메뉴 건너뛰기




Volumn 5, Issue 5, 2006, Pages 611-615

RTS,S/AS02A for malaria

Author keywords

Circumsporozoite protein; Clinical trial; Malaria vaccine

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ANTIMALARIAL AGENT; ARTEMISININ; CELL SURFACE PROTEIN; CIRCUMSPOROZOITE PROTEIN; DIPLOID CELL VACCINE; FANSIDAR; HEPATITIS B SURFACE ANTIGEN; IMMUNOSTIMULATING AGENT; INTRALIPID; MALARIA VACCINE; MALARIA VACCINE RTS S; PHOSPHORYL LIPID A; PLACEBO; SPOROZOITE VACCINE; SUBUNIT VACCINE; UNCLASSIFIED DRUG;

EID: 33845884042     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.5.5.611     Document Type: Review
Times cited : (25)

References (35)
  • 1
    • 23944469305 scopus 로고    scopus 로고
    • Health risks and benefits of bis (4-chlorophenyl)-1,1, 1-trichloroethane (DDT)
    • Rogan WJ, Chen A. Health risks and benefits of bis (4-chlorophenyl)-1,1, 1-trichloroethane (DDT). Lancet 366, 763-773 (2005).
    • (2005) Lancet , vol.366 , pp. 763-773
    • Rogan, W.J.1    Chen, A.2
  • 2
    • 84921430677 scopus 로고    scopus 로고
    • Lengeler C. Insecticide-treated bednets and curtains for preventing malaria. Cochrane Database Syst. Rev. 2, CD000363 (2000).
    • Lengeler C. Insecticide-treated bednets and curtains for preventing malaria. Cochrane Database Syst. Rev. 2, CD000363 (2000).
  • 4
    • 0037033984 scopus 로고    scopus 로고
    • The economic and social burden of malaria
    • Sachs J, Malaney P. The economic and social burden of malaria. Nature 415, 680-685 (2002).
    • (2002) Nature , vol.415 , pp. 680-685
    • Sachs, J.1    Malaney, P.2
  • 5
    • 0037090258 scopus 로고    scopus 로고
    • Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites
    • Hoffman SL, Goh LM, Luke TC et al. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 185, 1155-1164 (2002).
    • (2002) J. Infect. Dis , vol.185 , pp. 1155-1164
    • Hoffman, S.L.1    Goh, L.M.2    Luke, T.C.3
  • 6
    • 0347004636 scopus 로고    scopus 로고
    • Progress with new malaria vaccines
    • Webster D, Hill A. Progress with new malaria vaccines. Bull. World Health Organ. 81, 902-909 (2003)
    • (2003) Bull. World Health Organ , vol.81 , pp. 902-909
    • Webster, D.1    Hill, A.2
  • 7
    • 0024413594 scopus 로고
    • Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes
    • Hoffman SL, Isenbarger D, Long GW et al. Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes. Science 244, 1078-1081 (1989).
    • (1989) Science , vol.244 , pp. 1078-1081
    • Hoffman, S.L.1    Isenbarger, D.2    Long, G.W.3
  • 8
    • 33244471717 scopus 로고    scopus 로고
    • Pre-erythrocytic malaria vaccines: Towards greater efficacy
    • Hill AV. Pre-erythrocytic malaria vaccines: towards greater efficacy. Nat. Rev. Immunol. 6, 21-32 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 21-32
    • Hill, A.V.1
  • 9
    • 0242658694 scopus 로고    scopus 로고
    • Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine
    • Luke TC, Hoffman SL. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol. 206, 3803-3808 (2003).
    • (2003) J. Exp. Biol , vol.206 , pp. 3803-3808
    • Luke, T.C.1    Hoffman, S.L.2
  • 10
    • 37049184983 scopus 로고
    • Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum
    • Dame JB, Williams JL, McCutchan TF et al. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225(4662), 593-599 (1984).
    • (1984) Science , vol.225 , Issue.4662 , pp. 593-599
    • Dame, J.B.1    Williams, J.L.2    McCutchan, T.F.3
  • 11
    • 0025970808 scopus 로고
    • Fine specificities of monoclonal antibodies against the Plasmodium falciparum circumsporozoite protein: Recognition of both repetitive and non-repetitive regions
    • Burkot TR, Da ZW, Geysen HM, Wirtz RA, Saul A. Fine specificities of monoclonal antibodies against the Plasmodium falciparum circumsporozoite protein: recognition of both repetitive and non-repetitive regions. Parasite Immunol. 13, 161-170 (1991).
    • (1991) Parasite Immunol , vol.13 , pp. 161-170
    • Burkot, T.R.1    Da, Z.W.2    Geysen, H.M.3    Wirtz, R.A.4    Saul, A.5
  • 12
    • 0023182064 scopus 로고
    • Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites
    • Herrington DA, Clyde DF, Losonsky G et al. Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328, 257-259 (1987).
    • (1987) Nature , vol.328 , pp. 257-259
    • Herrington, D.A.1    Clyde, D.F.2    Losonsky, G.3
  • 13
    • 0023254214 scopus 로고
    • Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine
    • Ballou WR, Hoffman SL, Sherwood JA et al. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet 1(8545), 1277-1281 (1987).
    • (1987) Lancet , vol.1 , Issue.8545 , pp. 1277-1281
    • Ballou, W.R.1    Hoffman, S.L.2    Sherwood, J.A.3
  • 14
    • 0025892669 scopus 로고
    • Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: Boosting of antibody response in a population with prior natural exposure
    • Sherwood JA, Oster CN, Adoyo-Adoyo M et al. Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure. Trans. R. Soc. Trop. Med. Hyg. 85, 336-340 (1991).
    • (1991) Trans. R. Soc. Trop. Med. Hyg , vol.85 , pp. 336-340
    • Sherwood, J.A.1    Oster, C.N.2    Adoyo-Adoyo, M.3
  • 15
    • 0030176043 scopus 로고    scopus 로고
    • Plasmodium falciparum circumsporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria of Kenya
    • Sherwood JA, Copeland RS, Taylor KA et al. Plasmodium falciparum circumsporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria of Kenya. Vaccine 14(8), 817-827 (1996).
    • (1996) Vaccine , vol.14 , Issue.8 , pp. 817-827
    • Sherwood, J.A.1    Copeland, R.S.2    Taylor, K.A.3
  • 16
    • 0028181637 scopus 로고
    • Safety, immunogenicity and limited efficacy study of a recombinant Plasmodium falciparum circumsporozoite vaccine in Thai soldiers
    • Brown AE, Singharaj P, Webster HK et al. Safety, immunogenicity and limited efficacy study of a recombinant Plasmodium falciparum circumsporozoite vaccine in Thai soldiers. Vaccine 12, 102-108 (1994).
    • (1994) Vaccine , vol.12 , pp. 102-108
    • Brown, A.E.1    Singharaj, P.2    Webster, H.K.3
  • 17
    • 0025721933 scopus 로고
    • Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen
    • Vreden SGS, Verhave JP, Oettinger T, Sauerwein RW, Meuwissen JH. Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen. Am. J. Trop. Med. Hyg. 45, 533-538 (1991).
    • (1991) Am. J. Trop. Med. Hyg , vol.45 , pp. 533-538
    • Vreden, S.G.S.1    Verhave, J.P.2    Oettinger, T.3    Sauerwein, R.W.4    Meuwissen, J.H.5
  • 18
    • 20044362219 scopus 로고    scopus 로고
    • Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: Progress at the Walter Reed Army Institute of Research
    • Heppner DG Jr, Kester KE, Ockenhouse KF et al. Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine 23, 2243-2250 (2005).
    • (2005) Vaccine , vol.23 , pp. 2243-2250
    • Heppner Jr, D.G.1    Kester, K.E.2    Ockenhouse, K.F.3
  • 19
    • 0029057169 scopus 로고
    • Safety, immunogenicity and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein/HBsAg subunit vaccine
    • Gordon DM, McGovern TW, Krzych U et al. Safety, immunogenicity and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein/HBsAg subunit vaccine. J. Infect. Dis. 171, 1576-1585 (1995).
    • (1995) J. Infect. Dis , vol.171 , pp. 1576-1585
    • Gordon, D.M.1    McGovern, T.W.2    Krzych, U.3
  • 20
    • 0037654736 scopus 로고    scopus 로고
    • Development of RTS,S/AS02: A purified subunit-based malaria vaccine candidate formulated with a novel adjuvant
    • Garcon N, Heppner DG, Cohen J. Development of RTS,S/AS02: a purified subunit-based malaria vaccine candidate formulated with a novel adjuvant. Expert Rev. Vaccines 2(2), 231-238 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , Issue.2 , pp. 231-238
    • Garcon, N.1    Heppner, D.G.2    Cohen, J.3
  • 21
    • 0036092885 scopus 로고    scopus 로고
    • Pre-erythrocytic malaria vaccines to prevent Plasmodium falciparum malaria
    • Ballou WR, Kester KE, Heppner DG. Pre-erythrocytic malaria vaccines to prevent Plasmodium falciparum malaria. Chem. Immunol. 80, 253-261 (2002).
    • (2002) Chem. Immunol , vol.80 , pp. 253-261
    • Ballou, W.R.1    Kester, K.E.2    Heppner, D.G.3
  • 22
    • 0004170486 scopus 로고    scopus 로고
    • Stoute JA, Slaoui M, Heppner DG et al. A preliminary evaluation of a recombinant circumsporozoite protein malaria vaccine against Plasmodium falciparum. N. Engl. J. Med. 336, 86-91 (1997). •• First demonstration of significant efficacy of RTS,S/AS02A in malaria-naïve volunteers.
    • Stoute JA, Slaoui M, Heppner DG et al. A preliminary evaluation of a recombinant circumsporozoite protein malaria vaccine against Plasmodium falciparum. N. Engl. J. Med. 336, 86-91 (1997). •• First demonstration of significant efficacy of RTS,S/AS02A in malaria-naïve volunteers.
  • 23
    • 17344368403 scopus 로고    scopus 로고
    • Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine
    • Stoute JA, Kester KE, Krzych U et al. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J. Infect. Dis. 178, 1139-1144 (1998).
    • (1998) J. Infect. Dis , vol.178 , pp. 1139-1144
    • Stoute, J.A.1    Kester, K.E.2    Krzych, U.3
  • 24
    • 10744227629 scopus 로고    scopus 로고
    • + T cells producing IFN-γ
    • + T cells producing IFN-γ. J. Immunol. 171(12), 6961-6967 (2003).
    • (2003) J. Immunol , vol.171 , Issue.12 , pp. 6961-6967
    • Sun, P.1    Schwenk, R.2    White, K.3
  • 25
    • 0035865867 scopus 로고    scopus 로고
    • Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria
    • Kester KE, McKinney DA, Tornieporth N et al. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J. Infect. Dis. 183(4), 640-647 (2001).
    • (2001) J. Infect. Dis , vol.183 , Issue.4 , pp. 640-647
    • Kester, K.E.1    McKinney, D.A.2    Tornieporth, N.3
  • 26
    • 17344377596 scopus 로고    scopus 로고
    • A Phase I safety and immunogenicity trial with the candidate malaria vaccine, RTS,S/SBAS2, in semi-immune adults in The Gambia
    • Doherty JF, Pinder M, Tornieporth N et al. A Phase I safety and immunogenicity trial with the candidate malaria vaccine, RTS,S/SBAS2, in semi-immune adults in The Gambia. Am. J. Trop. Med. Hyg. 61, 865-868 (1999).
    • (1999) Am. J. Trop. Med. Hyg , vol.61 , pp. 865-868
    • Doherty, J.F.1    Pinder, M.2    Tornieporth, N.3
  • 27
    • 33747184555 scopus 로고    scopus 로고
    • Phase I safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya
    • Stoute JA, Heppner DG Jr, Mason CJ et al. Phase I safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya. Am. J. Trop. Med. Hyg. 75, 166-170 (2006).
    • (2006) Am. J. Trop. Med. Hyg , vol.75 , pp. 166-170
    • Stoute, J.A.1    Heppner Jr, D.G.2    Mason, C.J.3
  • 28
    • 0035830278 scopus 로고    scopus 로고
    • Bojang KA, Milligan PJ, Pinder M et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358, 1927-1934 (2001). •• First demonstration of efficacy trial of RTS,S/AS02A in an endemic country.
    • Bojang KA, Milligan PJ, Pinder M et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358, 1927-1934 (2001). •• First demonstration of efficacy trial of RTS,S/AS02A in an endemic country.
  • 29
    • 0037267842 scopus 로고    scopus 로고
    • Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific
    • Alloueche A, Milligan P, Conway DJ et al. Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific. Am. J. Trop. Med. Hyg. 68, 97-101(2003).
    • (2003) Am. J. Trop. Med. Hyg , vol.68 , pp. 97-101
    • Alloueche, A.1    Milligan, P.2    Conway, D.J.3
  • 30
    • 20444494911 scopus 로고    scopus 로고
    • Bojang KA, Olodude F, Pinder M et al. Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children. Vaccine 4(23), 4148-4157 (2005). • First demonstration of safety and immunogenicity of RTS,S/AS02A in children.
    • Bojang KA, Olodude F, Pinder M et al. Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children. Vaccine 4(23), 4148-4157 (2005). • First demonstration of safety and immunogenicity of RTS,S/AS02A in children.
  • 31
    • 5644228594 scopus 로고    scopus 로고
    • Alonso P, Sacarlal J, Aponte J et al. Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 364, 1411-1420 (2004). •• First demonstration of protective efficacy of RTS,S/AS02 in children.
    • Alonso P, Sacarlal J, Aponte J et al. Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 364, 1411-1420 (2004). •• First demonstration of protective efficacy of RTS,S/AS02 in children.
  • 32
    • 28844483001 scopus 로고    scopus 로고
    • Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: Single-blind extended follow-up of a randomized controlled trial
    • Alonso PL, Sacarlal J, Aponte JJ et al. Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomized controlled trial. Lancet 366, 2012-2018 (2005).
    • (2005) Lancet , vol.366 , pp. 2012-2018
    • Alonso, P.L.1    Sacarlal, J.2    Aponte, J.J.3
  • 33
    • 33749444615 scopus 로고    scopus 로고
    • Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A
    • Stewart VA, McGrath SM, Walsh DS et al. Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A. Vaccine 24(42-43), 6483-6492 (2006).
    • (2006) Vaccine , vol.24 , Issue.42-43 , pp. 6483-6492
    • Stewart, V.A.1    McGrath, S.M.2    Walsh, D.S.3
  • 34
    • 33644913115 scopus 로고    scopus 로고
    • A clinical trial of prime-boost immunization with the candidate malaria vaccines RTS,S/AS02A and MVA-CS
    • Dunachie SJ, Walther M, Vuola JM et al. A clinical trial of prime-boost immunization with the candidate malaria vaccines RTS,S/AS02A and MVA-CS. Vaccine 5(24), 2850-2859 (2006).
    • (2006) Vaccine , vol.5 , Issue.24 , pp. 2850-2859
    • Dunachie, S.J.1    Walther, M.2    Vuola, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.