICE; T-LYMPHOCYTES;

EID: 84855842745     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2011.10.001     Document Type: Review

References (64)

1. Wells H.G., Osborne T.B. The biological reactions of the vegetable proteins. I. Anaphylaxis. JInfect Dis 1911, 8:66-124.
2. Wells H.G. Studies on the chemistry of anaphylaxis (III). Experiments with isolated proteins, especially those of the hen's egg. JInfect Dis 1911, 9(2):147-171.
3. Chase M.W. Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 1946, 61:257-259.
4. Ngan J., Kind L.S. Suppressor T cells for IgE and IgG in Peyer's patches of mice made tolerant by the oral administration of ovalbumin. JImmunol 1978, 120(3):861-865.
5. Mattingly J.A., Kaplan J.M., Janeway C.A. Two distinct antigen-specific suppressor factors induced by the oral administration of antigen. JExp Med 1980, 152(3):545-554.
6. Chen Y., Inobe J., Weiner H.L. Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression. JImmunol 1995, 155(2):910-916.
7. Chen Y., Kuchroo V.K., Inobe J., et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265(5176):1237-1240.
8. Miller A., Lider O., Roberts A.B., et al. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both invitro and invivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 1992, 89(1):421-425.
9. Chen Y., Inobe J., Marks R., et al. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995, 376(6536):177-180.
10. Husby S., Mestecky J., Moldoveanu Z., et al. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. JImmunol 1994, 152(9):4663-4670.
11. Kraus T.A., Toy L., Chan L., et al. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004, 126(7):1771-1778.
12. Fukaura H., Kent S.C., Pietrusewicz M.J., et al. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. JClin Invest 1996, 98(1):70-77.
13. Mucida D., Kutchukhidze N., Erazo A., et al. Oral tolerance in the absence of naturally occurring Tregs. JClin Invest 2005, 115(7):1923-1933.
14. Curotto de Lafaille M.A., Kutchukhidze N., Shen S., et al. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 2008, 29(1):114-126.
15. Hadis U., Wahl B., Schulz O., et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 2011, 34(2):237-246.
16. Viney J.L., Mowat A.M., O'Malley J.M., et al. Expanding dendritic cells invivo enhances the induction of oral tolerance. JImmunol 1998, 160(12):5815-5825.
17. Bogunovic M., Ginhoux F., Helft J., et al. Origin of the lamina propria dendritic cell network. Immunity 2009, 31(3):513-525.
18. Schulz O., Jaensson E., Persson E.K., et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. JExp Med 2009, 206(13):3101-3114.
19. Niess J.H., Brand S., Gu X., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005, 307(5707):254-258.
20. Worbs T., Bode U., Yan S., et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. JExp Med 2006, 203(3):519-527.
21. Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., et al. Afunctionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. JExp Med 2007, 204(8):1757-1764.
22. Jaensson E., Uronen-Hansson H., Pabst O., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. JExp Med 2008, 205(9):2139-2149.
23. Matteoli G., Mazzini E., Iliev I.D., et al. Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 2010, 59(5):595-604.
24. van Wijk F., Hoeks S., Nierkens S., et al. CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. JImmunol 2005, 174(1):174-179.
25. Torgerson T.R., Linane A., Moes N., et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 2007, 132(5):1705-1717.
26. Ladics G.S., Knippels L.M., Penninks A.H., et al. Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops. Regul Toxicol Pharmacol 2010, 56(2):212-224.
27. Jackson H.A., Jackson M.W., Coblentz L., et al. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy. Vet Dermatol 2003, 14(4):181-187.
28. Jackson H.A., Hammerberg B. Evaluation of a spontaneous canine model of immunoglobulin E-mediated food hypersensitivity: dynamic changes in serum and fecal allergen-specific immunoglobulin E values relative to dietary change. Comp Med 2002, 52(4):316-321.
29. Forbes E.E., Groschwitz K., Abonia J.P., et al. IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. JExp Med 2008, 205(4):897-913.
30. Mathias C.B., Hobson S.A., Garcia-Lloret M., et al. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. JAllergy Clin Immunol 2011, 127(3). 795-805.e1-6.
31. Proust B., Astier C., Jacquenet S., et al. Asingle oral sensitization to peanut without adjuvant leads to anaphylaxis in mice. Int Arch Allergy Immunol 2008, 146(3):212-218.
32. Snider D.P., Marshall J.S., Perdue M.H., et al. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. JImmunol 1994, 153(2):647-657.
33. Li X.M., Serebrisky D., Lee S.Y., et al. Amurine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. JAllergy Clin Immunol 2000, 106(1 Pt 1):150-158.
34. Roth-Walter F., Berin M.C., Arnaboldi P., et al. Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches. Allergy 2008, 63(7):882-890.
35. Martos G., Lopez-Exposito I., Bencharitiwong R., et al. Mechanisms underlying differential food allergy response to heated egg. JAllergy Clin Immunol 2011, 127(4). 990-7.e1-2.
36. Foss N., Duranti M., Magni C., et al. Assessment of lupin allergenicity in the cholera toxin model: induction of IgE response depends on the intrinsic properties of the conglutins and matrix effects. Int Arch Allergy Immunol 2006, 141(2):141-150.
37. Capobianco F., Butteroni C., Barletta B., et al. Oral sensitization with shrimp tropomyosin induces in mice allergen-specific IgE, T cell response and systemic anaphylactic reactions. Int Immunol 2008, 20(8):1077-1086.
38. Williamson E., Westrich G.M., Viney J.L. Modulating dendritic cells to optimize mucosal immunization protocols. JImmunol 1999, 163(7):3668-3675.
39. Anjuere F., Luci C., Lebens M., et al. Invivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin. JImmunol 2004, 173(8):5103-5111.
40. Blazquez A.B., Berin M.C. Gastrointestinal dendritic cells promote Th2 skewing via OX40L. JImmunol 2008, 180(7):4441-4450.
41. Smit J.J., Bol-Schoenmakers M., Hassing I., et al. The role of intestinal dendritic cells subsets in the establishment of food allergy. Clin Exp Allergy 2011, 41(6):890-898.
42. Cardona I.D., Cho S.H., Leung D.Y. Role of bacterial superantigens in atopic dermatitis: implications for future therapeutic strategies. Am J Clin Dermatol 2006, 7(5):273-279.
43. Ganeshan K., Neilsen C.V., Hadsaitong A., et al. Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. JAllergy Clin Immunol 2009, 123(1). 231-8.e4.
44. Yang P.C., Xing Z., Berin C.M., et al. TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy. Gastroenterology 2007, 133(5):1522-1533.
45. Du Toit G., Katz Y., Sasieni P., et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. JAllergy Clin Immunol 2008, 122(5):984-991.
46. Fox A.T., Sasieni P., du Toit G., et al. Household peanut consumption as a risk factor for the development of peanut allergy. JAllergy Clin Immunol 2009, 123(2):417-423.
47. Lack G., Fox D., Northstone K., et al. Factors associated with the development of peanut allergy in childhood. NEngl J Med 2003, 348(11):977-985.
48. Birmingham N.P., Parvataneni S., Hassan H.M., et al. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int Arch Allergy Immunol 2007, 144(3):203-210.
49. Gonipeta B., Parvataneni S., Tempelman R.J., et al. An adjuvant-free mouse model to evaluate the allergenicity of milk whey protein. JDairy Sci 2009, 92(10):4738-4744.
50. Parvataneni S., Gonipeta B., Tempelman R.J., et al. Development of an adjuvant-free cashew nut allergy mouse model. Int Arch Allergy Immunol 2009, 149(4):299-304.
51. Jin H., Oyoshi M.K., Le Y., et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. JClin Invest 2009, 119(1):47-60.
52. Oyoshi M.K., Larson R.P., Ziegler S.F., et al. Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. JAllergy Clin Immunol 2010, 126(5):976-984. 984.e1-5.
53. Dioszeghy V., Mondoulet L., Dhelft V., et al. Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice. JImmunol 2011, 186(10):5629-5637.
54. Dunkin D., Berin M.C., Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. JAllergy Clin Immunol 2011, [Epub ahead of print].
55. Shreffler W.G., Castro R.R., Kucuk Z.Y., et al. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant invitro. JImmunol 2006, 177(6):3677-3685.
56. Kean D.E., Goodridge H.S., McGuinness S., et al. Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8. JImmunol 2006, 177(3):1561-1566.
57. Hsu S.C., Chen C.H., Tsai S.H., et al. Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells. JBiol Chem 2010, 285(11):7903-7910.
58. Hilmenyuk T., Bellinghausen I., Heydenreich B., et al. Effects of glycation of the model food allergen ovalbumin on antigen uptake and presentation by human dendritic cells. Immunology 2010, 129(3):437-445.
59. Ilchmann A., Burgdorf S., Scheurer S., et al. Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II. JAllergy Clin Immunol 2010, 125(1). 175-83.e1-11.
60. Khodoun M., Strait R., Orekov T., et al. Peanuts can contribute to anaphylactic shock by activating complement. JAllergy Clin Immunol 2009, 123(2):342-351.
61. Strainic M.G., Liu J., Huang D., et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 2008, 28(3):425-435.
62. Jyonouchi S., Abraham V., Orange J.S., et al. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. JAllergy Clin Immunol 2011, 128(1). 102-9.e13.
63. Masilamani M., Wei J., Bhatt S., et al. Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut. JAllergy Clin Immunol 2011, [Epub ahead of print].
64. Zhou Y., Kawasaki H., Hsu S.C., et al. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nat Med 2010, 16(10):1128-1133.